Sharing thoughts during the session Personalized Medicine at the Health Valley Event 2016, which again was a great event with 1100+ health care innovators !
2017 06-15 Ctbg Relatiedag 2017, Ede, Alain van GoolAlain van Gool
Keynote lecture for the Ctgb (Board for the Authorisation of Plant Protection Products and Biocides) conference where I was asked to sketch the parallel between precision medicine and precision agriculture for an interested audience of 400+ scientists and companies.
Can a Game improve People's Lives? The case of Serious Games?University of Geneva
Thank You for referencing this work, if you find it useful!
Reference/Citation: A. Bujari, M. Ciman, O. Gaggi, C. E. Palazzi: "Can a Game improve People's Lives? The case of Serious Games?", In Proceedings of the EAI International Conference on Smart Objects and Technologies for Social Good (GOODTECHS 2015), October 2015, Rome, Italy
The Thai National HIV Guidelines Working Group updated treatment guidelines for pediatric HIV in March 2010. Key aspects include:
1) ART should be initiated in infants <12 months regardless of symptoms and all children with CDC stage B/C or WHO stage 3/4 disease. CD4-guided thresholds are provided for mildly symptomatic children.
2) The preferred first-line regimen for children <3 years is AZT+3TC+NVP. For children >3 years it is AZT+3TC+EFV. Consider TDF+3TC+EFV for adolescents weighing >40kg.
3) The preferred second-line regimen for first-line failure comprises 2NRTI+LPV/r.
2016 08-22 Radboud Grand Round, Nijmegen, Alain van GoolAlain van Gool
Interactive lecture with a large group of healthcare professionals, scientists and patients to illustrate developments in personalized healthcare and the role of technology to support science, innovations and medical impact. (slides in English)
Lecture on biomarkers (principles, potentials, pitfalls) for 200 pharmaceutical professionals as part of the IMI Pharma Train course organised by the European Center for Pharmaceutical Medicine
2017 03-07 World Economic Forum - Dutch topsector Life Science Health, The Ha...Alain van Gool
The document discusses the Netherlands' approach to personalized medicine and health research. It outlines key principles of precision medicine including targeting the right drug, dose, and time for each patient. It also describes the Netherlands' national infrastructure supporting personalized medicine research through biobanks, clinical records, and other data sources. Mass spectrometry is highlighted as a technique enabling discovery of new glycoprotein biomarkers from human plasma samples.
2017 06-15 Ctbg Relatiedag 2017, Ede, Alain van GoolAlain van Gool
Keynote lecture for the Ctgb (Board for the Authorisation of Plant Protection Products and Biocides) conference where I was asked to sketch the parallel between precision medicine and precision agriculture for an interested audience of 400+ scientists and companies.
Can a Game improve People's Lives? The case of Serious Games?University of Geneva
Thank You for referencing this work, if you find it useful!
Reference/Citation: A. Bujari, M. Ciman, O. Gaggi, C. E. Palazzi: "Can a Game improve People's Lives? The case of Serious Games?", In Proceedings of the EAI International Conference on Smart Objects and Technologies for Social Good (GOODTECHS 2015), October 2015, Rome, Italy
The Thai National HIV Guidelines Working Group updated treatment guidelines for pediatric HIV in March 2010. Key aspects include:
1) ART should be initiated in infants <12 months regardless of symptoms and all children with CDC stage B/C or WHO stage 3/4 disease. CD4-guided thresholds are provided for mildly symptomatic children.
2) The preferred first-line regimen for children <3 years is AZT+3TC+NVP. For children >3 years it is AZT+3TC+EFV. Consider TDF+3TC+EFV for adolescents weighing >40kg.
3) The preferred second-line regimen for first-line failure comprises 2NRTI+LPV/r.
2016 08-22 Radboud Grand Round, Nijmegen, Alain van GoolAlain van Gool
Interactive lecture with a large group of healthcare professionals, scientists and patients to illustrate developments in personalized healthcare and the role of technology to support science, innovations and medical impact. (slides in English)
Lecture on biomarkers (principles, potentials, pitfalls) for 200 pharmaceutical professionals as part of the IMI Pharma Train course organised by the European Center for Pharmaceutical Medicine
2017 03-07 World Economic Forum - Dutch topsector Life Science Health, The Ha...Alain van Gool
The document discusses the Netherlands' approach to personalized medicine and health research. It outlines key principles of precision medicine including targeting the right drug, dose, and time for each patient. It also describes the Netherlands' national infrastructure supporting personalized medicine research through biobanks, clinical records, and other data sources. Mass spectrometry is highlighted as a technique enabling discovery of new glycoprotein biomarkers from human plasma samples.
Strategic planning involves defining a laboratory's strategy to withstand competitive forces by understanding industry structure, competitors' strengths and weaknesses, identifying a unique market position, and focusing on growth. It contrasts with operations management which efficiently uses resources. A laboratory should understand its industry's concentration, barriers to entry/exit, separate roles of payors/purchasers/beneficiaries, economies of scale, and powerful buyers/sellers to strategically position itself. Common positions include outpatient-centered, reference-centered, and hospital-centered testing. Strategies can fail due to straddling multiple positions, pursuing growth that does not fit capabilities, or exhibiting hubris. SWOT and competitor analyses help develop and implement effective strategies.
Reverse Innovation offers the unique opportunity to develop innovativ solutions for exponentially growing problems/markets in an often less regulated (emerging) markets leapfrogging incremental product and market developments in established markets.
InnVentis provides precision medicine through analyzing personal molecular profiles derived from multi-omics data and the internet of things to recommend diets and supplements personalized to each individual's daily schedule.
state_of_app_downloads_and_monetization_2015_APACTuan Anh Nguyen
The document discusses key metrics and insights about app installs and monetization in Asia Pacific and other regions based on data from InMobi's platform. Some of the main findings are that Chinese and Indonesian users drove high app installs in 2015, with the Philippines seeing expensive iOS installs. Shopping and lifestyle apps were popular across Asia, while education and entertainment apps earned developers higher eCPMs. App install costs and earnings varied by region and operating system.
- The Radboud University Medical Center in the Netherlands has established 18 Technology Centers to provide technological expertise and resources to researchers.
- The Technology Centers have over 250 dedicated staff and serve over 1,600 internal and external users through around 140 consortia.
- The goals of the Technology Centers are to maximize the use of technical capabilities, drive innovation through collaboration, and increase external funding.
- Lessons from the Radboud model could help inform a potential "DTL 2.0" by defining networks of expertise, obtaining joint funding, and establishing a focused strategic vision and infrastructure.
Targeted Threat (APT) Defense for Applications Featuring pxGrid: a deep diveCisco DevNet
A session in the DevNet Zone at Cisco Live, Berlin. Targeted Attacks, which the media refers to as APTs, are threats that must be addressed by any organization requiring networked computers to do business. In this session we will go over the run book techniques used by these threat actors and then go over strategies for mitigating those attacks. In this session we will focus on the concepts that developers of network applications need to be aware of to mitigate these styles of attacks and techniques to use. To finish off, we will delve into pxGrid and what it can offer to break these APT style attack playbooks. Backgrounder: We obtained knowledge of these run book techniques from trusted advisors, peers in the industry and from our own observations. Our own observations included information from our CSIRT, our security products in the field as well as our internal phishing awareness campaign. After studying these techniques we devised strategies to mitigate them. Those strategies were then tested and deployed throughout our ecosystem. The Cisco CSDL initiative and ACT2 chips will also be techniques and tools highlighted in this session.
This document discusses bridging research and healthcare by translating biomarkers into patient treatment. It provides background on Prof. Alain van Gool and his roles at TNO, Radboud University Nijmegen Medical Centre, and Radboud University Nijmegen. It outlines the need for biomarkers in pharmaceutical drug development and personalized healthcare to address the biomarker innovation gap and develop personal profiles for conditions like oncology and diabetes. Progress may be made through open innovation networks.
EU FP7 CarTarDis project overview April 2015Alain van Gool
The document describes CarTarDis, a 4-year public-private partnership with 13 partners from 8 countries and a budget of 8.0M Euros that began on October 1, 2013. The project aims to discover novel cardiovascular drug targets through a strong interdisciplinary team with expertise in cardiovascular disease biology, drug discovery, translational medicine, omics technologies, and more. CarTarDis will utilize unique human cohort data, biobanks, CVD models and samples to generate a candidate target database, review targets, validate a shortlist, and create online dossiers to share knowledge on selected targets. The goal is to prioritize 11 targets for further validation activities to identify new treatments for cardiovascular disease.
The document proposes a magazine called "Evolution of DBZ" targeted at Dragon Ball Z fans. The core audience would be any gender interested in Dragon Ball Z willing to spend £1 on the magazine. A secondary audience would include those interested in learning about anime or seeing Dragon Ball Z as an interest. The front cover would appeal to audiences with colorful images of a DBZ character and the creator portraying a fighting pose, along with a martial arts symbol relating to DBZ and the creator. The main article would provide bright, colorful information about the newest Dragon Ball franchise iteration in an engaging style. Advertisements would use big fonts to promote related anime games and cinema systems. The total proposed annual budget is £240,000,
The document describes a client acquisition program called Right Financial Advisor. It is a web-based matching program that connects individual investors to vetted financial advisors. It aims to help advisors clone their best A and B clients while pruning poorer C and D clients. The program uses personality and financial needs questions to make better matches than competitors that rely solely on location or assets. It markets itself online and on social media to acquire new investors and advisors. Investors pay $35 to join while advisors pay $200 per month for unlimited introductions.
This document discusses emerging digital marketing trends for 2016. It finds that the top trend is the rise of video across digital platforms, as consumers are increasingly consuming video content on websites, social media, and in online ads. It also discusses other trends like influencer marketing, increased "buy now" functionality on social media, using social listening to inform brand decisions, and mapping cross-device consumer journeys. The overarching theme is that all of these trends are focused on putting consumers at the center of marketing strategies. Brands will need to respond by soliciting consumer input and feedback to better understand and meet consumer needs.
Two-thirds of survey respondents reported using a subscription video on demand (SVOD) service. Nearly half use their SVOD service as much as or more than their pay TV service. Three-quarters of SVOD users experience buffering and slow stream starts, and nearly 20% consider technical problems serious enough to cancel their service. Password sharing is common, primarily between family members, though concerns about its impact are likely overblown according to the research. Consumers expect a high-quality, premium viewing experience from SVOD services.
Este manual explica cómo implementar Google Analytics en una tienda Magento para entender y mejorar el rendimiento. Detalla la configuración de perfiles y filtros en Google Analytics, así como el seguimiento de eventos, métricas de e-commerce y optimización on-site para mejorar el posicionamiento orgánico.
The document provides a micro-analysis of 5 scenes from the film The Descent. It analyzes the car crash scene in 5 snapshots, focusing on camera angles and sound effects used. It then analyzes the face-to-face confrontation scene between Sarah and Juno in 6 snapshots, highlighting makeup, editing and sound. Finally, it examines Sarah's escape scene in 5 snapshots, drawing attention to lighting, camera distance and angles. The analysis focuses on cinematography techniques used to convey emotion and build tension across the different scenes.
DEVNET-1148 Leveraging Cisco OpenStack Private Cloud for DevelopersCisco DevNet
The document discusses developing applications on Cisco OpenStack Private Cloud. It describes setting up a development environment using CoreOS, Docker, Gitlab, Jenkins, Slack, and Ansible. The environment automates the deployment of load balancers, web servers, and other application components from source code commits using continuous integration and continuous delivery practices. Jenkins is configured to build Docker containers from code commits and deploy them to instances in the private cloud.
Satish Reddy Pydimarla is seeking a senior position in testing and commissioning. He has over 8 years of experience in testing, commissioning, operation, and maintenance of high and low voltage electrical equipment. Currently he works as a senior testing and commissioning engineer. He has expertise in testing transformers, motors, generators, circuit breakers, and more. He is proficient in AutoCAD, MS Office, and has strong analytical and problem solving skills.
2016 04-21 Association of Dutch Producers of Children and Diet Nutrition (VNF...Alain van Gool
Keynote lecture at the 55-year lustrum conference of the Association of Dutch Producers of Children and Diet Nutrition (VNFKD) to reflect on the use of (specialized) nutrition in personalized healthcare.
2016 05-24 Kick-off The Danish Biomarker Network, Copenhagen, Alain van GoolAlain van Gool
Keynote lecture given at the kick-off of The Danish Biomarker Network in Copenhagen for a great audience of enthousiastic patients, biotech/pharma developers and ICT experts.
Strategic planning involves defining a laboratory's strategy to withstand competitive forces by understanding industry structure, competitors' strengths and weaknesses, identifying a unique market position, and focusing on growth. It contrasts with operations management which efficiently uses resources. A laboratory should understand its industry's concentration, barriers to entry/exit, separate roles of payors/purchasers/beneficiaries, economies of scale, and powerful buyers/sellers to strategically position itself. Common positions include outpatient-centered, reference-centered, and hospital-centered testing. Strategies can fail due to straddling multiple positions, pursuing growth that does not fit capabilities, or exhibiting hubris. SWOT and competitor analyses help develop and implement effective strategies.
Reverse Innovation offers the unique opportunity to develop innovativ solutions for exponentially growing problems/markets in an often less regulated (emerging) markets leapfrogging incremental product and market developments in established markets.
InnVentis provides precision medicine through analyzing personal molecular profiles derived from multi-omics data and the internet of things to recommend diets and supplements personalized to each individual's daily schedule.
state_of_app_downloads_and_monetization_2015_APACTuan Anh Nguyen
The document discusses key metrics and insights about app installs and monetization in Asia Pacific and other regions based on data from InMobi's platform. Some of the main findings are that Chinese and Indonesian users drove high app installs in 2015, with the Philippines seeing expensive iOS installs. Shopping and lifestyle apps were popular across Asia, while education and entertainment apps earned developers higher eCPMs. App install costs and earnings varied by region and operating system.
- The Radboud University Medical Center in the Netherlands has established 18 Technology Centers to provide technological expertise and resources to researchers.
- The Technology Centers have over 250 dedicated staff and serve over 1,600 internal and external users through around 140 consortia.
- The goals of the Technology Centers are to maximize the use of technical capabilities, drive innovation through collaboration, and increase external funding.
- Lessons from the Radboud model could help inform a potential "DTL 2.0" by defining networks of expertise, obtaining joint funding, and establishing a focused strategic vision and infrastructure.
Targeted Threat (APT) Defense for Applications Featuring pxGrid: a deep diveCisco DevNet
A session in the DevNet Zone at Cisco Live, Berlin. Targeted Attacks, which the media refers to as APTs, are threats that must be addressed by any organization requiring networked computers to do business. In this session we will go over the run book techniques used by these threat actors and then go over strategies for mitigating those attacks. In this session we will focus on the concepts that developers of network applications need to be aware of to mitigate these styles of attacks and techniques to use. To finish off, we will delve into pxGrid and what it can offer to break these APT style attack playbooks. Backgrounder: We obtained knowledge of these run book techniques from trusted advisors, peers in the industry and from our own observations. Our own observations included information from our CSIRT, our security products in the field as well as our internal phishing awareness campaign. After studying these techniques we devised strategies to mitigate them. Those strategies were then tested and deployed throughout our ecosystem. The Cisco CSDL initiative and ACT2 chips will also be techniques and tools highlighted in this session.
This document discusses bridging research and healthcare by translating biomarkers into patient treatment. It provides background on Prof. Alain van Gool and his roles at TNO, Radboud University Nijmegen Medical Centre, and Radboud University Nijmegen. It outlines the need for biomarkers in pharmaceutical drug development and personalized healthcare to address the biomarker innovation gap and develop personal profiles for conditions like oncology and diabetes. Progress may be made through open innovation networks.
EU FP7 CarTarDis project overview April 2015Alain van Gool
The document describes CarTarDis, a 4-year public-private partnership with 13 partners from 8 countries and a budget of 8.0M Euros that began on October 1, 2013. The project aims to discover novel cardiovascular drug targets through a strong interdisciplinary team with expertise in cardiovascular disease biology, drug discovery, translational medicine, omics technologies, and more. CarTarDis will utilize unique human cohort data, biobanks, CVD models and samples to generate a candidate target database, review targets, validate a shortlist, and create online dossiers to share knowledge on selected targets. The goal is to prioritize 11 targets for further validation activities to identify new treatments for cardiovascular disease.
The document proposes a magazine called "Evolution of DBZ" targeted at Dragon Ball Z fans. The core audience would be any gender interested in Dragon Ball Z willing to spend £1 on the magazine. A secondary audience would include those interested in learning about anime or seeing Dragon Ball Z as an interest. The front cover would appeal to audiences with colorful images of a DBZ character and the creator portraying a fighting pose, along with a martial arts symbol relating to DBZ and the creator. The main article would provide bright, colorful information about the newest Dragon Ball franchise iteration in an engaging style. Advertisements would use big fonts to promote related anime games and cinema systems. The total proposed annual budget is £240,000,
The document describes a client acquisition program called Right Financial Advisor. It is a web-based matching program that connects individual investors to vetted financial advisors. It aims to help advisors clone their best A and B clients while pruning poorer C and D clients. The program uses personality and financial needs questions to make better matches than competitors that rely solely on location or assets. It markets itself online and on social media to acquire new investors and advisors. Investors pay $35 to join while advisors pay $200 per month for unlimited introductions.
This document discusses emerging digital marketing trends for 2016. It finds that the top trend is the rise of video across digital platforms, as consumers are increasingly consuming video content on websites, social media, and in online ads. It also discusses other trends like influencer marketing, increased "buy now" functionality on social media, using social listening to inform brand decisions, and mapping cross-device consumer journeys. The overarching theme is that all of these trends are focused on putting consumers at the center of marketing strategies. Brands will need to respond by soliciting consumer input and feedback to better understand and meet consumer needs.
Two-thirds of survey respondents reported using a subscription video on demand (SVOD) service. Nearly half use their SVOD service as much as or more than their pay TV service. Three-quarters of SVOD users experience buffering and slow stream starts, and nearly 20% consider technical problems serious enough to cancel their service. Password sharing is common, primarily between family members, though concerns about its impact are likely overblown according to the research. Consumers expect a high-quality, premium viewing experience from SVOD services.
Este manual explica cómo implementar Google Analytics en una tienda Magento para entender y mejorar el rendimiento. Detalla la configuración de perfiles y filtros en Google Analytics, así como el seguimiento de eventos, métricas de e-commerce y optimización on-site para mejorar el posicionamiento orgánico.
The document provides a micro-analysis of 5 scenes from the film The Descent. It analyzes the car crash scene in 5 snapshots, focusing on camera angles and sound effects used. It then analyzes the face-to-face confrontation scene between Sarah and Juno in 6 snapshots, highlighting makeup, editing and sound. Finally, it examines Sarah's escape scene in 5 snapshots, drawing attention to lighting, camera distance and angles. The analysis focuses on cinematography techniques used to convey emotion and build tension across the different scenes.
DEVNET-1148 Leveraging Cisco OpenStack Private Cloud for DevelopersCisco DevNet
The document discusses developing applications on Cisco OpenStack Private Cloud. It describes setting up a development environment using CoreOS, Docker, Gitlab, Jenkins, Slack, and Ansible. The environment automates the deployment of load balancers, web servers, and other application components from source code commits using continuous integration and continuous delivery practices. Jenkins is configured to build Docker containers from code commits and deploy them to instances in the private cloud.
Satish Reddy Pydimarla is seeking a senior position in testing and commissioning. He has over 8 years of experience in testing, commissioning, operation, and maintenance of high and low voltage electrical equipment. Currently he works as a senior testing and commissioning engineer. He has expertise in testing transformers, motors, generators, circuit breakers, and more. He is proficient in AutoCAD, MS Office, and has strong analytical and problem solving skills.
2016 04-21 Association of Dutch Producers of Children and Diet Nutrition (VNF...Alain van Gool
Keynote lecture at the 55-year lustrum conference of the Association of Dutch Producers of Children and Diet Nutrition (VNFKD) to reflect on the use of (specialized) nutrition in personalized healthcare.
2016 05-24 Kick-off The Danish Biomarker Network, Copenhagen, Alain van GoolAlain van Gool
Keynote lecture given at the kick-off of The Danish Biomarker Network in Copenhagen for a great audience of enthousiastic patients, biotech/pharma developers and ICT experts.
2016-02-18 Innovation for Health 2016 conference, Rotterdam Alain van GoolAlain van Gool
Lecture on personalized healthcare in a great session at the Innovation for Health 2016 conference, discussing opportunities and challenges with 800 scientists, enterpreneurs and care professionals.
2015 12-09 Opening Radboud Translational Medicine, Nijmegen, Alain van GoolAlain van Gool
Keynote opening lecture at the grand opening of our new cyclotron facility, embedded in Radboud Translational Medicine and part of our Radboudumc Technology Centers. See http://www.radboudtranslationalmedicine.nl/nl/ for details.
Great evening with the Rotary Oss where I got the opportunity to discuss current and future prospects in personalized healthcare with a good group of interested people.
2015 07-03 Nanonext NL Alain van Gool, AmsterdamAlain van Gool
The document discusses implementing personalized healthcare through measuring biomarkers. It notes that while many biomarkers have been discovered, few are validated and applied in diagnostic tests. There is also a gap in translating biomarkers into point-of-care applications. The document advocates for open innovation networks to help validate biomarkers across multiple centers and standardize clinical applications. Ultimately, the focus of personalized healthcare should be on the patient by providing individualized follow-up based on their molecular and clinical measurements.
2015 09-14 Precision Medicine 2015, London, Alain van GoolAlain van Gool
Outline of my view hoe personalized health(care) is more than just targeted medicines, also including personal motivation and actions towards disease prevention. It also outlines 4 key factors that should be in order for optimal personalized health(care): 1. start with patients first, 2. Accelerate translation research to application, 3. Copy best practice, 4. Spread the word.
2017 05-18 Radboudumc Information Management Inspiration Point, Nijmegen, Ala...Alain van Gool
The document discusses the validation of interleukin-8 (IL-8) as a biomarker for melanoma. A study was conducted using 59 melanoma tumor tissue samples and matching serum and plasma to validate that IL-8 is elevated in melanoma. However, the results were inconsistent, as IL-8 protein levels appeared sensitive to freeze-thawing of samples. The author advocates for increasing the quality rather than quantity of biomarker research through improved collaboration to ensure better data and validation.
2020 08-28 SensUs Event 2020 keynote, Eindhoven, Alain van GoolAlain van Gool
Closing keynote for international students participating in the SensUs Event 2020, where they designed and created a novel sensor for drug level monitoring in epilepsy treatment. Lecture outlined innovations in biomarkers in personalized health(care).
2021 06-14 EATRIS-Plus summer school, Alain van GoolAlain van Gool
Introductory lecture for the 100 participant summer school of the EATRIS-Plus project, outlining personalized medicine, biomarker and multi-omics strategies and use cases.
2014 07-08 Selectbio Biomarkers 2014, CambridgeAlain van Gool
The document discusses biomarkers in personalized healthcare from discovery to clinical diagnostics, providing an overview of the speaker's experience in academia, pharmaceutical industry, and applied research focusing on biomarkers and omics technologies. It also describes the Radboud University Medical Center's focus on personalized healthcare through its technology centers and biomarker research on conditions like metabolic syndrome. The discussion emphasizes how biomarkers are evolving from diagnosis to tools that enable personalized and participatory healthcare approaches.
Presentation of current evidence for promotion of mental wellbeing and prevention of mental disorders. The presentation argues for moving from research to action, using the mental health in all policies approach.
This document provides library resources for a nursing course at HVCC. It lists the library liaison for health sciences, Cynthia Koman, and her contact information. It then provides links to the nursing research guide, information about APA citation style, medical research databases like CINAHL and PubMed. The document describes role-playing activities and case studies that will take place. It provides questions that will be used in the activities and studies. Finally, it provides tips on searching databases and keywords for finding nursing information.
2020 02-10 European Center Pharmaceutical Medicine course - biomarkers, Basel...Alain van Gool
This document discusses biomarkers and personalized healthcare. It begins with an overview of biomarkers in the pharmaceutical industry and how they are used from drug discovery through clinical trials. It then discusses biomarkers in academic research and healthcare, and how emerging digital biomarkers could enable personalized health monitoring. The presentation identifies some translational innovation gaps, and concludes with an outlook on how biomarkers and multi-omics approaches will continue to advance personalized diagnosis and therapies.
20191203 DOE Data Driven Healthcare- Expert EventDayOne
This document summarizes a presentation on data-driven healthcare given at the DayOne Experts conference in Basel on December 3rd, 2019. The presentation discusses whether the healthcare system is ready for data-driven approaches and what is needed to enable new data-driven health solutions. It notes that while digitalization in Swiss medical practices is increasing, coordination between different parts of the treatment chain remains a challenge. The Swiss Personalized Health Network aims to connect different health data sources and establish national infrastructure to enable interoperable exchange of health data for research purposes. University hospitals are working to structure, standardize and integrate different types of clinical and research data according to SPHN requirements.
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2023-11-14 Biomarkers Europe 2023, Berlin, Alain van Gool.pdfAlain van Gool
Lecture at the Biomarkers Europe 2023 conference for an audience of pharma scientists and omics/data solution providers. I outlined several initiatives of potential interest and discussed development of our sensitive personalized clinical biomarker test for minimal residual disease monitoring in multiple myeloma.
2023-11-09 HealthRI Biobanking day_Amsterdam_Alain van Gool.pdfAlain van Gool
Examples of lessons learned in Omics-based biomarker studies from myself and colleagues in X-omics and EATRIS, for an audience of biobankers, researchers and diagnostic/clinical chemistry experts.
2023-04-20 EATRIS-Plus Summerschool, Lisbon, Alain van GoolAlain van Gool
Closing keynote lecture at the EATRIS-Plus summerschool on personalised medicine, outlining developments, opportunities, challenges and recommendations to do next in this exciting era of personalised medicine.
2022-11-23 DTL Future of data-driven life sciences, Utrecht, Alain van Gool.pdfAlain van Gool
A pitch on directions to improve experimental reproducibility, illustrated by examples of past experiences. I made the plee to move from 'Proudly invented here' to 'Proudly copyied from', to re-use each other's eperiences in successes and failures.
2022-10-12 The future of population health_Alain van Gool.pdfAlain van Gool
1) Exponential developments in omics technologies like genomics, proteomics, and metabolomics are driving more personalized approaches to healthcare.
2) Mass spectrometry methods have been developed to sensitively detect minimal residual disease in multiple myeloma patients from plasma samples, allowing for dynamic monitoring and earlier detection of relapse compared to traditional methods.
3) Large-scale multi-omics studies incorporating data from various sources can provide a more holistic view of health and disease at both the individual and population levels, supporting personalized prevention and treatment approaches.
2022-09-08 ECPM Digital Biomarkers and AI, Basel, Alain van Gool.pdfAlain van Gool
Lecture for 150 pharma professionals to outline the potentials and things-to-do with digital biomarkers, as part of a ECPM training on digitization and AI in drug development.
2022-04-14 EuroMedLab, Munich, Alain van GoolAlain van Gool
Keynote lecture at the EuroMedLab 2021 providing an audience of clinical chemists and laboratory medicine scientists with advancements of multi-omics applications in personalized healthcare, and challenges that we need to solve as translational scientists.
2021 12-10 Amalia Science Day, Nijmegen, Alain van GoolAlain van Gool
This document discusses the use of omics technologies like genomics, proteomics, and glycoproteomics in pediatric healthcare. Specifically, it describes a study that used glycoproteomics to analyze blood samples from children with febrile illness to distinguish between viral and bacterial infections. The analysis identified glycoprotein biomarkers that could accurately classify 70-80% of samples as viral or bacterial. Integrating multiple omics data through machine learning approaches may provide a more comprehensive understanding of diseases and lead to personalized diagnosis and treatment.
2021 03-25 11th World Clinical Biomarkers & Companion Diagnostics, Alain van ...Alain van Gool
Closing keynote of a 3-day conference on clinical biomarkers and companion diagnostics, organised by Hanson Wade, outlining the power of omics approaches in healthcare and translation of inovations to impact.
2020 09-07 European Center Pharmaceutical Medicine course Biomarkers, Basel, ...Alain van Gool
Tutorial lecture on biomarkers for pharmaceutical industry R&D professionals, outlining status, potential and challenges of biomarkers in pharma, clinic and society.
2019 10-14 2nd Int Congress on Precision Medicine, Munich, Alain van GoolAlain van Gool
Opening lecture at the 2nd International Congress on Precision Medicine in Munich, outlining progress in omics-based biomarkers for rare diseases, biomarker innovation gaps and multi-partner initiatives to bridge those gaps to applications. Also reviewed the highlights of our recently published Handbook of Biomarkers and Precision Medicine.
2019 09-23 COST CliniMARK summerschool, Spetses, Alain van GoolAlain van Gool
Opening lecture of the COST CliniMARK summer school 'Approaches for Biomarker Discovery and Validation'. Extensive introduction in biomarker approached used in pharmaceutical industry, academic research and clinical care, and society, combined with review of biomarker innovation gaps and outlook.
2019 06-19 Dutch association for clinical chemistry and laboratory medicine -...Alain van Gool
Sharing my views on how X-omics biomarker analyses through next gen sequencing and mass spectrometry will change the landscape of diagnostics and clinical chemistry in the near future.
Lecture describing workflows and case studies from the Translational Metabolic Laboratory @Radboudumc how to translate x-omics biomarker signatures to clinical implementation. I also highlighted new developments to join forces in the Netherlands X-omics Initiative, United for Metabolic Disease and events/book launches in the next months.
2019 03-14 Health Valley Event 2019, Nijmegen, Alain van GoolAlain van Gool
Lecture on innovations in personalized healthcare using an integrated X-omics approach towards personalized diagnostics, as part of the regional ambitious TopFit program.
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2. 9:00-9:15 Alain van Gool, Radboudumc, TNO
9:15-9:35 Diederik Bruins, Fortified Food Coatings
9:35-9:55 Leon Terstappen, Utwente
9:55-10:15 Andrea van Elsas, Aduro Botech
10:15-10:25 Closure Alain van Gool
3. Personalized Medicine:
moving towards Personalized
Health(care)
Professor of Personalized Healthcare
Head Radboud Center for Proteomics, Glycomics
and Metabolomics
Coordinator Radboud Technology Centers
Senior Scientist Integrator Biomarkers
Prof Alain van Gool
Health Valley Event 2016
17 March 2016
Scientific lead DTL-Technologies Head Biomarker Platform
4. Source: Chakma, Journal of Young Investigators, 16, 2009
Principle of Personalized Medicine
4
• The right drug for right patient at right dose at right time
• Molecular biomarkers as key drivers of patient selection
• = Precision medicine or Targeted medicine
4 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016
5. Companion diagnostics
Good examples personalized medicine in Oncology and Neurosciences:
• Cyp450, Her2/neu, BRCA, BRAF, EGFR, EML4/ALK, etc
Emerging companion diagnostics, also linked to non-drug therapies:
• Volker: Intestinal surgery → XIAP → Cord blood
• Beery twins: Cerebral palsy → SPR → Diet 5HTP
• Wartman: Leukemia → FLT3 → Sunitinib
• Gilbert: Healthy → BRCA → Mas/Ovarectomy
• Snyder: T2Diabetes → GCKR, KCNJ11 → Diet, exercise
• Lauerman: Scotoma, leg → JAK2 → Aspirin
• Bradfield: Healthy → CDH1 → Gastrectomy
Coming up: metabolic biomarkers, imaging biomarkers
5 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016
6. Moving towards Personalized Health(care)
“The term "personalized medicine" is
often described as providing "the
right patient with the right drug at
the right dose at the right time."
More broadly, "personalized
medicine" may be thought of as the
tailoring of medical treatment to the
individual characteristics, needs, and
preferences of a patient during all
stages of care, including prevention,
diagnosis, treatment, and follow-up.”
(FDA, October 2013)
6
6 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016
7. Personal need in efficient personalized health(care)
It’s personal !
‘I want to stay healthy.’
‘If not, how do I get healthy?’
7 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016
8. 3 key aspects of personalized health(care)
‘I want to stay healthy. If not, how do I get healthy?’
1. What to measure?
2. How much can it change?
3. What should be the follow-up for me?
8 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016
9. Exponential technological developments
• Next generation sequencing
• DNA, RNA
• Risk analysis and therapy selection
• Mass spectrometry
• Proteins, metabolites
• Monitoring of disease and treatment effects
• Imaging
• Non invasive images, real time
• Spatial view of intact organs and organisms
500
1000
1500
2000
m/z
5 10 15 20 25 30 35 40 Time [min]
9 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016
11. Translation is key in personalized health(care)
Personal profile data
Knowledge
Understanding
Decision
Action
Shared decision making
11 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016
12. Translation is key in Personalized Healthcare !
“I’m afraid you’re
suffering from an
increased IL-1β and
an aberrant miR843
expression”
Adapted from:
?
12 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016
13. Personalized health(care) model
Personalized
Intervention
of patients-like-me
Personal thresholds
of persons-like-me
Big
Biomarker
Data
Molecular
Non-molecular
Environment
…
Time
Disease
Health
Selfmonitoring
Adapted from Jan van der Greef, TNO
Personal profile
Personalized health
Personalized medicine
13 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016
14. Personalized health(care) monitoring as part of our lives
• Monitor on background
• Alert when you are at risk
• Advice what to do
Examples from car dashboard:
• Empty gas tank
• Traffic jam ahead
14 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016
15. 15 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016
15
New data
(generators, owners)
16.
17. Not all innovations are useful
17 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016
Patient AdherenceCurrent
Disease
progression
Disease
stable
€
Effect
NEW innovative platform
(app to improve adherence to therapy)
Added
value ? Health Technology Assessment
Hemofilia NO
CML YES
Richard van der Broek
Sabine Mulders
18. 18 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016
What’s next?
Simulating YOUR health
Heleen Wortelboer
Herman van Wietmarschen
Jan van der Greef
Esther Zondervan
Wim van Hartingsveldt
19. 19 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016
What’s next?
Simulating YOUR health + Personalized advice + Feedback
20. Acknowledgements
Ron Wevers
Jolein Gloerich
Hans Wessels
Dirk Lefeber
Monique Scherpenzeel
Leo Kluijtmans
Lucien Engelen
Nathalie Bovy
Paul Smits
Maroeska Rovers
Bas Bloem
the Technology Centers
and many others
www.radboudumc.nl/personalizedhealthcare
www.radboudresearchfacilities.nl
www.radboudumc.nl/research/technologycenters
alain.vangool@tno.nl
alain.vangool@radboudumc.nl
www.linkedIn.com
www.slideshare.net/alainvangool
Many collaborators and funders
Jan van der Greef
Ben van Ommen
Bas Kremer
Cyrille Krul
Ivana Bobeldijk
Lars Verschuren
Marjan van Erk
Peter van Dijken
Peter Wielinga
Ronald Mooij
Suzan Wopereis
and many others
CarTarDis
20 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016
21. 9:00-9:15 Alain van Gool, Radboudumc, TNO
9:15-9:35 Diederik Bruins, Fortified Food Coatings
9:35-9:55 Leon Terstappen, Utwente
9:55-10:15 Andrea van Elsas, Aduro Botech
10:15-10:25 Closure Alain van Gool
22. Personalized Medicine:
Conclusions and follow-up
Professor of Personalized Healthcare
Head Radboud Center for Proteomics, Glycomics
and Metabolomics
Coordinator Radboud Technology Centers
Senior Scientist Integrator Biomarkers
Prof Alain van Gool
Health Valley Event 2016
17 March 2016
Scientific lead DTL-Technologies Head Biomarker Platform
32. Oprichting Special Interest Groups (S.I.G.)
- Krachtenbundeling in de regio
- Per thema één S.I.G.
- Kartrekkers gezocht (per S.I.G. 3 á 4 personen)
- Deelnemers actief via netwerkapp community
- S.I.G. brainstormt over content, sprekers, thema’s
- Health Valley zorgt voor sessies en events
- Meld je bij de sessievoorzitter, Marc Kalf of Victor Haze
(Meeting Point Health Valley of via de Netwerk app)
33. 9:00-9:15 Alain van Gool, Radboudumc, TNO
9:15-9:35 Diederik Bruins, Fortified Food Coatings
9:35-9:55 Leon Terstappen, Utwente
9:55-10:15 Andrea van Elsas, Aduro Botech
10:15-10:25 Closure Alain van Gool