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LECTURE PRESENTATIONS
For CAMPBELL BIOLOGY, NINTH EDITION
Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson
© 2011 Pearson Education, Inc.
Lectures by
Erin Barley
Kathleen Fitzpatrick
Animal Nutrition
Chapter 41
• Food is taken in, taken apart, and taken up in the
process of animal nutrition
• In general, animals fall into three categories:
– Herbivores eat mainly plants and algae
– Carnivores eat other animals
– Omnivores regularly consume animals as well
as plants or algae
• Most animals are also opportunistic feeders
© 2011 Pearson Education, Inc.
Overview: The Need to Feed
Figure 41.1
Concept 41.1: An animal’s diet must supply
chemical energy, organic molecules, and
essential nutrients
• An animal’s diet provides:
– Chemical energy, which is converted into ATP to
power cellular processes
– Organic building blocks, such as organic carbon
and organic nitrogen, to synthesize a variety of
organic molecules
– Essential nutrients, which are required by cells
and must be obtained from dietary sources
© 2011 Pearson Education, Inc.
Essential Nutrients
• There are four classes of essential nutrients:
– Essential amino acids
– Essential fatty acids
– Vitamins
– Minerals
© 2011 Pearson Education, Inc.
• Animals require 20 amino acids and can
synthesize about half from molecules in their diet
• The remaining amino acids, the essential amino
acids, must be obtained from food in
preassembled form
• Meat, eggs, and cheese provide all the essential
amino acids and are thus “complete” proteins
© 2011 Pearson Education, Inc.
Essential Amino Acids
• Most plant proteins are incomplete in amino acid
composition
• Individuals who eat only plant proteins need to
eat specific plant combinations to get all the
essential amino acids
• Some animals have adaptations that help them
through periods when their bodies demand
extraordinary amounts of protein
© 2011 Pearson Education, Inc.
Figure 41.2
Essential Fatty Acids
• Animals can synthesize most of the fatty acids
they need
• The essential fatty acids must be obtained from
the diet and include certain unsaturated fatty
acids (i.e., fatty acids with one or more double
bonds)
• Deficiencies in fatty acids are rare
© 2011 Pearson Education, Inc.
Vitamins
• Vitamins are organic molecules required in the
diet in small amounts
• Thirteen vitamins are essential for humans
• Vitamins are grouped into two categories: fat-
soluble and water-soluble
© 2011 Pearson Education, Inc.
Table 41.1
Minerals
• Minerals are simple inorganic nutrients, usually
required in small amounts
• Ingesting large amounts of some minerals can
upset homeostatic balance
© 2011 Pearson Education, Inc.
Table 41.2
Dietary Deficiencies
• Malnourishment is the long-term absence from
the diet of one or more essential nutrients
© 2011 Pearson Education, Inc.
Deficiencies in Essential Nutrients
• Deficiencies in essential nutrients can cause
deformities, disease, and death
• “Golden Rice” is an engineered strain of rice
with beta-carotene, which is converted to
vitamin A in the body
© 2011 Pearson Education, Inc.
Figure 41.3
• Undernutrition results when a diet does not
provide enough chemical energy
• An undernourished individual will
– Use up stored fat and carbohydrates
– Break down its own proteins
– Lose muscle mass
– Suffer protein deficiency of the brain
– Die or suffer irreversible damage
© 2011 Pearson Education, Inc.
Undernutrition
Assessing Nutritional Needs
• Genetic defects that disrupt food uptake provide
information about human nutrition
– For example, hemochromatosis causes iron
buildup without excessive iron intake
• Insights into human nutrition have come from
epidemiology, the study of human health and
disease in populations
• Neural tube defects were found to be the result of
a deficiency in folic acid in pregnant mothers
© 2011 Pearson Education, Inc.
Figure 41.4
RESULTS
Group
Number of
infants/fetuses
studied
Vitamin supplements
(experimental group)
No vitamin supplements
(control group)
141
204
1 (0.7%)
12 (5.9%)
Infants/fetuses
with a neural
tube defect
Concept 41.2: The main stages of food
processing are ingestion, digestion,
absorption, and elimination
• Ingestion is the act of eating
© 2011 Pearson Education, Inc.
Figure 41.5
Mechanical
digestion Chemical
digestion
(enzymatic
hydrolysis)
Nutrient molecules
enter body cells
Undigested
material
EliminationAbsorptionDigestionIngestion1 2 3 4
Figure 41.5a
Suspension Feeders
• Many aquatic animals are suspension feeders,
which sift small food particles from the water
© 2011 Pearson Education, Inc.
Bulk Feeders
Suspension Feeders and Filter Feeders
Fluid Feeders
Baleen
FecesCaterpillar
Substrate
Feeders
Figure 41.6
Figure 41.6a
Suspension Feeders and Filter Feeders
Baleen
Substrate Feeders
• Substrate feeders are animals that live in or on
their food source
© 2011 Pearson Education, Inc.
Figure 41.6b
FecesCaterpillar
Substrate Feeders
Fluid Feeders
• Fluid feeders suck nutrient-rich fluid from a
living host
© 2011 Pearson Education, Inc.
Figure 41.6c
Fluid Feeders
Bulk Feeders
• Bulk feeders eat relatively large pieces of food
© 2011 Pearson Education, Inc.
Figure 41.6d
Bulk Feeders
• Digestion is the process of breaking food down
into molecules small enough to absorb
• Mechanical digestion, including chewing,
increases the surface area of food
• Chemical digestion splits food into small
molecules that can pass through membranes;
these are used to build larger molecules
• In chemical digestion, the process of enzymatic
hydrolysis splits bonds in molecules with the
addition of water
© 2011 Pearson Education, Inc.
• Absorption is uptake of nutrients by body cells
• Elimination is the passage of undigested
material out of the digestive system
© 2011 Pearson Education, Inc.
Digestive Compartments
• Most animals process food in specialized
compartments
• These compartments reduce the risk of an
animal digesting its own cells and tissues
© 2011 Pearson Education, Inc.
Intracellular Digestion
• In intracellular digestion, food particles are
engulfed by phagocytosis
• Food vacuoles, containing food, fuse with
lysosomes containing hydrolytic enzymes
© 2011 Pearson Education, Inc.
Extracellular Digestion
• Extracellular digestion is the breakdown of
food particles outside of cells
• It occurs in compartments that are continuous
with the outside of the animal’s body
• Animals with simple body plans have a
gastrovascular cavity that functions in both
digestion and distribution of nutrients
© 2011 Pearson Education, Inc.
© 2011 Pearson Education, Inc.
Video: Hydra Eating Daphnia
Figure 41.7
Mouth
Tentacles
Food
Epidermis Gastrodermis
Food particles
engulfed and
digested
Food
particles broken
down
Digestive
enzymes released
1
2
3
• More complex animals have a digestive tube with
two openings, a mouth and an anus
• This digestive tube is called a complete
digestive tract or an alimentary canal
• It can have specialized regions that carry out
digestion and absorption in a stepwise fashion
© 2011 Pearson Education, Inc.
Crop
Gizzard
Intestine
Anus
Esophagus
Pharynx
Mouth
(a) Earthworm
Midgut Esophagus
Crop
Mouth
Stomach
Gizzard
Intestine
Anus
Anus
RectumEsophagus
Crop
HindgutForegut
Mouth Gastric cecae
(b) Grasshopper (c) Bird
Figure 41.8
Concept 41.3: Organs specialized for
sequential stages of food processing
form the mammalian digestive system
• The mammalian digestive system consists of an
alimentary canal and accessory glands that
secrete digestive juices through ducts
• Mammalian accessory glands are the salivary
glands, the pancreas, the liver, and the
gallbladder
© 2011 Pearson Education, Inc.
• Food is pushed along by peristalsis, rhythmic
contractions of muscles in the wall of the canal
• Valves called sphincters regulate the movement
of material between compartments
© 2011 Pearson Education, Inc.
Figure 41.9
Liver
Salivary
glands
Gall-
bladder
Esophagus
Pharynx
Oral cavity
Sphincter
Mouth
Stomach
Esophagus
Tongue
Pancreas
Small
intestine
Large
intestine
Rectum
Anus
Sphincter
Stomach
Duodenum of
small intestine
Pancreas
Schematic diagram
Anus
Rectum
Large
intestine
Small
intestineLiver
Salivary
glands
Gall-
bladder
Liver
Salivary
glands
Gall-
bladder
Esophagus
Pharynx
Oral cavity
Sphincter
Tongue
Pancreas
Small
intestine
Large
intestine
Rectum
Anus
Sphincter
Stomach
Duodenum of
small intestine
Figure 41.9a
Figure 41.9b
Mouth
Stomach
Esophagus
Pancreas
Schematic diagram
Anus
Rectum
Large
intestine
Small
intestineLiver
Salivary
glands
Gall-
bladder
The Oral Cavity, Pharynx, and Esophagus
• The first stage of digestion is mechanical and
takes place in the oral cavity
• Salivary glands deliver saliva to lubricate food
• Teeth chew food into smaller particles that are
exposed to salivary amylase, initiating
breakdown of glucose polymers
• Saliva also contains mucus, a viscous mixture of
water, salts, cells, and glycoproteins
© 2011 Pearson Education, Inc.
• The tongue shapes food into a bolus and
provides help with swallowing
• The throat, or pharynx, is the junction that opens
to both the esophagus and the trachea
• The esophagus connects to the stomach
• The trachea (windpipe) leads to the lungs
© 2011 Pearson Education, Inc.
• The esophagus conducts food from the pharynx
down to the stomach by peristalsis
• Swallowing causes the epiglottis to block entry to
the trachea, and the bolus is guided by the larynx,
the upper part of the respiratory tract
• Coughing occurs when the swallowing reflex fails
and food or liquids reach the windpipe
© 2011 Pearson Education, Inc.
Tongue
Pharynx
Glottis
Larynx
Bolus of
food
Epiglottis
up
Esophageal
sphincter
contracted
Esophagus
To lungs To stomach
Trachea
Figure 41.10-1
Tongue
Pharynx
Glottis
Larynx
Bolus of
food
Epiglottis
up
Esophageal
sphincter
contracted
Esophagus
To lungs To stomach
Trachea
Figure 41.10-2
Tongue
Pharynx
Glottis
Larynx
Bolus of
food
Epiglottis
up
Esophageal
sphincter
contracted
Esophagus
To lungs To stomach
Relaxed
muscles
Contracted
muscles
Sphincter
relaxed
Stomach
Trachea
Figure 41.10-3
Digestion in the Stomach
• The stomach stores food and secretes gastric
juice, which converts a meal to acid chyme
© 2011 Pearson Education, Inc.
Chemical Digestion in the Stomach
• Gastric juice has a low pH of about 2, which kills
bacteria and denatures proteins
• Gastric juice is made up of hydrochloric acid
(HCl) and pepsin
• Pepsin is a protease, or protein-digesting
enzyme, that cleaves proteins into smaller
peptides
© 2011 Pearson Education, Inc.
• Parietal cells secrete hydrogen and chloride ions
separately into the lumen (cavity) of the stomach
• Chief cells secrete inactive pepsinogen, which
is activated to pepsin when mixed with
hydrochloric acid in the stomach
• Mucus protects the stomach lining from gastric
juice
© 2011 Pearson Education, Inc.
Gastric gland
Gastric pits on
interior surface
of stomach
Sphincter
Small
intestine
Epithelium
Mucous cell
Chief cell
Parietal cell
Chief
cell
Pepsinogen
Parietal
cell
Pepsin
Folds of
epithelial
tissue
Sphincter
Esophagus
Stomach
3
2
1
10µm
HCl
H+
Cl−
Figure 41.11
Figure 41.11a
10 µm
Figure 41.11b
Gastric gland
Gastric pits on
interior surface
of stomach
Epithelium
Mucous cell
Chief cell
Parietal cell
Chief
cell
Pepsinogen
Parietal
cell
Pepsin
2
1
HCl
H+
Cl−
3
• Gastric ulcers, lesions in the lining, are caused
mainly by the bacterium Heliobacter pylori
© 2011 Pearson Education, Inc.
Stomach Dynamics
• Coordinated contraction and relaxation of
stomach muscle churn the stomach’s contents
• Sphincters prevent chyme from entering the
esophagus and regulate its entry into the small
intestine
© 2011 Pearson Education, Inc.
Digestion in the Small Intestine
• The small intestine is the longest section of the
alimentary canal
• It is the major organ of digestion and absorption
© 2011 Pearson Education, Inc.
Figure 41.12-1
Carbohydrate digestion
Polysaccharides
Salivary amylase
Smaller
polysaccharides
Maltose
Oral cavity,
pharynx,
esophagus
Figure 41.12-2
Protein digestion
Small polypeptides
Proteins
Pepsin
Carbohydrate digestion
Polysaccharides
Salivary amylase
Smaller
polysaccharides
Maltose
Stomach
Oral cavity,
pharynx,
esophagus
Figure 41.12-3
Fat digestionNucleic acid digestion
Protein digestion
Fat (triglycerides)DNA, RNA
Nucleotides
Pancreatic
nucleases
Pancreatic lipase
Glycerol, fatty acids,
monoglyceridesSmall peptides
Pancreatic carboxypeptidase
Smaller
polypeptides
Pancreatic trypsin and
chymotrypsin
Small polypeptides
Proteins
Pepsin
Carbohydrate digestion
Polysaccharides
Salivary amylase
Smaller
polysaccharides
Maltose
Pancreatic amylases
Disaccharides
Small
intestine
(enzymes
from
pancreas)
Stomach
Oral cavity,
pharynx,
esophagus
Fat digestionNucleic acid digestion
Protein digestion
Fat (triglycerides)DNA, RNA
Nucleotides
Pancreatic
nucleases
Pancreatic lipase
Glycerol, fatty acids,
monoglycerides
Nucleotidases
Nucleosides
Nucleosidases
and
phosphatases
Nitrogenous bases,
sugars, phosphatesAmino acids
Dipeptidases, carboxy-
peptidase, and
aminopeptidase
Small peptides
Pancreatic carboxypeptidase
Smaller
polypeptides
Pancreatic trypsin and
chymotrypsin
Small polypeptides
Proteins
Pepsin
Carbohydrate digestion
Polysaccharides Disaccharides
Salivary amylase
Smaller
polysaccharides
Maltose
Pancreatic amylases
Disaccharides
Disaccharidases
Monosaccharides
Small
intestine
(enzymes
from
epithelium)
Small
intestine
(enzymes
from
pancreas)
Stomach
Oral cavity,
pharynx,
esophagus
Figure 41.12-4
• The first portion of the small intestine is the
duodenum, where chyme from the stomach
mixes with digestive juices from the pancreas,
liver, gallbladder, and the small intestine itself
© 2011 Pearson Education, Inc.
Pancreatic Secretions
• The pancreas produces proteases trypsin and
chymotrypsin that are activated in the lumen of
the duodenum
• Its solution is alkaline and neutralizes the acidic
chyme
© 2011 Pearson Education, Inc.
Bile Production by the Liver
• In the small intestine, bile aids in digestion and
absorption of fats
• Bile is made in the liver and stored in the
gallbladder
• Bile also destroys nonfunctional red blood cells
© 2011 Pearson Education, Inc.
Secretions of the Small Intestine
• The epithelial lining of the duodenum produces
several digestive enzymes
• Enzymatic digestion is completed as peristalsis
moves the chyme and digestive juices along the
small intestine
• Most digestion occurs in the duodenum; the
jejunum and ileum function mainly in absorption
of nutrients and water
© 2011 Pearson Education, Inc.
Absorption in the Small Intestine
• The small intestine has a huge surface area,
due to villi and microvilli that are exposed to
the intestinal lumen
• The enormous microvillar surface creates a
brush border that greatly increases the rate of
nutrient absorption
• Transport across the epithelial cells can be
passive or active depending on the nutrient
© 2011 Pearson Education, Inc.
Figure 41.13
Vein carrying
blood to liver
Muscle layers
Blood
capillaries
Villi
Intestinal wall
Epithelial
cells
Large
circular
folds
Key
Nutrient
absorption
Villi
Microvilli (brush
border) at apical
(lumenal) surface
Epithelial
cells
Lumen
Basal
surface
Lacteal
Lymph
vessel
Figure 41.13a
Vein carrying
blood to liver
Muscle layers
Villi
Intestinal wall
Large
circular
folds
Key
Nutrient
absorption
Key
Nutrient
absorption
Blood
capillaries
Epithelial
cells
Villi
Microvilli (brush
border) at apical
(lumenal) surface
Epithelial
cells
Lumen
Basal
surface
Lacteal
Lymph
vessel
Figure 41.13b
• The hepatic portal vein carries nutrient-rich
blood from the capillaries of the villi to the liver,
then to the heart
• The liver regulates nutrient distribution,
interconverts many organic molecules, and
detoxifies many organic molecules
© 2011 Pearson Education, Inc.
• Epithelial cells absorb fatty acids and
monoglycerides and recombine them into
triglycerides
• These fats are coated with phospholipids,
cholesterol, and proteins to form water-soluble
chylomicrons
• Chylomicrons are transported into a lacteal, a
lymphatic vessel in each villus
• Lymphatic vessels deliver chylomicron-containing
lymph to large veins that return blood to the heart
© 2011 Pearson Education, Inc.
Figure 41.14
LUMEN
OF SMALL
INTESTINE
Triglycerides
Epithelial
cell Fatty acids
Mono-
glycerides
Triglycerides
Chylomicron
Phospho-
lipids,
cholesterol,
and proteins
Lacteal
Figure 41.14a
LUMEN
OF SMALL
INTESTINE
Triglycerides
Epithelial
cell Fatty acids
Mono-
glycerides
Triglycerides
Figure 41.14b
Triglycerides
Chylomicron
Phospho-
lipids,
cholesterol,
and proteins
Lacteal
Absorption in the Large Intestine
• The colon of the large intestine is connected to
the small intestine
• The cecum aids in the fermentation of plant
material and connects where the small and large
intestines meet
• The human cecum has an extension called the
appendix, which plays a very minor role in
immunity
© 2011 Pearson Education, Inc.
Figure 41.15
Ascending
portion
of colon
Small
intestine
Appendix
Cecum
• A major function of the colon is to recover water
that has entered the alimentary canal
• The colon houses bacteria (e.g., Escherichia
coli) which live on unabsorbed organic material;
some produce vitamins
• Feces, including undigested material and
bacteria, become more solid as they move
through the colon
© 2011 Pearson Education, Inc.
• Feces are stored in the rectum until they can be
eliminated through the anus
• Two sphincters between the rectum and anus
control bowel movements
© 2011 Pearson Education, Inc.
Concept 41.4: Evolutionary adaptations of
vertebrate digestive systems correlate with
diet
• Digestive systems of vertebrates are variations
on a common plan
• However, there are intriguing adaptations, often
related to diet
© 2011 Pearson Education, Inc.
Dental Adaptations
• Dentition, an animal’s assortment of teeth, is one
example of structural variation reflecting diet
• The success of mammals is due in part to their
dentition, which is specialized for different diets
• Nonmammalian vertebrates have less
specialized teeth, though exceptions exist
– For example, the teeth of poisonous snakes are
modified as fangs for injecting venom
© 2011 Pearson Education, Inc.
Figure 41.16
Carnivore
Herbivore Omnivore
MolarsPremolarsCaninesIncisorsKey
Stomach and Intestinal Adaptations
• Many carnivores have large, expandable
stomachs
• Herbivores and omnivores generally have longer
alimentary canals than carnivores, reflecting the
longer time needed to digest vegetation
© 2011 Pearson Education, Inc.
Figure 41.17
Small
intestine Stomach
Cecum
Carnivore
Colon
(large
intestine)
Small intestine
Herbivore
Figure 41.17a
Figure 41.17b
Mutualistic Adaptations
• Many herbivores have fermentation chambers,
where mutualistic microorganisms digest
cellulose
• The most elaborate adaptations for an
herbivorous diet have evolved in the animals
called ruminants
© 2011 Pearson Education, Inc.
Reticulum
Esophagus
OmasumAbomasum
Intestine
Rumen1 2
34
Figure 41.18
Concept 41.5: Feedback circuits regulate
digestion, energy storage, and appetite
• The intake of food and the use of nutrients
varies with an animal’s diet and environment
© 2011 Pearson Education, Inc.
Regulation of Digestion
• Each step in the digestive system is activated as
needed
• The enteric division of the nervous system helps
to regulate the digestive process
• The endocrine system also regulates digestion
through the release and transport of hormones
© 2011 Pearson Education, Inc.
Figure 41.19
Liver
Gallbladder
Food
Stomach
Duodenum
of small intestine
Gastric
juices
Pancreas
Bile
Chyme
1 2 3
Gastrin
CCK
Key
Stimulation
Inhibition
HCO3
−
, enzymes
CCK
Secretin
Secretin
and CCK
Gastric
juices
+
+
+ +
−
+
−
Figure 41.19a
Liver
Gallbladder
Food
Stomach
Duodenum
of small intestine
Gastric
juices
Pancreas
1
Gastrin
Key
Stimulation
Inhibition
+
−
+
Figure 41.19b
Bile
Chyme
CCK
HCO3
−
, enzymes
Secretin
Key
Stimulation
Inhibition
2
CCK
+
+ +
+
−
Figure 41.19c
Secretin
and CCK
Gastric
juices
3
Key
Stimulation
Inhibition
+
−
−
Regulation of Energy Storage
• The body stores energy-rich molecules that are
not needed right away for metabolism
• In humans, energy is stored first in the liver and
muscle cells in the polymer glycogen
• Excess energy is stored in adipose tissue, the
most space-efficient storage tissue
© 2011 Pearson Education, Inc.
Glucose Homeostasis
• Oxidation of glucose generates ATP to fuel
cellular processes
• The hormones insulin and glucagon regulate the
breakdown of glycogen into glucose
• The liver is the site for glucose homeostasis
– A carbohydrate-rich meal raises insulin levels,
which triggers the synthesis of glycogen
– Low blood sugar causes glucagon to stimulate
the breakdown of glycogen and release glucose
© 2011 Pearson Education, Inc.
Figure 41.20
Transport of
glucose into
body cells
and storage
of glucose
as glycogen
Breakdown
of glycogen
and release
of glucose
into blood
Homeostasis:
70–110 mg glucose/
100 mL blood
Stimulus:
Blood glucose
level drops
below set point.
Pancreas
secretes
glucagon.
Stimulus:
Blood glucose
level rises
after eating.
Pancreas
secretes
insulin.
© 2011 Pearson Education, Inc.
Regulation of Appetite and Consumption
• Overnourishment causes obesity, which results
from excessive intake of food energy with the
excess stored as fat
• Obesity contributes to diabetes (type 2), cancer
of the colon and breasts, heart attacks, and
strokes
• Researchers have discovered several of the
mechanisms that help regulate body weight
Figure 41.21
Satiety
center
Ghrelin
Insulin
Leptin
PYY
+
−
−
−
• Hormones regulate long-term and short-term
appetite by affecting a “satiety center” in the brain
• Studies on mice revealed that the hormone leptin
plays an important role in regulating obesity
• Leptin is produced by adipose tissue and can
help to suppress appetite
© 2011 Pearson Education, Inc.
EXPERIMENT
Obese mouse with mutant
ob gene (left) next to wild-type
mouse
RESULTS
Genotype pairing
(red type indicates
mutant genes)
Average change
in body mass (g)
of subject
8.3
38.7
8.2
−14.9*
Paired with
ob+
ob+
, db+
db+
ob+
ob+
, db+
db+
ob ob, db+
db+
ob ob, db+
db+
ob ob, db+
db+
ob+
ob+
, db+
db+
ob ob, db+
db+
ob+
ob+
, db db
Subject
*Due to pronounced weight loss and weakening, subjects in this pairing were
reweighed after less than eight weeks.
Figure 41.22
Figure 41.22a
Obese mouse with mutant
ob gene (left) next to wild-type
mouse
Figure 41.22b
RESULTS
Genotype pairing
(red type indicates
mutant genes)
Average change
in body mass (g)
of subject
8.3
38.7
8.2
−14.9*
Paired with
ob+
ob+
, db+
db+
ob+
ob+
, db+
db+
ob ob, db+
db+
ob ob, db+
db+
ob ob, db+
db+
ob+
ob+
, db+
db+
ob ob, db+
db+
ob+
ob+
, db db
Subject
*Due to pronounced weight loss and weakening, subjects in this pairing were
reweighed after less than eight weeks.
Obesity and Evolution
• A species of birds called petrels become obese
as chicks; in order to consume enough protein
from high-fat food, chicks need to consume more
calories than they burn
© 2011 Pearson Education, Inc.
Figure 41.23
© 2011 Pearson Education, Inc.
• The problem of maintaining weight partly stems
from our evolutionary past, when fat hoarding
was a means of survival
• Individuals who were more likely to eat fatty food
and store energy as adipose tissue may have
been more likely to survive famines
Figure 41.UN01
Veins to heart
Mouth Stomach
Esophagus
Lymphatic system
Lipids
Absorbed food
(except lipids)
Hepatic portal vein
Absorbed
water
Liver
Secretions
from salivary
glands
Secretions
from gastric
glands
Small intestine
Secretions from liver
Secretions from pancreas
Rectum
Anus
Large
intestine
Figure 41.UN02

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Ch41

  • 1. LECTURE PRESENTATIONS For CAMPBELL BIOLOGY, NINTH EDITION Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson © 2011 Pearson Education, Inc. Lectures by Erin Barley Kathleen Fitzpatrick Animal Nutrition Chapter 41
  • 2. • Food is taken in, taken apart, and taken up in the process of animal nutrition • In general, animals fall into three categories: – Herbivores eat mainly plants and algae – Carnivores eat other animals – Omnivores regularly consume animals as well as plants or algae • Most animals are also opportunistic feeders © 2011 Pearson Education, Inc. Overview: The Need to Feed
  • 4. Concept 41.1: An animal’s diet must supply chemical energy, organic molecules, and essential nutrients • An animal’s diet provides: – Chemical energy, which is converted into ATP to power cellular processes – Organic building blocks, such as organic carbon and organic nitrogen, to synthesize a variety of organic molecules – Essential nutrients, which are required by cells and must be obtained from dietary sources © 2011 Pearson Education, Inc.
  • 5. Essential Nutrients • There are four classes of essential nutrients: – Essential amino acids – Essential fatty acids – Vitamins – Minerals © 2011 Pearson Education, Inc.
  • 6. • Animals require 20 amino acids and can synthesize about half from molecules in their diet • The remaining amino acids, the essential amino acids, must be obtained from food in preassembled form • Meat, eggs, and cheese provide all the essential amino acids and are thus “complete” proteins © 2011 Pearson Education, Inc. Essential Amino Acids
  • 7. • Most plant proteins are incomplete in amino acid composition • Individuals who eat only plant proteins need to eat specific plant combinations to get all the essential amino acids • Some animals have adaptations that help them through periods when their bodies demand extraordinary amounts of protein © 2011 Pearson Education, Inc.
  • 9. Essential Fatty Acids • Animals can synthesize most of the fatty acids they need • The essential fatty acids must be obtained from the diet and include certain unsaturated fatty acids (i.e., fatty acids with one or more double bonds) • Deficiencies in fatty acids are rare © 2011 Pearson Education, Inc.
  • 10. Vitamins • Vitamins are organic molecules required in the diet in small amounts • Thirteen vitamins are essential for humans • Vitamins are grouped into two categories: fat- soluble and water-soluble © 2011 Pearson Education, Inc.
  • 12. Minerals • Minerals are simple inorganic nutrients, usually required in small amounts • Ingesting large amounts of some minerals can upset homeostatic balance © 2011 Pearson Education, Inc.
  • 14. Dietary Deficiencies • Malnourishment is the long-term absence from the diet of one or more essential nutrients © 2011 Pearson Education, Inc.
  • 15. Deficiencies in Essential Nutrients • Deficiencies in essential nutrients can cause deformities, disease, and death • “Golden Rice” is an engineered strain of rice with beta-carotene, which is converted to vitamin A in the body © 2011 Pearson Education, Inc.
  • 17. • Undernutrition results when a diet does not provide enough chemical energy • An undernourished individual will – Use up stored fat and carbohydrates – Break down its own proteins – Lose muscle mass – Suffer protein deficiency of the brain – Die or suffer irreversible damage © 2011 Pearson Education, Inc. Undernutrition
  • 18. Assessing Nutritional Needs • Genetic defects that disrupt food uptake provide information about human nutrition – For example, hemochromatosis causes iron buildup without excessive iron intake • Insights into human nutrition have come from epidemiology, the study of human health and disease in populations • Neural tube defects were found to be the result of a deficiency in folic acid in pregnant mothers © 2011 Pearson Education, Inc.
  • 19. Figure 41.4 RESULTS Group Number of infants/fetuses studied Vitamin supplements (experimental group) No vitamin supplements (control group) 141 204 1 (0.7%) 12 (5.9%) Infants/fetuses with a neural tube defect
  • 20. Concept 41.2: The main stages of food processing are ingestion, digestion, absorption, and elimination • Ingestion is the act of eating © 2011 Pearson Education, Inc.
  • 21. Figure 41.5 Mechanical digestion Chemical digestion (enzymatic hydrolysis) Nutrient molecules enter body cells Undigested material EliminationAbsorptionDigestionIngestion1 2 3 4
  • 23. Suspension Feeders • Many aquatic animals are suspension feeders, which sift small food particles from the water © 2011 Pearson Education, Inc.
  • 24. Bulk Feeders Suspension Feeders and Filter Feeders Fluid Feeders Baleen FecesCaterpillar Substrate Feeders Figure 41.6
  • 25. Figure 41.6a Suspension Feeders and Filter Feeders Baleen
  • 26. Substrate Feeders • Substrate feeders are animals that live in or on their food source © 2011 Pearson Education, Inc.
  • 28. Fluid Feeders • Fluid feeders suck nutrient-rich fluid from a living host © 2011 Pearson Education, Inc.
  • 30. Bulk Feeders • Bulk feeders eat relatively large pieces of food © 2011 Pearson Education, Inc.
  • 32. • Digestion is the process of breaking food down into molecules small enough to absorb • Mechanical digestion, including chewing, increases the surface area of food • Chemical digestion splits food into small molecules that can pass through membranes; these are used to build larger molecules • In chemical digestion, the process of enzymatic hydrolysis splits bonds in molecules with the addition of water © 2011 Pearson Education, Inc.
  • 33. • Absorption is uptake of nutrients by body cells • Elimination is the passage of undigested material out of the digestive system © 2011 Pearson Education, Inc.
  • 34. Digestive Compartments • Most animals process food in specialized compartments • These compartments reduce the risk of an animal digesting its own cells and tissues © 2011 Pearson Education, Inc.
  • 35. Intracellular Digestion • In intracellular digestion, food particles are engulfed by phagocytosis • Food vacuoles, containing food, fuse with lysosomes containing hydrolytic enzymes © 2011 Pearson Education, Inc.
  • 36. Extracellular Digestion • Extracellular digestion is the breakdown of food particles outside of cells • It occurs in compartments that are continuous with the outside of the animal’s body • Animals with simple body plans have a gastrovascular cavity that functions in both digestion and distribution of nutrients © 2011 Pearson Education, Inc.
  • 37. © 2011 Pearson Education, Inc. Video: Hydra Eating Daphnia
  • 38. Figure 41.7 Mouth Tentacles Food Epidermis Gastrodermis Food particles engulfed and digested Food particles broken down Digestive enzymes released 1 2 3
  • 39. • More complex animals have a digestive tube with two openings, a mouth and an anus • This digestive tube is called a complete digestive tract or an alimentary canal • It can have specialized regions that carry out digestion and absorption in a stepwise fashion © 2011 Pearson Education, Inc.
  • 41. Concept 41.3: Organs specialized for sequential stages of food processing form the mammalian digestive system • The mammalian digestive system consists of an alimentary canal and accessory glands that secrete digestive juices through ducts • Mammalian accessory glands are the salivary glands, the pancreas, the liver, and the gallbladder © 2011 Pearson Education, Inc.
  • 42. • Food is pushed along by peristalsis, rhythmic contractions of muscles in the wall of the canal • Valves called sphincters regulate the movement of material between compartments © 2011 Pearson Education, Inc.
  • 46. The Oral Cavity, Pharynx, and Esophagus • The first stage of digestion is mechanical and takes place in the oral cavity • Salivary glands deliver saliva to lubricate food • Teeth chew food into smaller particles that are exposed to salivary amylase, initiating breakdown of glucose polymers • Saliva also contains mucus, a viscous mixture of water, salts, cells, and glycoproteins © 2011 Pearson Education, Inc.
  • 47. • The tongue shapes food into a bolus and provides help with swallowing • The throat, or pharynx, is the junction that opens to both the esophagus and the trachea • The esophagus connects to the stomach • The trachea (windpipe) leads to the lungs © 2011 Pearson Education, Inc.
  • 48. • The esophagus conducts food from the pharynx down to the stomach by peristalsis • Swallowing causes the epiglottis to block entry to the trachea, and the bolus is guided by the larynx, the upper part of the respiratory tract • Coughing occurs when the swallowing reflex fails and food or liquids reach the windpipe © 2011 Pearson Education, Inc.
  • 51. Tongue Pharynx Glottis Larynx Bolus of food Epiglottis up Esophageal sphincter contracted Esophagus To lungs To stomach Relaxed muscles Contracted muscles Sphincter relaxed Stomach Trachea Figure 41.10-3
  • 52. Digestion in the Stomach • The stomach stores food and secretes gastric juice, which converts a meal to acid chyme © 2011 Pearson Education, Inc.
  • 53. Chemical Digestion in the Stomach • Gastric juice has a low pH of about 2, which kills bacteria and denatures proteins • Gastric juice is made up of hydrochloric acid (HCl) and pepsin • Pepsin is a protease, or protein-digesting enzyme, that cleaves proteins into smaller peptides © 2011 Pearson Education, Inc.
  • 54. • Parietal cells secrete hydrogen and chloride ions separately into the lumen (cavity) of the stomach • Chief cells secrete inactive pepsinogen, which is activated to pepsin when mixed with hydrochloric acid in the stomach • Mucus protects the stomach lining from gastric juice © 2011 Pearson Education, Inc.
  • 55. Gastric gland Gastric pits on interior surface of stomach Sphincter Small intestine Epithelium Mucous cell Chief cell Parietal cell Chief cell Pepsinogen Parietal cell Pepsin Folds of epithelial tissue Sphincter Esophagus Stomach 3 2 1 10µm HCl H+ Cl− Figure 41.11
  • 57. Figure 41.11b Gastric gland Gastric pits on interior surface of stomach Epithelium Mucous cell Chief cell Parietal cell Chief cell Pepsinogen Parietal cell Pepsin 2 1 HCl H+ Cl− 3
  • 58. • Gastric ulcers, lesions in the lining, are caused mainly by the bacterium Heliobacter pylori © 2011 Pearson Education, Inc.
  • 59. Stomach Dynamics • Coordinated contraction and relaxation of stomach muscle churn the stomach’s contents • Sphincters prevent chyme from entering the esophagus and regulate its entry into the small intestine © 2011 Pearson Education, Inc.
  • 60. Digestion in the Small Intestine • The small intestine is the longest section of the alimentary canal • It is the major organ of digestion and absorption © 2011 Pearson Education, Inc.
  • 61. Figure 41.12-1 Carbohydrate digestion Polysaccharides Salivary amylase Smaller polysaccharides Maltose Oral cavity, pharynx, esophagus
  • 62. Figure 41.12-2 Protein digestion Small polypeptides Proteins Pepsin Carbohydrate digestion Polysaccharides Salivary amylase Smaller polysaccharides Maltose Stomach Oral cavity, pharynx, esophagus
  • 63. Figure 41.12-3 Fat digestionNucleic acid digestion Protein digestion Fat (triglycerides)DNA, RNA Nucleotides Pancreatic nucleases Pancreatic lipase Glycerol, fatty acids, monoglyceridesSmall peptides Pancreatic carboxypeptidase Smaller polypeptides Pancreatic trypsin and chymotrypsin Small polypeptides Proteins Pepsin Carbohydrate digestion Polysaccharides Salivary amylase Smaller polysaccharides Maltose Pancreatic amylases Disaccharides Small intestine (enzymes from pancreas) Stomach Oral cavity, pharynx, esophagus
  • 64. Fat digestionNucleic acid digestion Protein digestion Fat (triglycerides)DNA, RNA Nucleotides Pancreatic nucleases Pancreatic lipase Glycerol, fatty acids, monoglycerides Nucleotidases Nucleosides Nucleosidases and phosphatases Nitrogenous bases, sugars, phosphatesAmino acids Dipeptidases, carboxy- peptidase, and aminopeptidase Small peptides Pancreatic carboxypeptidase Smaller polypeptides Pancreatic trypsin and chymotrypsin Small polypeptides Proteins Pepsin Carbohydrate digestion Polysaccharides Disaccharides Salivary amylase Smaller polysaccharides Maltose Pancreatic amylases Disaccharides Disaccharidases Monosaccharides Small intestine (enzymes from epithelium) Small intestine (enzymes from pancreas) Stomach Oral cavity, pharynx, esophagus Figure 41.12-4
  • 65. • The first portion of the small intestine is the duodenum, where chyme from the stomach mixes with digestive juices from the pancreas, liver, gallbladder, and the small intestine itself © 2011 Pearson Education, Inc.
  • 66. Pancreatic Secretions • The pancreas produces proteases trypsin and chymotrypsin that are activated in the lumen of the duodenum • Its solution is alkaline and neutralizes the acidic chyme © 2011 Pearson Education, Inc.
  • 67. Bile Production by the Liver • In the small intestine, bile aids in digestion and absorption of fats • Bile is made in the liver and stored in the gallbladder • Bile also destroys nonfunctional red blood cells © 2011 Pearson Education, Inc.
  • 68. Secretions of the Small Intestine • The epithelial lining of the duodenum produces several digestive enzymes • Enzymatic digestion is completed as peristalsis moves the chyme and digestive juices along the small intestine • Most digestion occurs in the duodenum; the jejunum and ileum function mainly in absorption of nutrients and water © 2011 Pearson Education, Inc.
  • 69. Absorption in the Small Intestine • The small intestine has a huge surface area, due to villi and microvilli that are exposed to the intestinal lumen • The enormous microvillar surface creates a brush border that greatly increases the rate of nutrient absorption • Transport across the epithelial cells can be passive or active depending on the nutrient © 2011 Pearson Education, Inc.
  • 70. Figure 41.13 Vein carrying blood to liver Muscle layers Blood capillaries Villi Intestinal wall Epithelial cells Large circular folds Key Nutrient absorption Villi Microvilli (brush border) at apical (lumenal) surface Epithelial cells Lumen Basal surface Lacteal Lymph vessel
  • 71. Figure 41.13a Vein carrying blood to liver Muscle layers Villi Intestinal wall Large circular folds Key Nutrient absorption
  • 72. Key Nutrient absorption Blood capillaries Epithelial cells Villi Microvilli (brush border) at apical (lumenal) surface Epithelial cells Lumen Basal surface Lacteal Lymph vessel Figure 41.13b
  • 73. • The hepatic portal vein carries nutrient-rich blood from the capillaries of the villi to the liver, then to the heart • The liver regulates nutrient distribution, interconverts many organic molecules, and detoxifies many organic molecules © 2011 Pearson Education, Inc.
  • 74. • Epithelial cells absorb fatty acids and monoglycerides and recombine them into triglycerides • These fats are coated with phospholipids, cholesterol, and proteins to form water-soluble chylomicrons • Chylomicrons are transported into a lacteal, a lymphatic vessel in each villus • Lymphatic vessels deliver chylomicron-containing lymph to large veins that return blood to the heart © 2011 Pearson Education, Inc.
  • 75. Figure 41.14 LUMEN OF SMALL INTESTINE Triglycerides Epithelial cell Fatty acids Mono- glycerides Triglycerides Chylomicron Phospho- lipids, cholesterol, and proteins Lacteal
  • 76. Figure 41.14a LUMEN OF SMALL INTESTINE Triglycerides Epithelial cell Fatty acids Mono- glycerides Triglycerides
  • 78. Absorption in the Large Intestine • The colon of the large intestine is connected to the small intestine • The cecum aids in the fermentation of plant material and connects where the small and large intestines meet • The human cecum has an extension called the appendix, which plays a very minor role in immunity © 2011 Pearson Education, Inc.
  • 80. • A major function of the colon is to recover water that has entered the alimentary canal • The colon houses bacteria (e.g., Escherichia coli) which live on unabsorbed organic material; some produce vitamins • Feces, including undigested material and bacteria, become more solid as they move through the colon © 2011 Pearson Education, Inc.
  • 81. • Feces are stored in the rectum until they can be eliminated through the anus • Two sphincters between the rectum and anus control bowel movements © 2011 Pearson Education, Inc.
  • 82. Concept 41.4: Evolutionary adaptations of vertebrate digestive systems correlate with diet • Digestive systems of vertebrates are variations on a common plan • However, there are intriguing adaptations, often related to diet © 2011 Pearson Education, Inc.
  • 83. Dental Adaptations • Dentition, an animal’s assortment of teeth, is one example of structural variation reflecting diet • The success of mammals is due in part to their dentition, which is specialized for different diets • Nonmammalian vertebrates have less specialized teeth, though exceptions exist – For example, the teeth of poisonous snakes are modified as fangs for injecting venom © 2011 Pearson Education, Inc.
  • 85. Stomach and Intestinal Adaptations • Many carnivores have large, expandable stomachs • Herbivores and omnivores generally have longer alimentary canals than carnivores, reflecting the longer time needed to digest vegetation © 2011 Pearson Education, Inc.
  • 89. Mutualistic Adaptations • Many herbivores have fermentation chambers, where mutualistic microorganisms digest cellulose • The most elaborate adaptations for an herbivorous diet have evolved in the animals called ruminants © 2011 Pearson Education, Inc.
  • 91. Concept 41.5: Feedback circuits regulate digestion, energy storage, and appetite • The intake of food and the use of nutrients varies with an animal’s diet and environment © 2011 Pearson Education, Inc.
  • 92. Regulation of Digestion • Each step in the digestive system is activated as needed • The enteric division of the nervous system helps to regulate the digestive process • The endocrine system also regulates digestion through the release and transport of hormones © 2011 Pearson Education, Inc.
  • 93. Figure 41.19 Liver Gallbladder Food Stomach Duodenum of small intestine Gastric juices Pancreas Bile Chyme 1 2 3 Gastrin CCK Key Stimulation Inhibition HCO3 − , enzymes CCK Secretin Secretin and CCK Gastric juices + + + + − + −
  • 94. Figure 41.19a Liver Gallbladder Food Stomach Duodenum of small intestine Gastric juices Pancreas 1 Gastrin Key Stimulation Inhibition + − +
  • 97. Regulation of Energy Storage • The body stores energy-rich molecules that are not needed right away for metabolism • In humans, energy is stored first in the liver and muscle cells in the polymer glycogen • Excess energy is stored in adipose tissue, the most space-efficient storage tissue © 2011 Pearson Education, Inc.
  • 98. Glucose Homeostasis • Oxidation of glucose generates ATP to fuel cellular processes • The hormones insulin and glucagon regulate the breakdown of glycogen into glucose • The liver is the site for glucose homeostasis – A carbohydrate-rich meal raises insulin levels, which triggers the synthesis of glycogen – Low blood sugar causes glucagon to stimulate the breakdown of glycogen and release glucose © 2011 Pearson Education, Inc.
  • 99. Figure 41.20 Transport of glucose into body cells and storage of glucose as glycogen Breakdown of glycogen and release of glucose into blood Homeostasis: 70–110 mg glucose/ 100 mL blood Stimulus: Blood glucose level drops below set point. Pancreas secretes glucagon. Stimulus: Blood glucose level rises after eating. Pancreas secretes insulin.
  • 100. © 2011 Pearson Education, Inc. Regulation of Appetite and Consumption • Overnourishment causes obesity, which results from excessive intake of food energy with the excess stored as fat • Obesity contributes to diabetes (type 2), cancer of the colon and breasts, heart attacks, and strokes • Researchers have discovered several of the mechanisms that help regulate body weight
  • 102. • Hormones regulate long-term and short-term appetite by affecting a “satiety center” in the brain • Studies on mice revealed that the hormone leptin plays an important role in regulating obesity • Leptin is produced by adipose tissue and can help to suppress appetite © 2011 Pearson Education, Inc.
  • 103. EXPERIMENT Obese mouse with mutant ob gene (left) next to wild-type mouse RESULTS Genotype pairing (red type indicates mutant genes) Average change in body mass (g) of subject 8.3 38.7 8.2 −14.9* Paired with ob+ ob+ , db+ db+ ob+ ob+ , db+ db+ ob ob, db+ db+ ob ob, db+ db+ ob ob, db+ db+ ob+ ob+ , db+ db+ ob ob, db+ db+ ob+ ob+ , db db Subject *Due to pronounced weight loss and weakening, subjects in this pairing were reweighed after less than eight weeks. Figure 41.22
  • 104. Figure 41.22a Obese mouse with mutant ob gene (left) next to wild-type mouse
  • 105. Figure 41.22b RESULTS Genotype pairing (red type indicates mutant genes) Average change in body mass (g) of subject 8.3 38.7 8.2 −14.9* Paired with ob+ ob+ , db+ db+ ob+ ob+ , db+ db+ ob ob, db+ db+ ob ob, db+ db+ ob ob, db+ db+ ob+ ob+ , db+ db+ ob ob, db+ db+ ob+ ob+ , db db Subject *Due to pronounced weight loss and weakening, subjects in this pairing were reweighed after less than eight weeks.
  • 106. Obesity and Evolution • A species of birds called petrels become obese as chicks; in order to consume enough protein from high-fat food, chicks need to consume more calories than they burn © 2011 Pearson Education, Inc.
  • 108. © 2011 Pearson Education, Inc. • The problem of maintaining weight partly stems from our evolutionary past, when fat hoarding was a means of survival • Individuals who were more likely to eat fatty food and store energy as adipose tissue may have been more likely to survive famines
  • 109. Figure 41.UN01 Veins to heart Mouth Stomach Esophagus Lymphatic system Lipids Absorbed food (except lipids) Hepatic portal vein Absorbed water Liver Secretions from salivary glands Secretions from gastric glands Small intestine Secretions from liver Secretions from pancreas Rectum Anus Large intestine

Editor's Notes

  1. Figure 41.1 How does a lean fish help a bear make fat?
  2. Figure 41.2 Storing protein for growth.
  3. Table 41.1 Vitamin Requirements of Humans
  4. Table 4.2 Mineral Requirements of Humans
  5. Figure 41.3 Obtaining essential nutrients.
  6. Figure 41.4 Inquiry: Can diet influence the frequency of birth defects?
  7. Figure 41.5 The four stages of food processing.
  8. Figure 41.5 The four stages of food processing.
  9. Figure 41.6 Exploring: Four Main Feeding Mechanisms of Animals
  10. Figure 41.6 Exploring: Four Main Feeding Mechanisms of Animals
  11. Figure 41.6 Exploring: Four Main Feeding Mechanisms of Animals
  12. Figure 41.6 Exploring: Four Main Feeding Mechanisms of Animals
  13. Figure 41.6 Exploring: Four Main Feeding Mechanisms of Animals
  14. Figure 41.7 Digestion in a hydra.
  15. Figure 41.8 Variation in alimentary canals.
  16. Figure 41.9 The human digestive system.
  17. Figure 41.9 The human digestive system.
  18. Figure 41.9 The human digestive system.
  19. Figure 41.10 From mouth to stomach: the swallowing reflex and esophageal peristalsis.
  20. Figure 41.10 From mouth to stomach: the swallowing reflex and esophageal peristalsis.
  21. Figure 41.10 From mouth to stomach: the swallowing reflex and esophageal peristalsis.
  22. Figure 41.11 The stomach and its secretions.
  23. Figure 41.11 The stomach and its secretions.
  24. Figure 41.11 The stomach and its secretions.
  25. Figure 41.12 Chemical digestion in the human digestive system.
  26. Figure 41.12 Chemical digestion in the human digestive system.
  27. Figure 41.12 Chemical digestion in the human digestive system.
  28. Figure 41.12 Chemical digestion in the human digestive system.
  29. Figure 41.13 Nutrient absorption in the small intestine.
  30. Figure 41.13 Nutrient absorption in the small intestine.
  31. Figure 41.13 Nutrient absorption in the small intestine.
  32. Figure 41.14 Absorption of fats.
  33. Figure 41.14 Absorption of fats.
  34. Figure 41.14 Absorption of fats.
  35. Figure 41.15 Junction of the small and large intestines.
  36. Figure 41.16 Dentition and diet.
  37. Figure 41.17 The alimentary canals of a carnivore (coyote) and herbivore (koala).
  38. Figure 41.17 The alimentary canals of a carnivore (coyote) and herbivore (koala).
  39. Figure 41.17 The alimentary canals of a carnivore (coyote) and herbivore (koala).
  40. Figure 41.18 Ruminant digestion.
  41. Figure 41.19 Hormonal control of digestion.
  42. Figure 41.19 Hormonal control of digestion.
  43. Figure 41.19 Hormonal control of digestion.
  44. Figure 41.19 Hormonal control of digestion.
  45. Figure 41.20 Homeostatic regulation of cellular fuel.
  46. Figure 41.21 A few of the appetite-regulating hormones.
  47. Figure 41.22 Inquiry: What are the roles of the ob and db genes in appetite regulation?
  48. Figure 41.22 Inquiry: What are the roles of the ob and db genes in appetite regulation?
  49. Figure 41.22 Inquiry: What are the roles of the ob and db genes in appetite regulation?
  50. Figure 41.23 A plump petrel.
  51. Figure 41.UN01 Summary figure, Concept 41.3
  52. Figure 41.UN02 Appendix A: answer to Test Your Understanding, question 7