This slide explain adrenergic drug and cholinergic drug and its structure activity relationship

1. Advanced Medicinal Chemistry
Topic :- Adrenergic & Cholinergic Drug
Name:- Puja Basule
M-Pharm 1st Year
Department of P’ceutical Chemistry

2. Adrenergic Nervous System
• Adrenergic nervous system is a group of
organs and nerves in which adrenaline and/or
noradrenaline are release as
neurotransmitters.
• Adrenergic nerve release neurotransmitter:
Noradrenaline, Adrenaline, Dopamine and
produce their effect.

3. Adrenergic Drug
• Drug that produce similar effect to those
produced by sympathetic nervous system thus
they are also called sympathomimetic drug.
• It may refer to something which is susceptible
to epinephrine or similar to substances, such
as biological receptor especially adrenergic
receptor.
• A great number of drugs available which can
affect adrenergic receptor e.g. Dopamine,
noradrenaline, adrenaline, isoprenaline etc.

4. Classification

6. Structures of Adrenergic Drug
Catecholamine Noradrenaline
Adrenaline Dopamine

7. Synthesis of Catecholamine

8. Metabolism of Catecholamine

9. Synthesis of Adrenaline
• Adrenaline

10. Mechanism of action
• The action of adrenaline is receptor mediated.
• It produces both excitatory & inhibitory
effects.
• Excitatory effect due to stimulation of alpha
receptor except the intestine where it is
inhibitory.
• Inhibitory effect due to stimulation of beta
receptor except the heart where it is
excitatory.

11. Synthesis of Noradrenaline

12. Dopamine

16. Cholinergic Drug
• Often called parasympathomimetic drug, because
their action mimics the action of PSNS.
• Also called as cholinomimetic
• Stimulate parasympathetic nervous system in
same manner as dose acetylcholine.
• May stimulate cholinergic receptors directly or
slow acetylcholine metabolism at synapses( affect
the enzyme acetylcholinesterase)
• Cholinergic agonists are two types:-
 Direct acting
 Indirect acting

17. Classification

19. 1. Direct acting cholinergic drug

20. Biosynthesis of acetylcholine