Exploring protein-protein interactions by Weak Affinity Chromatography (WAC) ...
Pratik swarup das
1. A Seminar onA Seminar on
CO-PROCESSED EXCIPIENTCO-PROCESSED EXCIPIENT
Noida Institute of Engineering and Technology,Pharmacy Institute
Presented by
Pratik Swarup Das
M.Pharm(Pharmaceutics),1st
yr
2. Co-processing
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Co-processing is a process in which two or more
excipients interacting at the sub particle level, the
objective of which is to provide a synergy of
functionality improvements as well as masking the
undesirable properties of individual excipients.
The main aim of co processing is to obtain a product‐
with added value related to the ratio of its
functionality / price.
3. Need for developing Co-processed
Excipients
The growing popularity of the direct compression‐
process & demand for an ideal filler–binder that can
substitute two or more excipients.
The ability to modulate the solubility, permeability, or
stability.
To address the issues of flowability, compressibility,
and disintegration potential.
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4. Properties
Improved Flow Properties
Improved compressibility
Absence of chemical change
Reduced lubricant sensitivity
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9. Advantages
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Provide a single excipient with multiple functionalities.
Better mouth feel and improved palatibility.
Removal of undesirable properties.
Improvement of organoleptic properties.
10. Conclusion
The concepts of advanced technologies have shown an
alternate path to obtain a new class of excipients known as
Co-processed excipients.
Their manufacturing is very simple with marginal cost of
production.
They serve as multipurpose excipients.
Provides a better option of Excipient selection to the growing
industries.
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11. References
1. Chougule Ajay Subhash, Dikpati Amarita, Trimbake Tushar,
Formulation development technique of co-processed excipient,
Journal Of Advanced Pharmaceutical Sciences, 2012,Vol.2, 231-
249.
2. Ushari.S, Prasanthi C.H, Reassessment of novel co-processed multi-
functional excipient, International Research journal Of
Pharmaceutical and Applied Sciences,2013 ,122-128.
3. Marwaha Minakshi ,Sandhu Dipak, Marwaha Rakesh Kumar, Co-
processing of excipient: A review on excipient development for
improved tableting performance, International Journal Of Applied
Pharmaceutics, vol 2,41-47.
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12. 12
4. Aulton’s Michel E, The design and manufacture of
medicine,churchill livingstone elsevier, third edition, 2007,
355-356