This document discusses drug interactions, with a focus on antiretroviral medications. It defines drug interactions and describes types and mechanisms, including pharmacokinetic and pharmacodynamic interactions. It provides details on cytochrome P450 enzymes and common substrates, inhibitors, and inducers. Several case studies are presented to demonstrate potential drug interactions in HIV patients, such as between nevirapine and ergotamine, and antifungals and antiretrovirals. The document emphasizes the importance of considering all medications a patient is taking to avoid harmful interactions.
Identify primary drug interaction concepts
Describe types and mechanisms of interactions
Identify drug interactions commonly encountered with antiretroviral drugs
Describe how to manage known interactions
This document discusses drug interactions, providing examples of potential interactions between antiretroviral drugs and other medications. It defines a drug interaction as when one drug affects another, and describes types of interactions including pharmacokinetic and pharmacodynamic. The document examines case studies of patients taking multiple drugs and identifies possible interaction issues, such as between ketoconazole and an antiretroviral regimen. It emphasizes the importance of considering interactions when starting or changing medications.
Priciples of therapeutics, Dosage Indiviualization, Herbal SupplimentsFarazaJaved
This presentation briefly covers the general aspect of therapeutics and drug development then its dose adjustment according to the pt. need and checking either patient comply to that therapy or not. last portion based on herbal supplements and its use.
This document discusses drug interactions in psychiatry. It begins by defining drug interactions and explaining why they are important, noting the increased risk for psychiatric patients on multiple medications. It then describes how interactions can present and lists various risk factors. The document outlines the main types of interactions - pharmacokinetic involving absorption, distribution, metabolism and excretion, and pharmacodynamic involving receptor-level effects. Finally, it analyzes specific drug interaction case examples and consequences like serotonin syndrome or increased sedation.
This document defines drug interactions and describes the main types including drug-drug, drug-food, drug-disease, and drug-laboratory test interactions. It explains that interactions occur via changes to a drug's pharmacokinetics or pharmacodynamics. The major mechanisms of drug-drug interactions are pharmaceutical interactions when drugs are mixed, and pharmacokinetic interactions which influence absorption, distribution, metabolism, or excretion of a drug. Pharmacodynamic interactions can be direct, acting on the same site, or indirect through other body systems. Factors that increase risk of interactions and strategies to reduce interactions are also outlined.
The document defines adverse drug reactions (ADRs) and describes the different types and classifications of ADRs. It states that according to WHO, an ADR is an unintended or unwanted effect of a drug that occurs at standard therapeutic doses. The document then outlines various factors that can influence ADRs like age, sex, dosage, and genetic factors. It describes the different types of ADRs as Type A, B, C, D and E reactions and provides examples of each type. Finally, it discusses methods of assessing ADR severity and causality.
The document discusses clinical pharmacy and how it differs from traditional pharmacy by focusing on patient-centered care and drug therapy management. It outlines the various roles of clinical pharmacists, which include taking medical histories, patient education, drug information services, and monitoring patients for drug efficacy and interactions. The document also examines some of the risks associated with medication use like errors, interactions, and adverse drug reactions that clinical pharmacists aim to prevent or mitigate through various functions and services.
Identify primary drug interaction concepts
Describe types and mechanisms of interactions
Identify drug interactions commonly encountered with antiretroviral drugs
Describe how to manage known interactions
This document discusses drug interactions, providing examples of potential interactions between antiretroviral drugs and other medications. It defines a drug interaction as when one drug affects another, and describes types of interactions including pharmacokinetic and pharmacodynamic. The document examines case studies of patients taking multiple drugs and identifies possible interaction issues, such as between ketoconazole and an antiretroviral regimen. It emphasizes the importance of considering interactions when starting or changing medications.
Priciples of therapeutics, Dosage Indiviualization, Herbal SupplimentsFarazaJaved
This presentation briefly covers the general aspect of therapeutics and drug development then its dose adjustment according to the pt. need and checking either patient comply to that therapy or not. last portion based on herbal supplements and its use.
This document discusses drug interactions in psychiatry. It begins by defining drug interactions and explaining why they are important, noting the increased risk for psychiatric patients on multiple medications. It then describes how interactions can present and lists various risk factors. The document outlines the main types of interactions - pharmacokinetic involving absorption, distribution, metabolism and excretion, and pharmacodynamic involving receptor-level effects. Finally, it analyzes specific drug interaction case examples and consequences like serotonin syndrome or increased sedation.
This document defines drug interactions and describes the main types including drug-drug, drug-food, drug-disease, and drug-laboratory test interactions. It explains that interactions occur via changes to a drug's pharmacokinetics or pharmacodynamics. The major mechanisms of drug-drug interactions are pharmaceutical interactions when drugs are mixed, and pharmacokinetic interactions which influence absorption, distribution, metabolism, or excretion of a drug. Pharmacodynamic interactions can be direct, acting on the same site, or indirect through other body systems. Factors that increase risk of interactions and strategies to reduce interactions are also outlined.
The document defines adverse drug reactions (ADRs) and describes the different types and classifications of ADRs. It states that according to WHO, an ADR is an unintended or unwanted effect of a drug that occurs at standard therapeutic doses. The document then outlines various factors that can influence ADRs like age, sex, dosage, and genetic factors. It describes the different types of ADRs as Type A, B, C, D and E reactions and provides examples of each type. Finally, it discusses methods of assessing ADR severity and causality.
The document discusses clinical pharmacy and how it differs from traditional pharmacy by focusing on patient-centered care and drug therapy management. It outlines the various roles of clinical pharmacists, which include taking medical histories, patient education, drug information services, and monitoring patients for drug efficacy and interactions. The document also examines some of the risks associated with medication use like errors, interactions, and adverse drug reactions that clinical pharmacists aim to prevent or mitigate through various functions and services.
1. The most common route is oral, as it is noninvasive, convenient, and inexpensive. However, oral drugs may irritate the GI tract or have an unpleasant taste.
2. Other common routes include topical administration to the skin, eyes, ears, or nose. Subcutaneous, intramuscular, and intravenous routes involve injection under the skin, into muscles, or directly into veins or arteries.
3. The route chosen depends on factors like the drug's intended site of action, ability to be absorbed, potential for side effects, and patient factors like ability to swallow. Invasive routes result in faster onset but have greater risks
1. The most common route is oral, as it is noninvasive, convenient, and inexpensive. However, oral drugs may irritate the GI tract or have an unpleasant taste.
2. Other common routes include topical application to the skin, eyes, ears, nose, or lungs. Sublingual administration allows for rapid absorption into the bloodstream.
3. Parenteral routes like intravenous, intramuscular, and subcutaneous injection deliver drugs systemically but break the skin barrier, requiring sterile technique. They can administer large volumes or act more rapidly than oral drugs.
1. The most common route is oral, as it is noninvasive, convenient, and inexpensive. However, oral drugs may irritate the GI tract or have an unpleasant taste.
2. Other common routes include topical application to the skin, eyes, ears, nose, or lungs. Sublingual administration allows for rapid absorption into the bloodstream.
3. Parenteral routes like subcutaneous, intramuscular, intravenous, and intradermal injections deliver drugs systemically but break the skin barrier, requiring sterile technique. Intramuscular injections can deliver larger volumes of drugs than subcutaneous injections.
1. The most common route is oral, as it is noninvasive, convenient, and inexpensive. However, oral drugs may irritate the GI tract or have an unpleasant taste.
2. Other common routes include topical application to the skin, eyes, ears, nose, or lungs. Sublingual administration allows for rapid absorption into the bloodstream.
3. Parenteral routes like subcutaneous, intramuscular, intravenous, and intradermal injections deliver drugs systemically but break the skin barrier, requiring sterile technique. Intramuscular injections can deliver larger volumes of drugs than subcutaneous injections.
This document discusses herb-drug interactions, noting that herbal-drug interactions are more common than drug-drug interactions. It provides examples of pharmacokinetic and pharmacodynamic interactions between certain herbs and drugs. St. John's Wort is shown to interact with many prescription drugs by inducing cytochrome P450 enzymes. Ginkgo biloba and green tea may prolong bleeding time when taken with anticoagulant or antiplatelet medications due to effects on platelet function. The document stresses the importance of patients disclosing herbal supplement use to physicians to avoid potential interactions.
The document discusses key principles of pharmacology including:
1. Pharmacology is the study of drugs and their interaction with living systems, specifically how they bind to regulatory molecules and affect body processes.
2. Pharmacokinetics describes what the body does to drugs including absorption, distribution, metabolism, and excretion.
3. Pharmacodynamics describes what drugs do to the body including their effects, mechanisms of action, and interactions with receptors.
Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous molecule which exerts a biochemical or physiological effect on the cell, tissue, organ, or organism.
General prescribing guidelines for Pediatrics geriatrics pregnancy lactating...Koppala RVS Chaitanya
1. The document discusses physiological differences between pediatric and adult patients that are important to consider when selecting and dosing medications.
2. It outlines age classifications for pediatric patients from preterm neonates to adolescents and describes how drug absorption, distribution, metabolism, and excretion can vary significantly across age groups.
3. Selecting appropriate doses and accounting for changing pharmacokinetics is essential for safe and effective pharmacotherapy in pediatric patients.
An adverse drug reaction (ADR) is an undesirable effect of a drug that occurs at normal dosages during normal use. ADRs can occur after a single dose or prolonged administration and may be beneficial or harmful effects. Major causes of ADRs include drug-drug and drug-food interactions that can alter pharmacokinetics and pharmacodynamics. ADRs are classified as Type A-E with Types A and B being dose-related and idiosyncratic reactions respectively. Over 2 million serious ADRs occur yearly in the US, resulting in 100,000 deaths making ADRs a leading cause of death. Troglitazone was withdrawn from the market in 2000 due to idiosyncratic
1. Adverse drug reactions (ADRs) refer to harmful, unintended effects of drugs that occur at normal doses used for treatment or diagnosis.
2. ADRs are commonly classified based on their onset, severity, and whether they are due to the known pharmacological effects of a drug (Type A) or unpredictable reactions (Type B). Type A reactions are more common while Type B reactions tend to be more serious.
3. The document discusses various types of ADRs in detail, their causes and risk factors. Factors like age, gender, genetic variations, concurrent diseases, and polypharmacy can increase a patient's risk of experiencing an ADR.
this ppt deals with different types of drug interactions with examples and highlights important principles in monitoring drug therapy....for better understanding of complexity of multiple drug usage (polypharmacy)
Antituberculosis Drugs 1 Manisacan Et Al( Midterm 2)guest151c
The document summarizes guidelines for treating tuberculosis using three lines of antituberculosis drugs. First-line drugs like isoniazid and rifampin are usually effective but second and third-line drugs may be needed if resistance develops. The drugs have various mechanisms of action and are always used together to improve outcomes and prevent resistance. Close monitoring is needed due to potential adverse effects and drug interactions that require dosage adjustments.
This document outlines 12 lectures on ocular pharmacology given by Dr. Asma Iqbal. The lectures cover topics including: introduction to pharmacology; drug pharmacokinetics; biotransformation, distribution, and pharmacodynamics; cycloplegics and mydriatics; local anesthetics; routes of drug administration; anti-inflammatory, antifungal, antiviral, and antiallergy drugs; antiglaucoma drugs; and principles of antimicrobial therapy. The lectures provide information on the basic concepts, mechanisms, and applications of pharmacological agents used in ophthalmology.
Personalized medicine involves the prescription of specific therapeutics best suited for an individual based on their genetic or proteomic profile. This talk discusses current approaches in drug discovery/development, the role of genetics in drug metabolism, and lawful/ethical issues surrounding the deployment of new health technology. I highlight some bioinformatic roles in the drug discovery process, and discuss the use of semantic web technologies for data integration and knowledge discovery..
Pharmacology is the study of drugs and their actions on the body. Drugs are chemicals used to diagnose, treat, and prevent disease. This document outlines general principles of pharmacology, including drug names, classifications, routes of administration, and factors that can influence drug response. It emphasizes the importance of understanding pharmacokinetics and following legal and safety guidelines when providing patient care using medications.
Drugs can have both beneficial and harmful effects. While drugs save lives and improve health, they can also threaten life. Whether the potential benefits of a medication outweigh the risks depends on the individual taking it. Adverse drug reactions (ADRs) are a common clinical problem that can have serious consequences for patients, from mere inconvenience to death. Anyone taking medication can experience an ADR, but some groups are at higher risk, such as the elderly, those taking multiple drugs, and those with multiple medical conditions. ADRs should be considered if new symptoms appear after starting or increasing a drug dose and disappear after stopping the drug. The most common causes of ADRs are antibiotics, anticancer drugs, cardiovascular drugs,
Ar medical conditions and dental care-dental toxicologyIyad Abou Rabii
The document discusses important considerations for dentists when treating patients who take medications. It identifies medical conditions that may necessitate certain drugs and how those drugs could impact dental care. It emphasizes categorizing a patient's medications to identify safety issues, potential complications, and effects on treatment outcomes. It also provides examples of natural products and drug interactions that require altered dental management.
1. The most common route is oral, as it is noninvasive, convenient, and inexpensive. However, oral drugs may irritate the GI tract or have an unpleasant taste.
2. Other common routes include topical administration to the skin, eyes, ears, or nose. Subcutaneous, intramuscular, and intravenous routes involve injection under the skin, into muscles, or directly into veins or arteries.
3. The route chosen depends on factors like the drug's intended site of action, ability to be absorbed, potential for side effects, and patient factors like ability to swallow. Invasive routes result in faster onset but have greater risks
1. The most common route is oral, as it is noninvasive, convenient, and inexpensive. However, oral drugs may irritate the GI tract or have an unpleasant taste.
2. Other common routes include topical application to the skin, eyes, ears, nose, or lungs. Sublingual administration allows for rapid absorption into the bloodstream.
3. Parenteral routes like intravenous, intramuscular, and subcutaneous injection deliver drugs systemically but break the skin barrier, requiring sterile technique. They can administer large volumes or act more rapidly than oral drugs.
1. The most common route is oral, as it is noninvasive, convenient, and inexpensive. However, oral drugs may irritate the GI tract or have an unpleasant taste.
2. Other common routes include topical application to the skin, eyes, ears, nose, or lungs. Sublingual administration allows for rapid absorption into the bloodstream.
3. Parenteral routes like subcutaneous, intramuscular, intravenous, and intradermal injections deliver drugs systemically but break the skin barrier, requiring sterile technique. Intramuscular injections can deliver larger volumes of drugs than subcutaneous injections.
1. The most common route is oral, as it is noninvasive, convenient, and inexpensive. However, oral drugs may irritate the GI tract or have an unpleasant taste.
2. Other common routes include topical application to the skin, eyes, ears, nose, or lungs. Sublingual administration allows for rapid absorption into the bloodstream.
3. Parenteral routes like subcutaneous, intramuscular, intravenous, and intradermal injections deliver drugs systemically but break the skin barrier, requiring sterile technique. Intramuscular injections can deliver larger volumes of drugs than subcutaneous injections.
This document discusses herb-drug interactions, noting that herbal-drug interactions are more common than drug-drug interactions. It provides examples of pharmacokinetic and pharmacodynamic interactions between certain herbs and drugs. St. John's Wort is shown to interact with many prescription drugs by inducing cytochrome P450 enzymes. Ginkgo biloba and green tea may prolong bleeding time when taken with anticoagulant or antiplatelet medications due to effects on platelet function. The document stresses the importance of patients disclosing herbal supplement use to physicians to avoid potential interactions.
The document discusses key principles of pharmacology including:
1. Pharmacology is the study of drugs and their interaction with living systems, specifically how they bind to regulatory molecules and affect body processes.
2. Pharmacokinetics describes what the body does to drugs including absorption, distribution, metabolism, and excretion.
3. Pharmacodynamics describes what drugs do to the body including their effects, mechanisms of action, and interactions with receptors.
Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous molecule which exerts a biochemical or physiological effect on the cell, tissue, organ, or organism.
General prescribing guidelines for Pediatrics geriatrics pregnancy lactating...Koppala RVS Chaitanya
1. The document discusses physiological differences between pediatric and adult patients that are important to consider when selecting and dosing medications.
2. It outlines age classifications for pediatric patients from preterm neonates to adolescents and describes how drug absorption, distribution, metabolism, and excretion can vary significantly across age groups.
3. Selecting appropriate doses and accounting for changing pharmacokinetics is essential for safe and effective pharmacotherapy in pediatric patients.
An adverse drug reaction (ADR) is an undesirable effect of a drug that occurs at normal dosages during normal use. ADRs can occur after a single dose or prolonged administration and may be beneficial or harmful effects. Major causes of ADRs include drug-drug and drug-food interactions that can alter pharmacokinetics and pharmacodynamics. ADRs are classified as Type A-E with Types A and B being dose-related and idiosyncratic reactions respectively. Over 2 million serious ADRs occur yearly in the US, resulting in 100,000 deaths making ADRs a leading cause of death. Troglitazone was withdrawn from the market in 2000 due to idiosyncratic
1. Adverse drug reactions (ADRs) refer to harmful, unintended effects of drugs that occur at normal doses used for treatment or diagnosis.
2. ADRs are commonly classified based on their onset, severity, and whether they are due to the known pharmacological effects of a drug (Type A) or unpredictable reactions (Type B). Type A reactions are more common while Type B reactions tend to be more serious.
3. The document discusses various types of ADRs in detail, their causes and risk factors. Factors like age, gender, genetic variations, concurrent diseases, and polypharmacy can increase a patient's risk of experiencing an ADR.
this ppt deals with different types of drug interactions with examples and highlights important principles in monitoring drug therapy....for better understanding of complexity of multiple drug usage (polypharmacy)
Antituberculosis Drugs 1 Manisacan Et Al( Midterm 2)guest151c
The document summarizes guidelines for treating tuberculosis using three lines of antituberculosis drugs. First-line drugs like isoniazid and rifampin are usually effective but second and third-line drugs may be needed if resistance develops. The drugs have various mechanisms of action and are always used together to improve outcomes and prevent resistance. Close monitoring is needed due to potential adverse effects and drug interactions that require dosage adjustments.
This document outlines 12 lectures on ocular pharmacology given by Dr. Asma Iqbal. The lectures cover topics including: introduction to pharmacology; drug pharmacokinetics; biotransformation, distribution, and pharmacodynamics; cycloplegics and mydriatics; local anesthetics; routes of drug administration; anti-inflammatory, antifungal, antiviral, and antiallergy drugs; antiglaucoma drugs; and principles of antimicrobial therapy. The lectures provide information on the basic concepts, mechanisms, and applications of pharmacological agents used in ophthalmology.
Personalized medicine involves the prescription of specific therapeutics best suited for an individual based on their genetic or proteomic profile. This talk discusses current approaches in drug discovery/development, the role of genetics in drug metabolism, and lawful/ethical issues surrounding the deployment of new health technology. I highlight some bioinformatic roles in the drug discovery process, and discuss the use of semantic web technologies for data integration and knowledge discovery..
Pharmacology is the study of drugs and their actions on the body. Drugs are chemicals used to diagnose, treat, and prevent disease. This document outlines general principles of pharmacology, including drug names, classifications, routes of administration, and factors that can influence drug response. It emphasizes the importance of understanding pharmacokinetics and following legal and safety guidelines when providing patient care using medications.
Drugs can have both beneficial and harmful effects. While drugs save lives and improve health, they can also threaten life. Whether the potential benefits of a medication outweigh the risks depends on the individual taking it. Adverse drug reactions (ADRs) are a common clinical problem that can have serious consequences for patients, from mere inconvenience to death. Anyone taking medication can experience an ADR, but some groups are at higher risk, such as the elderly, those taking multiple drugs, and those with multiple medical conditions. ADRs should be considered if new symptoms appear after starting or increasing a drug dose and disappear after stopping the drug. The most common causes of ADRs are antibiotics, anticancer drugs, cardiovascular drugs,
Ar medical conditions and dental care-dental toxicologyIyad Abou Rabii
The document discusses important considerations for dentists when treating patients who take medications. It identifies medical conditions that may necessitate certain drugs and how those drugs could impact dental care. It emphasizes categorizing a patient's medications to identify safety issues, potential complications, and effects on treatment outcomes. It also provides examples of natural products and drug interactions that require altered dental management.
pharmacology of Female Sex Hormones final.pptNorhanKhaled15
This document discusses estrogens, including both natural and synthetic types. It describes their sources, effects on the body, mechanisms of action, pharmacokinetics, and clinical uses for conditions like menopause, hypogonadism, and contraception. Potential side effects are also outlined, such as uterine bleeding and increased cancer risk with long-term use.
clinical pharmacology of opioid analgesics .pptNorhanKhaled15
This document discusses opioids and their use for pain management. It begins by introducing opioids and their mechanisms of action, binding to opioid receptors in the central nervous system. It then discusses the different types of opioid receptors and their distributions in the body. The remainder of the document focuses on specific opioid drugs, including morphine, meperidine, and methadone. It provides details on the pharmacological properties, therapeutic uses, pharmacokinetics, adverse effects, and dependencies associated with each drug.
Vasodilators & the Treatment of Angina Pectoris.pptNorhanKhaled15
Vasodilators such as organic nitrates and calcium channel blockers are used to treat angina pectoris, which is caused by inadequate blood flow to the heart. Nitrates provide immediate relief of angina by dilating blood vessels and reducing the heart's workload, while calcium channel blockers are also important for preventing episodes of angina, especially alongside beta-blockers. A new class of drugs called fatty acid oxidation inhibitors are being researched as they may reduce the heart's oxygen needs without affecting blood flow.
The document summarizes thyroid physiology and the biosynthesis and metabolism of thyroid hormones. It discusses how iodide is transported into thyroid cells and incorporated into thyroglobulin to form T3 and T4. It also describes the regulation of thyroid hormones through feedback between the hypothalamus, pituitary gland and thyroid gland. Common tests used to evaluate thyroid function are also mentioned.
pharmacology of Antiparkinsonism final.pptNorhanKhaled15
Parkinsonism is characterized by motor symptoms like rigidity, tremors, and postural instability. It is usually caused by degeneration of dopaminergic neurons in the substantia nigra. Levodopa is effective at treating Parkinsonism by converting to dopamine in the brain, but long term use can cause dyskinesias and response fluctuations. While levodopa provides motor benefits, its effectiveness declines over time and it has side effects like nausea, hypotension, hallucinations, and dyskinesias when taken long term. Combining levodopa with carbidopa helps reduce peripheral side effects but does not prevent long term motor complications.
pharmacology of Adrenocorticosteroids final.pptNorhanKhaled15
The document discusses adrenocortical hormones and corticosteroids. It covers their production, secretion controlled by ACTH, classification, pharmacokinetics, mechanisms of action, physiologic effects, synthetic corticosteroids, use for diagnostic purposes, treatment of adrenal disorders like Cushing's syndrome and congenital adrenal hyperplasia, and toxicity. The major points are the production and regulation of corticosteroids, their metabolic, anti-inflammatory and other effects, uses in diagnosis and treatment of adrenal disorders, and risks of long-term use.
pharmacology of Antipsychotic Agents & Lithium.pptNorhanKhaled15
This document discusses antipsychotic agents and lithium. It provides details on the types and mechanisms of action of antipsychotic drugs. The main points are:
1) Antipsychotic drugs work primarily by blocking dopamine D2 receptors in the brain. Newer "atypical" antipsychotics also block serotonin receptors.
2) Common types include phenothiazines, thioxanthenes, and butyrophenones. Newer drugs have varied chemical structures.
3) Antipsychotics are used mainly to treat schizophrenia but also other psychoses. They help control positive symptoms but are less effective for negative symptoms.
4) Side effects vary by drug but can include extra
pharmacology of Antiviral Agents final.pptNorhanKhaled15
Viral replication consists of several steps that can be targeted by antiviral agents. Acyclovir and related drugs like valacyclovir and famciclovir inhibit herpes virus replication through phosphorylation within infected cells and inhibition of viral DNA polymerase. Foscarnet inhibits viral DNA and RNA polymerases without requiring phosphorylation. Ganciclovir and cidofovir also inhibit viral polymerases after intracellular phosphorylation. Antiretroviral drugs used to treat HIV include nucleoside analog reverse transcriptase inhibitors like zidovudine, non-nucleoside reverse transcriptase inhibitors, and protease inhibitors which inhibit viral enzymes and replication at different stages of the viral life cycle.
- The female gonad is relatively inactive during childhood but begins cyclic function called the menstrual cycle at puberty due to increased secretion of hormones like follicle-stimulating hormone and luteinizing hormone from the pituitary gland. This cyclic ovarian function continues for 30-40 years until menopause.
- At puberty, increased secretion of hormones like estrogen causes development of secondary sex characteristics and leads to the first menstrual period marking the beginning of the reproductive cycle. This cycle involves follicular development, ovulation, formation of the corpus luteum, and shedding of the endometrium if pregnancy does not occur.
- Estrogen production is important for normal female maturation and has effects on development of the breasts, uterus, and other
This document discusses various immunosuppressant drugs used to prevent rejection of transplanted organs and tissues. It describes how earlier drugs nonselectively suppressed both arms of the immune system, leading to infections, while newer drugs more selectively inhibit rejection. The document categorizes drugs based on their mechanisms of action, including inhibiting cytokine production/function, disrupting lymphocyte proliferation, and blocking T-cell surface molecules. It provides details on cyclosporine, tacrolimus, sirolimus, azathioprine, mycophenolate mofetil, and enteric-coated mycophenolate sodium.
Clinical Pharmacology of the Anthelmintic Drugs.pptNorhanKhaled15
This document summarizes several anthelmintic drugs including albendazole, bithionol, diethylcarbamazine, and ivermectin. It provides information on the chemistry, pharmacokinetics, anthelmintic actions, clinical uses, adverse reactions, and contraindications for each drug. Albendazole is the drug of choice for many intestinal helminth infections. Bithionol is used for fascioliasis and paragonimiasis. Diethylcarbamazine treats filariasis and loiasis. Ivermectin is primarily used for strongyloidiasis and onchocerciasis. Each drug requires careful administration and monitoring for
1) Antidepressants work by increasing levels of neurotransmitters like serotonin and norepinephrine in the brain. Selective serotonin reuptake inhibitors (SSRIs) specifically inhibit the reabsorption of serotonin while serotonin-norepinephrine reuptake inhibitors (SNRIs) inhibit both serotonin and norepinephrine reabsorption.
2) Tricyclic antidepressants non-selectively inhibit the reuptake of serotonin, norepinephrine, and other neurotransmitters. They also block various receptors which can cause side effects.
3) All antidepressants take 2-4 weeks to have an effect and maximum benefits may take 12 weeks. They are used to treat depression and other conditions like anxiety disorders.
Pharmacolgy of heart failuer 19-2-2024 .pptNorhanKhaled15
This document discusses drugs used to treat heart failure. It explains that heart failure occurs when the heart cannot provide enough oxygen to the body. The most common cause in the US is coronary artery disease. Drugs that target processes outside the heart, like the kidneys, have been shown to be effective long-term treatments. Specifically, ACE inhibitors, beta-blockers, and spironolactone have been proven to prolong life for those with chronic heart failure. Positive inotropic drugs can help with acute heart failure but only reduce symptoms in chronic cases.
This study investigated the effects of polyphenols from Conyza dioscoridis (L.) extract (PCDE) on Alzheimer's disease features in two animal models. PCDE ameliorated memory and learning impairment in rats given scopolamine or a high-fat/high-fructose diet plus streptozotocin. It reduced hippocampal cholinesterase activity and modulated markers of oxidative stress, inflammation, tau phosphorylation, and amyloid beta generation in the models. The study suggests PCDE is a multi-target agent that could provide a novel therapeutic strategy for Alzheimer's disease by combating multiple disease features.
A 56-year-old woman presents with recent onset chest discomfort during vigorous exercise that disappears with rest. She has risk factors for cardiovascular disease including hyperlipidemia and a family history. Her exam is notable for elevated blood pressure. She is diagnosed with angina and treatment options are discussed.
Bronchial asthma is a chronic inflammatory airway disease characterized by wheezing, breathlessness, and coughing. Allergens like dust or pollen can trigger an immune response releasing inflammatory mediators from mast cells that cause bronchospasm and obstruction. Asthma treatments include short-acting beta-2 agonists for acute symptoms, inhaled corticosteroids as primary treatment to reduce inflammation, and other drugs that dilate airways or block inflammatory pathways like leukotriene receptors. Managing asthma requires identifying and avoiding triggers while maintaining treatment to prevent symptoms and exacerbations.
Bronchial asthma is a chronic inflammatory disorder of the airways characterized by cough, dyspnea, and wheezing. Symptoms occur due to hyperresponsive and hypersensitive airways that become obstructed by bronchoconstriction, mucus, and inflammation when exposed to stimuli. Treatment includes bronchodilators, anti-inflammatories like corticosteroids, cromolyn sodium, leukotriene antagonists, and other drugs to relieve symptoms and prevent exacerbations. Status asthmaticus is a severe, prolonged asthma attack requiring mechanical ventilation. Antitussives are used to suppress nonproductive coughs through central or peripheral mechanisms of action.
This document discusses various aspects of phase I drug metabolism. It begins by defining phase I metabolism as the modification of drugs through oxidation, reduction, and hydrolysis. Some of the key enzymes involved in phase I reactions include cytochrome P450 enzymes, cholinesterases, monoamine oxidases, and alcohol dehydrogenases. Specific substrates and inhibitors of various cytochrome P450 isoenzymes are listed. General inducers and inhibitors of CYP3A4 are identified. Phase I metabolism of biogenic amines by monoamine oxidase and the oxidation pathway of different alcohols are briefly described. A clinical vignette is provided regarding a patient presenting with intoxication from ingestion of an alcohol.
বাংলাদেশের অর্থনৈতিক সমীক্ষা ২০২৪ [Bangladesh Economic Review 2024 Bangla.pdf] কম্পিউটার , ট্যাব ও স্মার্ট ফোন ভার্সন সহ সম্পূর্ণ বাংলা ই-বুক বা pdf বই " সুচিপত্র ...বুকমার্ক মেনু 🔖 ও হাইপার লিংক মেনু 📝👆 যুক্ত ..
আমাদের সবার জন্য খুব খুব গুরুত্বপূর্ণ একটি বই ..বিসিএস, ব্যাংক, ইউনিভার্সিটি ভর্তি ও যে কোন প্রতিযোগিতা মূলক পরীক্ষার জন্য এর খুব ইম্পরট্যান্ট একটি বিষয় ...তাছাড়া বাংলাদেশের সাম্প্রতিক যে কোন ডাটা বা তথ্য এই বইতে পাবেন ...
তাই একজন নাগরিক হিসাবে এই তথ্য গুলো আপনার জানা প্রয়োজন ...।
বিসিএস ও ব্যাংক এর লিখিত পরীক্ষা ...+এছাড়া মাধ্যমিক ও উচ্চমাধ্যমিকের স্টুডেন্টদের জন্য অনেক কাজে আসবে ...
A review of the growth of the Israel Genealogy Research Association Database Collection for the last 12 months. Our collection is now passed the 3 million mark and still growing. See which archives have contributed the most. See the different types of records we have, and which years have had records added. You can also see what we have for the future.
A workshop hosted by the South African Journal of Science aimed at postgraduate students and early career researchers with little or no experience in writing and publishing journal articles.
How to Setup Warehouse & Location in Odoo 17 InventoryCeline George
In this slide, we'll explore how to set up warehouses and locations in Odoo 17 Inventory. This will help us manage our stock effectively, track inventory levels, and streamline warehouse operations.
How to Make a Field Mandatory in Odoo 17Celine George
In Odoo, making a field required can be done through both Python code and XML views. When you set the required attribute to True in Python code, it makes the field required across all views where it's used. Conversely, when you set the required attribute in XML views, it makes the field required only in the context of that particular view.
The simplified electron and muon model, Oscillating Spacetime: The Foundation...RitikBhardwaj56
Discover the Simplified Electron and Muon Model: A New Wave-Based Approach to Understanding Particles delves into a groundbreaking theory that presents electrons and muons as rotating soliton waves within oscillating spacetime. Geared towards students, researchers, and science buffs, this book breaks down complex ideas into simple explanations. It covers topics such as electron waves, temporal dynamics, and the implications of this model on particle physics. With clear illustrations and easy-to-follow explanations, readers will gain a new outlook on the universe's fundamental nature.
This presentation was provided by Steph Pollock of The American Psychological Association’s Journals Program, and Damita Snow, of The American Society of Civil Engineers (ASCE), for the initial session of NISO's 2024 Training Series "DEIA in the Scholarly Landscape." Session One: 'Setting Expectations: a DEIA Primer,' was held June 6, 2024.
2. Learning Objectives
Identify primary drug interaction concepts
Describe types and mechanisms of
interactions
Identify drug interactions commonly
encountered with antiretroviral drugs
Describe how to manage known
interactions
3. Definition:
The pharmacological result, either desirable
or undesirable, of drugs interacting with
themselves or with other endogenous
chemical agents, components of the diet, or
with chemicals used in or resulting from
diagnostic tests.
4. Case Study: Lake
Lake, a 50 year-old male who has been HIV+ for 5
years and is stable on therapy, presents to the
clinic to get more medication to treat his thrush
He has been taking his brother’s medication, which
seemed to help at first and then stopped working.
He would like to get some more to clear the white
plaques on his tongue
6. Case Study: Lake (3)
His current ARV regimen is:
Nevirapine 200 mg bid
Zidovudine 300 mg bid
Lamivudine 150 mg bid
He has one pill of his brother’s medication left.
The physician brings it to the pharmacy to
determine what medication it is. The tablet is
identified as ketoconazole 200 mg
7. Case Study: Lake (4)
Is this an appropriate medication to use with his
current ARV regimen?
What are some counseling points for this patient?
8. Beware
A drug interaction can occur whenever a:
New medication is started
Medication is discontinued
Dose is changed
Drug is changed
Remember:
Inducing interactions
Gradual onset/offset
Inhibiting interactions
Quick onset/offset
9. Mechanisms for Drug Interactions
Pharmacokinetic Interactions
Altered drug absorption and tissue distribution
Chelation, pH, efflux proteins or drug transporters)
Altered drug metabolism
Induction/inhibition
Reduced renal excretion
Altered intracellular activation
Impairment of phosphorylation (D4T, ZDV)
The outcome of these interactions could be
additive/synergistic, antagonistic/opposing or
potentiation
10. Mechanisms for Drug Interactions (2)
Pharmacodynamic interactions
Additive or synergistic interactions
Antagonistic or opposing interactions
11. Recognize that metabolism can occur in the intestines,
liver or blood
Route of orally administered drugs:
Absorbed in the gastrointestinal tract
Then pass through the portal venous system to the
liver where they are exposed to first pass effect,
which may limit systemic circulation
Once in the systemic circulation, drugs interact with
receptors in target tissues
First Pass Effect
12. Cytochrome P450 (CYP450)
Substrate
Medication depends on enzymatic pathway(s) for
metabolism
Object drug which is affected by inducer or inhibitor
Inducer
Speeds up metabolism
Decreases substrate level (lack of efficacy is concern)
Gradual onset/offset
Inhibitor
Slows metabolism
Increases substrate level (toxicity is concern)
Quick onset/offset
13. Cytochrome P450 Enzymes
Outcome of
Drug
Interaction
Variability
Patient Factors Drug Factors
•Genetics
•Diseases
•Diet/Nutrition
•Environment
•Smoking
•Alcohol
•Dose
•Duration
•Dosing Times
•Sequence
•Route
•Dosage Form
17. Interactions among HIV drugs
itself: NRTIs
Most important are 2 types of interactions:
• Do not combine 2 NRTIs that require same
enzymes for intracellular phosphorylation:
– d4T + AZT
– ddC, FTC, 3TC
• Do not combine TDF with ddI
– Increased ddI toxicity
– Loss of immunological response
18. NNRTIs are inducers of CYP3A
• PIs are substrates of CYP3A
• When combining NNRTIs with PIs, usually
the dose of the PI is increased, for
example:
– LPV/r 533/133 (4 caps) BID + EFV, or
– LPV/r 600/150 (3 tabs) BID + EFV
Interactions among HIV drugs
itself: NRTIs…
19. Red Flags for Potential Interactions
PIs or NNRTIs and
Ergot alkaloids
Azole antifungals
Antihistamines
Anticonvulsants
Anti-tuberculars (rifamycins)
Warfarin
Benzodiazepines
Cardiac medicine
Amiodarone, quinidine
Oral contraceptives
Containing estradiol
Macrolide antibiotics
Methadone
20. PI/ NNRTI/ Antidepressant
Drug Interactions
As above
Levels of
sertraline may
be increased.
ARV levels
not likely to
change.
ritonavir,
lopinavir/r, all
other Pis,
efavirenz
Sertraline
As above
Levels of both
fluoxetine and
ARVs may be
increased
ritonavir,
lopinavir/r, all
other PIs,
efavirenz
Fluoxetine
Start with lower dose
(50%) of amitriptyline,
adjust dose when
addIng ritonavir.
Monitor for side
effects
Levels of
amitriptyline may
be increased
ritonavir,
lopinavir/r,
amprenavir,
Amitriptyline
Management
Effects
Potential for
Interaction
Antidepressant
22. NNRTIs: Do NOT Co-administer
Ergot derivatives (ergotamine)
Benzodiazepine: midazolam, triazolam
Rifampicin (Nevirapine) – unless there is NO
alternative
Terfenadine (Efavirenz)
Herbal – St. Johns wort
23. Food-Drug Interactions
A food-drug interaction can occur when the food
you eat affects the ingredients in a medication you
are taking, preventing the medicine from working
the way it should. Food-drug interactions can
happen with both prescription and over-the-counter
medications, including antacids, vitamins, and iron
pills.
24. Food-Drug Interactions…
Points to note
-Advise patients to take medication with a full glass of
water.
-Not stir medication into food or take capsules apart (unless
directed by your physician).
-Do not take vitamin pills at the same time you take
medication (i.e, take medication 1 hour after taking
vitamins).
-Not mix medication into hot drinks, because the heat from
the drink may destroy the effectiveness of the drug.
-Never take medication with alcoholic drinks.
-Ask the patient about all medications they are taking, both
prescription and non-prescription.
25. Antiretroviral/Food Interactions
Take with food:
Lopinavir (capsules or
solution): ↑ 50-130%
Avoid food:
ddI: 47% ↓ with meal
Efavirenz: ↑ 79% high fat meal
increases toxicity
Rifampin: food may ↑ levels
Isoniazid
28. Case Study: Endalk
Endalk is 45 year-old HIV+ male presenting for
routine follow-up. He has been on HAART for two
years. CD4 count: 480 cells/mm3 HIV RNA < 50
copies/mL.
He comes into the pharmacy after seeing a
physician for his migraines. He is glad to try a new
medication as his headaches have been a problem
for years. He is so distraught about them that he
has begun to take an herbal product to help with
his mood
29. Case Study: Endalk (2)
His current medication regimen, which is:
Nevirapine 200 mg bid
Lamivudine 150mg bid
Zidovudine 300 mg bid
An herbal medicine when he feels “down”
New medications prescribed today: Ergotamine
+ caffeine
30. Case Study: Endalk (3)
Which of the following combinations
represents a potential drug-drug
interaction?
A. Nevirapine and herbal medicine
B. Zidovudine and ergotamine
C. Ergotamine and nevirapine
D. Caffeine and zidovudine
31. Case Study II: Sara
Sara is a 41 year-old female with esophageal
candida and has just completed a 10 day course
of fluconazole. She has lost weight because
symptoms of thrush made it difficult to swallow.
She weighs 62 kg. She is to begin ARV therapy
today.
32. Case Study: Sara (2)
She presents with the following
prescription:
Zidovudine 300 mg bid
Stavudine 40 mg bid
Nevirapine 200 mg once daily for the first 2
weeks, then increase to 200 mg bid
Cotrimoxazole DS, 1 tablet daily
2. Is this an appropriate regimen for her? Can
you identify any possible drug interactions
33. Case Study: Lake
Lake, a 50 year-old male who has been HIV+ for 5
years and is stable on therapy, presents to the
clinic to get more medication to treat his thrush
He has been taking his brother’s medication, which
seemed to help at first and then stopped working.
He would like to get some more to clear the white
plaques on his tongue
35. Case Study: Lake (3)
His current ARV regimen is:
Nevirapine 200 mg bid
Zidovudine 300 mg bid
Lamivudine 150 mg bid
He has one pill of his brother’s medication left.
The physician brings it to the pharmacy to
determine what medication it is. The tablet is
identified as ketoconazole 200 mg
36. Case Study: Lake (4)
Is this an appropriate medication to use with his
current ARV regimen?
What are some counseling points for this patient?