Model liver

•

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rakeshsrivastava89

Model Liver Cancer Sharmila Shankar and Rakesh Srivastava

Health & Medicine

Risk Factors
Obesity
Genetic factors
Sedentary lifestyle
Fe
Peripheral Insulin resistance
Insulin (↑)
IGF (↑)
Insulin resistance
In the liver
Increase
Inflammation and
fibrosis
Inflammed and
expanded Visceral fat
Visceral fat
Absorption
Chronic low grade
inflammation
Alterations of Intestinal
Microbiota
cu
ROS
NAFLD
CIRRHOSIS
NASH
HCC
12-40%
15-17%
1-3%
Immune Cells
M1 Macrophages
MDSCs, Treg

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Model liver

1. Risk Factors Obesity Genetic factors Sedentary lifestyle Fe Peripheral Insulin resistance Insulin (↑) IGF (↑) Insulin resistance In the liver Increase Inflammation and fibrosis Inflammed and expanded Visceral fat Visceral fat Absorption Chronic low grade inflammation Alterations of Intestinal Microbiota cu ROS NAFLD CIRRHOSIS NASH HCC 12-40% 15-17% 1-3% Immune Cells M1 Macrophages MDSCs, Treg

Model liver

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