This document summarizes information about the mode of action of SPIRIVA Respimat for treating asthma. It explains that SPIRIVA is an anticholinergic that works by binding to M3 receptors for over 24 hours to antagonize the effects of acetylcholine, resulting in bronchodilation by reducing smooth muscle contraction, mucus secretion, and inflammation. By blocking acetylcholine's stimulation of M3 receptors on airway smooth muscle, submucosal glands, and inflammatory cells, SPIRIVA treats bronchoconstriction and is approved in some countries for adult asthma patients who experienced severe exacerbations while treated with other medications.
Somatropin human growth hormone (HGH) dosage & administrationJS Biology
Somatropin human growth hormone (HGH) dosage & administration schedule should be individualized for each patient. Therapy should not be continued if epiphyseal fusion has occurred. Response to growth hormone therapy tends to decrease with time. However, failure to increase growth rate, particularly during the first year of therapy, should prompt close assessment of compliance and evaluation of other causes of growth failure such as hypothyroidism, under-nutrition, and advanced bone age. Growth hormone-deficient pediatric patients --The recommended weekly dosage is 0.18 mg/kg (0.54 IU/kg) of body weight. The maximal replacement weekly dosage is 0.3 mg/kg (0.90 IU/kg) of body weight. It should be divided into equal doses given either on 3 alternate days, 6 times per week, or daily. The subcutaneous route of administration is preferable; intramuscular injection is also acceptable. The dosage and administration schedule for Somatropin should be individualized for each patient.
Seroflo Rotacaps (Generic Fluticasone Propionate and Salmeterol Xinafoate I...Clearsky Pharmacy
Seroflo (Generic Fluticasone Propionate and Salmeterol Xinafoate Inhalation Powder) a combination product containing a corticosteroid and a long-acting beta2-adrenergic agonist, is used in the regular treatment of asthma in patients aged 4 years and older, where use of a combination medication (long-acting beta2-agonist and inhaled corticosteroid) has been found to be appropriate, as well as a maintenance treatment of airflow obstruction and reducing exacerbations in patients with severe chronic obstructive pulmonary disease (COPD).
This medicine should not be used for the relief of acute bronchospasm.
Somatropin human growth hormone (HGH) dosage & administrationJS Biology
Somatropin human growth hormone (HGH) dosage & administration schedule should be individualized for each patient. Therapy should not be continued if epiphyseal fusion has occurred. Response to growth hormone therapy tends to decrease with time. However, failure to increase growth rate, particularly during the first year of therapy, should prompt close assessment of compliance and evaluation of other causes of growth failure such as hypothyroidism, under-nutrition, and advanced bone age. Growth hormone-deficient pediatric patients --The recommended weekly dosage is 0.18 mg/kg (0.54 IU/kg) of body weight. The maximal replacement weekly dosage is 0.3 mg/kg (0.90 IU/kg) of body weight. It should be divided into equal doses given either on 3 alternate days, 6 times per week, or daily. The subcutaneous route of administration is preferable; intramuscular injection is also acceptable. The dosage and administration schedule for Somatropin should be individualized for each patient.
Seroflo Rotacaps (Generic Fluticasone Propionate and Salmeterol Xinafoate I...Clearsky Pharmacy
Seroflo (Generic Fluticasone Propionate and Salmeterol Xinafoate Inhalation Powder) a combination product containing a corticosteroid and a long-acting beta2-adrenergic agonist, is used in the regular treatment of asthma in patients aged 4 years and older, where use of a combination medication (long-acting beta2-agonist and inhaled corticosteroid) has been found to be appropriate, as well as a maintenance treatment of airflow obstruction and reducing exacerbations in patients with severe chronic obstructive pulmonary disease (COPD).
This medicine should not be used for the relief of acute bronchospasm.
Ondansetron Oral Solution IP 2mg-5ml Manufacturers, Suppliers in India.pdfTajPharmaIndia
Ondansetron is used to treat nausea and vomiting caused by chemotherapy. It is also used to prevent or treat nausea and vomiting after surgery.
Ondansetron should be considered for infants and children age six months and older who present to the ED with vomiting related to suspected acute gastroenteritis, and who have mild to moderate dehydration or who have failed oral rehydration therapy.
Pharma cokinetics of drugs assignment helpNicole Valerio
This assignment is aiming to identify and discuss pharma cokinetics of drugs given to a patient suffering from asthma, GERD and hypothyroidism. Case study is already been given, drugs given to the patient are protonix, synthroid and metaclopromide.
Originators and Princeps: How to face Biosimilars and Generics Joseph Pategou
Concerning the levers a originators producer can put in place to face the biosimilars competition and maintain his position, benchmarking on biosimilars, generics (13 companies from 2000 to 2015) and the results of our interview allow us to observe 10 levers:
Price Prescription
Patent Market saturation
Legal action New market
Cooperation Environmental strategy
Product Brand strategy
Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Tartarate Inhaler)Clearsky Pharmacy
Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Tartarate Inhaler) is used in the treatment of chronic obstructive pulmonary disease (bronchitis and emphysema) when there is evidence of spasm (narrowing) of the airways (bronchi).
These two medicines work together to help open the airways in the lungs. Ipratropium Bromide and Albuterol Sulfate is used to help treat airway narrowing (bronchospasm) that happens with chronic obstructive pulmonary disease (COPD) in adult patients who need to use more than one bronchodilator medicine.
A Comparative Study of Cost Effectiveness of Ibuprofen Suspensions with Other...iosrjce
The use of medicines in our society follows no rules and ethics however there are detail regulations
available for this. Both patients and general physicians are responsible for this trend. Patients from middle to
lower class are affected by high cost of medicine this is the reason they tend to buy medicine of cheap price and
sometime agree to compromise with quality of medicines. On the other hand general physicians are influenced
by the unethical pressure of pharmaceutical companies. In this study similar problem is addressed and detailed
investigation has been performed. This study revealed the trends in the prescription of medicine addressing pain
and fever mostly relevant to children by general physicians. This is a survey based research and analysis which
showed that general physicians are influenced by the brand and the manufacturer’s name.
A comparison between two medicines namely Ibuprofen and Paracetamol was also discussed which are
commonly prescribed by the general physician for the management of pain and fever in children.. Although both
are regarded as alternate to each other, as reveled from the survey but an Ibuprofen brand is prescribed more
than the other brands. There are many factors associated with this phenomenon such as brand names,
manufacturer’s name, marketing strategies and cost. The strategies need to gain market share were also
discussed. It is concluded from the research that Ibuprofen suspension has an advantage on its competitors
prevailing in the market. Ibuprofen suspension has a cost effective advantage and its response is fast as
compare to acetaminophen. Moreover dosage time between two dosages of Ibuprofen is greater than
acetaminophen. For quick relief doctors prefers to prescribe popular brand of Ibuprofen suspension as compare
to acetaminophen.
Aguettant launches the first Sulfite Free EPINEPHRINE plastic Pre-Filled syringeDanielle Labreche
Aguettant launches in Europe the first Sulphate Free EPINEPHRINE (Adrenaline) polypropylene Pre-Filled syringe
Individually blisterized - Sterile Field Ready - Luer Lock Connectivity (smPC available on demand)
Ondansetron Oral Solution IP 2mg-5ml Manufacturers, Suppliers in India.pdfTajPharmaIndia
Ondansetron is used to treat nausea and vomiting caused by chemotherapy. It is also used to prevent or treat nausea and vomiting after surgery.
Ondansetron should be considered for infants and children age six months and older who present to the ED with vomiting related to suspected acute gastroenteritis, and who have mild to moderate dehydration or who have failed oral rehydration therapy.
Pharma cokinetics of drugs assignment helpNicole Valerio
This assignment is aiming to identify and discuss pharma cokinetics of drugs given to a patient suffering from asthma, GERD and hypothyroidism. Case study is already been given, drugs given to the patient are protonix, synthroid and metaclopromide.
Originators and Princeps: How to face Biosimilars and Generics Joseph Pategou
Concerning the levers a originators producer can put in place to face the biosimilars competition and maintain his position, benchmarking on biosimilars, generics (13 companies from 2000 to 2015) and the results of our interview allow us to observe 10 levers:
Price Prescription
Patent Market saturation
Legal action New market
Cooperation Environmental strategy
Product Brand strategy
Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Tartarate Inhaler)Clearsky Pharmacy
Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Tartarate Inhaler) is used in the treatment of chronic obstructive pulmonary disease (bronchitis and emphysema) when there is evidence of spasm (narrowing) of the airways (bronchi).
These two medicines work together to help open the airways in the lungs. Ipratropium Bromide and Albuterol Sulfate is used to help treat airway narrowing (bronchospasm) that happens with chronic obstructive pulmonary disease (COPD) in adult patients who need to use more than one bronchodilator medicine.
A Comparative Study of Cost Effectiveness of Ibuprofen Suspensions with Other...iosrjce
The use of medicines in our society follows no rules and ethics however there are detail regulations
available for this. Both patients and general physicians are responsible for this trend. Patients from middle to
lower class are affected by high cost of medicine this is the reason they tend to buy medicine of cheap price and
sometime agree to compromise with quality of medicines. On the other hand general physicians are influenced
by the unethical pressure of pharmaceutical companies. In this study similar problem is addressed and detailed
investigation has been performed. This study revealed the trends in the prescription of medicine addressing pain
and fever mostly relevant to children by general physicians. This is a survey based research and analysis which
showed that general physicians are influenced by the brand and the manufacturer’s name.
A comparison between two medicines namely Ibuprofen and Paracetamol was also discussed which are
commonly prescribed by the general physician for the management of pain and fever in children.. Although both
are regarded as alternate to each other, as reveled from the survey but an Ibuprofen brand is prescribed more
than the other brands. There are many factors associated with this phenomenon such as brand names,
manufacturer’s name, marketing strategies and cost. The strategies need to gain market share were also
discussed. It is concluded from the research that Ibuprofen suspension has an advantage on its competitors
prevailing in the market. Ibuprofen suspension has a cost effective advantage and its response is fast as
compare to acetaminophen. Moreover dosage time between two dosages of Ibuprofen is greater than
acetaminophen. For quick relief doctors prefers to prescribe popular brand of Ibuprofen suspension as compare
to acetaminophen.
Aguettant launches the first Sulfite Free EPINEPHRINE plastic Pre-Filled syringeDanielle Labreche
Aguettant launches in Europe the first Sulphate Free EPINEPHRINE (Adrenaline) polypropylene Pre-Filled syringe
Individually blisterized - Sterile Field Ready - Luer Lock Connectivity (smPC available on demand)
Similar to 170522 Spiriva PPT MOA v2.6 MM.pptx (20)
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
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1. Downloaded from www.spirivaglobal.com/asthma. This website and the presentation are intended for healthcare
professionals not located in the United States of America and the United Kingdom
Mode of Action
3. Downloaded from www.spirivaglobal.com/asthma. This website and the presentation are intended for healthcare
professionals not located in the United States of America and the United Kingdom
This short animated video shows the mode of
action (MoA) of SPIRIVA® Respimat® (tiotropium)
in the treatment of asthma.
Binding to M3 receptors, SPIRIVA® Respimat® blocks acetylcholine, which plays a significant
role in the pathophysiology of asthma, and antagonises the bronchoconstrictive effects,
resulting in bronchial smooth muscle relaxation.
4. Downloaded from www.spirivaglobal.com/asthma. This website and the presentation are intended for healthcare
professionals not located in the United States of America and the United Kingdom
Acetylcholine is the primary
parasympathetic neuro-transmitter in the
airways and plays a significant role in the
pathophysiology of asthma1.
Mode of Action
5. Downloaded from www.spirivaglobal.com/asthma. This website and the presentation are intended for healthcare
professionals not located in the United States of America and the United Kingdom
When released acetylcholine
Mode of Action
6. Downloaded from www.spirivaglobal.com/asthma. This website and the presentation are intended for healthcare
professionals not located in the United States of America and the United Kingdom
stimulates muscarinic M3 receptors
Mode of Action
7. Downloaded from www.spirivaglobal.com/asthma. This website and the presentation are intended for healthcare
professionals not located in the United States of America and the United Kingdom
on airway smooth muscle2,
Mode of Action
8. Downloaded from www.spirivaglobal.com/asthma. This website and the presentation are intended for healthcare
professionals not located in the United States of America and the United Kingdom
On submucosal glands,2
Mode of Action
9. Downloaded from www.spirivaglobal.com/asthma. This website and the presentation are intended for healthcare
professionals not located in the United States of America and the United Kingdom
And on inflammatory cells3
Mode of Action
10. Downloaded from www.spirivaglobal.com/asthma. This website and the presentation are intended for healthcare
professionals not located in the United States of America and the United Kingdom
In asthma patient’s activation of M3
receptors by acetylcholine leads to smooth
muscle contraction4,5
Mode of Action
11. Downloaded from www.spirivaglobal.com/asthma. This website and the presentation are intended for healthcare
professionals not located in the United States of America and the United Kingdom
resulting in bronchoconstriction,3
Mode of Action
12. Downloaded from www.spirivaglobal.com/asthma. This website and the presentation are intended for healthcare
professionals not located in the United States of America and the United Kingdom
with mucus secretion into the airway
lumen,4 and mucus over secretion4
Mode of Action
13. Downloaded from www.spirivaglobal.com/asthma. This website and the presentation are intended for healthcare
professionals not located in the United States of America and the United Kingdom
and inflammatory cell activation5which
contributes to airway inflammation4,5 and
remodelling in asthma animal models4,5
Mode of Action
14. Downloaded from www.spirivaglobal.com/asthma. This website and the presentation are intended for healthcare
professionals not located in the United States of America and the United Kingdom
Mode of Action
15. Downloaded from www.spirivaglobal.com/asthma. This website and the presentation are intended for healthcare
professionals not located in the United States of America and the United Kingdom
SPIRIVA® (tiotropium) Respimat® is an
anticholinergic6
and binds to the M3 receptors, for more
than 24 hours, antagonising the effects of
acetylcholine1,2,3,5
Mode of Action
16. Downloaded from www.spirivaglobal.com/asthma. This website and the presentation are intended for healthcare
professionals not located in the United States of America and the United Kingdom
resulting in increased airflow3
Mode of Action
17. Downloaded from www.spirivaglobal.com/asthma. This website and the presentation are intended for healthcare
professionals not located in the United States of America and the United Kingdom
reducing mucus secretion1,2
and may have effects in airway remodeling
and inflammation1,4
Mode of Action
18. Downloaded from www.spirivaglobal.com/asthma. This website and the presentation are intended for healthcare
professionals not located in the United States of America and the United Kingdom
SPIRIVA® Respimat®, approved for asthma.6
Mode of Action
19. Downloaded from www.spirivaglobal.com/asthma. This website and the presentation are intended for healthcare
professionals not located in the United States of America and the United Kingdom
References
1. Moulton BC and Fryer AD, Br J Pharmacol. 2011; 163(1): 44–52
2. Kistemaker LEM, et al. Trends Pharmacol Sci 2015; 36:3, 164–171
3. Buels KS and Fryer AD Handb Exp Pharmacol. 2012; (208): 317-341
4. Kistemaker LEM, et al. Life Sci 2012;91:1126–1133
5. Gosens R, et al. Respir Res 2006;7:73
6. Summary of Product Characteristics. SPIRIVA Respimat®. 13 Jan 2017
20. Downloaded from www.spirivaglobal.com/asthma. This website and the presentation are intended for healthcare
professionals not located in the United States of America and the United Kingdom
Spiriva Respimat 2.5 microgram, inhalation solution Active substance: tiotropium bromide
Qualitative and quantitative composition: The delivered dose is 2.5 microgram tiotropium per
puff (2 puffs comprise one medicinal dose). List of excipients: benzalkonium chloride;
disodium edetate; water, purified; 1M hydrochloric acid (for pH adjustment) Indication: Spiriva
Respimat is indicated as an add-on maintenance bronchodilator treatment in adult patients
with asthma who are currently treated with the maintenance combination of inhaled
corticosteroids (≥800 µg budesonide/day or equivalent) and long-acting ß2 agonists and who
experienced one or more severe exacerbations in the previous year. Contraindications:
Hypersensitivity to tiotropium bromide or to any of the excipients listed above or to atropine
or its derivatives, e.g. ipratropium or oxitropium. Undesirable effects: Common: dry mouth.
Uncommon: dizziness; headache; insomnia; palpitations; cough; pharyngitis; dysphonia;
bronchospasm; oropharyngeal candidiasis. Rare: constipation; gingivitis; stomatitis; rash;
pruritus; angioneurotic oedema; urticaria; hypersensitivity (including immediate reactions).
Not known: dehydration; glaucoma; intraocular pressure increased; vission blurred; aterial
fibrillation; supraventricular tachycardia; tachycardia; epistaxix; laryngitis; sinusitis; dysphagia;
gastrooesophageal reflux disease; dental caries; glossitis; intestinal obstruction, including ileus
paralytic; nausea; skin infection/skin ulcer; dry skin; anaphylactic reaction; joint swelling;
urinary retention; dysuria; urinary tract infection.
Medicinal product subject to medical prescription. Marketing Authorisation Holder:
Boehringer Ingelheim Pharma GmbH & Co. KG, Binger Strasse 173, D-55216 Ingelheim am
Rhein, Germany. Date of revision of text: 13 Jan 2017
21. Downloaded from www.spirivaglobal.com/asthma. This website and the presentation are intended for healthcare
professionals not located in the United States of America and the United Kingdom
For more information visit:
www.spirivaglobal.com/asthma