Introduction: Chalcone, isoxazole and acridines have diverse biological activities. A series of novel chalcone and isoxazole substituted 9-anilinoacridines were synthesized for their antibacterial, larvicidal, activities. Methods: A series of novel chalcone and isoxazole substituted 9-anilinoacridines (3a-h and 4a-h) were synthesized from 9-chloroacridine by microwave irradiation method. The antibacterial evaluation was performed by cup-plate method and screened for their larvicidal activity by larval bioassay method.

1. Peertechz Journal of
Medicinal Chemistry and
Research
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2. Research Article
Microwave Irradated Synthesis, Characterization and Evaluation
for their Antibacterial and Larvicidal Activities of some Novel
Chalcone and Isoxazole Substituted 9-Anilino Acridines
 R Kalirajan*, S Jubie and B Gowramma
 *Corresponding author: R Kalirajan, Department of Pharmaceutical Chemistry, JSS College
of Pharmacy, (A Constituent college of JSS University, Mysore), Udhagamandalam – 643001
(Tamilnadu), India, Tel-+91-423-2443393 (Ext-223) Fax- +91-4232442937
 Dates: Received: 03 August, 2015; Accepted: 25 August, 2015; Published: 27 August, 2015
 Citation: Kalirajan R, Jubie S, Gowramma B (2015) Microwave Irradated Synthesis,
Characterization and Evaluation for their Antibacterial and Larvicidal Activities of some
Novel Chalcone and Isoxazole Substituted 9-Anilino Acridines. Peertechz J Med Chem Res
1(1): 001-007

3. Abstract
Introduction: Chalcone, isoxazole and acridines have diverse
biological activities. A series of novel chalcone and isoxazole
substituted 9-anilinoacridines were synthesized for their
antibacterial, larvicidal, activities.
Methods: A series of novel chalcone and isoxazole substituted 9-
anilinoacridines (3a-h and 4a-h) were synthesized from 9-
chloroacridine by microwave irradiation method. The
antibacterial evaluation was performed by cup-plate method
and screened for their larvicidal activity by larval bioassay
method.

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