#3dconfny16

1. Jeremy J. Mao
Columbia University
3D Printed Materials in Vivo: Healing
by Endogenous Stem Cells
April 11, 2016
New York, NY

2. § One in five adults diagnosed of arthritis
§ Half of those 65 or older
§ By 2030, ~67 million Americans (>18)
§ Could 3D printing be a solution for arthritis

3. § ~22 people die each day waiting for organ transplants
§ What does 3D printing have to do with organ transplantation

5. a b
c
gf
Bone
d e
400 µm 200 µm
Cartilage
80 wt% poly-ε-caprolactone (PCL) (Mw ~65,000)
20 wt% of hydroxyapatite (HA)
Lee et al. 2010 Lancet Aug 7;376(9739):440-8. PMID: 20692530

6. f g
h i
Lee et al. 2010 Lancet Aug 7;376(9739):440-8. PMID: 20692530

7. Lee et al. 2010 Lancet Aug 7;376(9739):440-8. PMID: 20692530

8. Lee et al. 2010 Lancet Aug 7;376(9739):440-8. PMID: 20692530

9. Nature Reviews Rheumatology 6, 677-678 (2011)
Daniel A. Grande, Nicholas A. Sgaglione
Regenerative medicine:Self-directed articular resurfacing: a new paradigm?

10. Recruitment
Cell homing
Differentiation

11. >1M meniscus repairs/yr
Meniscectomy (+/- allograft)
1o factor for osteoarthritis

13. (100 μm) (50 μm)
C DA B
E F
Day 1 Day 8
Dextran (40 kDa)
Dextran (10 kDa)
G

15. A B
15 mm
C
D E
Scott Rodeo, HSS
Lisa Fortier, Cornell

16. Native+CTGF/TGFβ3-µS
Outer Middle Inner
BA
ED
C
F
(100μm)
Scott Rodeo, HSS
Lisa Fortier, Cornell

18. A B C

21. Root canal
therapy
BioPulp

22. To Avoid Root Canals, Teeth That Replace
Themselves
Stem-Cell ResearchMakes Progress in Quest to
Avoid the DreadedDrill
§ 18 million root canal
patients/yr
§ $22B annual
expenditure
2014

23. https://www.google.com/search?q=organ+shor
tage&espv=2&biw=1209&bih=704&source=ln
ms&tbm=isch&sa=X&ved=0ahUKEwi2wfze2o
TMAhVLGT4KHcy5CPMQ_AUIBygC#imgrc=8
cEvQPUTai1AvM%3A
3D printing
Organ shortage

24. 3D printing…holds considerable
promise in generating implantable
organ scaffolds that may reduce or
eliminate organ shortage.