- Flushing unused pharmaceuticals is not recommended by the FDA, EPA, or other organizations due to concerns about contaminating water supplies. Trace amounts of drugs have been found in streams, rivers, and drinking water. - The FDA only recommends flushing a small number of drugs that could cause harm if ingested. For most drugs, the recommended disposal method is to throw them in the trash mixed with an undesirable substance like kitty litter. - Take-back programs, drug collection sites, and hazardous waste facilities are better options than flushing or throwing drugs in the trash if available in your area. Proper disposal helps protect water quality and the environment.