This document summarizes the top 20 pieces of advice people wish they knew at age 20 based on responses from Twitter. The advice falls under four main themes: 1) The importance of relationships and surrounding yourself with good peers. 2) The importance of hustle and perseverance to achieve your goals. 3) Prioritizing working on meaningful problems and optimizing for impact. 4) If starting a company, aim for great things and don't be afraid of risk if success could make a difference.