This document describes the treatment of a 68-year-old woman undergoing dialysis who developed a severe peristomal complication after surgery for sigmoid colon-rectum resection. She developed a fistula connecting the peristomal wound to the laparotomy incision. The patient was treated with surgical debridement followed by application of negative pressure wound therapy and a protective drainage sheet for 32 days. This combined treatment successfully managed the exposed peristomal tissue, healed the dehiscence without further complications, and protected the bowel loop, resolving the issue within 40 days.