Interleukin-6 plays a protective role in cisplatin-induced acute renal failure through upregulation of anti-oxidative stress factors. The researchers conducted experiments using IL-6 knockout mice to simulate the human condition. They found that lack of IL-6 led to increased lipid peroxidation, showing that IL-6 prevents progression of acute renal failure by reducing oxidative stress. The findings suggest IL-6 promotes protective activities in the kidneys and applying this knowledge could help clinical practice.
factor protector de IL-6 en la insuficiencia renal aguda
1. INTERLEUKIN-6 PLAYS A PROTECTIVE ROLE IN
DEVELOPMENT OF CISPLATIN-INDUCED ACUTE RENAL
FAILURE THROUGH UPREGULATION OF ANTI-OXIDATIVE
STRESS FACTORS
Daniel Saldarriaga
Melissa Zapata
III SEMESTER –MEDICINE
UPB
Satoru Mitazaki, Shigeyoshi Honma, Minwako Suto, Naho Kato,
Kouichi Haraiwa, Makoto Yoshida, Sumiko Abe
3. INTRODUCTION
INTERLEUKIN
Synthesized primarily by
Function is to regulate events such
leukocytes or endothelial
as activation, differentiation
cells, stromal thymus or
or proliferation, antibody secretion,
bone marrow.
chemotaxis, regulation of cytokines
and other factors.
Set of proteins that act as
chemical
messengers within
walking distance.
4. INTRODUCTION
INTERLEUKIN-6
Is a glycoprotein
Secreted by macrophages, T cells, endothelial cells and fibroblasts
inflammatory and proinflammatory activity
Involved in the production of immunoglobulins
the differentiation of B cells, activated cytotoxic T lymphocytes,
plasma cells, modulates hematopoiesis and fibrinógeno
IL-6 with IL1 act with proteins in the acute phase
5. INTRODUCTION
Abrupt and
sustained deterioration
of glomerular
filtration expressed
initially by inability to
excrete nitrogenous
products and a
tendency to oliguria
Has a high mortality - on
average 50%
6. INTRODUCTION
CAUSES
Tubular lumen Alterations of
obstruction the glomerular filtration
Intrarenal Backscatter
vasoconstriction glomerular filtration
rate
7. INTRODUCTION
OXIDATIVE STRESS
Oxidative stress is caused by
an imbalance between
production of reactive
oxygen and the ability of a
biological system to
detoxify reactive
intermediates or quickly repa
ir the damage resulting.
8. INTRODUCTION
Can cause toxic effects
through the production of
peroxides and free radicals
that damage all
components of the cell,
including proteins, lipids
and DNA.
10. INTRODUCTION
CISPLATIN
Platinum-
based drug used in
chemotherapy to treat
various types of
cancer, which include
sarcomas, some
carcinomas lymphomas
and germ cell tumor
25. RESEARCHER ENDS YES NO
Mitazaki et al., 2009 IL-6 produced in renal tubular X
cells is thought to prevent
progression of acute renal
failure at the early stage.
Matsushima et al., 1998 IL-6 plays a protective role in X
lameire et al., 2005 the development of cisplatin-
induced acute renal failure
through upregulation of anti-
oxidativ stress factors.
26. RESEARCHER ENDS YES NO
Dixit et al., 2009 Increase of A-HNE modified X
proteins is commonly used as
an indicator of lipid
peroxidation. Therefore, lack of
IL-6 migh be responsible for the
increase of lipid peroxidation.
James et al., 2005 Unregulated cox-2 X
expression and
prostaglandin synthesis
influence inflammation
28. CONCLUSIONS
Such activities promote student skills in
developing experimental and innovative
research to generate awareness
investigative.
It is important to apply the findings to
clinical practice, because they feed the
knowledge learned in formal education.
29. CONCLUSIONS
The current development of medicine has
been marked by many discoveries about
the metabolic function of cells and the
development of multiple types of analysis
in biological samples, these are of great
importance of medical diagnostic.
30. CONCLUSIONS
The importance of molecular
biomarkers such as IL-6, the protective
acute renal failure are useful elements
for its association to diseases.
