Model liver

•

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Liver Cancer Model Sharmila Shankar and Rakesh Srivastava

Risk Factors
Obesity
Genetic factors
Sedentary lifestyle
Fe
Peripheral Insulin resistance
Insulin (↑)
IGF (↑)
Insulin resistance
In the liver
Increase
Inflammation and
fibrosis
Inflammed and
expanded Visceral fat
Visceral fat
Absorption
Chronic low grade
inflammation
Alterations of Intestinal
Microbiota
cu
ROS
NAFLD
CIRRHOSIS
NASH
HCC
12-40%
15-17%
1-3%
Immune Cells
M1 Macrophages
MDSCs, Treg

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