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INFLAMMATIONInflammation Defined-- a tissue reaction to irritation- in.docx
- 1. INFLAMMATION Inflammation Defined: - a tissue reaction to irritation, infection or injury - a morbid change or series of reactions produced in the tissues by an irritant - there must be death of cells for this to occur A. FUNCTIONS OF INFLAMMATION 1. to destroy the irritating agent and remove it 2. if that fails, the process will attempt to keep the irritant localized 3. to provide the mechanisms for repair or replacement of damaged tissue B. CAUSES OF INFLAMMATION: 1. Physical Irritants 2. Chemical Irritants 3. Infectious Agents 4. Immunological Reactions C. CARDINAL SIGNS/SYMPTOMS OF INFLAMMATION: 1. 2. 3. 4. 5. Calor - Rubor -
- 2. Dolor - Tumor - Altered Function Heat Redness Pain Swelling Functio laesa - D. PROCESS OF INFLAMMATION: 1. Congestion - a form of pathological active hyperemia - a vascular reaction - the arteries dilate allowing excess blood or tissue fluid into the affected organ or tissue - the release of histamine causes the capillary walls to become more permeable * - to “flush out― the tissue of any foreign matter 2. Exudation - the outpouring of normally intra- vascular cells into injured tissue - Chemotaxis occurs here - dilutes the toxin - the attraction of white blood cells to the site of inflammation - fluid or cellular debris exuding from blood vessels and deposited in tissues 3. Suppuration
- 3. - the formation of pus - is often due to the presence of pyogenic bacteria or some other infectious agent - a protein-rich fluid containing white blood cells and cell debris - if there is not a need for extra leukocytes to fight an infection, this step may not occur 4. Resolution - the termination of the inflammatory response with the affected part returning to its normal state occurs by either physiological or pathological regeneration E. INFLAMMATORY LESIONS: 1. Abscess a circumscribed collection of pus - surrounded by a wall of inflammatory tissue - there are many different types E. INFLAMMATORY LESIONS: 1. Abscess 2. Ulcer - an open sore or lesion of the skin or a mucous membrane accompanied by sloughing of inflamed necrotic tissue Ex. decubitus ulcer - bed sore 3. Furuncle (boil) - an abscess or pyogenic infection of a sweat gland or hair follicle 4. Carbuncle - several communicating boils with the production and discharge of pus and dead tissue
- 4. - often located deep in the sub-cutaneous tissues of the neck or buttocks 5. Cellulitis or Phlegmon - a diffuse, non-circumscribed, inflammatory infiltration of the tissues - also usually subcutaneous - forms pus pockets 5. Cellulitis or Phlegmon 6. Pustule - a small, circumscribed elevation on the skin containing pus - as in a pimple 7. Vesicle - a small, circumscribed elevation of the skin containing a thin, non-purulent fluid - commonly known as a blister F. Types of Lesions based on the composition of the exudate: a. Serous - protein-rich with white blood cells F. Types of Lesions based on the composition of the exudate: b. Purulent - pus caused by pyogenic organisms F. Types of Lesions based on the composition of the exudate: c. Hemorrhagic - red blood cells Inflammatory exudates are formed by the accumulation of cells and fluid from the lumens of blood vessels in the injured area. The microbe causing infection, if present, plays an important part in determining the nature of the exudate.
- 5. G. Postmortem Conditions of Inflamed Tissue 1. 2. 3. 4. Virulent Bacteria - for pus formation Rapid Decomposition Reduced Circulation Possible Odor DISTURBANCES IN CIRCULATION A. Edema or Dropsy - accumulation of fluid in the tissues 1. Causes a. b. c. d. increased permeability of capillary walls increased capillary pressure due to venous obstruction or heart failure inflammatory conditions
- 6. fluid and electrolyte disturbances A. Edema or Dropsy 2. a. Anasarca - generalized edema in the sub-cutaneous tissues - often seen with: - Heart Failure - especially around the feet and ankles - Liver Disease - Kidney Disease EXAMPLES - may be the result of generalized passive hyperemia b. Ascites - serous fluid in the abdominal (peritoneal) cavity d. Hydropericardium - serous fluid in the pericardial sac e. Hydrocele - serous fluid in a sac-like cavity - often occurs in the scrotum due to inflammation of the testes or other parts c. Hydrothorax - serous fluid in the thoracic or pleural cavity B. Hyperemia or Congestion - an excessive amount of blood in a body part
- 7. B. Hyperemia or Congestion - an excessive amount of blood in a body part 1. Active or Arterial Hyperemia - due to an increased arterial supply Physiological active hyperemia - supplies increased nourishment to organs or tissues doing increased work b. Pathological active hyperemia - initiates inflammation and forms one of the most important features of inflammation * 2. Passive or Venous Hyperemia - due to decreased venous drainage or a blockage - always pathological Local - usually due to an obstruction of a vein by a thrombus or embolus, thickening of the vessel wall, or pressure from an outside lesion such as a neoplasm or enlarged organ - may lead to local edema b. Generalized - the flow of blood through the lungs is often reduced - may lead to anasarca - therefore, less blood is oxygenated - usually due to a heart disorder - anoxemia - less oxygen is in the tissues - hypoxia
- 8. - leading to shortness of breath - and a bluish discoloration of the skin, lips, nail beds and mucous membranes - dyspnea - cyanosis C. Ischemia - a crucial temporary reduction in the arterial supply of blood to a given part of the body - a local anemia caused by obstruction of arterial blood supply Causes: 2. 3. 4. thrombosis embolism athero/arteriosclerosis outside pressure on an artery Ischemia may lead to or cause an: - Infarction - the formation of an area of necrosis caused by an obstruction of arterial supply D. Thrombosis - the formation of a solid mass or blood clot within the heart or a blood vessel during life - formed from one or more of the normal constituents of the blood 1. Difference between a thrombus and a postmortem clot: Thrombus
- 9. - a mass attached to a vessel wall Postmortem clot - not attached to a vessel wall 2. CAUSES OF THROMBOSIS: a. b. c. d. Injury to the blood vessel by trauma, degeneration, or inflammation Slow rate of blood flow Disease of the blood itself Alterations in blood composition 3. LOCATIONS OF THROMBI: - the most common sites for thrombus formation are in the - Heart & Veins!!!! - when thrombosis of an artery does occur, the most common sites are the: a. b. c. cerebral arteries coronary arteries aorta 4. CHANGES IN THROMBI:
- 10. a. Digestion or Resolution - absorption of part or all of the thrombus by the activity of leukocytes and/or enzymes 4. CHANGES IN THROMBI: b. Organization - the proliferation of a vascular and fibrous tissue is stimulated - characteristic of arterial as opposed to venous thrombosis - the thrombus is changed into a mass of fibrous tissue 4. CHANGES IN THROMBI: c. Canalization - capillaries taking part in the organization dilate to form new canals through which the blood can pass Fibrous tissue New canals forming 4. CHANGES IN THROMBI: d. Calcification arteriosclerosis - hardening of the arteries - deposits of calcium salts in the veins - forms a phlebolith - a “stone― in the veins e. Fragmentation - a thrombus attached to a vessel wall becomes fragmented - may break loose to form an embolus 4. CHANGES IN THROMBI:
- 11. f. Septic softening - a thrombus infected with pyogenic bacteria may become softened and disintegrate - may possibly be converted into an abscess 4. CHANGES IN THROMBI: As a general rule: MOST THROMBI ARE ASEPTIC 5. CONSEQUENCES OF THROMBOSIS: a. b. c. d. Ischemia Infarction Passive Hyperemia Gangrene E. Embolism - obstruction of a blood vessel by foreign matter carried in the bloodstream - the object is known as an embolus 1. TYPES OF EMBOLI: a. Fragment of thrombi - post-operative thrombosis is of special danger e. Fat - fat cells in the bone marrow or fat deposits in soft tissue are ruptured by trauma and broken into smaller globules which are then sucked into torn veins
- 12. c. Tumor Cells d. Animal Parasite b. Agglutinated Bacteria g. Foreign bodies h. Atheromatous material - from a vessel wall i. Clumps of fibrin - from diseased heart valves f. Gas or Air results from operations on the neck or thorax, blood transfusions when a vein is only partially severed preventing collapse there is danger of an air embolism 2. CONSEQUENCES OF EMBOLISM - sudden death in coronary or cerebral arteries - no damage if part has good collateral circulation a. b. c. d. Ischemia Infarction or gangrene Spread of infection Spread of tumors F. Hemorrhage
- 13. - the escape of blood from the vascular system 1. Per rhexis - due to a ruptured blood vessel or heart chamber 2. Per diapedesis - the passage of blood cells through the unruptured walls of vessels 3. CAUSES OF HEMORRHAGE: a. b. c. d. Trauma Disease of the blood vessels Hypertension(high blood pressure) Diseases of the blood 4. TERMS THAT APPLY TO HEMORRHAGE: a. - small pinpoint hemorrhages - due to leakage from a capillary Petechia 4. TERMS THAT APPLY TO HEMORRHAGE: b. Ecchymosis a small purplish patch caused by extravasation of blood into a tissue
- 14. (a bruise) c. Purpura - refers to the presence of varying sizes of hemorrhages in widespread areas of the skin and mucous membranes d. Hematoma a tumor-like swelling or mass of blood confined to an organ, tissue, or space (common in head injuries) e. f. Hematemesis - vomiting of blood - blood is generally dark and acid - of gastric origin Hemoptysis - blood in the sputum arising from the oral cavity, larynx, trachea, bronchi, or lungs - blood is bright red g. Epistaxis - bleeding from the nose h. Melena - from the greek word for “black―
- 15. - dark, tarry feces or vomit - result of the action of gastro-intestinal secretions upon blood in the digestive tract i. j. Hematuria Exsanguination - the loss of blood to the point where life can no longer be sustained - blood in the urine - an important sign in tumors of the urinary system G. Postmortem Conditions of Disturbances in Circulation 1. Diminished circulation 2. Abscesses 3. Hemorrhage 4. Emaciation 5. Dehydration 6. Rapid decomposition 7. Discoloration Exam # 3 audio1.wav image1.jpeg image2.wmf
- 18. image39.jpeg image40.png image41.png audio4.wav Week 3 - Disturbances in Circulation & Inflammation (Case Study) Week 3 - Disturbances in Circulation & Inflammation (Case Study) Discussion Topic and 2 Replies Top of Form Create a case study from one of the circulatory issues described in this unit as your original post. Ask some questions from your case study that you would like your classmates to comment on. Then, reply to two other case studies from other students. This is an exercise in getting to know patients condition before death. Knowing these pathologies will help you, as the embalmer, to know what possible plan of action to take in preparing the deceased. Here is an example of a simple case study: A 21 year old man died on his birthday in his college dorm room. His friends took him out to celebrate his birthday, and he became severely intoxicated. The man's blood alcohol level was over 0.40, which resulted in a lethal alcohol intoxication. Prior to convulsions and coma, he spent the night vomiting. During your case analysis, you notice that the man's face is covered with small red dots under the skin. He also has some blood in his mouth and nose, and the whites of his eyes have red dots similar to those on his face. 1) What disorder do you think the person had at the time of death? Petechia due to vomiting and seizures related to alcohol poisoning 2) What potential complications do you anticipate? The stain caused by petechiae is permanent and will not be removed by arterial embalming fluids 3) What precautions should you take as the embalmer to limit the effects of these complications?
- 19. Ensure that proper distribution takes place within the tissues of the face, and prepare the use of heavier cosmetics to restore proper coloring to the face Let me know if you need clarification on anything. There are many disorders to choose from. Use your text and credible medical websites to help you. The discussions are a great way to learn and exchange information with others in the class. Christina’s post: CCCKCBottom of Form A 45 year old female, who is a recovering alcoholic and a diagnosed stomach ulcer starts to throw up at random times throughout the day. She hasn't had a drink in over two years but decides to go to the doctor and is diagnosed with cirrhosis of the liver. She notices her skin is starting to jaundice and her throwing up begins to happen more frequently. She then notices she is vomiting up blood and does so for a few weeks. One day she picks up the phone to call her sister to take her to the hospital but when her sister arrives she is found in the bathroom floor unresponsive and is pronounced dead. 1. What disorder do you think she had at the time of death? 2. What potential complications do you anticipate? 3. What precaution should you take as the embalmer to limit these effects of these complications? Shirley’s post: A 22 year old, healthy, athletic, male with no pre-existing conditions, leaves his house on a normal afternoon to play basketball on a warm summer day. He does not do drug and has an occasional beer. He eat breakfast with water before leaving the house that morning. He engages in rigorous physical activities while playing hard street ball with other players. During a fast break, he receives the ball and sprints down court for a layup, while midflight towards the hoop he collapses. Upon falling, he hits his head on the outdoor turf and is unresponsive. The other players rally around the 22 year old to find him not breathing. No one in the crowd administers CPR but calls 911. By the time the paramedics arrive 12 minutes later, they perform CPR and attempt to restart the player's heart. To no avail, he is still unresponsive and pronounced dead on the scene. 1) What disorder do you think the person had at the time of death? 2) What potential complications do you anticipate? 3) What precautions should you take as the embalmer to limit the effects of these complications? Week 3 Assignment Week 3 Assignment
- 20. Top of Form Bottom of Form Assignment ContentTop of Form Create an informational pamphlet on a specific circulatory disturbance, such as hyperemia or edema. Make sure to cover the basics of pathogenesis and prognosis, as well as how they affect you as an embalmer. Be sure to include visual aids such as graphs and visual representations of the circulatory disturbance.. This is not meant to be an assignment where the student copies and pastes the information from a website. You may use direct quotes where applicable, but they should be kept to a minimum and the rest should be in your own words. Make sure to include a bibliography and cite all of your sources. Wikipedia and WebMD are not acceptable sources. Bottom of Form