1. MRS PRASHALI GORAKH SHINDE
M.Pharm. (Pharmaceutical Chemistry)
Assistant Professor
SPM’S College of Pharmacy –Akluj
Subject –Pharmaceutical Inorganic Chemistry
(PIC) Theory &Practical
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8. Vitamins and mineral such as
iron,copper,cobalt,Vitamin A ,B12
,B6,C,E,Riboflavin ,nicotinic acid and various
haemopoietic factor are essential for normal
production of blood cells.
The production or process of blood cellular
component formation called haematopoiesis.
Main component of haematopoiesis –
Blood,bone marrow,lymph
node,thymus,kidney,liver,spllen as impotant organs.
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13. FERROUS SULPHASTE
0 Ferrous sulfate is also prepared commercially
by oxidation of pyrites in heap leaching
process.
2 FeS2 + 7 O2 + 2 H2O →2 FeSO4 + 2
H2SO4
14. FERROUS SULPHATE
0 Iron(II) sulfate or iron(II) sulphate) or ferrous sulfate
denotes a range of salts with the formula FeSO4·xH2O.
0 These compounds exist most commonly as the
heptahydrate (x = 7) but are known for several values of
x.
0 FeSO4.H2O (Mineral, relatively rare)
0 FeSO4.4H2O (Mineral, relatively common, white)
0 FeSO4.5H2O (Mineral, relatively rare)
0 FeSO4.6H2O (Mineral, relatively rare)
0 FeSO4.7H2O (Mineral, relatively common, blue-green)
15. PHYSICAL PROPERTIES
Formula: FeSO4.7 H2o
Synonym : Green Vitriol
Mol Wt : 279 g/mol
Category :Haematinic
PHYSICALPROPERTIES
Appearance: It occurs in greenish crystals or crystalline powder
Odor: Odorless
Colour; Bluish green crystalline powder
Density: 1.895 g/cm3 (heptahydrate)
Solubility: soluble in water.
Melting Point: 60–64 °C (heptahydrate) decomposes
PH: Acidic.
16. CHEMICAL PROPERTIES
0 On heating, iron(II) sulfate first loses its water of
crystallization and the original green crystals are
converted into a brown colored anhydrous solid. When
further heated, the anhydrous material releases sulfur
dioxide and white fumes of sulfur trioxide, leaving a
reddish-brown iron(III) oxide.
Decomposition of iron(II) sulfate begins at about
680 °C (1,256 °F).
2 FeSO4 →Fe2O3 + SO2 + SO3
17. Identification – It gives reaction of iron and sulphate
Test for Purity :- It has tobe tested for acidity,arsenic
,copper,heavy metal and basic sulphate
Assay- Type –Oxidation –Reduction type assay
Indicator –Itself ferric ion
End point- Red to blue colour
Storage –In a well closed container
Uses – As haematinic
Promote the formation of haemoglobin
Used in iron deficiency disease.
18. PREPARATION
0 The best grade of ferrous sulfate is obtained by
dissolving iron in diluted H2SO4 and concentrating to
crystallization.
Iron is dissolve in dilute H2SO4, after efflorescence
diminishing, the liquid is filtered, concentrated and
finally cooled at room temperature, green crystals will
appear.
Fe + H2SO4 →FeSO4+ H2
0 In the finishing of steel prior to plating or coating, the
steel sheet or rod is passed through pickling baths of
sulfuric acid. This treatment produces large quantities of
iron(II) sulfate too as a by-product.
20. FERROUS GLUCONATE
Formula: C12H22FeO14.2H2O
Mol Wt : 482.2
Category :Haematinic
PHYSICALPROPERTIES
Colour: It occurs in fine yellowish gray,pale greenish yellow powder.
Odour: slight that of burnt sugar.
Solubility: soluble in water., Insoluble in ethanol .
Physical Properties
21. METHOD OF PREPARATION:
1)Preparation of gluconic acid: Gluconic acid is prepared by
oxidation of glucose.
Glucose on oxidation gives gluconic acid
2)Preparation of ferrous gluconate
Gluconic acid treated with barium chloride solution then
treated with ferrous sulphate solution.and barrium sulphate
ppt is formed which is removed by filteration
Filtrate is on evaporate and cooled ferrous gluconate crystal
out.
22. Identification – It gives reaction of ferrous and
gluconic acid
Test for Purity :- It has tobe tested for acidity,arsenic
,,heavy metal ,sulphate ,ferric,chloride.
Storage –In a well closed container
Protect from light
Uses – As haematinic
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24. Antidote:
‘The substance that nullify the effect of an ingested
poison’
Either by
1.Chemically neutralizing the poison
2.Convert poison into less toxic form
3.Antagonistic action ( Opposite effect)
4.Toxic form to non toxic form
28. Identification – It gives reaction of sodium and
thiosulphate.
Test for Purity :- It has tobe tested for,arsenic
,heavy metal ,sulphate,calcium,chloride,sulphide
Assay: Type-Iodometric titration
Indicator: Starch
End point- Yellow colour
Storage –In a well closed container
Protect from light
Uses – Antidote in cyanide poisoning
Used in skin infection such as
dermatophytosis
