31 Dr Ahmed Esawy imaging oral board of chest imaging (brachial plexus ,MRI lung cancer) part VIII
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31 dr ahmed esawy imaging oral board of chest imaging (brachial plexus ,mri lung cancer) part viii include different cases for oral radiodiagnosis examination all over the world CT /MRI Plain X ray images traumatic brachial plexus injury brachial plexus infiltration neurofibroma thoracic outlet syndrome MRI lung technique MRI lung cancer
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30 Dr Ahmed Esawy imaging oral board of chest imaging (variety C) part VII
30 dr ahmed esawy imaging oral board of chest imaging (variety c) part vii
include different cases for oral radiodiagnosis examination all over the world
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28 Dr Ahmed Esawy imaging oral board of chest imaging (variety) part VI
28 dr ahmed esawy imaging oral board of chest imaging (variety) part vi
include different cases for oral radiodiagnosis examination all over the world
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lung metastases
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29 Dr Ahmed Esawy imaging oral board of chest imaging (variety B) part VII
29 dr ahmed esawy imaging oral board of chest imaging (variety b) part vii
include different cases for oral radio diagnosis examination all over the world
CT /MRI Plain X ray images
PNEUMATOCELE
PNEUMOCYSTIC CARINI
EMPYEMA
LUNG CARCINOMA
Obstetric brachial plexus injury (OBPI)
My seminar While Pursuing Master of Physiotherapy (MPT) at Manipal University
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30 Dr Ahmed Esawy imaging oral board of chest imaging (variety C) part VII
30 dr ahmed esawy imaging oral board of chest imaging (variety c) part vii
include different cases for oral radiodiagnosis examination all over the world
CT /MRI Plain X ray images
right middle lobe syndrome
pneumocystis carini
empyema
pneumonia
scleroderma
28 Dr Ahmed Esawy imaging oral board of chest imaging (variety) part VI
28 dr ahmed esawy imaging oral board of chest imaging (variety) part vi
include different cases for oral radiodiagnosis examination all over the world
CT /MRI Plain X ray images
lung collpase
lung carcinoma
lung metastases
vasculitis
29 Dr Ahmed Esawy imaging oral board of chest imaging (variety B) part VII
29 dr ahmed esawy imaging oral board of chest imaging (variety b) part vii
include different cases for oral radio diagnosis examination all over the world
CT /MRI Plain X ray images
PNEUMATOCELE
PNEUMOCYSTIC CARINI
EMPYEMA
LUNG CARCINOMA
Obstetric brachial plexus injury (OBPI)
My seminar While Pursuing Master of Physiotherapy (MPT) at Manipal University
Brachial plexus anatomy, diagnosis and orthopaedic treatment
Brachial plexus lesion, diagnosis and management
How does it occur,Erb klumpke.
MAnagement, surgeries etc
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An detailed Lumbar & Sacral Plexus with Muscles and nerves supply to lower limb. lower limb Muscles action and clinical anatomy "Sciatica".
Brachial plexus - Made so Easy
Brachial plexus is one of the tough topic to remember by anyone undergoing MBBS course. This slide gives you in detail about the Origin / Course / Formation / Distribution / Anatomical variations & Applied anatomy & Made so easy to Remember & Draw as well.
Breast cyst imaging
Breast mammogram ultrasound lipoma, oil cyst, galactocele intramammary lymph node in UOQ hamartoma Simple cyst (typical) calcification Surgical scar Breast implants, scirrhous carcinoma lobular carcinoma Skin calcifications vascular calcifications Sutural Dystrophic popcorn Large Rodlike rim Round/punctuate Fat necrosis Milk of calcium Fibrocystic FCC fibroadenomas Fat necrosis with oil cyst mastitis with Abscess Haematoma atypical ductal hyperplasia Intracystic papilloma ductal carcinoma in situ, invasive ductal carcinoma BIRAD
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Breast mammogram ultrasound lipoma, oil cyst, galactocele intramammary lymph node in UOQ hamartoma Simple cyst (typical) calcification Surgical scar Breast implants, scirrhous carcinoma lobular carcinoma Skin calcifications vascular calcifications Sutural Dystrophic popcorn Large Rodlike rim Round/punctuate Fat necrosis Milk of calcium Fibrocystic FCC fibroadenomas Fat necrosis with oil cyst mastitis with Abscess Haematoma atypical ductal hyperplasia Intracystic papilloma ductal carcinoma in situ, invasive ductal carcinoma BIRAD
Breast duct ectasia us mammogram mri
Breast mammogram ultrasound lipoma, oil cyst, galactocele intramammary lymph node in UOQ hamartoma Simple cyst (typical) calcification Surgical scar Breast implants, scirrhous carcinoma lobular carcinoma Skin calcifications vascular calcifications Sutural Dystrophic popcorn Large Rodlike rim Round/punctuate Fat necrosis Milk of calcium Fibrocystic FCC fibroadenomas Fat necrosis with oil cyst mastitis with Abscess Haematoma atypical ductal hyperplasia Intracystic papilloma ductal carcinoma in situ, invasive ductal carcinoma BIRAD
Comparison between ct mri in ischemic stroke
Comparison between ct MRI in ischemic stroke .1-Definition
2-Pathology
3-Vascular territory
4-Staging
5-hemorrhagic transformation of the infarct
Difference between simple hemorrhage and hemorrhagic neoplasm
difference between Hemorrhagic infarct and primary intracerebral hemorrhage
6-Comparison between CT/MRI
7-CTA, MRA
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Duplex peripheral veins
Duplex peripheral veins cephalic vein basilic vein subclavian vein axillary vein brachial vein inferior vena cava external iliac vein common femoral vein superficial femoral vein profunda femoral vein popliteal vein anterior tibial vein posterior tibial vein peroneal vein medial and lateral circumflex vein gastrocnemius vein soleal vein great saphenous vein anterior accessory great saphenous posterior accessory great saphenous lateral subdermal venous plexus superficial external pudendal deep external pudendal superficial and deep epigastric superficial circumflex iliac thigh extension (te) of the ssv Giacomini vein perforating veins Boyd's perforators dodd's perforators Hunterian perforators recanalization hypoplastic lsv duplex us primary varicose tortuous dilated varicose veins varicosities of the vein of Giacomini recurrent varicose vein superficial phlebitis deep venous thrombosis acute deep venous thrombosis subacute deep venous thrombosis acute occlusive deep venous thrombosis partial thrombosis acute deep venous thrombosis leg calf veins thrombosis superficial venous system thrombosis thrombophlebitis compression ultrasound venous thrombosis segmental iliac vein thrombus venous stasis popliteal cysts haematoma superficial thrombophlebitis arteriovenous fistula lymphoedema hyperperfusion syndrome muscle tears
Duplex Ultrasound waveform changes
Duplex Ultrasound Doppler waveform changes.peripheral arterial triplex ultrasound Aorta innominate subclavian vein axillary artery brachial artery radial/ulnar veins palmar arch Common iliac artery External iliac artery Common femoral artery Profunda femoris artery Superficial femoral artery Popliteal artery Tibio-peroneal trunk Posterior tibial artery Anterior tibial artery Peroneal artery Dorsalis pedis artery Angle Color Gain Doppler gain PRF BOX(size,direction) steering Sample volume Gate size,Site of sample Base line Velocity scale Depth Wall filter Settings appropriate for specific examinations assigned by set-up/application keys Focus triphasic waveform Systolic Acceleration time spectral window laminar flow Color Doppler peripheral arterial disease Causes of leg pain ARTERIAL OCCLUSIVE DISEASE CAUSES Classification of vasculitis Biphasic waveform flow monophasic waveform flow bidirectional flow Loss of third and then second phase of the wave¬form Increased acceleration time (rapid rise of systolic deflection) Widening of the ystolic complex (5-Spectral broadening) Damping of the waveform Spectral broadening fill in spectral windowe Loss of sharpness of spectrum(irregular) Turbulance aliasing Rounding of PSV tip Absent flow in occlusion rising of PSV reverse flow opposite systole rapid fall of systolic deflection rising of end diastolic velocity Active Hyperemia postoperative vasospasm limb ischemia peripheral arterial triplex ultrasound waveform change peripheral arterial triplex ultrasound arterial stenosis ,occlusion peripheral arterial triplex ultrasound vasculitis inflamed arteries (arteritis) macaroni sign Takayasu’s arteritis Giant cell arteritis Temporal artery Giant cell arteritis polyarteritis nodosa Kawasaki progressive systemic sclerosis Buerger disease Thromboangiitis obliterans (Buerger’s disease) Ormond's Disease peripheral arterial triplex ultrasound hand,foot Triplex Raynaud Phenomenon secondary raynaud's phenomenon BAKER CYST Blind ended channels bypass graft surveillance lerich arterial steal syndrome Complex Regional Pain Syndrome dialysis arteriovenous fistula Cystic Adventitial Disease
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Duplex carotid vertebral jaguar extra cranial vessel
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All thing breast ultrasound breast mammography part 3
All thing breast ultrasound breast mammography part 3
Breast mammogram ultrasound lipoma ,oil cyst ,galactocele intramammary lymph node in UOQ hamartoma Simple cyst (typical) calcification Surgical scar Breast implants, scirrhuc carcinoma lobular carcinoma Skin calcifications vascular calcifications Sutural Dystrophic popcorn Large Rod like rim Round/punctuate Fat necrosis Milk of calcium Fibrocystic FCC fibroadenosis Fat necrosis with oil cyst mastitis with Abscess Haematoma atypical ductal hyperplasia Intracystic papilloma ductal carcinoma in situ ,invasive ductal carcinoma BIRAD
All thing breast ultrasound breast mammography part 2
Breast mammogram ultrasound lipoma ,oil cyst ,galactocele intramammary lymph node in UOQ hamartoma Simple cyst (typical) calcification Surgical scar Breast implants, scirrhuc carcinoma lobular carcinoma Skin calcifications vascular calcifications Sutural Dystrophic popcorn Large Rod like rim Round/punctuate Fat necrosis Milk of calcium Fibrocystic FCC fibroadenosis Fat necrosis with oil cyst mastitis with Abscess Haematoma atypical ductal hyperplasia Intracystic papilloma ductal carcinoma in situ ,invasive ductal carcinoma BIRAD
All thing breast ultrasound breast mammography part 1
All thing breast ultrasound breast mammography part 1
Breast mammogram ultrasound lipoma ,oil cyst ,galactocele intramammary lymph node in UOQ hamartoma Simple cyst (typical) calcification Surgical scar Breast implants, scirrhuc carcinoma lobular carcinoma Skin calcifications vascular calcifications Sutural Dystrophic popcorn Large Rod like rim Round/punctuate Fat necrosis Milk of calcium Fibrocystic FCC fibroadenosis Fat necrosis with oil cyst mastitis with Abscess Haematoma atypical ductal hyperplasia Intracystic papilloma ductal carcinoma in situ ,invasive ductal carcinoma BIRAD
Telangiectasia ,reticular ,varicose communicating vein
Telangiectasia ,reticular ,varicose communicating vein
All things adnexal ovarian mass iota algorithm .acr 0 rads
Endometrioma,Benign cystic teratoma – dermoid,Simple cyst or cystadenoma,Functional cyst haemorrhagic cyst,Malignant tumour with ascites,Most follicular cyst,hemorrhagic corpus luteal cyst,benign serous tumor,Endometrioma,cystic teratoma,Most serous cystadenocarcinoma endometrioid adenocarcinoma,clear cell carcinoma,serous borderline malignancies,cystadenofibroma Most mucinous cystadenoma Endometrioma theca lutein cyst mature cystic teratoma tubo-ovarian abscess polycystic ovarian syndrome ovarian hyperstimulation syndrome mucinous borderline malignancies Most mucinous cystadenocarcinoma mucinous borderline malignancies cystadenofibroma, struma ovarii granulosa cell tumor Most sex cord-stromal tumor such as fibroma fibrothecoma,granulosa cell tumor sclerosing stromal tumor surface epithelial tumor such as Brenner tumor serous papillary carcinoma Malignant germ cell tumor such as dysgerminoma endodermal sinus tumor Lymphoma metastatic tumor
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Brachial plexus anatomy, diagnosis and orthopaedic treatment
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How does it occur,Erb klumpke.
MAnagement, surgeries etc
Lumbosacral plexus and Sciatica
An detailed Lumbar & Sacral Plexus with Muscles and nerves supply to lower limb. lower limb Muscles action and clinical anatomy "Sciatica".
Brachial plexus - Made so Easy
Brachial plexus is one of the tough topic to remember by anyone undergoing MBBS course. This slide gives you in detail about the Origin / Course / Formation / Distribution / Anatomical variations & Applied anatomy & Made so easy to Remember & Draw as well.
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Brachial plexus anatomy, diagnosis and orthopaedic treatment
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Breast cyst imaging
Breast mammogram ultrasound lipoma, oil cyst, galactocele intramammary lymph node in UOQ hamartoma Simple cyst (typical) calcification Surgical scar Breast implants, scirrhous carcinoma lobular carcinoma Skin calcifications vascular calcifications Sutural Dystrophic popcorn Large Rodlike rim Round/punctuate Fat necrosis Milk of calcium Fibrocystic FCC fibroadenomas Fat necrosis with oil cyst mastitis with Abscess Haematoma atypical ductal hyperplasia Intracystic papilloma ductal carcinoma in situ, invasive ductal carcinoma BIRAD
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Breast mammogram ultrasound lipoma, oil cyst, galactocele intramammary lymph node in UOQ hamartoma Simple cyst (typical) calcification Surgical scar Breast implants, scirrhous carcinoma lobular carcinoma Skin calcifications vascular calcifications Sutural Dystrophic popcorn Large Rodlike rim Round/punctuate Fat necrosis Milk of calcium Fibrocystic FCC fibroadenomas Fat necrosis with oil cyst mastitis with Abscess Haematoma atypical ductal hyperplasia Intracystic papilloma ductal carcinoma in situ, invasive ductal carcinoma BIRAD
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8-Fogging
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10-Protocol
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Duplex peripheral veins
Duplex peripheral veins cephalic vein basilic vein subclavian vein axillary vein brachial vein inferior vena cava external iliac vein common femoral vein superficial femoral vein profunda femoral vein popliteal vein anterior tibial vein posterior tibial vein peroneal vein medial and lateral circumflex vein gastrocnemius vein soleal vein great saphenous vein anterior accessory great saphenous posterior accessory great saphenous lateral subdermal venous plexus superficial external pudendal deep external pudendal superficial and deep epigastric superficial circumflex iliac thigh extension (te) of the ssv Giacomini vein perforating veins Boyd's perforators dodd's perforators Hunterian perforators recanalization hypoplastic lsv duplex us primary varicose tortuous dilated varicose veins varicosities of the vein of Giacomini recurrent varicose vein superficial phlebitis deep venous thrombosis acute deep venous thrombosis subacute deep venous thrombosis acute occlusive deep venous thrombosis partial thrombosis acute deep venous thrombosis leg calf veins thrombosis superficial venous system thrombosis thrombophlebitis compression ultrasound venous thrombosis segmental iliac vein thrombus venous stasis popliteal cysts haematoma superficial thrombophlebitis arteriovenous fistula lymphoedema hyperperfusion syndrome muscle tears
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ostium secundum
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Ultasound in dyspnea & intensive care unit
Chest ultrasound Anterior lung : sliding sign B-line pneumothorax Lung bases effusion consolidation pulmonary edema Diaphraamatic paralysis Pneumothorax Effusion Pneumonia ARDS Fibrosis COPD asthma Pneumothorax Absent sliding sign (unilateral) + Lung point barcode or stratosphere sign sign on M-mode =pneumothorax Cardiac ultrasound : normal (not in tension pneumo) B-line B3 interstitial edema B7 alveolar edema Pleural effusion Anechioc fluid in pleura quad sign sinusoid sign spine sign consolidation (Pneumonia) Tissue pattern /hepatization shred sign Air bronchograms Fluid bronchograms Dynamic air and fluid bronchogram .Diaphragmatic paralysis Diaphragmatic movement (excursion) reduced movement Paradoxical movement Thickness of diaphragm M-mode study IVC normal (dilated in tension pneumo) cardiac Acute coronary syndrome Global function(CHF) Valvular heart disease Right ventricle Strain Tamponade pulmonary embolism aneurysm ascending aorta Global cardaic dysfunction sliding B-lines (anterior &bilateral) pleural effusion poor cardaic function systolic dysfunction diastolic dysfunction Tamponed Severe pericardial effusion diastolic collapse of right ventricle water bed sign Tampoline sign Pulmonary embolism (PE) RV mid free wall hypokinesis with apical sparing (a.k.a. McConnell’s sign) free-floating right-heart thrombus ,PA Dilated right ventricle D shape RV .Abnormal interventricular septal motion (Septal bowing) TR ,raised PASP PA dilatation Lack of inspiratory collapse of IVC , Dilated uncollapsed IVC Underfilled left ventricle with normal function lung sliding : Normal bilaterally Right ventricle Strain Right ventricle dysfunction PE ,PH Focal wall injury (infraction) Dilatation (RV dilation IVC dilatation and loss of respiratory variations respiratory increase of inter-ventricular dependence Inferior vena cava IVC : respiratory Collapse dilatation Deep venous thrombosis No Compression By ultrasound Absent or abnormal flow on spectral or color Doppler venous distention Intraluminal material free floating thrombus Abdominal liver cirrhosis renal failure
Case review ct mri brain part 7 dr ahmed esawy
Lymphoma Glioma Meningioma en plaque Metastases .Intracrainal infections Ventriculitis Encephalitis Septic meningitis toxoplasmosis Cytomegalovirus ACUTE DEMELINATING ENCEPHALOMYELITIS Para sagittal subdural empyema Cerebritis brain Abscess Tuberculous meningitis Cysticercosis periventricular calcifications .Intracranial hemorrhage Calverial bones epidural Subdural Subarachnoid Intra-cerebral Intra-ventricular Infarction Hemorrhagic infarction Lacunar infarction Sub cortical arteriosclerotic encephalopathy Hydrocephalus Aquiductal stenosis Brain stem glioma .Pineal body germinoma Atresia of the outlet foramina Obstructive communicating hydrocephalus Basal meningitis Subarachroid hemorrhage Meningeal carcinomatosis Dural sinus thrombosis Holoprosencephaly Semi lobar Holoprosencephaly Dandy-Walker malformation Hydrancephaly Mega cisterna magna Agenesis of corpus callosum Corpus Callosum anomalies Agenesis of corpus callosum Intraventricular lesions Choriod plexus papilloma Intraventricular Meningioma Subependymal Giant Cell Astrocytoma Vascular malformation Bilateral internal carotid aneurysms Arteriovenous malformation Cavernous hemangiomas Venous angioma Sturge webber syndrome Ependymoma Medulloblastoma
Primitive Neuroepithelial tumors [PNET] Medulloblastoma Acoustic neuroma Epidermiod cyst Cerebellar Hemorrhage Cerebellar Infarction Pontine infarction Pilocytic Astrocytoma Hemangioblastoma Multiple sclerosis Brain stem hematoma Brain stem glioma Osmotic demyelination syndrome Central pontine myelinolysis Colloid cyst Intra-ventricular dermoid cyst Anaplastic astrocytoma Falcine meningioma with cystic component Tuberous sclerosis with Subependymal Giant Cell Astrocytoma ARACHNOID CYSTcorpus callosum lipoma corpus callosum marchiafava CORPUS CALLOSUM MS CNS Herniations descending trasnstentorial herniation cholesterol granuloma endolymphatic sac tumor glomus tympanicum .malignent otitis externa, osteomyelitis base skull chordoma germinoma neuroenteric cyst schizencephaly septic cavernous sinus thrombosis superficial siderosis epidermoid pineal diffusion LEFORT fracture tripod fracture adrenoleukodystrophy leigh disease AIDS PML progressive multifocal leukoencephalopathy karappe disease , dysmyelinition , thalamic involvement leukodystrophy alexander metachromatic leuckodystrophy melas meerf ...leukodystrophy zellweger subacute sclerosing pan encephalitis jugular schwannoma .Neuroblastoma metastasis TRIGEMINAL SCHWANNOMA Neurofibroma Tuberous Sclerosis
Von Hippel-Lindau Disease cerberallar haemangioblastoma basal ganglia calcifications .karappe disease LYSOSOMAL STORAGE DISEASES metachromatic leukodystrophy krabbe
mucopolysaccharidosis PEROXISOMAL DISORDERS .adrenoleukodystrophy zellweger syndrome MITOCHONDRIAL DYSFUNCTION MELAS syndrome Leigh's disease Ke
Case review ct mri brain part 6 dr ahmed esawy
Convexity Meningioma Lymphoma Glioma Meningioma en plaque Metastases Intracrainal infections Ventriculitis Encephalitis Septic meningitis toxoplasmosis Cytomegalovirus ACUTE DEMELINATING ENCEPHALOMYELITIS Para sagittal subdural empyema Cerebritis brain Abscess Tuberculous meningitis Cysticercosis periventricular calcifications Intracranial hemorrhage Calverial bones epidural Subdural Subarachnoid Intra-cerebral Intra-ventricular Infarction Hemorrhagic infarction Lacunar infarction Sub cortical arteriosclerotic encephalopathy Hydrocephalus Aquiductal stenosis Brain stem glioma Pineal body germinoma Atresia of the outlet foramina Obstructive communicating hydrocephalus Basal meningitis thrombosis Holoprosencephaly Semi lobar Holoprosencephaly Dandy-Walker malformation Hydrancephaly Mega cisterna magna Agenesis of corpus callosum Corpus Callosum anomalies Agenesis of corpus callosum Intraventricular lesions Choriod plexus papilloma Intraventricular Meningioma Subependymal Giant Cell Astrocytoma Vascular malformation Bilateral internal carotid aneurysms Arteriovenous malformation Cavernous hemangiomas Venous angioma Sturge webber syndrome Ependymoma Medulloblastoma
Primitive Neuroepithelial tumors [PNET] Medulloblastoma Acoustic neuroma Epidermiod cyst Cerebellar Hemorrhage Cerebellar Infarction Pontine infarction Pilocytic Astrocytoma Hemangioblastoma Multiple sclerosis Brain stem hematoma Brain stem glioma Osmotic demyelination syndrome Central pontine myelinolysis Colloid cyst Intra-ventricular dermoid cyst Anaplastic astrocytoma Falcine meningioma with cystic component Tuberous sclerosis with Subependymal Giant Cell Astrocytoma ARACHNOID CYSTcorpus callosum lipoma corpus callosum marchiafava CORPUS CALLOSUM MS CNS Herniations descending trasnstentorial herniation cholesterol granuloma endolymphatic sac tumor glomus tympanicum malignent otitis externa, osteomyelitis base skull chordoma germinoma neuroenteric cyst schizencephaly septic cavernous sinus thrombosis superficial siderosis epidermoid pineal diffusion LEFORT fracture tripod fracture adrenoleukodystrophy leigh disease AIDS PML progressive multifocal leukoencephalopathy karappe disease , dysmyelinition , thalamic involvement leukodystrophy alexander metachromatic leuckodystrophy melas meerf ..zellweger subacute sclerosing pan encephalitis jugular schwannoma Neuroblastoma metastasis TRIGEMINAL SCHWANNOMA Neurofibroma Tuberous Sclerosis
Von Hippel-Lindau Disease cerberallar haemangioblastoma basal ganglia calcifications karappe disease LYSOSOMAL STORAGE DISEASES metachromatic leukodystrophy krabbe
mucopolysaccharidosis PEROXISOMAL DISORDERS adrenoleukodystrophy zellweger syndrome MITOCHONDRIAL DYSFUNCTION MELAS syndrome Leigh's disease Kearn-sayre syndrome CANAVAN DISEASE UNKNOWN CAUSES Pelizaeus-
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1. Enlist the non-respiratory functions of the respiratory tract
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Study Resources:
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4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
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Physiology of Special Chemical Sensation of Taste
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Physiology of Chemical Sensation of smell.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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