1. Exploring New Frontiers of Brain Preservation and Protection Vladimir Zelman, M.D., Ph.D., Department of Anesthesiology, University of Southern California, Keck School of Medicine Member of Russian Academy of Medical Science

2. Anesthesia Neurosurgery Cardiothoracic Surgery

3. Heart and Brain: From Cooling to Mutual Comfort Novosibirsk -> Moscow -> Los Angeles 50,000 cases Authors: Drs. V. Zelman, Cheung, Guvakov

7. Congress of the USA named 1990-2000 as the “Decade of Brain” Stanley van den Noort 1970, Irvine Joseph P. Van Der Meulen 1971 . USC

10. Excitatory Neurotoxicity and Cerebral Ischemia Ischemic Injury ↓ Presynaptic Neuronal Depolarization ↓ Neurotransmitter Release (ie glutamate, aspartate) ↓ Postsynaptic Neuronal Depolarization ↓ Calcium Influx ↓ Early gene activation ↓ Proteolysis, apoptosis, cell death

11. We still do not know how to prevent delayed (apoptotic) neuronal death secondary to ischemia and stress…. pre- post- delayed Forms of Conditioning

22. Toxic Stress Changes Brain Architecture Normal Toxic stress Prefrontal Cortex and Hippocampus Typical neuron— many connections Damaged neuron— fewer connections Sources: Radley et al. (2004); Bock et al. (2005)

40. Neurovascular Unit

47. PMC PMC H. Damasio

49. Brain Preservation UNIVERSAL CHANNEL BLOCKERS RECEPTOR SPECIFIC PHARMACOLOGY STEM CELLS HUMAN GENOME DISCOVERIES GENETIC ENGINEERING CEREBRAL PLASTICITY NEURONAL PRECONDITIONING NEW HORIZONS NANOTECHNOLOGY

50. Carl Kesselman – Director of biomedical informatics research network Larry Swanson – Director of national brain connectome initiative Carlos Pato and Michelle Pato – Directors of National Psychosis Genomics Initiative Leaders of Neuroscience Research at USC Michael Jakowec Center for Vision Science and Technology Institute for Robotics and Intelligent Systems Brain and Creativity Institute Center for Neural Engineering Alfred E. Mann Institute for Biomedical Engineering Center for Excellence in Genomic Studies (CEGS) Laboratory for Molecular Robots Nanotechnology Research Lab Institute for Genetic Medicine Pat Levitt, Director, Zilkha Neurogenetic Institute and co-director of the National Developing Human Brain Transcriptomics initiative Dorne Cognitive Neuroscience Imaging Center USC is emerging as a leader in this respect because of the unique, multi-disciplinary approach to science. Key to advancing this research agenda is leadership. The very best scientists and leaders can bring together others and motivate them to work in highly collaborative ways to solve mysteries of brain diseases in ways that others cannot in their isolated laboratories. James Knowles- Director of the National Developing Human Brain Transcriptomics initiative