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(for undergraduates 3rd year Integrated Medicine)
Compiled by Ahmed Redwan, 2021 © COPYRIGHTED
Assist. Lecturer Int. Med. Depart.
El-Minia University, EGYPT.
Introduction:
Side effects of commonly prescribed drugs:
 Diuretics
 NSAIDs.
 Antiplatelet.
 Corticosteroids.
 Drug induced Hemolytic Anemia.
 Lipid lowering agents.
 Anticoagulants
 Iron
NSAIDS
Corticosteroids role in bronchial
astma
Stria rubra in long steroid therapy:
Marevan Tablets
Bruising, red or dark brown urine, red or
black bowel motions, nose bleeds, bleeding
from gums after brushing, vomiting or
coughing up blood, increased menstrual flow
or heavier periods, purplish & mottled toes,
prolonged bleeding from cuts, swollen ankles,
painful swelling or discomfort stomach pain
chest pain joint pain persistent headache or
fever, difficulty breathing or swallowing,
severe skin wounds, non-healing wounds or
lesions or mottling of skin, persistent diarrhea
a serious fall or injury.
Skin lesion as a rare Marevan
SE:
Drug induced HA
The immune system responds by making
antibodies to attack the body's own red blood cells.
The antibodies attach to red blood cells and cause
them to break down too early.
Drugs that can cause this type of hemolytic
anemia include:• Cephalosporins, (most common
cause)• Dapsone• Levodopa• Levofloxacin•
Methyldopa• Nitrofurantoin (urinary antiseptic)•
Nonsteroidal anti-inflammatory drugs (NSAIDs)•
Penicillin and its derivatives• Phenazopyridine
(pyridium)• Quinidine.
Lipid lowering drugs:
There are several classes of drugs used to
decrease cholesterol. These include:
Statins, PCSK9 inhibitors, Fibric acid derivatives
(also called fibrates), Bile acid sequestrants (also
called bile acid resins), Nicotinic acid (also called
niacin), Selective cholesterol absorption
inhibitors, Omega 3 fatty acids (and fatty acid
esters), and Adenosine triphosphate-citrate lyase
(ACL) inhibitors.
Statins
Statins may produce unwanted side effects.
These may include:
Constipation or nausea, Headaches and cold-like
symptoms, Sore muscles, with or without muscle
injury (rhabdomyolisis and AKI), Liver defects,
Increased blood glucose levels, Reversible memory
issues.
If you’re unable to take statins because of the
side effects, you’re said to be statin-intolerant. If you
are taking a statin, you should avoid grapefruit
products because they can increase side effects.
You should limit the amount of alcohol that you
drink because combining alcohol and statin usage
can increase your risk of liver damage.
Fibrates:
Possible side effects of fibrates include:
 Constipation or diarrhea.
 Weight loss.
 Bloating, belching or vomiting.
 Stomacheache.
 Headache or backache.
 Muscle pain and weakness.
Cholestyramine
Possible side effects of bile acid
sequestrants include:
 Sore throat, stuffy nose.
 Constipation, diarrhea.
 Weight loss.
 Belching, bloating.
 Nausea, vomiting, stomach pain.
Nicotinic acid
Nicotinic acid, also called niacin, is a
B-complex vitamin. You can get over-the-
counter versions of this, but some versions
are prescription only.
Niacin decreases LDL cholesterol
and triglycerides and increases HDL. If
you have gout or severe liver disease, you
should not take niacin.
The main side effect of niacin is
flushing of the face and upper body, which
might be lessened if you take it with meals.
You might have less flushing if you take
aspirin about 30 minutes before taking
niacin.
Other side effects include: Skin
issues, such as itching or tingling.
Headache. Stomach upset. Can lead to
increased blood sugars. Coughing.
Omega-3
Possible side effects of omega-3
products include:
Belching.
Skin issues like rash or itching.
Gases.
Fishy taste.
Increased bleeding time.
Iron
iron oral supplements may cause some
side effects.
These include: stomach pain; constipation
or diarrhea; heartburn; nausea or vomiting; black
stools (D.D. GIT bleeding).
Parenteral:
 Chills due to hypersensitivity reaction (test by
slow IV infusion at the start of administration)
 dizziness
 Backache , groin, side, or muscle pain
 chest pain
 Skin pigmentation (IM administration)
Thank You
‫هللا‬ ‫بحمد‬ ‫تم‬

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common drugs side effects

  • 1. (for undergraduates 3rd year Integrated Medicine) Compiled by Ahmed Redwan, 2021 © COPYRIGHTED Assist. Lecturer Int. Med. Depart. El-Minia University, EGYPT.
  • 2. Introduction: Side effects of commonly prescribed drugs:  Diuretics  NSAIDs.  Antiplatelet.  Corticosteroids.  Drug induced Hemolytic Anemia.  Lipid lowering agents.  Anticoagulants  Iron
  • 3.
  • 4.
  • 6.
  • 7. Corticosteroids role in bronchial astma
  • 8.
  • 9.
  • 10.
  • 11.
  • 12.
  • 13.
  • 14. Stria rubra in long steroid therapy:
  • 15.
  • 16.
  • 17. Marevan Tablets Bruising, red or dark brown urine, red or black bowel motions, nose bleeds, bleeding from gums after brushing, vomiting or coughing up blood, increased menstrual flow or heavier periods, purplish & mottled toes, prolonged bleeding from cuts, swollen ankles, painful swelling or discomfort stomach pain chest pain joint pain persistent headache or fever, difficulty breathing or swallowing, severe skin wounds, non-healing wounds or lesions or mottling of skin, persistent diarrhea a serious fall or injury.
  • 18. Skin lesion as a rare Marevan SE:
  • 19. Drug induced HA The immune system responds by making antibodies to attack the body's own red blood cells. The antibodies attach to red blood cells and cause them to break down too early. Drugs that can cause this type of hemolytic anemia include:• Cephalosporins, (most common cause)• Dapsone• Levodopa• Levofloxacin• Methyldopa• Nitrofurantoin (urinary antiseptic)• Nonsteroidal anti-inflammatory drugs (NSAIDs)• Penicillin and its derivatives• Phenazopyridine (pyridium)• Quinidine.
  • 20. Lipid lowering drugs: There are several classes of drugs used to decrease cholesterol. These include: Statins, PCSK9 inhibitors, Fibric acid derivatives (also called fibrates), Bile acid sequestrants (also called bile acid resins), Nicotinic acid (also called niacin), Selective cholesterol absorption inhibitors, Omega 3 fatty acids (and fatty acid esters), and Adenosine triphosphate-citrate lyase (ACL) inhibitors.
  • 21. Statins Statins may produce unwanted side effects. These may include: Constipation or nausea, Headaches and cold-like symptoms, Sore muscles, with or without muscle injury (rhabdomyolisis and AKI), Liver defects, Increased blood glucose levels, Reversible memory issues. If you’re unable to take statins because of the side effects, you’re said to be statin-intolerant. If you are taking a statin, you should avoid grapefruit products because they can increase side effects. You should limit the amount of alcohol that you drink because combining alcohol and statin usage can increase your risk of liver damage.
  • 22. Fibrates: Possible side effects of fibrates include:  Constipation or diarrhea.  Weight loss.  Bloating, belching or vomiting.  Stomacheache.  Headache or backache.  Muscle pain and weakness.
  • 23. Cholestyramine Possible side effects of bile acid sequestrants include:  Sore throat, stuffy nose.  Constipation, diarrhea.  Weight loss.  Belching, bloating.  Nausea, vomiting, stomach pain.
  • 24. Nicotinic acid Nicotinic acid, also called niacin, is a B-complex vitamin. You can get over-the- counter versions of this, but some versions are prescription only. Niacin decreases LDL cholesterol and triglycerides and increases HDL. If you have gout or severe liver disease, you should not take niacin.
  • 25. The main side effect of niacin is flushing of the face and upper body, which might be lessened if you take it with meals. You might have less flushing if you take aspirin about 30 minutes before taking niacin. Other side effects include: Skin issues, such as itching or tingling. Headache. Stomach upset. Can lead to increased blood sugars. Coughing.
  • 26. Omega-3 Possible side effects of omega-3 products include: Belching. Skin issues like rash or itching. Gases. Fishy taste. Increased bleeding time.
  • 27. Iron iron oral supplements may cause some side effects. These include: stomach pain; constipation or diarrhea; heartburn; nausea or vomiting; black stools (D.D. GIT bleeding). Parenteral:  Chills due to hypersensitivity reaction (test by slow IV infusion at the start of administration)  dizziness  Backache , groin, side, or muscle pain  chest pain  Skin pigmentation (IM administration)
  • 28.