This document summarizes the research of Jon Cooper's lab on various forms of Batten disease. The lab is moving from London to Los Angeles to further its research. The lab studies how protein and DNA mutations lead to Batten disease and aims to determine where in the body and brain pathology occurs. Research suggests pathology begins early in the spinal cord and peripheral nervous system before affecting the brain. The lab grows brain cells from mice models of different forms of Batten disease to study how nerve and glial cells are differently affected and how this impacts disease progression and symptoms. Understanding these disease mechanisms could help identify new treatment approaches.