Specialized in custom synthesis of organic molecules. Broad experience of working on multiple business models - FTEs, FFS, Milestone services of pharmaceutical industry. Commited to deliver highest quality products in a timely manner and value to the customers.

1. CHEMPRO PHARMA
PRIVATE LIMITED
Superior Quality
Higher Affordability
Reliable Service

2. Introduction
2
Specialized in custom synthesis of organic molecules. Broad experience of working on multiple business
models - FTEs, FFS, Milestone services of pharmaceutical industry.
Commited to deliver highest quality products in a timely manner and value to the customers.
Synthetic Chemistry Services
 Design and Synthesis of NCEs, Scaffold libraries, Analogues and Privileged structures
 Preparation of Specialty chemicals such as Nucleosides/tides, Lipids, Peptides and Oligos
 Synthesis of Reference compounds and Metabolites
 Expertise in Enzymatic Reactions
 API and advanced intermediates

3. Business Model
3
 Based on research requirements of the clients we offer the following multiple business services.
 PO based projects
 FTE (Full-time-equivalent)
 FFS (Fee-for-service)

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CHEMPRO PHARMA PVT.
LTD.
 New Route Scouting
 Process Optimization
 Tech transfer
 Impurity Profiling
APIS : Resreach & Development
Speciality Chemicals (Niche Chemicals)
 Nucleoside, Nucleotides,
Oligonucleotides, Peptides
 Lipids, Macrocycles
 Prodrugs and Prtotacs
 Enzymatic Reaction
Medicinal Chemistry
 NCE's
 SAR Development
 Privileged scaffolds
 Focused Libraries
Reference Standards for Small
Molecule research and Synthesis

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 We offer a broad range of chemistry services from drug discovery to custom synthesis to specialty
chemicals with the highest quality standards
 Collaborate with research institutions and academia to accelerate the generation of knowledge and
leverage innovation and technology platform
 ALS offers cost-effective solutions within the stipulated timelines without compromising on the
quality of deliverables
 Our experience, dedication and commitment to maintain quality standards make us an ideal partner
for chemistry services and discovery research
 We are capable of designing molecules for various therapeutic targets using a structure based or
ligand-based approaches and also virtual screening

6.  Supplied New Chemical Entities (NCE’s) to big pharma companies: Developed a robust, cost-effective,
environmental friendly scalable process route for the synthesis of NCE’s for Pre-Clinical Studies of
Antiviral Targets
 Experience in handling Integrated Drug Discovery and Development projects ranging from Hit-finding
strategies, Hit-to-Lead and Lead Optimization (LO) to Pre-Clinical Candidate (PCC)
 Extensive experience in specialty chemicals such as Nucleosides, Nucleotides, Oligonucleotides, Peptides,
Lipids and Protacs
 Successful execution of different projects for Pharmaceutical Companies: Optimization and Process
Improvement of different drugs with improved yields and reducing effluent waste
 Technology Transfer of Antipsychotic Drug: Developed Non-Infringing synthetic route and transferred
technology for commercialization
 Chemo-Enzymatic Synthesis: Developed Enzymatic Synthesis for Anticancer Drug for an external client
and reduced significant reduction in cost compared to regular chemical synthesis
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Target Hit Idenfication Lead Optmization Candidate Selection
HTS virtual screening
 Docking analysis using homology model
 SBDD and FBDD approach
 Decent potency
 ADME
 Novel IP Space
 Focussed library synthesis to
improve potency and selectivity
 Multi Parameter Optimizations
 Scaffold Hopping
 ADME
 CYP inhibition/Induction
 PK In vivo efficacy
 Scale-up from mg to g
 Salt/Crystal form
screening
 Tox studies
 Target Idenfication
 Target Validation
 We provide Integrated Drug Discovery and Development Services ranging from Hit-finding strategies, Hit-to-Lead and Lead
Optimization (LO) to Pre-Clinical Candidate (PCC)
 Experience in Drug Discovery of Major Target Classes
 Reference Compounds Synthesis and Profiling
 Assessment of IP space, Optimization of In Vitro potency, Multi Parameter Optimizations (MPO)
 ADME, PK and In Vivo efficacy and safety profiling to deliver a PCC

8. Speciality Chemicals
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Synthesis of Nucleosides, Nucleotides and its Analogues

9. Speciality Chemicals
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Synthesis of Modified Nucleosides and Nucleotides RNA Capping Agents
 Nucleoside analogues have potential applications in pharmaceutical
industry as Antiviral and Anticancer agents. Phosphoramidites are used
to synthesize oligonucleotides.
 MRNA cap structures are involved in modulating
nuclear export and splicing

10. 1
Chemistry approaches to ODNs: Phosphoramidite
Oligonucleotid Synthesis DNA-Synthesizer
Custom oligonucleotide synthesis utilizes a DNA/RNA synthesizer.
 Phosphoramidite oligo synthesis proceeds in the 3’- to 5’- direction.
One nucleotide is added per synthesis cycle.
 Phosphoramidite DNA synthesis cycle consists of the series of steps outlined
in the adjacent figure.

11. 1
GalNAc Modified Oligonucleotides
 Oligonucleotides are predominantly hydrophilic species and require help in permeating cell membranes. One strategy to improve
cellular uptake of therapeutic oligonucleotides is to conjugate them with non-toxic, lipophilic molecules.
 GalNAc oligonucleotide conjugates demonstrate improved potency in vivo due to selective and efficient delivery to hepatocytes
in the liver via receptor-mediated endocytosis.

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Synthesis of 1,2,3-Triazole Oligonucleotide-Dye Conjugates

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Lipids
Development of lipids for mRNA delivery
 Lipids are amphiphilic molecules
that contain three domains: a polar
head group, a hydrophobic tail
region and a linker between the two
domains. Cationic lipids, ionizable
lipids and other types of lipid have
been explored for mRNA delivery.
 We have designed new lipids and
supplied several lipids in gram scale
to different pharma companies

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Prodrug Concept
 Prodrugs are medications that turn into an active form once they enter the body
 About 10% of all medications in the world are prodrugs. Their design seems to
be gaining in popularity with time. For example, between 2008 and 2017, about
12% of all new FDA-approved medications were prodrugs
 There are two general benefits of prodrugs. One main benefit is improving a
medication’s effectiveness. Another benefit is reducing a medication’s toxicity or
side effects.

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Why Prodrugs

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Phosphonate Prodrugs

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Product list
 Phosphate group was introduced into different drugs by using the above reagents
 We can provide these reagents in commercial scale
 Several Pharmaceutical companies are looking for Prodrug reagents
 At Chempro we have developed cost effective and robust process route for the large scale synthesis of above
reagents
 Minimized formation of impurities and produced high quality materials with high purity
 TBPP was used as a key SM for Fosaprepitant and several other drugs as a source of phosphate moiety

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Enzymatic Reactions
 Extensive expertise in enzymatic reactions to introduce specific chiral centers in molecules

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 Process Optimizations focusing on optimum reaction conditions
 New route scouting and feasibility studies
 Fast technology transfer from laboratory to industrial scale
 Identification of viable and cost-effective synthetic routes
 Scale-up synthesis of intermediates and building blocks from grams to Kg quantities
 R & D for green and clean technologies
 Collaborative Research on new product / process development
 Impurity Profiling: Study and determination of root cause of impurity formation

20. THAN K Y O U !
Superior Quality
Higher Affordability
Reliable Service