This document covers therapeutic considerations related to pregnancy, lactation, and breastfeeding. It discusses changes in pharmacokinetics during pregnancy and outlines principles for drug selection. Common conditions in pregnancy like nausea/vomiting and hypertension are addressed. Teratogenic risks of medications are categorized by the FDA. Labor/delivery issues like preterm labor and induction are also covered. The document provides guidance on managing chronic conditions and breastfeeding safety based on infant drug exposure factors.
Our aim is to alleviate human suffering related to diabetes and its complications among those least able to withstand the burden of the disease. From 2002 to March 2017, the World Diabetes Foundation provided USD 130 million in funding to 511 projects in 115 countries. For every dollar spent, the Foundation raises approximately 2 dollars in cash or as in-kind donations from other sources. The total value of the WDF project portfolio reached USD 377 million, excluding WDF’s own advocacy and strategic platforms.
Our aim is to alleviate human suffering related to diabetes and its complications among those least able to withstand the burden of the disease. From 2002 to March 2017, the World Diabetes Foundation provided USD 130 million in funding to 511 projects in 115 countries. For every dollar spent, the Foundation raises approximately 2 dollars in cash or as in-kind donations from other sources. The total value of the WDF project portfolio reached USD 377 million, excluding WDF’s own advocacy and strategic platforms.
Polycystic Ovarian Syndrome is heterogeneous, multisystem endocrinopathy in women of reproductive age characterized by chronic anovulation resulting in infertility, irregular bleeding, obesity and hirsutism. Most common, although the least understood, cause of androgen excess. Initially it was described in 1935.Also known as Stein-Leventhal syndrome
The slide includes:
Introduction
Incidence
Pathophysiology
Pathology
Clinical features
Investigation
Treatment
Combined pill ,phased pill, post cotal pilla and mini pill.
Advantages and disadvantages with a note on adverse effects and contraindications of oral contraceptives with a note synthetic agents.
Drugs used in hormonal disorders supplementation etc.Abhay Rajpoot
The endocrine system is a chemical messenger system comprising feedback loops of the hormones released by internal glands of an organism directly into the circulatory system, regulating distant target organs.
Polycystic Ovarian Syndrome is heterogeneous, multisystem endocrinopathy in women of reproductive age characterized by chronic anovulation resulting in infertility, irregular bleeding, obesity and hirsutism. Most common, although the least understood, cause of androgen excess. Initially it was described in 1935.Also known as Stein-Leventhal syndrome
The slide includes:
Introduction
Incidence
Pathophysiology
Pathology
Clinical features
Investigation
Treatment
Combined pill ,phased pill, post cotal pilla and mini pill.
Advantages and disadvantages with a note on adverse effects and contraindications of oral contraceptives with a note synthetic agents.
Drugs used in hormonal disorders supplementation etc.Abhay Rajpoot
The endocrine system is a chemical messenger system comprising feedback loops of the hormones released by internal glands of an organism directly into the circulatory system, regulating distant target organs.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
2. Introduction
• Covers many complex issues that affect both
the mother and her child from planning for
pregnancy through lactation
• The duration of pregnancy is approximately
280 days
• Pregnancy is divided into three
periods/trimesters; each 3-months
3. Pharmacokinetic changes during
pregnancy
• Drug absorption during pregnancy may be
altered by delayed gastric emptying and
vomiting.
• An increased gastric pH may affect absorption
of weak acids.
• Higher estrogen and progesterone levels may
alter liver enzyme activity and increase
elimination of some drugs
4. PK…cont’d
• Maternal plasma volume, cardiac output, and
glomerular filtration increase by 30% to 50%
during pregnancy, possibly lowering the plasma
concentration of renally cleared drugs.
• Body fat increases; thus volume of distribution of
fat-soluble drugs may increase.
• Plasma albumin concentrations decrease; thus
volume of distribution of highly protein bound
drugs may increase.
• However, the net effect may not be affected
5. PK…cont’d
• Factors that determine placental transfer of
drugs
– Drug with molecular weights less than 500 daltons
cross readily while molecular weights greater than
1,000 daltons (e.g., insulin and heparin) do not
cross in significant amounts.
– Lipophilic drugs (e.g., opiates and antibiotics)
cross more easily than do water-soluble drugs
6. Teratogenic effect of drugs
• More than half of pregnant women take
prescription or nonprescription (over-the-
counter) drugs or use social drugs (such as
tobacco and alcohol) or illicit drugs at some
time during pregnancy.
• Drugs use during pregnancy should be
avoided unless absolutely necessary
7. Teratogenic effect…cont’d
• The incidence of congenital malformation is
approximately 3% to 5%, and about 2% to
3% of all birth defects are caused by
medication exposure.
• Adverse fetal drug effects depend on
– Dosage, route of administration
– Concomitant exposure to other agents
– Stage of pregnancy
8. Teratogenic effect…cont’d
• Exposure to the fetus in the first 2 weeks after
conception -“all or nothing” effect.
• Exposure during the period of organogenesis (18 to
60 days postconception) may result in structural
anomalies (e.g., methotrexate, cyclophosphamide,
diethylstilbestrol, lithium, retinoids, thalidomide,
certain antiepileptic drugs, and coumarin
derivative).
9. Teratogenic effect…cont’d
• Exposure after the period of organogenesis
may result in growth retardation, skeletal and
CNS abnormalities, or death (e.g., NSAIDs,
ACEIs and tetracycline)
10. Teratogenic effect…cont’d
Time Frame Possible Drug Effects Status of the Fetus
Within the first
2weeks after
fertilization
An ‘all-or-nothing’ effect
(death of the fetus or no
effect at all)
The fetus is highly
resistant to birth
defects.
3-8 weeks after
fertilization
Possibly no effect, A
miscarriage, An obvious
birth defect, A permanent
but subtle defect that is
noticed only later in life
The fetus's organs are
developing, making the
fetus particularly
vulnerable to birth
defects.
2nd and 3rd
trimesters
Changes in the growth and
function of normally
formed organs and tissue
Unlikely to cause obvious
birth defects Unknown
long-term effects
Organ development is
complete
11. FDA category for Teratogenic Effects of
Drugs
• Most widely used system to grade the
teratogenic effects of medications
• Categorizes medications by using a 5-letter
system: A, B, C, D, and X
• This safety category must be displayed on the
labels of all drugs
12. FDA category …cont’d
• Category A
• Adequate and well-controlled studies have
failed to demonstrate a risk to the fetus in the
first trimester of pregnancy (and there is no
evidence of risk in later trimesters).
• levothyroxine, folic acid
13. FDA category …cont’d
• Category B
• Animal reproduction studies have failed to
demonstrate a risk to the fetus and there are
no adequate and well-controlled studies in
pregnant women.
• metformin, hydrochlorothiazide, amoxicillin,
pantoprazole
14. FDA category …cont’d
• Category C
• Animal reproduction studies have shown an
adverse effect on the fetus and there are no
adequate and well-controlled studies in
humans, but potential benefits may warrant
use of the drug in pregnant women despite
potential risks.
• tramadol, gabapentin, prednisone,
Duloxetine, Tinidazole
15. FDA category …cont’d
• Category D
• There is positive evidence of human fetal risk
based on adverse reaction data from
investigational or marketing experience or studies
in humans, but potential benefits may warrant
use of the drug in pregnant women despite
potential risks.
• lisinopril, alprazolam, losartan, clonazepam,
lorazepam, Aminoglycosides, first-
generationAnticonvulsants, Aspirin, Atenolol,
Fluoxetine, Fluconazole, Tetracyclines
16. FDA category …cont’d
• Category X
• Studies in animals or humans have demonstrated fetal
abnormalities and/or there is positive evidence of
human fetal risk based on adverse reaction data from
investigational or marketing experience, and the risks
involved in use of the drug in pregnant women clearly
outweigh potential benefits.
• atorvastatin, simvastatin, warfarin, methotrexate,
flurazepam, temazepam, triazolam, oral
contraceptives, Misoprostol, Retinoids, Thalidomide
17. Drug selection during pregnancy
• Principles for selecting medications for use during
pregnancy include:
✓ Select drugs that have been used safely for long
periods of time.
✓ Prescribe doses at the lower end of the dosing range.
✓ Eliminate nonessential medication and discourage self-
medication.
✓ Avoid medications known to be harmful.
✓ Adjust doses to optimize health of mother while
minimizing risk to fetus.
18. Preconception planning
• Ingestion of folic acid by all women of
childbearing potential should be encouraged, as
it reduces the risk for neural tube defects.
– low risk should take 400 mcg/day throughout the
reproductive years
– high risk (e.g., those who take certain seizure
medications or who have had a previously affected
pregnancy) should take 4 mg/day
• Avoid use of alcohol, tobacco, and other
substances prior to pregnancy
19. Pregnancy induced illnesses
Constipation
• Nondrug modalities such as education,
physical exercise, and increased intake of
dietary fiber and fluid should be instituted
first.
• use of supplemental fiber with or without a
stool softener (Lactulose, sorbitol, bisacodyl,
or senna) is appropriate.
• Castor oil and mineral oil should be avoided
20. Gastroesophageal Reflux Disease
• lifestyle and dietary modifications such as small,
frequent meals; alcohol, tobacco, and caffeine
avoidance; food avoidance 3 hours before
bedtime; and elevation of the head of the bed.
• Drug therapy, if necessary, may be initiated with
aluminum, calcium, or magnesium antacids;
sucralfate; or cimetidine or ranitidine.
Lansoprazole, omeprazole, and metoclopramide
are also options
• Sodium bicarbonate and magnesium trisilicate
should be avoided
21. Hemorrhoids
• Hemorrhoids during pregnancy are common.
• Therapy includes high intake of dietary fiber,
adequate oral fluid intake;
• Topical anesthetics, skin protectants and
astringents may also be used.
• Treatment for refractory hemorrhoids includes
rubber band ligation, sclerotherapy, and
surgery
22. Nausea and Vomiting
• Up to 80% of all pregnant women experience some
degree of nausea and vomiting.
• Eating small, frequent meals; avoiding fatty foods
decreases N & V.
• Antihistamines (e.g., doxylamine), vitamins (e.g.,
pyridoxine, cyanocobalamin), anticholinergics (e.g.,
dicyclomine, scopolamine), dopamine antagonists
(e.g., metoclopramide). Ondansetron can be used
when other agents have failed, and ginger is
considered safe and effective.
• Dexamethasone or prednisolone have been effective
for hyperemesis gravidarum, but the risk of oral
clefts is increased
23. Gestational diabetes
• Screening for gestational diabetes mellitus utilizes
the oral glucose challenge test.
• Non pharmacologic: nutritional and exercise
interventions for all women, and caloric restrictions
for obese women
• If nutritional intervention fails therapy with
recombinant human insulin should be instituted;
24. Hypertension
• Hypertension during pregnancy includes
gestational hypertension (pregnancy-induced
hypertension without proteinuria),
preeclampsia (hypertension with proteinuria),
and chronic hypertension (diagnosed prior to
pregnancy with or without overlying
preeclampsia).
• Eclampsia, a medical emergency, is
preeclampsia with seizures.
25. Hypertension…cont’d
• For women at high risk for preeclampsia, low-
dose aspirin after 12 weeks’ gestation reduces
the risk for preeclampsia by 19%. Aspirin may
reduce the risk of preterm birth by 7% and
fetal or neonatal death by 16%.
• Calcium, 1 g/day, is recommended for all
pregnant women, as it may help prevent
hypertension in pregnant women and reduce
the risk of preeclampsia by 31% to 67%.
26. Hypertension…cont’d
• Commonly used drugs for hypertension in
pregnancy include methyldopa, labetalol, and
calcium channel blockers.
• ACEIs should be avoided throughout
pregnancy.
• Other drugs to avoid are magnesium sulfate
(except for eclampsia prevention and to treat
eclamptic seizures), high-dose diazoxide,
nimodipine, and chlorpromazine.
27. Venous Thromboembolism
• Risk factors for venous thromboembolism in
pregnancy include increasing age, history of
thromboembolism, hypercoagulable conditions,
operative vaginal delivery or cesarean section,
obesity, and a family history of thrombosis.
• low-molecularweight heparin or unfractionated
heparin should be used for the duration of
pregnancy and for 6 weeks after delivery.
• Warfarin should be avoided after the first 6
weeks of gestation
28. ACUTE CARE ISSUES IN PREGNANCY
HEADACHE
• Nonpharmacologic: -exercise, rest, reassurance,
ice packs, and massage.
• If drug therapy is needed, acetaminophen is the
first choice
• NSAIDs are contraindicated after 37 weeks’
gestation.
• For refractory migraines, narcotics may be used.
• Salicylates and indomethacin should be avoided
throughout pregnancy if possible.
• The use of sumatriptan is controversial.
29. Urinary tract infection
• Cephalexin is considered safe and effective.
• Nitrofurantoin should not be used after week 37 due
to concern for hemolytic anemia in the newborn.
• Sulfa-containing drugs may increase risk for kernicterus
in the newborn and should be avoided during the last
weeks of gestation.
• Folate antagonists, such as trimethoprim, are
relatively contraindicated during the first trimester
because of their association with cardiovascular
malformations.
• Fluoroquinolones and tetracyclines are
contraindicated
30. Sexually transmitted infections
Chlamydia
• The current recommendation for the
treatment of Chlamydia cervicitis is
azithromycin, 1 g orally as a single dose, or
amoxicillin, 500 mg three times daily for 7
days.
• Other options include erythromycin base or
ethylsuccinate.
31. Sexually transmitted…cont’d
Syphilis
• Penicillin is the drug of choice, and it is effective
for preventing transmission to the fetus. No
alternatives to penicillin are available for the
pregnant woman who is allergic to penicillin.
Neisseria gonorrhoeae
• The treatment of choice is ceftriaxone, 125 mg
intramuscularly (IM) as a single dose or cefixime,
400 mg orally in a single dose. Spectinomycin 2 g
IM as a single dose is appropriate as a second
choice.
32. Sexually transmitted…cont’d
Genital Herpes
• Acyclovir can be used safely. For valacyclovir and
famciclovir, safety data are more limited.
Bacterial Vaginosis
• The recommended regimen for treatment is
metronidazole, 500 mg twice daily for 7 days;
metronidazole, 250 mg three times daily for 7
days; or clindamycin, 300 mg twice daily for 7
days.
33. Management of chronic diseases
during pregnancy
EPILEPSY
• Malformations occur in 6% to 20% of pregnancies
affected by epilepsy.
• Major malformations occur in 4% to 6% of the
offspring of women taking benzodiazepines,
carbamazepine, phenobarbital, phenytoin, or valproic
acid.
• Ways to minimize teratogenic risk
– Drug therapy should be optimized prior to conception
– Antiepileptic drug monotherapy is recommended
– All women with epilepsy should take a folic acid
supplement, 0.4 to 5 mg daily
– Women should take 10 mg oral vitamin K1 daily during the
last month of gestation
34. HIV/AIDS
• Pregnant women should start ART regardless of CD4
count or stage
• TDF + 3TC + EFV is recommended as first-line ART in
pregnant women the first trimester of pregnancy
• Infants of mothers who are receiving ART and are
breastfeeding should receive six weeks of infant
prophylaxis with daily NVP.
35. Depression
• If antidepressants are used, the lowest
possible dose should be used for the shortest
possible time to minimize adverse fetal and
maternal pregnancy outcomes.
36. Labor and delivery
Preterm Labor
• labor before 37 weeks of gestation
• Tocolytic Therapy
– To postpone delivery long enough to allow for
administration of antenatal corticosteroids
– Magnesium sulfate, β-adrenergic agonists (terbutaline),
NSAIDs, and calcium channel blockers (nifedipine)
• Antenatal Glucocorticoids
– For fetal lung maturation to prevent respiratory distress
syndrome, intraventricular hemorrhage, and death in
infants delivered prematurely
– betamethasone, 12 mg IM every 24 hours for two doses,
or dexamethasone, 6 mg IM every 12 hours for four doses
37. Cervical ripening and labor induction
• For cervical ripening: Prostaglandin E2 analogs
(e.g., dinoprostone) is the most commonly
used.
• Misoprostol, a prostaglandin E1 analog is used
effective for cervical ripening and labor
induction
• Oxytocin is the most commonly used agent
for labor induction after cervical ripening.
38. Labor analgesia
• The IV or IM administration of parenteral
narcotics (meperidine, morphine, fentanyl) is
commonly used to treat the pain associated
with labor
39. Drug use during breast feeding
• Factors that can affect medications entry into
breast milk:
– Molecular weights
– Lipid solubility
– Ionization
– Protein binding
– Concentration of drug in the mother’s serum
– Timing and frequency of feedings
40. Drug use during breast feeding…
• Medications enter breast milk via passive
diffusion
– Nonionized and non–protein-bound medication
can enter into the milk
41. Drug use during breast feeding…
• Principles for selecting medications during
breastfeeding
– Select medications for the mother that is safe for
use in the infant
– Choose medications with shorter half-lives
– Select those that are more protein bound, have
lower bioavailability, and have lower lipid
solubility