This document provides guidelines for the management of chronic stable angina. It recommends comprehensive patient education on lifestyle modifications, medications, and symptoms. Medical therapy should focus on risk factor modification through statins, blood pressure control, diabetes management, and physical activity. Antiplatelet, beta-blocker, ACE inhibitor/ARB therapy are recommended. For symptom relief, beta-blockers, calcium channel blockers, or nitrates should be used. A heart team approach is advised for revascularization decisions in complex cases. CABG is recommended for significant left main coronary artery stenosis while PCI may be an alternative in selected cases.

1. Management guideline of
chronic stable angina(CSA)
Chairperson:Assoc.Prof.Manzoor Mahmud
Presenter:
Dr.Md.Sajjad Safi
Phase-B,Resident
BSMMU

2. 2014 ACC/AHA/AATS/PCNA/SCAI/STS
Focused Update Incorporated Into the 2012
ACCF/AHA/ACP/AATS/PCNA/SCAI/STS
Guideline for the Diagnosis and Management
of Patients With Stable Ischemic Heart
Disease
© American College of Cardiology Foundation and American Heart Association, Inc.

3. Introduction
Guideline for SIHD

4. Diagnosis of SIHD
Guideline for SIHD

5. Diagnosis of SIHD
• Clinical Evaluation of Patients With
Chest Pain
• Electrocardiography
• Stress Testing and Advanced Imaging
• Invasive Testing

6. Clinical Classification of Chest Pain

7. Risk Assessment
Guideline for SIHD

8. Pretest Likelihood of CAD in Symptomatic Patients
According to Age and Sex* (Combined Diamond/Forrester
and CASS Data)
*Each value represents the percent with significant CAD on
catheterization.

9. Noninvasive Risk Stratification
*Although the published data are limited; patients with these findings will probably not be at low risk in the
presence of either a high-risk treadmill score or severe resting LV dysfunction (LVEF <35%).

10. Algorithm for Risk Assessment of
Patients With SIHD*
*Colors correspond to the ACCF/AHA Classification of Recommendations and Levels
of Evidence Table.

11. Algorithm for Risk Assessment of Patients
With SIHD (cont.)*
*Colors correspond to the ACCF/AHA Classification of Recommendations and Levels
of Evidence Table.

12. Treatment
Guideline for SIHD

13. Patient Education
Treatment

14. a.education on the importance of medication adherence for
managing symptoms and retarding disease progression ;
b. an explanation of medication management and
cardiovascular risk reduction strategies
c. comprehensive review of all therapeutic options
I IIa IIb III
I IIa IIb III
Patient Education

15. d. a description of appropriate levels of exercise
e. introduction to self-monitoring skills; and
f. information on how to recognize worsening cardiovascular
symptoms and take appropriate action.
I IIa IIb III
Patient Education (cont.)

16.  Weight control,
maintenance of a BMI of 18.5 to 24.9 kg/m2,
waist circumference :102 cm (40 inches) in men
and <88 cm (35 inches) in women.
 Lipid management
 BP control
 Smoking cessation
 Avoidance of exposure to secondhand smoke;
 Patients with diabetes mellitus to supplement
diabetes treatment goals and education
 Individualized medical, nutrition, and life-style
changes
I IIa IIb III
Patient Education (cont.)

17. a. adherence to a diet : low in saturated fat,
cholesterol, and trans fat; high in fresh fruits, whole
grains, and vegetables; and reduced in sodium intake
b. common symptoms of stress and depression to
minimize stress related angina symptoms;
I IIa IIb III
I IIa IIb III
Patient Education (cont.)

18. Guideline-Directed Medical
Therapy
Treatment

19. Risk Factor Modification
Treatment

20. Statin therapy should be prescribed, in the
absence of contraindications or documented
adverse effects.
For patients who do not tolerate statins, LDL
cholesterol–lowering therapy with bile acid
sequestrants,* niacin,† or both is reasonable.
*The use of bile acid sequestrant is relatively contraindicated when
triglycerides are ≥200 mg/dL and is contraindicated when triglycerides are
≥500 mg/dL.
†Dietary supplement niacin must not be used as a substitute for
prescription niacin.
Lipid Management (cont.)
I IIa IIb III
I IIa IIb III

21. In patients with SIHD with BP 140/90 mm Hg or higher,
antihypertensive drug therapy should be instituted in
addition to or after a trial of lifestyle modifications.
ACE inhibitors and/or beta blockers, with addition of other
drugs, such as thiazide diuretics or calcium channel
blockers, if needed to achieve a goal BP of less than
140/90 mm Hg.
I IIa IIb III
I IIa IIb III
Blood Pressure Management

22. Short duration of diabetes mellitus and a long life
expectancy, a goal HbA1c of 7% or less is
reasonable.
A goal HbA1c between 7% and 9% is reasonable
for certain patients according to age, history of
hypoglycemia, presence of complications, or
coexisting medical conditions.
I IIa IIb III
I IIa IIb III
Diabetes Management

23. Should encourage 30 to 60 minutes of moderate-
intensity aerobic activity, such as brisk walking, at
least 5 days and preferably 7 days per week
For all patients, risk assessment with a physical
activity history and/or an exercise test is
recommended to guide prognosis and prescription.
I IIa IIb III
Physical Activity
I IIa IIb III

24. Additional Medical Therapy
to Prevent MI and Death
Treatment

25. Aspirin 75 to 162 mg daily should be continued
indefinitely in the absence of contraindications in
patients with SIHD.
Clopidogrel is reasonable when aspirin is
contraindicated in patients with SIHD.
I IIa IIb III
I IIa IIb III
Antiplatelet Therapy

26. Beta-blocker therapy should be started and continued for
3 years in all patients with normal LV function after MI or
ACS.
Beta-blocker therapy should be used in all patients with
LV systolic dysfunction (EF ≤40%) with heart failure or
prior MI, unless contraindicated. (Use should be limited
to carvedilol, metoprolol succinate, or bisoprolol, which
have been shown to reduce risk of death.)
Beta blockers may be considered as chronic therapy for
all other patients with coronary or other vascular
disease.
I IIa IIb III
I IIa IIb III
I IIa IIb III
Beta-Blocker Therapy

27. ACE inhibitors should be prescribed in all patients
with SIHD who also have hypertension, diabetes
mellitus, LVEF 40% or less, or CKD, unless
contraindicated.
ARBs are recommended for patients with SIHD
who have hypertension, diabetes mellitus, LV
systolic dysfunction, or CKD and have indications
for, but are intolerant of, ACE inhibitors.
I IIa IIb III
Renin-Angiotensin-Aldosterone
Blocker Therapy
I IIa IIb III

28. Indications for Individual Drug Classes
in the Treatment of Hypertension in
Patients With SIHD*
*Table indicates drugs that should be considered and does not indicate that all drugs
should necessarily be prescribed in an individual patient (e.g., ACE inhibitors and
ARB typically are not prescribed together).

29.
An annual influenza vaccine is recommended for
patients with SIHD.
I IIa IIb III
Influenza Vaccination

30. Medical Therapy for Relief of
Symptoms
Treatment

31. Use of Anti-Ischemic
Medications
Treatment

32. Beta blockers should be prescribed as initial therapy
for relief of symptoms
Calcium channel blockers or long-acting nitrates
should be prescribed for relief of symptoms when beta
blockers are contraindicated or cause unacceptable
side effects
Calcium channel blockers or long-acting nitrates, in
combination with beta blockers
I IIa IIb III
Use of Anti-Ischemic Medications
I IIa IIb III
I IIa IIb III

33. Sublingual nitroglycerin or nitroglycerin spray is
recommended for immediate relief of angina
Long-acting nondihydropyridine calcium channel blocker
(verapamil or diltiazem) instead of a beta blocker as initial
therapy for relief of symptoms
Ranolazine can be useful when prescribed as a substitute
for beta blockers for relief of symptoms
I IIa IIb III
Use of Anti-Ischemic Medications
(cont.)
I IIa IIb III
I IIa IIb III

34. Ranolazine in combination with beta blockers can
be useful when prescribed for relief of symptoms
when initial treatment with beta blockers is not
successful in patients with SIHD.
I IIa IIb III
Use of Anti-Ischemic Medications
(cont.)

35. Algorithm for Guideline-Directed Medical
Therapy for Patients With SIHD*
*Colors correspond to the ACCF/AHA Classification of Recommendations and Levels
of Evidence Table.

36. Algorithm for Guideline-Directed Medical
Therapy for Patients With SIHD* (cont.)
*Colors correspond to the
ACCF/AHA Classification
of Recommendations and
Levels of Evidence Table.

37. Algorithm for Guideline-Directed Medical
Therapy for Patients With SIHD* (cont.)
*Colors correspond to the
ACCF/AHA Classification of
Recommendations and Levels
of Evidence Table. †The use
of bile acid sequestrant is
relatively contraindicated when
triglycerides are ≥200 mg/dL
and is contraindicated when
triglycerides are ≥500 mg/dL.
‡Dietary supplement niacin
must not be used as a
substitute for prescription
niacin.

38. Alternative Therapies for
Relief of Symptoms in
Patients With Refractory
Angina
Treatment

39. EECP may be considered for relief of refractory angina in
patients with SIHD.*
Spinal cord stimulation may be considered for relief of
refractory angina in patients with SIHD.
I IIa IIb III
I IIa IIb III
Alternative Therapies for Relief of
Symptoms in Patients with Refractory
Angina
*This recommendation was reviewed as part of the 2014 Focused Update and the writing group decided
that it remains current, and no changes were made.

40. TMR may be considered for relief of refractory
angina
Acupuncture should not be used for the purpose
of improving symptoms or reducing
cardiovascular risk
I IIa IIb III
I IIa IIb III
No Benefit
Alternative Therapies for Relief of
Symptoms in Patients with Refractory
Angina (cont.)

41. CAD Revascularization
SIHD Guideline

42. Heart Team Approach to
Revascularization Decisions
CAD Revascularization

43. A Heart Team approach to revascularization is
recommended in patients with unprotected left
main or complex CAD.
Calculation of the STS and SYNTAX scores is
reasonable in patients with unprotected left main
and complex CAD.
I IIa IIb III
I IIa IIb III
Heart Team Approaches to
Revascularization Decisions

44. Revascularization to Improve
Survival
CAD Revascularization

45. Left Main CAD Revascularization
CAD Revascularization

46. I IIa IIb III
I IIa IIb III
CABG to improve survival is recommended for patients
with significant (≥50% diameter stenosis) left main
coronary artery stenosis.
PCI to improve survival is reasonable as an alternative to
CABG in selected stable patients with significant (≥50%
diameter stenosis) unprotected left main CAD.
Left Main CAD Revascularization

47. I IIa IIb III
Harm
PCI to improve survival should not be performed
in stable patients with significant (≥50% diameter
stenosis) unprotected left main CAD who have
unfavorable anatomy for PCI and who are good
candidates for CABG.
Left Main CAD Revascularization
(cont.)

48. Non–Left Main CAD
Revascularization
CAD Revascularization

49. I IIa IIb III CABG to improve survival is beneficial in patients with
significant (≥70% diameter) stenoses in 3 major
coronary arteries (with or without involvement of the
proximal LAD artery) or in the proximal LAD artery
plus 1 other major coronary artery.
CABG or PCI to improve survival is beneficial in
survivors of sudden cardiac death with presumed
ischemia-mediated ventricular tachycardia caused by
significant (≥70% diameter) stenosis in a major
coronary artery.
I IIa IIb III
I IIa IIb III
CABG
PCI
Non-Left Main CAD
Revascularization

50. Non-Left Main CAD
Revascularization (cont.)
I IIa IIb III
CABG is generally recommended in preference to PCI to
improve survival in patients with diabetes mellitus and
multivessel CAD for which revascularization is likely to
improve survival (3-vessel or complex 2-vessel CAD
involving the proximal LAD), particularly if a LIMA graft can
be anastomosed to the LAD artery, provided the patient is
a good candidate for surgery.
A Heart Team approach to revascularization is
recommended in patients with diabetes mellitus and
complex multivessel CAD.
Modified
2014
I IIa IIb III
New 2014

51. I IIa IIb III
Non-Left Main CAD
Revascularization (cont.)
I IIa IIb III
CABG to improve survival is reasonable in patients with
significant (≥70% diameter) stenoses in 2 major coronary
arteries with severe or extensive myocardial ischemia
CABG to improve survival is reasonable in patients with
mild–moderate LV systolic dysfunction (EF 35% to 50%)
and significant (≥70% diameter stenosis) multivessel CAD
or proximal LAD stenosis

52. I IIa IIb III CABG with a LIMA graft to improve survival is reasonable in
patients with significant (≥70% diameter) stenosis in the
proximal LAD artery and evidence of extensive ischemia.
It is reasonable to choose CABG over PCI to improve
survival in patients with complex 3-vessel CAD (e.g.,
SYNTAX score >22), with or without involvement of the
proximal LAD artery who are good candidates for CABG.
Non-Left Main CAD
Revascularization (cont.)
I IIa IIb III

53. Revascularization to Improve Symptoms With
Significant Anatomic (≥50% Left Main or ≥70%
Non-Left Main CAD) or Physiological (FFR ≤0.80)
Coronary Stenoses

54. Algorithm for Revascularization to Improve
Survival of Patients With SIHD*
*Colors correspond to the
ACCF/AHA Classification
of Recommendations
and Levels of Evidence
Table.

55. Algorithm for Revascularization to Improve
Survival of Patients With SIHD (cont.)*
*Colors correspond to the ACCF/AHA Classification of Recommendations and Levels of
Evidence Table.

56. CAD Revascularization
Revascularization to Improve
Symptoms

57. CABG or PCI to improve symptoms is beneficial in
patients with 1 or more significant (≥70% diameter)
coronary artery stenoses amenable to
revascularization and unacceptable angina despite
GDMT.
CABG or PCI to improve symptoms is reasonable in
patients with 1 or more significant (≥70% diameter)
coronary artery stenoses and unacceptable angina for
whom GDMT cannot be implemented because of
medication contraindications, adverse effects, or
patient preferences.
I IIa IIb III
I IIa IIb III
Revascularization to Improve
Symptoms

58. I IIa IIb III
I IIa IIb III
PCI to improve symptoms is reasonable in patients
with previous CABG, 1 or more significant (≥70%
diameter) coronary artery stenoses associated with
ischemia, and unacceptable angina despite
GDMT.
It is reasonable to choose CABG over PCI to
improve symptoms in patients with complex 3-
vessel CAD (e.g., SYNTAX score >22), with or
without involvement of the proximal LAD artery,
who are good candidates for CABG.
Revascularization to Improve
Symptoms (cont.)

59. Dual Antiplatelet Therapy
Compliance and Stent
Thrombosis
CAD Revascularization

60. Harm
I IIa IIb III PCI with coronary stenting (BMS or DES) should
not be performed if the patient is not likely to be
able to tolerate and comply with DAPT for the
appropriate duration of treatment based on the
type of stent implanted.
Dual Antiplatelet Therapy
Compliance and Stent Thrombosis

61. Hybrid Coronary
Revascularization
CAD Revascularization

62. Key Guideline Messages
• Management of SIHD should be based on strong scientific
evidence and the patient’s preferences.
• Moderate or high risk should be treated emergently for
acute coronary syndrome.
• Exercise test is the first choice to diagnose IHD for patients
with an interpretable ECG and able to exercise, especially if
the likelihood is intermediate (10-90%).
– An uninterpretable ECG
• Can exercise: exercise stress test with nuclear MPI or echocardiography.
• Unable to exercise: MPI or echocardiography with pharmacologic stress is
recommended.
• Coronary angiography(CAG)

63. Key Guideline Messages
• A “package” of GDMT
– Diet, weight loss and regular physical activity;
– If a smoker, smoking cessation;
– Aspirin 75-162mg daily;
– Statin medication in moderate dosage;
– If hypertensive, medication to achieve a BP <140/90; If diabetic,
appropriate glycemic control.
– Anti-anginal medication:
• Nitroglycerin(GTN)
• Beta blockers(BB)
• Calcium channel blockers(CCB)/long acting nitrates
– Revascularization :CABG /PCI

64. Treatment Strategy for CSA:
A = Aspirin and Antianginal therapy
B = Beta-blocker and Blood pressure
C = Cigarette smoking and Cholesterol
D = Diet and Diabetes
E = Education and Exercise

65. THANK YOU