This study evaluated the use of a new ulcer cleansing system and platelet gel in treating non-healing leg ulcers in elderly patients. 16 patients with 27 lesions were treated. Objective measures like wound area, pain, and exudate levels all significantly improved after treatment. Quality of life scores also increased. The cleansing system effectively removed debris from wounds before application of autologous platelet gel, which promoted wound healing. This multi-center observational study suggests the combined treatment may help accelerate healing of hard-to-treat leg ulcers in elderly patients.

1. USE
OF
A
NEW
ULCER
CLEANSING
SYSTEM
AND
OF
PLATELET
GEL
IN
THE
MANAGEMENT
OF
“NON
HEALING”
LEG
ULCERS
IN
ELDERLY
PALUMBO
F.P.1
–
SERANTONI
S.2
–
ABBRITTI
F.3
–
MAZZOLA
G.
4-­‐
FAILLA
G.5-­‐
DI
SALVO
M.M.5
1
–
LABORATORIO
DI
VULNOLOGIA
–
PALERMO
2
–
CASA
DI
CURA
“VILLA
FIORITA”
–
PRATO
3
–
U.O.
CHIRURGIA
VASCOLARE
–
A.O.
G.
SALVINI,
GARBAGNATE
MILANESE
4
–
U.O.
MEDICINA
TRASFUSIONALE
–
A.O.U.
POLICLINICO,
PALERMO
5
-­‐
U.O.
ANGIOLOGIA
–
A.O.U.
VITTORIO
EMANUELE
–
“FERRAROTTO”,
CATANIA

2. USE OF A NEW ULCER CLEANSING SYSTEM AND OF PLATELET GEL IN THE
MANAGEMENT OF “NON HEALING” LEG ULCERS IN ELDERLY
Age: 74 - 92 years Average age 81,6 yy
AETIOLOGY
Venous 5
Arterial 2
Mixed 3
Vasculitis 3
Diabetic 3
A
new
technological
advanced
device
was
tested
on
27
lesions
selected
in
16
paTents
in
a
mulTcentric
observaTonal
study.
PALUMBO F.P. – SERANTONI S. – ABBRITTI F.– MAZZOLA G.- FAILLA G.- DI SALVO M.M.
0
2
4
6
8
10
6
10
MALES
FEMALES

3. METHODS
All
paTents
underwent
to
an
anamnesTc
and
clinical
and
instrumental
evaluaTon
(when
required).
Data
were
collected
using
a
schedule
to
detect
wound
characterisTcs.
QL
index
was
administred
to
all
paTents.
In
selected
paTents,
a
mulTlayer,
mulTcomponent,
inelasTc
bandage
was
applied.
Ulcer
Cleansing
System
Device
was
administred
before
platelet
gel
applicaTon.
Autologous
PLT
Gel
was
administred
in
14
paTents.
Only
in
2
paTents
homologous
PLT
Gel
was
administred.
PaTents
were
selected
according
to
condiTons
of
the
injury
at
Tme
T0,
regardless
of
Tme
of
onset
and
treatment
prior
to
enrollment
date.
Criteria
exclusion:
severe
infected
lesions.
PALUMBO F.P. – SERANTONI S. – ABBRITTI F.– MAZZOLA G.- FAILLA G.- DI SALVO M.M.
USE OF A NEW ULCER CLEANSING SYSTEM AND OF PLATELET GEL IN THE
MANAGEMENT OF “NON HEALING” LEG ULCERS IN ELDERLY

4. USE
OF
A
NEW
SURFACTANT
GEL
WITH
SILVER
SULPHADIAZINE
IN
THE
TREATMENT
OF
CHRONIC
LEG
ULCERS
AND
DIABETIC
FOOT:
ITALIAN
MULTICENTRIC
EXPERIENCE
ULCERS
AREA
PLANIMETRIC
METHOD
PAIN
VISUAL
SCALE
EXUDATE
N.
DRESSING
CHANGE/WEEK
QUALITY
OF
LIFE
INDEX
(QL)
ACTIVITY,
DAILY
LIVING,
HEALTH,
SUPPORT,
OUTLOOK
PALUMBO F.P. – SERANTONI S. – ABBRITTI F.– MAZZOLA G.- FAILLA G.- DI SALVO M.M.
USE OF A NEW ULCER CLEANSING SYSTEM AND OF PLATELET GEL IN THE
MANAGEMENT OF “NON HEALING” LEG ULCERS IN ELDERLY

5. USE
OF
A
NEW
SURFACTANT
GEL
WITH
SILVER
SULPHADIAZINE
IN
THE
TREATMENT
OF
CHRONIC
LEG
ULCERS
AND
DIABETC
FOOT:
ITALIAN
MULTICENTRIC
EXPERIENCE
RESULTS
In
all
almost
paTents
an
improvement
of
obiecTve
data
was
observed.
ReducTon
of
exudaTon
and
of
inflamaTon
in
the
skin
around
the
ulcers
were
observed
since
the
first
week
of
gel
applicaTon.
These
were
accompanished
by
reducTon
of
average
wound
areas
and
of
pain.
Also
malodour
decreased
since
the
first
week.
Some
paTents
have
reported
the
occurrence
of
burning
in
the
first
two
days
of
applicaTon
of
platelet
gel.
PALUMBO F.P. – SERANTONI S. – ABBRITTI F.– MAZZOLA G.- FAILLA G.- DI SALVO M.M.
USE OF A NEW ULCER CLEANSING SYSTEM AND OF PLATELET GEL IN THE
MANAGEMENT OF “NON HEALING” LEG ULCERS IN ELDERLY

6.
USE
OF
A
NEW
SURFACTANT
GEL
WITH
SILVER
SULPHADIAZINE
IN
THE
TREATMENT
OF
CHRONIC
LEG
ULCERS
AND
DIABETIC
FOOT:
ITALIAN
MULTICENTRIC
EXPERIENCE
PAIN
WOUND
AREAS
0
5
10
15
20
25
30
t0
t1
29,2
20,1
0
1
2
3
4
5
6
7
t0
t1
6,6
2,7
PALUMBO F.P. – SERANTONI S. – ABBRITTI F.– MAZZOLA G.- FAILLA G.- DI SALVO M.M.
USE OF A NEW ULCER CLEANSING SYSTEM AND OF PLATELET GEL IN THE
MANAGEMENT OF “NON HEALING” LEG ULCERS IN ELDERLY
-­‐
59,9
%
-­‐
31,1
%

7. USE
OF
A
NEW
SURFACTANT
GEL
WITH
SILVER
SULPHADIAZINE
IN
THE
TREATMENT
OF
CHRONIC
LEG
ULCERS
AND
DIABETIC
FOOT:
ITALIAN
MULTICENTRIC
EXPERIENCE
QL-­‐INDEX
EXUDATE
PALUMBO F.P. – SERANTONI S. – ABBRITTI F.– MAZZOLA G.- FAILLA G.- DI SALVO M.M.
USE OF A NEW ULCER CLEANSING SYSTEM AND OF PLATELET GEL IN THE
MANAGEMENT OF “NON HEALING” LEG ULCERS IN ELDERLY
0
0,5
1
1,5
2
2,5
3
3,5
t0
t1
3,4
1,3
8,2
8,4
8,6
8,8
9
9,2
9,4
9,6
9,8
t0
t1
8,8
9,7
-­‐61,7%
10,2%

8. USE
OF
A
NEW
SURFACTANT
GEL
WITH
SILVER
SULPHADIAZINE
IN
THE
TREATMENT
OF
CHRONIC
LEG
ULCERS
AND
DIABETIC
FOOT:
ITALIAN
MULTICENTRIC
EXPERIENCE
PALUMBO F.P. – SERANTONI S. – ABBRITTI F.– MAZZOLA G.- FAILLA G.- DI SALVO M.M.
USE OF A NEW ULCER CLEANSING SYSTEM AND OF PLATELET GEL IN THE
MANAGEMENT OF “NON HEALING” LEG ULCERS IN ELDERLY
Cleansing of a pressure ulcer in a patient affected of PAD by device and application of PLT Gel. After 2 weeks
growth of proliferative tissue.
Cleansing of an ulcer occurring in a woman affected of thrombocytemia and application of PLT Gel.

9. USE
OF
A
NEW
SURFACTANT
GEL
WITH
SILVER
SULPHADIAZINE
IN
THE
TREATMENT
OF
CHRONIC
LEG
ULCERS
AND
DIABETIC
FOOT:
ITALIAN
MULTICENTRIC
EXPERIENCE
DISCUSSION
The
aim
of
the
study
was
to
verify
the
effecTveness
a
new
system
of
debridment
using
a
soluTon
based
on
poloxamer
and
moisturisers
like
aloe
vera.
Cleansing
and
debridment,
obtained
with
a
tovel
soaked
in
this
liquid,
was
followed
immediately
by
a
feeling
of
freshness
even
on
very
exuding
and
inflamed
ulcers.
The
applicaTon
of
platelet
gel
in
some
paTent
was
followed
by
the
onset
of
burning
of
vaTable
duraTon
from
a
few
hours
up
to
two
days.
Since
the
first
two
applicaTons
it
was
observed
a
decrease
of
exudate
and
dressing
changes
to
the
reducTon
of
inflamaTon
of
the
Tssue
surrounding
the
wound.
Also
the
bad
odor
was
reduced
unTl
the
disappareance
and
this
has
improved
the
social
life
of
the
elderly
subjects.
The
handling
and
ease
of
use
of
the
new
debridment
system
has
considerably
shortened
Tme
of
PLT
gel
applicaTon.
PALUMBO F.P. – SERANTONI S. – ABBRITTI F.– MAZZOLA G.- FAILLA G.- DI SALVO M.M.
USE OF A NEW ULCER CLEANSING SYSTEM AND OF PLATELET GEL IN THE
MANAGEMENT OF “NON HEALING” LEG ULCERS IN ELDERLY

10. USE
OF
A
NEW
SURFACTANT
GEL
WITH
SILVER
SULPHADIAZINE
IN
THE
TREATMENT
OF
CHRONIC
LEG
ULCERS
AND
DIABETIC
FOOT:
ITALIAN
MULTICENTRIC
EXPERIENCE
AKNOWLEDGEMENTS
A
SPECIAL
THANKS
TO
DR.
ELSA
LO
IACONO
AND
DR.
ELENA
PATORNO
FOR
THE
PREPARATION
OF
DATA
ON
PATIENTS.
PALUMBO F.P. – SERANTONI S. – ABBRITTI F.– MAZZOLA G.- FAILLA G.- DI SALVO M.M.
USE OF A NEW ULCER CLEANSING SYSTEM AND OF PLATELET GEL IN THE
MANAGEMENT OF “NON HEALING” LEG ULCERS IN ELDERLY
CONCLUSIONS
In
almost
all
cases
we
observed
an
improvement
in
the
wounds,
indicated
by:
§ Regression
of
signs
of
inflamaTon;
§ ReducTon
of
exudate
and
fibrin;
§ ReducTon
of
pain
assessed
by
the
paTents;
§ Good
compliance
at
dressing
change;
§ ReducTon
of
malodour;
§ Improving
QL-­‐Index
rate.
These
result
suggest
that
a
good
bed
wound
preparaTon
is
important
to
the
next
PLT
gel
acTon,
No
collateral
effects
and
complicaTons
were
reported
in
all
paTents: