Adenovirus - Dr. S. Sivasankara Narayani

1. 17CY312 – MEDICAL
MICROBIOLOGY (UNIT –II)
Dr. S. SIVASANKARA NARAYANI
ASSISTANT PROFESSOR
DEPARTMENT OF MICROBIOLOGY
AYYA NADAR JANAKI AMMAL COLLEGE
SIVAKASI
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Adeno Virus (HIV)

2. ADENOVIRUS
• Common pahogens for humans and animals
• Mammalian – mastoadenovirus , avian - aviadenovirus
• 100 antigenic types
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3. ADENOVIRUS
• 1953 – Rowe and associate – plasma clot culture
• 1954 – throat washings – military recruits with respiratory illness
• 1962 – Huebner –adenovirus types 12and 18 – lead to study of genetic and
molecular levels
• Adenovirus classified into 6 sub genus with several serotypes
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4. 11-08-2020Dr.SS
• Double stranded DNA
• Non Enveloped virus (70 -75nm
in size)
• Capsid – 252 capsomeres
• Icosahedron – 20 tri, 12 vertices
• Space vehicle

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7. 11-08-2020Dr.SS PATHOGENESIS

8. 1
2
3
Pneumonia
Acute respiratory disease
Pharyngitis
Adenoviral infection

9. 1
2
3
Epidemic keratoconjunctivitis
Acute follicular conjuctivitis
Pharyngoconjunctival fever
Adenoviral infection

10. DIAGNOSIS
• Sample
Throat, eye, urine or feces
• Complement fixation test
• Hemagglutination
• Neutralisation test
• Electron microscopy
• Immunofluorescence
• Eliza Test
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11. PROPHYLAXIS
• Killed and live vaccines
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12. TREATMENT
• Cidofovir
• Ribavirin
• Ganciclovor
• Vidarabine
• Gene therapy
• Aerosolized ribavirin
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13. REFERENCE
• Textbook of Microbiology – Ananthanarayan and Paniker’s – 8th Edition,
2009
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sivasan91@gmail.com

14. QUESTIONS TO THINK
• Types of adenovirus
• Is there any Adenovirus associated disease will arise?
• On what basis differentiate adenovirus?
• mechanism of adenovirus infection
• Name the methods used for the treatment of adenoviral infection?
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