A presentation about the Journal of Medical Internet Research, a founding member of the Open Access Scholarly Publishers Association (OASPA) - A contribution to Open Access Week 2010!
10 Years Experience in Pioneering Open Access Publishing in Health Informatic...Gunther Eysenbach
Peer-reviewed journals remain important vehicles for knowledge transfer and dissemination in health informatics, yet, their format, processes and business models are changing only slowly. Up to the end of last century, it was common for individual researchers and scientific organizations to leave the business of knowledge transfer to professional publishers, signing away their rights to the works in the process, which in turn impeded wider dissemination. Traditional medical informatics journals are poorly cited and the visibility and uptake of articles beyond the medical informatics community remain limited. In 1999, the Journal of Medical Internet Research (JMIR; http://www.jmir.org) was launched, featuring several innovations including 1) ownership and copyright retained by the authors, 2) electronic-only, "lean" non-for-profit publishing, 3) openly accessible articles with a reversed business model (author pays instead of reader pays), 4) technological innovations such as automatic XML tagging and reference checking, on-the-fly PDF generation from XML, etc., enabling wide distribution in various bibliographic and full-text databases. In the past 10 years, despite limited resources, the journal has emerged as a leading journal in health informatics, and is presently ranked the top journal in the medical informatics and health services research categories by impact factor. The paper summarizes some of the features of the Journal, and uses bibliometric and access data to compare the influence of the Journal on the discipline of medical informatics and other disciplines. While traditional medical informatics journals are primarily cited by other Medical Informatics journals (33%-46% of citations), JMIR papers are to a more often cited by "end-users" (policy, public health, clinical journals), which may be partly attributable to the "open access advantage".
This presentation was given at Medinfo 2010 (13th World Congress on Medical and Health Informatics) in Cape Town in September 2010.
A self-archived full paper is available on Scribd:
http://tinyurl.com/jmir10yrs
Please cite as:
Eysenbach G. 10 years experience with pioneering open access publishing in health informatics: the Journal of Medical Internet Research (JMIR). Stud Health Technol Inform. 2010;160(Pt 2):1329-3
(cc-by) can be freely distributed under the Creative Commons Attribution License
Open Access - PeerJ Presentation to Lawrence Berkeley Labs (LBL)Peter Binfield
Slides from the PeerJ presentation to Lawrence Berkeley Labs (LBL) on May 23rd 2013. As hosted by Mark Biggin. Originally titled “What's All the Fuss About Open Access? What Do I Need to Know, and How Does it Benefit Me?”
Altmetrics - Measuring the impact of scientific activitiesKim Holmberg
An introduction to altmetrics, the complementary metrics of research impact. The presentation covers some of the challenges with more traditional measures, and the potential of and challenges with altmetrics. The presentation gives a brief overview of the background to a new research project about measuring the societal impact of open science.
Open Access for Early Career ResearchersRoss Mounce
My talk for the University of Bath Open Access Week session; 23rd October 2013.
http://www.bath.ac.uk/learningandteaching/rdu/courses/pgskills/modules/RP00335.htm
10 Years Experience in Pioneering Open Access Publishing in Health Informatic...Gunther Eysenbach
Peer-reviewed journals remain important vehicles for knowledge transfer and dissemination in health informatics, yet, their format, processes and business models are changing only slowly. Up to the end of last century, it was common for individual researchers and scientific organizations to leave the business of knowledge transfer to professional publishers, signing away their rights to the works in the process, which in turn impeded wider dissemination. Traditional medical informatics journals are poorly cited and the visibility and uptake of articles beyond the medical informatics community remain limited. In 1999, the Journal of Medical Internet Research (JMIR; http://www.jmir.org) was launched, featuring several innovations including 1) ownership and copyright retained by the authors, 2) electronic-only, "lean" non-for-profit publishing, 3) openly accessible articles with a reversed business model (author pays instead of reader pays), 4) technological innovations such as automatic XML tagging and reference checking, on-the-fly PDF generation from XML, etc., enabling wide distribution in various bibliographic and full-text databases. In the past 10 years, despite limited resources, the journal has emerged as a leading journal in health informatics, and is presently ranked the top journal in the medical informatics and health services research categories by impact factor. The paper summarizes some of the features of the Journal, and uses bibliometric and access data to compare the influence of the Journal on the discipline of medical informatics and other disciplines. While traditional medical informatics journals are primarily cited by other Medical Informatics journals (33%-46% of citations), JMIR papers are to a more often cited by "end-users" (policy, public health, clinical journals), which may be partly attributable to the "open access advantage".
This presentation was given at Medinfo 2010 (13th World Congress on Medical and Health Informatics) in Cape Town in September 2010.
A self-archived full paper is available on Scribd:
http://tinyurl.com/jmir10yrs
Please cite as:
Eysenbach G. 10 years experience with pioneering open access publishing in health informatics: the Journal of Medical Internet Research (JMIR). Stud Health Technol Inform. 2010;160(Pt 2):1329-3
(cc-by) can be freely distributed under the Creative Commons Attribution License
Open Access - PeerJ Presentation to Lawrence Berkeley Labs (LBL)Peter Binfield
Slides from the PeerJ presentation to Lawrence Berkeley Labs (LBL) on May 23rd 2013. As hosted by Mark Biggin. Originally titled “What's All the Fuss About Open Access? What Do I Need to Know, and How Does it Benefit Me?”
Altmetrics - Measuring the impact of scientific activitiesKim Holmberg
An introduction to altmetrics, the complementary metrics of research impact. The presentation covers some of the challenges with more traditional measures, and the potential of and challenges with altmetrics. The presentation gives a brief overview of the background to a new research project about measuring the societal impact of open science.
Open Access for Early Career ResearchersRoss Mounce
My talk for the University of Bath Open Access Week session; 23rd October 2013.
http://www.bath.ac.uk/learningandteaching/rdu/courses/pgskills/modules/RP00335.htm
Luciano informs healthcare_2015 Nashville, TN USA July 30 2015Joanne Luciano
This talk presents and explains Health Web Science, Health Web Observatories, and the technologies needed to create and utilize them as an approach towards preferable health outcomes in the 21st century. Health Web Science (HWS), which impact of the Web on health and wellbeing, aims towards a preventative, participatory, personalized, and predictive (P4) model of healthcare. HWS posits this can be achieved by the leveraging of the Web’s data, resources and nature. In studying the Web, it is impossible to ignore the evolving social, political, economic, policy questions that emerge as a result of the use of the Web. Health Web Observatories play a role by enabling the study of these data, make available the metadata, and thereby enable it as a feedback mechanism for preferable futures.
VIVO conference Aug 2011: The VIVO platform and ORCID in the scholarly identi...Gudmundur Thorisson
A major challenge facing VIVO is the retrieval of published works associated with specific authors from participating institutions, and automated disambiguation & identification of authors and scholarly works. VIVO thus shares many of the same goals as the Open Researcher and Contributor ID not-for-profit organization (ORCID: http://www.orcid.org). ORCID is working to solve the long-standing name ambiguity problem in scholarly communication globally, not only for researchers affiliated with academic institutions, but for contributors to scholarly works of all kinds. The aim of this mini-grant collaborative project is to explore how VIVO and ORCID could interact in the scholarly identity ecosystem, by way of small-scale implementation work and technology evaluation&review. The presentation will provide a brief introduction to ORCID and a background to the project, summarize the technical development undertaken thus far and outline the work remaining, and discuss some possilities for future work beyond this specific short-term project.
Telling your research story with (alt)metricsPaul Groth
Presentation on the use of altmetrics to inform stories about altmetrics. Presented for Open Access week 2013 in Amsterdam. See http://uba.uva.nl/home/componenten/agenda-2/agenda-2/content/folder/lezingen/13/10/altmetrics.html
Opportunities and Challenges of establishing Open Access Repositories: A case...Sukhdev Singh
National Informatics Centre had established a subject repository in May 2005. It is meant for Medical and Allied Sciences and named as OpenMED@NIC . It has MeSH® based subject categorization and this makes it one of its own kind. Taking OpenMED@NIC as a case – this paper discusses key issues in establishing and maintaining an open access repository. Librarians and information science professionals can play active role in providing access and exposure to quality research and academic content generated in their institutions. Mature and standard open sources softwares are now available for setting up repositories. Libraries can install one of these on existing institutional or library servers to setup repositories. However to ensure better access and faster response time dedicated hardware and reliable connectivity would be required. Librarians and information science professional can play important role in exposing intellectual content produced by their organizations. They can take of various roles like – generating awareness among staff, researchers and students about benefits of self arching in institutional or subject repositories; training them in uploading their articles and other documents in such repositories; acting as meta-data editors and repositories managers. Establishing a repository, administrating and inviting authors to deposit their articles and other works in it is golden opportunity available to librarians and information science professionals. This opportunity should be grabbed with open hands.
Open scholarship [a FOSTER open science talk]Ross Mounce
A talk by Dr Ross Mounce, given at the FOSTER Open Science event 4th September, King's College London http://www.fosteropenscience.eu/event/foster-discovering-open-practices-pgr-and-early-career-researchers-0
Benefits and Implementation of Open Access Policies with Sue KriegsmanLeslie Christianson
Presentation made at the 2014 Pennsylvania Libraries Association College and Research Division spring program “Open and Shut: The Case for OA in Libraries”
Going farther together - Why Communities are essential for the future of scienceErin Robinson
Ignite@AGU Talk - Scientific problems are often no longer single person or single lab problems. In this talk, I will cover why community is critical, how to be a good citizen of communities you are a part of and further your own career at the same time and what we can hope for if communities are successful.
This paper reviews and analyzes the impact of Open Access (OA) publishing on medical research work. The aim is to establish, through literature review, how digital resources might provide an opportunity to house future medical scholarship outputs and the advantages or disadvantages versus traditional publishing.
Altmetrics Day Workshop - Internet Librarian International 2014Andy Tattersall
Altmetrics in the Academy - Implementing strategies in the library for better academic engagement, dissemination and measurement
Workshop abstract:
Altmetrics are increasingly gaining support and interest as an alternative way of disseminating and measuring scholarly output. Championed by early career researchers, librarians and information professionals, Altmetrics are to research as MOOCs are to learning. Like MOOCs most still do not understand their potential or how they could fit with or replace existing modes of delivery and assessment.
The first half of the workshop will help delegates gain an understanding of what Altmetrics are and how they can fit within academic library services. The second half of the session will deliver case studies, tools and techniques to help LIS professionals encourage better usage of Altmetrics.
10:00: What do you want from the day? What are your experiences of Altmetrics
10.40am: Altmetrics: an overview or Altmetrics and the day/where are we now?
A history, roadmap, how it fits in
11 am: Altmetrics within institutions: data, IR integration/other tools/library catalogue integration
what data is there? coverage of articles/datasets/other research outputs, mendeley demographic data
case studies of uses
examples of IR integration/motivations
primo/summon/other ones..
altmetric for institutions - integration with existing platforms
free explorer (and we’ll explore the data using this later)
11.30 Break
12.00pm Altmetrics in the Academy - getting academics and librarians on board
12.40 Brainstorming session: Value in Altmetrics: what questions do people have around this? what are their biggest concerns?
13.00 Lunch
2 pm: Getting familiar with the tools - practical session experimenting with the Altmetric explorer - half an hour (set tasks - eg create a list, pull out the most interesting mentions)
Good practice, guidelines, tips
2:45pm: At the coal face - experiences of a researcher using Altmetrics in practice
3.30pm: Break
3.45 pm: Getting mobile, how using mobile apps can help you engage more with Altmetrics
4.05 pm What’s on the horizon? What does the future for scholarly dissemination and impact.
4.40 wrap up and questions
Luciano informs healthcare_2015 Nashville, TN USA July 30 2015Joanne Luciano
This talk presents and explains Health Web Science, Health Web Observatories, and the technologies needed to create and utilize them as an approach towards preferable health outcomes in the 21st century. Health Web Science (HWS), which impact of the Web on health and wellbeing, aims towards a preventative, participatory, personalized, and predictive (P4) model of healthcare. HWS posits this can be achieved by the leveraging of the Web’s data, resources and nature. In studying the Web, it is impossible to ignore the evolving social, political, economic, policy questions that emerge as a result of the use of the Web. Health Web Observatories play a role by enabling the study of these data, make available the metadata, and thereby enable it as a feedback mechanism for preferable futures.
VIVO conference Aug 2011: The VIVO platform and ORCID in the scholarly identi...Gudmundur Thorisson
A major challenge facing VIVO is the retrieval of published works associated with specific authors from participating institutions, and automated disambiguation & identification of authors and scholarly works. VIVO thus shares many of the same goals as the Open Researcher and Contributor ID not-for-profit organization (ORCID: http://www.orcid.org). ORCID is working to solve the long-standing name ambiguity problem in scholarly communication globally, not only for researchers affiliated with academic institutions, but for contributors to scholarly works of all kinds. The aim of this mini-grant collaborative project is to explore how VIVO and ORCID could interact in the scholarly identity ecosystem, by way of small-scale implementation work and technology evaluation&review. The presentation will provide a brief introduction to ORCID and a background to the project, summarize the technical development undertaken thus far and outline the work remaining, and discuss some possilities for future work beyond this specific short-term project.
Telling your research story with (alt)metricsPaul Groth
Presentation on the use of altmetrics to inform stories about altmetrics. Presented for Open Access week 2013 in Amsterdam. See http://uba.uva.nl/home/componenten/agenda-2/agenda-2/content/folder/lezingen/13/10/altmetrics.html
Opportunities and Challenges of establishing Open Access Repositories: A case...Sukhdev Singh
National Informatics Centre had established a subject repository in May 2005. It is meant for Medical and Allied Sciences and named as OpenMED@NIC . It has MeSH® based subject categorization and this makes it one of its own kind. Taking OpenMED@NIC as a case – this paper discusses key issues in establishing and maintaining an open access repository. Librarians and information science professionals can play active role in providing access and exposure to quality research and academic content generated in their institutions. Mature and standard open sources softwares are now available for setting up repositories. Libraries can install one of these on existing institutional or library servers to setup repositories. However to ensure better access and faster response time dedicated hardware and reliable connectivity would be required. Librarians and information science professional can play important role in exposing intellectual content produced by their organizations. They can take of various roles like – generating awareness among staff, researchers and students about benefits of self arching in institutional or subject repositories; training them in uploading their articles and other documents in such repositories; acting as meta-data editors and repositories managers. Establishing a repository, administrating and inviting authors to deposit their articles and other works in it is golden opportunity available to librarians and information science professionals. This opportunity should be grabbed with open hands.
Open scholarship [a FOSTER open science talk]Ross Mounce
A talk by Dr Ross Mounce, given at the FOSTER Open Science event 4th September, King's College London http://www.fosteropenscience.eu/event/foster-discovering-open-practices-pgr-and-early-career-researchers-0
Benefits and Implementation of Open Access Policies with Sue KriegsmanLeslie Christianson
Presentation made at the 2014 Pennsylvania Libraries Association College and Research Division spring program “Open and Shut: The Case for OA in Libraries”
Going farther together - Why Communities are essential for the future of scienceErin Robinson
Ignite@AGU Talk - Scientific problems are often no longer single person or single lab problems. In this talk, I will cover why community is critical, how to be a good citizen of communities you are a part of and further your own career at the same time and what we can hope for if communities are successful.
This paper reviews and analyzes the impact of Open Access (OA) publishing on medical research work. The aim is to establish, through literature review, how digital resources might provide an opportunity to house future medical scholarship outputs and the advantages or disadvantages versus traditional publishing.
Altmetrics Day Workshop - Internet Librarian International 2014Andy Tattersall
Altmetrics in the Academy - Implementing strategies in the library for better academic engagement, dissemination and measurement
Workshop abstract:
Altmetrics are increasingly gaining support and interest as an alternative way of disseminating and measuring scholarly output. Championed by early career researchers, librarians and information professionals, Altmetrics are to research as MOOCs are to learning. Like MOOCs most still do not understand their potential or how they could fit with or replace existing modes of delivery and assessment.
The first half of the workshop will help delegates gain an understanding of what Altmetrics are and how they can fit within academic library services. The second half of the session will deliver case studies, tools and techniques to help LIS professionals encourage better usage of Altmetrics.
10:00: What do you want from the day? What are your experiences of Altmetrics
10.40am: Altmetrics: an overview or Altmetrics and the day/where are we now?
A history, roadmap, how it fits in
11 am: Altmetrics within institutions: data, IR integration/other tools/library catalogue integration
what data is there? coverage of articles/datasets/other research outputs, mendeley demographic data
case studies of uses
examples of IR integration/motivations
primo/summon/other ones..
altmetric for institutions - integration with existing platforms
free explorer (and we’ll explore the data using this later)
11.30 Break
12.00pm Altmetrics in the Academy - getting academics and librarians on board
12.40 Brainstorming session: Value in Altmetrics: what questions do people have around this? what are their biggest concerns?
13.00 Lunch
2 pm: Getting familiar with the tools - practical session experimenting with the Altmetric explorer - half an hour (set tasks - eg create a list, pull out the most interesting mentions)
Good practice, guidelines, tips
2:45pm: At the coal face - experiences of a researcher using Altmetrics in practice
3.30pm: Break
3.45 pm: Getting mobile, how using mobile apps can help you engage more with Altmetrics
4.05 pm What’s on the horizon? What does the future for scholarly dissemination and impact.
4.40 wrap up and questions
Assess quality level of the final product by using Demerit system: A case stu...inventy
This research aims to use a demerit system as a method to evaluate the level of the quality of the final product. Demerit system was applied as a case study to obtain the research objectives in the factory of transformers and household appliances, which represents as a majority factory in the formations of the general company for Electronic Industries. In this research, the Reflective Product was selected as a sample research. Several of the quantitative and scientific instruments that represent demerit system were used to achieve the research objectives. The results demonstrations that adopted identified each of the level of the quality of the final Reflective Product and standard level of quality are very important during the period of the assessment final product
Research Inventy : International Journal of Engineering and Scienceinventy
Research Inventy : International Journal of Engineering and Science is published by the group of young academic and industrial researchers with 12 Issues per year. It is an online as well as print version open access journal that provides rapid publication (monthly) of articles in all areas of the subject such as: civil, mechanical, chemical, electronic and computer engineering as well as production and information technology. The Journal welcomes the submission of manuscripts that meet the general criteria of significance and scientific excellence. Papers will be published by rapid process within 20 days after acceptance and peer review process takes only 7 days. All articles published in Research Inventy will be peer-reviewed.
Don’t like risk? Stop gambling in your accounts payable and start to take sys...sharedserviceslink.com
To be SOX compliant and for the purposes of internal audit you need to look at risk from a process perspective. You need to ensure your process is controlled and compliant. Mitzi Mitchell will share how to reduce risk to achieve systematic control of the highest P2P risk areas, including:
- Three-way matching errors
- Ensuring approval limits are correct and monitoring approval authority changes
- Minimising employee fraud (using Concur’s T & E tool)
- Avoiding duplicate payments (using APEX Analytics' audit recovery tool)
- Ensuring users in the process are following the rules to ensure compliance
Yugant Foundation, committed to serve the societyLovejeet Kaur
This is a quick formatted presentation done for Yugant Foundation, Nashik. The foundation, an NGO, was founded in 2009, as Asmita Social Group. It was registered under the Bombay Public Trust (BPT) Act 1950 and The Societies Registration Act 1860 on March 5, 2012. It basically works for the up liftment and development of tribal section of society.
Slides and Audio of "Open Access - What's Happening" - PeerJ presentation the at UC Berkeley Oxyopia Seminar Series 4th June 2013 (http://vision.berkeley.edu/?p=2889) as hosted by Dr Suzanne Fleiszig.
Note: A similar slidedeck was presented at UC Davis (May 29th 2013 - http://blogs.lib.ucdavis.edu/schcomm/2013/05/06/peerj_may2013/), and UCSF (June 17th 2013 - http://blogs.library.ucsf.edu/inplainsight/2013/06/14/peerj-innovating-scholarly-publishing/)
Publishing your research: Open Access (introduction & overview)Jamie Bisset
Open Access: what is it and what do I need to do? (November 2013) slides. Delivered as part of the Durham University Researcher Development Programme. Further Training available at https://www.dur.ac.uk/library/research/training/
A Guided Tour of Issues and Trends (The 13th Annual Health Sciences Lively Lu...Charleston Conference
Ramune K Kubilius (speaker), Andrea Twiss-Brooks (speaker), Anneliese Taylor (speaker), Deborah Blecic (speaker), Elizabeth Ketterman (speaker), Marysue Schaffer (speaker), Robin Champieux (speaker)
Open Access and Publishers - Michael Mabe (2007)faflrt
Michael Mabe, formerly VP at Elsevier and currently CEO of the International Association of STM Publishers (with membership representing nearly all major society and commercial publishers); presented the commercial and society publisher perspective on the Open Access debate including the Brussels Declaration opposed to many of the tenants of Open Access. Sponsored by ALA Federal and Armed Forces Libraries Roundtable (FAFLRT). Presented on June 25, 2007 at ALA Annual Conference in Washington, DC.
Eysenbach AMIA Keynote: From Patient Needs to Personal Health ApplicationsGunther Eysenbach
AMIA Spring Conference, May 29th-31st, 2008, Phoenix/AZ. PHR Track Keynote covers: An international perspective on the importance of PHR/PHA development & research; patient needs (and other drivers of Personal Health Records); Emerging technological trends, with an emphasis on what Eysenbach calls PHR 2.0 – impact of Web 2.0 approaches e.g. to reduce attrition in ehealth applications
Eysenbach: Personal Health Applications and Personal Health RecordsGunther Eysenbach
Keynote talk at the AMIA Spring Conference in the PHR track (Personal Health Records), focussing on international develoments and a new paradigm which I call PHR 2.0
Reputation, impact, and the role of libraries in the world of open scienceKeith Webster
An overview of the relationship between open science, research assessment, university rankings, and the role of librarians in advancing the research university
Online information 2010_track_two_final_correctedBasset Hervé
Must Libraries Fully Engage with Web 2.0 Without Discernment? The Science Business Case
According some professional magazines, Scientists are leader of the Web 2.0 pack. Many online services appeared on the market for a few years and these technologies would reshape the future of research and science communication. But, at the time being, it is not obvious whether Scientists have really embraced these new services on their daily routine, as the adoption seems to be low. The question for science libraries is to know f they have to invest on wikis and other blogs. How can they choose appropriate tools among dozens of web 2.0's applications? Is it so critical to maintain a presence on social networks? Libraries strategy must consider real impact of web 2.0 in their specific environment before to engage their energy and time.
Similar to Open Access Publishing - The Journal of Medical Internet Research (20)
Researchers and public health practitioners increasingly use Internet big data as data source. What are some of the ethical problems, and how should they be tackled? The author advocates the creation of a self-regulatory body of researchers, a code of conduct, and a notice/opt-out infrastructure, to avoid a public backlash against social media tracking/monitoring for public health, similar to the Facebook fiasko in 2014 (Cornell study).
Presentation at AMIA 2013 Washington DC, Nov 19th, Panel S50 Social Media and Me. I am focussing on the use of social media for research, in particular as tool for filtering the literature, twimpact factor, altmetrics...
How to post you slides/poster on the Medicine 2.0 event page at SlideshareGunther Eysenbach
In case you are confused, here is how to upload your files to slideshare and associate it with the Medicine 2.0 event (for participants at Medicine 2.0 ONLY!).
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Open Access Publishing - The Journal of Medical Internet Research
1. Pioneering Open Access Publishing in Health Informatics The Journal of Medical Internet Research (JMIR) 1998-2010 Gunther Eysenbach MD MPH Gunther Eysenbach MD MPH Editor/Publisher, J Med Internet Reswww.jmir.org Associate Professor Department of Health Policy, Management and Evaluation, University of Toronto; Senior Scientist, Centre for Global eHealth Innovation,Division of Medical Decision Making and Health Care Research; Epublishing and Open Access Research Group Toronto General Research Institute of the UHN, Toronto General Hospital, Canada
2. Gunther Eysenbach MD MPH Editor/Publisher, J Med Internet Reswww.jmir.org Associate Professor Department of Health Policy, Management and Evaluation, University of Toronto; Senior Scientist, Centre for Global eHealth Innovation,Division of Medical Decision Making and Health Care Research; Epublishing and Open Access Research Group PI, Consumer Health Informatics & Public Health Informatics Lab Toronto General Research Institute of the UHN, Toronto General Hospital, Canada
3. This talk focuses on 7 Publishing Innovations of JMIR First Open Access journal in health informatics / health services research (* 1999) Impact, Article Level Metrics XML Copyediting and Typesetting Scripts WebCite: Archiving cited webpages / grey reports Innovative business model Open Peer-Review iJMR (interactive Journal of Medical Research) - knol-based (wiki-like) peer-reviewed journal (spin-off)
7. Background: Knowledge Transfer in Health Informatics Journals remain the most important KT activity Traditional medical informatics journals are poorly cited and the visibility and uptake beyond a relatively small medical informatics community remains limited Disruptive technology (Internet) allows for experiments with new publishing models (incl bypassing traditional publishers and leaving publishing in the hands of scientists) and new business models (OPEN ACCESS)
8. Why the world needed JMIR in 1998 No openly accessible high-impact journals in health informatics / health service research Health informatics researchers know the value of information and knowledge buried in the medical literature (often inaccessible for textmining) No journal devoted to the burgeoning areas of “Internet medicine”, consumer health informatics, participatory medicine Most medical informatics journals paper-based, slow review processes
9. JMIR: An OA pioneer 1998. JMIR assembles editorial board 1999. First JMIR issue published May 5, 1999. E-Biomed proposed by Harold Varmus October 22, 1999. Sante Fe Convention (OAI) issued. February 2000. PubMed Central (free full-text articles) launched July 19, 2000. BioMed Central published its first free online article. March 23, 2001. Open Letter launched by the Public Library of Science (PLoS) February 14, 2002. Budapest Open Access Initiative (BOAI) launched October 13, 2003. The Public Library of Science launched its first open-access journal, PLoS Biology October 2004. PloS Medicine launched Innovation #1: Open Access http://www.earlham.edu/~peters/fos/timeline.htm
11. Achievements Now indexed in Medline, CINAHL, Information Science Abstracts, INSPEC, Communication Abstracts, The Informed Librarian Online, LISA, EMBASE, Scopus, Current Contents/Clinical Medicine (CC/CM) and Science Citation Index Expanded (SCIE), PsycINFO, Google Scholar, LISTA, … Impact Factor: 3.9 (2009) top ranked in medical informatics category (with JAMIA) (among 21 journals) and health sciences & health services research category (#2 after Health Techn Assessment review journal) (among 62 journals)
12. JMIR milestones 1999: Launch 2001: NLM/Medline indexing 2002: Introduction of Article Processing Fee [APF] ($500) Dec 2002: named Official Journal of IHCC Aug 2003: named Official Journal of SIM (Society for Internet in Medicine), abandons Medical Informatics and the Internet (Taylor & Francis) as Official Journal Aug 2003: Fast-Track Fee [FTF] ($150), guarantees an editorial decision within 2 weeks after submission, and publication of the article within 4 wks after acceptance. Nov 2003: Use of OJS 1.0 2003: Institutional Membership Scheme introduced Nov 2004: Major site relaunch: PDFs available, all articles available as XML 2005: ISI begins monitoring JMIR 2006: JMIR in PubMed Central 2007: First Impact Factor (2006) published by ISI: 2.9 (#2/20 in Medical Informatics [MI], #6/56 in Health Care Sciences & Services [HCSS]) 2007: Upgrade to OJS 2.0 2007: 30k SSHRC grant for open access journals 2008: Impact Factor (2007): 3.0 (almost the same as the #1 JAMIA: 3.1) 2008: 90k SSHRC grant for 3 years 2008: OASPA (OA Scholarly Publishers Assoc) founded, JMIR founding member 2009: Impact Factor (2008): 3.6 (now ranked #1 in Med Informatics and #2 in Health Sciences & Health Services Research categories [with #1 being a review journal]) 2010: iJMIR, eProceedings launch (spin-off journals) 2010: Impact Factor (2009): 3.9
15. Article Level Metrics Top cited (top articles got >100 citations) Top viewed (top articles get >1000 views per month) Top tweeted (top articles get >50 tweets per month), Tweets Influence Factor Top purchased (PDF purchases)
16. Manuscript Management Software Early adopter of Open Journal Systems (OJS) (open source manuscript management system) Development work in the area of XML workflow, subscription/member administration plugins, payment modules etc. (now contributed to OJS 2.x) XML typesetting scripts (now branded as Lemon8/PKP product, originally developed by the JMIR team*) Unique web-based reference checking & correction workflow for copyeditor (“OrangeX”) Innovation #3: Open Source ContributionsXML Workflows * MJ Suhonos, Juan Alperin
20. In one study published in the journal Science, 13% of Internet references in scholarly articles were inactive after only 27 months. Dellavalle RP, Hester EJ, Heilig LF, Drake AL, Kuntzman JW, Graber M, et al. Information science. Going, going, gone: lost Internet references. Science 2003 Oct 31;302(5646):787-788. DOI:10.1126/science.1088234
26. Semantics of “Openess” in peer-review Transparent: Disclosing reviewer names, perhaps even reviews Participatory: Open for anybody to join, collaborative
27. Open peer-review - solution for peer-review challenges “After 30 years of practicing peer review and 15 years of studying it experimentally, I’m unconvinced of its value” (Richard Smith) A lot of reviewers’ time is wasted (authors just submit to another journal, w/o making changes) Reviewers do a poor job spotting errors (9 maj errors, each spotted by 10-50% - J R Soc Med. 2008;101: 507-14) Possible future: Publish first into a moderated collection, solicit broad input, publish/index “version of record”
30. Conclusions Open Access was clearly a success factor in making JMIR a leading scholarly journal The JMIR example shows that with creativity and a lean publishing model sustainable OA is possible Resource constraints and non-profit model lead to innovation Small journals face uphill battles
31. Future Prospects JMIR has to focus on quality, not quantity, to preserve high impact factor, making publishing expensive In the process becoming a multi-journal publisher (economies of scale) Spin-off, “second-tier” journal(s), e.g. iJMR, to enable publication of submissions not suitable for JMIR Eproceedings journal(s)
32. Please cite as:Eysenbach G. 10 years experience with pioneering open access publishing in health informatics: the Journal of Medical Internet Research (JMIR).Stud Health Technol Inform. 2010;160(Pt 2):1329-3 (cc-by) can be freely distributed under the Creative Commons Attribution License
33. Thank you! Dr G. Eysenbach, Email: geysenba at uhnres.utoronto.ca or @gmail.com, My peer-reviewed Journal: http://www.jmir.org My Blog: http://gunther-eysenbach.blogspot.com My Conferences: http://www.medicine20congress.com http://www.ehealthcongresss.org My Slides: http://www.slideshare.net/eysen Funding Change Foundation, Canadian Institutes for Health Research, NSERC, European Union, SSHRC