01 Lo que debes saber de Strategic Planning y no morir en el intento 2017Comisuras
Colección de documentos de difusión que busca de forma continuada difundir y poner en conocimiento todos aquellos “conceptos extraños y rimbombantes” que usamos los que trabajamos en comunicación. Los cuales no son más que herramientas para ayudar a las marcas a conectar con las personas.
Quantification of variability and uncertainty in systems medicine modelsNatal van Riel
BioSB2016 Conference
Abstract: Computational modelling in systems biology addresses biological processes at different levels and scales. The quantification of model parameters from experimental data is a complicated task. To develop accurate, predictive models it is necessary to analyze how variance in data propagates into parameter estimates and, more importantly, model predictions. The network structure of the biological systems imposes strong constraints on possible solutions of a model. Amounts of data, available at molecular and physiological level, continue to increase. Often, model results are only partly in agreement with data, despite that model parameters are fitted. In contrast to existing belief that calibration of systems biology models to experimental data is prone to overfitting, we argue that dynamical models, despite their size and complexity, are not flexible enough to correctly describe all data.
Approaches are explored to introduce more degrees of freedom in models, but simultaneously enforcing sparsity if extra flexibility is not required. Estimation tools for dynamical systems are complemented with ‘regularization’ methods to reduce the error (bias) in models without escalating uncertainties (variance). This paradigm shift will be illustrated in two examples: 1) modelling of longitudinal data in a cohort of Type 2 Diabetics using different medication, and 2) the application in preclinical research studying the effect of liver X receptor activation on HDL metabolism and liver steatosis.
Compendio de lo que necesitas saber sobre la nueva generación
que se encuentra transformando los diferentes aspectos de la sociedad como la educación y el trabajo.
¿Una época de cambios o un cambio de época? Sin duda algo esta claro, los nativos digitales de ahora serán los futuros líderes de las organizaciones públicas y privadas de aquí a 30 años.
Si escribimos la palabra “millennial” en el buscador de Google vamos a encontrar una gran cantidad de información que generaría indigestión de información. Por ello, desde Comisuras, se nos ocurrió una forma de ordenar tanta cantidad de información y presentarla a través de la historia “Un Cuento de Navidad” de Charles Dickens, que nos ayude a comprender a los millennials.
Roche Quantitative Systems Pharmacology methodology workshop
February 4th-5th, 2016, Basel, Switzerland
Bringing multi-level systems pharmacology models to life
Natal van Riel
Abstract
Computational modelling in Systems Medicine and Systems Pharmacology addresses biological processes at different levels and scales. The quantification of model parameters from experimental data is a complicated task. It will be addressed how variance in data propagates into parameter estimates and, more importantly, model predictions. The Analysis of Dynamic Adaptations in Parameter Trajectories (ADAPT) approach is discussed as method to model dynamics at multiple time-scales. Two examples will be provided: 1) modelling of longitudinal data in a cohort of Type 2 Diabetics using different medication, and 2) the application in preclinical research studying the effect of liver X receptor activation on HDL metabolism and liver steatosis.
22. HelloWorld コントローラー
2016/8/19 株式会社 リンクバル 22
app > controllers > application_controller.rb
class ApplicationController < ActionController::Base
# Prevent CSRF attacks by raising an exception.
# For APIs, you may want to use :null_session instead.
protect_from_forgery with: :exception
def hello
render text: "Hello World!!"
end
end
24. HelloWorld
2016/8/19 株式会社 リンクバル 24
config > routes
Rails.application.routes.draw do
# The priority is based upon order of creation:
first created -> highest priority.
# See how all your routes lay out with "rake
routes".
# You can have the root of your site routed with
"root"
# root 'welcome#index'
root 'application#hello'