This document discusses strategies for optimizing cord blood unit selection and transplantation outcomes. It begins by outlining factors that determine transplant success, including patient characteristics, disease biology, and stem cell source. It then examines how to select optimal cord blood units based on dose, quality, and donor-recipient HLA matching. The rest of the document explores ways to improve outcomes, such as selecting units based on high-resolution 8/8 allele matching, and considering double unit transplantation. It also reviews strategies to speed engraftment beyond optimal unit selection, such as ex vivo expansion and adding third-party cells.
HIV Alert:Emerging Updates on Dual Therapy.2018hivlifeinfo
In this downloadable slideset, Joseph J. Eron, Jr., MD, and Babafemi Taiwo, MBBS, provide expert insight into the use of a recently-approved dual-therapy regimen and review data surrounding investigational two-drug regimens.
Format: Microsoft PowerPoint (.ppt)
File size: 375 KB
Date posted: 1/5/2018
From Alzahra Oncology Center in Dubai, in the heart of Middle East lead by Dr Sadir Alrawi AMERICAN boarded, minimal invasive surgery, with Dr Thamir Alkasab, Khaled Koutech and Dr Ziad Aluobiadi
HIV Alert:Emerging Updates on Dual Therapy.2018hivlifeinfo
In this downloadable slideset, Joseph J. Eron, Jr., MD, and Babafemi Taiwo, MBBS, provide expert insight into the use of a recently-approved dual-therapy regimen and review data surrounding investigational two-drug regimens.
Format: Microsoft PowerPoint (.ppt)
File size: 375 KB
Date posted: 1/5/2018
From Alzahra Oncology Center in Dubai, in the heart of Middle East lead by Dr Sadir Alrawi AMERICAN boarded, minimal invasive surgery, with Dr Thamir Alkasab, Khaled Koutech and Dr Ziad Aluobiadi
Michael Davies, MD, PhD discusses where we go from here in the melanoma field to conclude the 2017 MD Anderson Melanoma Patient Symposium held in Austin, TX on May 6, 2017.
Stereotactic radiation requires precision and accuracy to treat patients safely. With a couch surface that can tilt in 6 directions, treatment can be given with less difficult, more quickly and more safely.
A charity, Golf Fights Cancer, is generously supporting Lowell General Hospital in making this 6 degree of freedom couch available to help my patients. Thank you to everyone who attended the Good Guys Invitational!
The management of painful bone metastases requires multidisciplinary care, with external beam radiation therapy (EBRT) providing relief that is effective and time efficient.
In our study the efficacy of external beam irradiation in the palliation of bone metastasis-related symptoms is confirmed by this study, even with short treatments and single-dose administrations. This is important for both patient expectations and the necessity for improved resource allocation with reference to the territorial distribution and waiting lists of radiotherapy centers. The issue of their efficacy in combination with antiblastic drugs (Bisphosphonates drugs such as Zoledronic acid) and/or external beam irradiation(EBRT) remains open and will be clarified only with further randomized clinical trials.
Hydrogel use in prostate cancer radiation therapyMatthew Katz
Hydrogel use represents a technical advance in trying to decrease the risk of treatment toxicity in prostate cancer radiation therapy. I presented this talk at the Fall Conference of the Southern NH chapter of Oncology Nursing Society yesterday.
Michael Davies, MD, PhD discusses where we go from here in the melanoma field to conclude the 2017 MD Anderson Melanoma Patient Symposium held in Austin, TX on May 6, 2017.
Stereotactic radiation requires precision and accuracy to treat patients safely. With a couch surface that can tilt in 6 directions, treatment can be given with less difficult, more quickly and more safely.
A charity, Golf Fights Cancer, is generously supporting Lowell General Hospital in making this 6 degree of freedom couch available to help my patients. Thank you to everyone who attended the Good Guys Invitational!
The management of painful bone metastases requires multidisciplinary care, with external beam radiation therapy (EBRT) providing relief that is effective and time efficient.
In our study the efficacy of external beam irradiation in the palliation of bone metastasis-related symptoms is confirmed by this study, even with short treatments and single-dose administrations. This is important for both patient expectations and the necessity for improved resource allocation with reference to the territorial distribution and waiting lists of radiotherapy centers. The issue of their efficacy in combination with antiblastic drugs (Bisphosphonates drugs such as Zoledronic acid) and/or external beam irradiation(EBRT) remains open and will be clarified only with further randomized clinical trials.
Hydrogel use in prostate cancer radiation therapyMatthew Katz
Hydrogel use represents a technical advance in trying to decrease the risk of treatment toxicity in prostate cancer radiation therapy. I presented this talk at the Fall Conference of the Southern NH chapter of Oncology Nursing Society yesterday.
Dr. Manuel Hidalgo - Simposio Internacional ' Terapias oncológicas avanzadas'Fundación Ramón Areces
Los días 15 y 16 de octubre de 2014, la Fundación Ramón Areces y la Real Academia Nacional de Farmacia, en colaboración con la Fundación de la Innovación Bankinter, reunieron en Madrid a algunos de los mayores expertos mundiales en nuevas terapias contra el cáncer. El Simposio Internacional, coordinado por la profesora y académica María José Alonso, analizó el momento actual de la lucha contra esta enfermedad. También fue un punto de encuentro para científicos de los más innovadores institutos de investigación en oncología, quienes debatieron sobre tres grandes temas: la Medicina Personalizada contra el cáncer, los nanomedicamentos en la terapia del cáncer y las terapias basadas en la inmunomodulación.
Report Back from San Antonio Breast Cancer Symposium: Spotlight on MBCbkling
Dr. Virginia Kaklamani, Leader of the Breast Cancer Program at UT Health San Antonio MD Anderson Cancer Center, will share her biggest takeaways from the latest research presented at the San Antonio Breast Cancer Symposium (SABCS) 2019 with a focus on metastatic breast cancer.
HIV Alert:Новые стратегии и агенты в лечении ВИЧ/Novel Strategies and Agents ...hivlifeinfo
HIV Alert-Новые стратегии и агенты в лечении ВИЧ/Novel Strategies and Agents for HIV Management.2017
In this downloadable slideset, Daniel R. Kuritzkes, MD, and Paul E. Sax, MD, review potential future HIV treatment strategies—including dual-therapy regimens, long-acting ART, and investigational agents—and discuss where these might fit into the current therapeutic landscape.
Format: Microsoft PowerPoint (.ppt)
File size: 570 KB
Date posted: 9/27/2017
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Honest Reviews of Tim Han LMA Course Program.pptxtimhan337
Personal development courses are widely available today, with each one promising life-changing outcomes. Tim Han’s Life Mastery Achievers (LMA) Course has drawn a lot of interest. In addition to offering my frank assessment of Success Insider’s LMA Course, this piece examines the course’s effects via a variety of Tim Han LMA course reviews and Success Insider comments.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Donor Selection: Cord Blood. Prof Elizabeth J Shpall
1. ELIZABETH J SHPALL, MD
Houston, USA
• Professor of Medicine and Chair of Cord Blood Transplant
Program, UT MD Anderson Cancer Center
• As a nationally recognized expert in stem cell
transplantation, Medical Director of the GMP Cell Therapy
Laboratory since 2002, and the Director of the Cord Blood
Bank (CBB) at M. D. Anderson Cancer Center since 2004,
Dr. Shpall's research covers a range of applications, among
them: leukemia, lymphoma treatment, anti-tumor
immunity enhancement, and tissue repair. Dr. Shpall’s
influence is felt beyond the Texas Medical Center. She is the
current vice-president of FACT Netcord, having chaired their
Cord Blood Standards Committee since 1999, and she was
the founding president and has been a board member of
the Foundation Accreditation of Hematopoietic Cell Therapy
since 1995.
5. Double Unit CBT: Why Does One Unit Win?
Interplay of hematopoietic potential
of each unit &
unit vs unit immune interactions
(T-cell mediated). Association with higher
infused CD3+ dose.
As important: what determines
engraftment success in patients?
Barker, Blood 2005; Scaradavou, BBMT
2010;
Eldjerou, Blood 2011; Avery, Blood 2011
6. MSKCC: Neut Engraftment after dCBT (n = 92)
0.00.20.40.60.81.0
Days Post-Transplant
CumulativeIncidence
0 10 20 30 40
• Engraftment mediated by 1 unit
• High rates of sustained donor engraftment.
Children: 93%
@ median 20 days
(range 12-33) Adults: 95%
@ median 25 days
(range 13-43)
Barker et al, unpublished 2013
Median inf. TNC:
Peds 4.4 + 2.9,
Adults 2.7 + 2.0
7. dCBT DFS in Engrafting Adults by Speed of
Neutrophil Recovery: Day 45 Landmark Analysis
P = 0.02
0.00.20.40.60.81.0
Months Post-Transplant
DFS
45 days 6 12 18 24
Neut. recovery < 25 days (n = 32):
84% (95%CI: 72-98)
Neut. recovery > 25 days (n = 29):
54% (95%CI: 39-76)
Marked survival advantage if rapid engraftment
Barker et al, unpublished,
8. PROBLEM:
Delayed or failed engraftment
increased TRM
SOLUTIONS
• Ex vivo
expansion
• 3rd party cells
• Facilitate homing
• Improved
unit
selection*
Traditional criteria: TNC dose –
can we do better?
11. Pre-freeze CD34+ count
Post-thaw CD34+ recovery
CD34+ viability*
What Determines
Infused Viable CD34+ Cell Dose
and
Can it be Predicted at Unit Selection?:
* Tested at MSKCC by flow cytometry & 7-AAD
exclusion
Purtill et al, Blood 2014
12. Median viability: 92% (34-99%)
< 75% viability: n = 33 (8%)
Post-thawtotalCD34+cellcount
Post-thaw CD34+ Cell Recovery & Viability
Bank pre-freeze total CD34+ cell count
< 75% viability
Purtill et al, Blood 2014
15. 10957303650
CIofTransplant-RelatedMortality
Years Post-Transplant
2 MM/ TNC <2.5
2 MM/ TNC ≥5.0
2 MM/ TNC 2.5-4.9
1 MM/ TNC 2.5-4.9
1 MM/ TNC <2.5
1 MM/ TNC ≥5.0
80
100
20
40
60
0 1 2 3
0 MM (all doses, mean TNC
4.4)
Any 6/6 Unit: Superior to 5/6 >2.5, or 4/6 >5.0
Barker et al, Blood 2010
TRM after Single Unit Ablative CBT (n=1061):
Better HLA-Match Compensates for Lower Dose
16. 8 Allele Donor-Recipient HLA-Match
NumberofCBUnits(CBU)
High resolution typing permits selection of better
matched units.
Dahi et al, BMT 2014
8 Allele Donor-Recipient HLA-Match
Eg 4/6 units: 2/8 - 6/8
17. Eapen et al, Blood 2013
CIBMTR: 3-Year TRM by 3-8/8 HLA-match
after Single Unit CBT (n = 1,568)
Donor-recipient allele match is critical. 8/8 units very good.
Problem: how low can you go? MSKCC median: 5/8
18. 20
40
60
80
100
0
4-6/6 Allele
1-3/6 Allele
Months Post-Transplant
0
100
80
60
40
20
0
1-7/10 Allele
8-9/10 Allele
1 2 3 4 5 6 0 1 2 3 4 5 6
Ponce, D., BBMT 2013
Gr. III-IV Acute GVHD after DCBT
by Winning Unit HLA-Allele Match to Patient (n = 115)
HLA-allele match of winning unit to patient is important.
20. 100
0
20
40
60
80
Probability,%
Months 0 3 6 9 12
Double CBT: 64% (54 – 72)
Single CBT: 68% (58 –
76)
BMT CTN 0501 Pediatric Ablative Randomized
Trial: 1-Yr Disease-free Survival
P = 0.22
Wagner et al, NEJM 2014
Ped. myeloablative CBT: don’t need DCBT?
Median cryo. TNC (x107per Kg):
singles 4.8, doubles 8.9.
21. 2-year DFS after RIC CBT in Adult Acute
Leukemia - CR1
P = 0.03
In multivariate
analysis,
double CBT
associated
with improved
DFS (p = 0.04).
Advantage
attributed
to reduced
relapse risk
Double CBT (n = 136):
51 ± 5%
Single CBT (n = 76):
32 ± 3%
Slide courtesy of
V. Rocha, 2013
22. Loser TNC > 3.0 (n = 36)
Median ANC 19 days
(Median dominant CD34+ 1.28)
Loser TNC < 2.0 (n = 37)
Median ANC 27 days
(Median dominant CD34+ 0.80)
Loser TNC 2.0 - 3.0 (n =56)
Median ANC 25 days
(Median dominant CD34+ 0.89)
p =
0.001
MSKCC dCBT Engraftment (n = 129) by
Losing Unit TNC Dose: High, Middle or Low
Purtill, ASH 2014
23. Graft Variable
Multivariate
HR (95%CI) p value
Dominant unit viable
CD34+ cell dose (continuous)
1.72
(1.41-2.10) < 0.001
Dominant unit % viable
CD34+ cells (by decile)
1.31
(1.03-1.65) 0.026
Non-dominant unit
TNC dose (continuous)
1.19
(1.01-1.40) 0.035
MSKCC dCBT: Role of Non-Dominant Unit
(n = 129 myeloablative transplants)
Purtill, ASH 2014 (manuscript submitted
Winner determines speed & success of engraftment,
but non-dominant unit has facilitation effect.
Most pronounced if winning unit has low CD34+ dose: loser has
role in overcoming allogeneic barrier to engraftment.
24. A B
Double CBT: HLA matching between the dominant CB
unit and the recipient by standard criteria and high
resolution typing at (A) HLA –A, -B, andDRB1 (B) HLA –
A, -B, C andDRB1
0
5
10
15
20
25
30
35
40
45
No
4/6, n=72 5/6, n=53 6/6, n=8
HLA matching by standard criteria
3-4/8
5-6/8
7-8/8
0
10
20
30
40
50
60
No
4/6, n=72 5/6, n=53 6/6, n=8
HLA matching by standard criteria
2-3/6
4/6
5-6/6
Oran et al, submitted
25. 0 3 6 9 12 15 18 21 24
Time (months)
0.0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1.0
High Risk
Intermediate Risk
Low Risk
Treatment Related Mortality Disease-Free Survival
0 3 6 9 12 15 18 21 24
Time (Months)
0.0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1.0
High Risk
Low Risk
Intermediate Risk
Molecular HLA matching defined three risk groups
Low: 7-8/8
Intermediate: 5-6/8
High Risk: 3-4/8
Oran et al.
26. Strategy Investigator Comments
Single Unit Graft
IBMI Frassoni Lancet Oncol 2008 Abandoned by U of MN.
sCBT + Haplo Van Besien Blood 2011 ATG based
Sitagliptin Broxmeyer Nat. Med. 2012 DDP4 inhibitor in Ph.II
Double Unit Graft
Notch Delaney Nat. Med. 2010
Now moved to 3rd party.
Problem-rejection.
Mesoblast Shpall NEJM 2012 Logistics.
Gamida: NiCord Horwitz JCI 2014 Logistics. Add back T-cells
Novartis: SR1 Wagner ASH 2014 Logistics. Add back T-cells
Endothelial
based expansion Rafii Blood 2013 No clinical data yet
PGE2 Cutler Blood 2013 Short incubation
Fucosylation Shpall Exp Hematol 2012 Short incubation
dCBT + Haplo Barker ASH 2013, 2014
No ATG: haplo can be
rejected
Speeding Engraftment Beyond Unit Selection