1. Eligibility to work in USA : Does not require sponsorship.
Personal Profile
I would describe myself as a self motivated, dedicated and hardworking professional. I have five years of
post doctoral research experience in the field of Biochemistry and cancer biology. My research has mainly
focused on developing efficient therapeutics for cancer. The major contribution of my post doctoral
research is that my studies have identified and characterized a compound [(N-(3-(benzo[d]thiazol-2-yl)-6-
isopropyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide] which is currently in preclinical trials
for cancer. My research would stimulate the development of new pharmacotherapeutics in the field of
tumor oncology.
Current work experience
 Adjunct faculty, Biology department, Harrisburg Area Community College, York campus
(January 2015 – present) : teaching Anatomy and physiology I for undergraduate and nursing
students
 Adjunct faculty (Science and technology department) in Pennsylvania University (penn
state, Harrisburg) (January 2015– present) : teaching biology lab techniques for Sesquhanna
high school students
 Adjunct faculty (Science and technology department) in Pennsylvania University (penn
state, Harrisburg) (August 2014 – December 2014) : taught developmental biology (240W) for
undergraduate students
 Took practical classes (taught protein biology and molecular biology techniques) for masters
students during my doctoral studies at university of Hyderabad, India.
 Mentored master’s students and corrected their master’s thesis.
Previous work Experience
Research Associate (January 2013- January 2014)
University of Virginia, Radiation Oncology, Charlottesville, Virginia
Project summary
My research involved identifying and characterizing novel ubiquitin ligases which regulate the expression
of cell cycle protein Cyclin D1. Cyclin D1 is crucial for the progression of cell cycle from G1 to S phase
of cell cycle and it is highly deregulated in different types of cancer. This over expression of cyclin D1 is
controlled by a ubiquitin ligase yet to be identified and my studies led to identification of a novel
ubiquitin ligase controlling cyclin D1 stability.
Post doctoral Fellowship (February 2009 – February 2012)
CURRICULUM VITAE
Name: Naga Vyjayanti Vaddadi
Green card holder
E-mail: vaddadinv@gmail.com; cell:5166738895
Cell: 5166738895

2. Post Doctoral Fellow in Laboratory of Molecular Gerontology, National Institute on Aging, NIH,
Baltimore, Maryland.
Project summary
At NIA my work focussed on identifying inhibitors against DNA repair enzyme human
apurinic/apyrimidinic endonuclease 1 (APE1). APE1 plays a pivotal role in the repair of base damage via
participation in the Base Excision Repair pathway (BER). Increased activity of APE1, often observed in
tumor cells, is thought to contribute to resistance to various anticancer drugs, whereas down-regulation of
APE1 sensitizes cells to DNA damaging agents. Thus, inhibiting APE1 endonuclease function in cancer
cells is considered a promising strategy to overcome therapeutic agent resistance. I screened and
characterised compounds from t he NIH Molecular Libraries Small Molecule Repository (MLSMR) that
were identified as candidate inhibitors against the human APE1 protein. I characterized a compound (N-
(3-(benzo[d]thiazol-2-yl)-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide] which is
currently in preclinical trials for cancer.
Post Doctoral Fellowship (July 2007- February 2009)
Institute of Life Sciences, Hyderabad, India.
Project summary
I worked on the regulation of special AT rich sequence binding protein (SATB1) by 3-hydroxy-3-
methylglutaryl coenzymeA (HMG-CoA) reductase inhibitors (statin drugs). SATB1 regulates many
oncogenes and its expression has been implicated in metastasis. My studies showed for the first time that
one of the anti cancer action of statins is due to down regulation of SATB1 by different mechanisms in
various cancer cell lines. SATB1 is master regulator of many oncogenes but nothing is known about its
regulation. My research was the first to show that SATB1 is regulated by statins. This study would
unbolt avenues for novel treatments for cancer and has opened new possibilities for deciphering
mechanisms concerning the use of statins as anticancer drugs.
Doctorate (Ph.D) (August 2000- September 2007)
Department of Biochemistry, University of Hyderabad, Hyderabad, India.
Title of doctoral thesis - “Studies on DNA repair in Aging Rat Cortical Neurons”
Thesis advisor – Prof. Kalluri Subba Rao.
Project summary
Defective DNA repair leads to cancer and age related neurological disorders. Most of the diseases
manifest with increasing age and if one can combat these at the root or early stages then it would promote
healthy aging. My doctoral studies involved checking the efficiency of base excision repair and non
homologous end joining repair pathways in rat cortical neurons of different age groups, identification of
the DNA repair proteins whose activity declines with age and restoration of DNA repair in aged cortical
neurons by external supplementation of the deficient repair proteins.
Education
Doctorate (Ph.D) (August 2000- September 2007)
Department of Biochemistry, University of Hyderabad, Hyderabad, India.
Master of Science (August 1998 – May 2000)
Master of Science in Biochemistry, University of Hyderabad, Hyderabad, India.

3. Bachelor of Science (June 1995 – May 1998)
Bachelor of Science in Genetics, Nizam College, Osmania University, Hyderabad, India.
Research Fellowships
Recipient of CSIR (Council of Scientific and Industrial Research) Fellowship for meritorious students in
graduate studies by the Department of Science and Technology, Government of India.
Certifications
National Institute on Aging, NIH, Baltimore, MD
 2009 Advance course in Animal handling
 2009 Radiation Safety Orientation Training
 2009 Laboratory Safety at the NIH
 2009 Working Safely with HIV and Bloodborne Pathogens
 2010 Environmental Management System Awareness Training
University of Virginia, Charlottesville VA
• 2013 Advance course in Flow cytometry
Publications
Research Papers
1. Rai G, Vyjayanti VN, Dorjsuren D, Simeonov A, Jadhav A, Wilson DM, Maloney DJ. Small
Molecule Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). Probe Reports
from the NIH Molecular Libraries Program. Bethesda (MD): National Center for Biotechnology
Information (US) (2013).
2. McNeill DR, Paramasivam M, Baldwin J, Huang J, Vyjayanti VN, Seidman MM, Wilson DM 3rd
NEIL1 Responds and Binds to Psoralen-induced DNA Interstrand Crosslinks. J Biol Chem.
(2013) 288(18):12426-36.
3. Dorjsuren D, Kim D, V.N. Vyjayanti Maloney DJ, Jadhav A, Wilson DM 3rd, Simeonov A.
Diverse Small Molecule Inhibitors of Human Apurinic/Apyrimidinic Endonuclease APE1
Identified from a Screen of a Large Public Collection. PLoS One. (2012)7(10):e47974.
4. Vaddadi N. Vyjayanti *, Ganesha Rai*,Dorjbal Dorjsuren, Anton Simeonov, Ajit Jadhav, David
M. Wilson III, David J. Maloney. Synthesis, Biological Evaluation and Structure-Activity
Relationships of a Novel Class of APE1 Inhibitors. Journal of Medicinal Chemistry. (2012)
55(7):3101-12. *authors contributed equally
5. V.N. Vyjayanti, Swain U, Rao KS. Age related decline in DNA polymerase β activity in rat brain
and other tissues. Neurochemical Research. (2012) 37(5):991-5.
6. Mohammed MZ, Vyjayanti V. N., Laughton CA, Dekker LV, Fischer PM, Wilson DM 3rd,
Abbotts R, Shah S, Patel PM, Hickson ID, Madhusudan S. Development and evaluation of human
AP endonuclease inhibitors in melanoma and glioma cell lines. Br J Cancer. (2011)104(4):653-
63.
7. Vyjayanti V.N., Lakshminarayana Reddy CN, Notani D, Galande S, Kotamraju S. Down-
regulation of the global regulator SATB1 by statins in COLO205 colon cancer cells. Mol Med
Report. (2010) 3(5):857-61.

4. 8. V.N. Vyjayanti, N. S. Chary and Kalluri Subba Rao. On the inhibitory affect of some Dementia
drugs on DNA polymerase β activity. Neurochemical Research (2008) 33(11):2187-96.
9. V.N. Vyjayanti and Kalluri Subba Rao DNA double strand break repair in brain: Reduced NHEJ
activity in aging rat neurons. Neuroscience Letters, (2006), 393 (1): 18–22.
Abstracts
1. V. N. Vyjayanti, S. Sharma and K. Subba Rao “DNA double strand breaks repair by rat neuronal
extracts by non homologous end joining”.. Journal of Neurochemistry. Vol. 88, Supplement I,
February 2004, p 23.
2. Chary N.S, Vyjayanti V.N and Kalluri Subba Rao. “Dementia drugs show inhibitory action on the
activity of DNA polymerase , an important DNA repair enzyme”. Abstracts of 3rd
international
symposium on “Neurodegeneration and Neuroprotection” (2006).
Poster presentations
 Presented poster “Identification and characterization of small molecule inhibitors of APE1” at the
NIA retreat, held in Baltimore from March 23th
-25th
, 2011.
 Presented poster “Identification and characterization of small molecule inhibitors of APE1” at the
Mammalian DNA Repair Gordon Research Conference, held at Ventura from February 6th
-11th
,
2011.
 Presented poster “Identification and structure activity relationship of small molecule inhibitors of
APE1” at the NIA retreat, held in Baltimore from March 23th
-25th
, 2010.
 Presented poster “DNA Double Strand breaks repair by Rat neuronal extracts by Non
Homologous end joining” in the symposium “Emerging Concepts in Brain Function” held at
National Centre for Biological Sciences (NCBS), tata institute of fundamental research,
Bangalore, March 4th
- 5th
, 2005.
 Presented poster “DNA Double Strand breaks repair by Rat neuronal extracts by Non
Homologous end joining” in the 6th
Biennial Meeting of the Asian-Pacific Society for
Neurochemistry (APSN 2004) held at Hong Kong conventional Centre, Hong kong, February 4th
-
7th
, 2004.
References: Available upon request.