Similar to INTERLEUKIN-6 PLAYS A PROTECTIVE ROLE IN DEVELOPMENT OF CISPLATIN-INDUCED ACUTE RENAL FAILURE THROUGH UPREGULATION OF ANTI-OXIDATIVE STRESS FACTORS
Similar to INTERLEUKIN-6 PLAYS A PROTECTIVE ROLE IN DEVELOPMENT OF CISPLATIN-INDUCED ACUTE RENAL FAILURE THROUGH UPREGULATION OF ANTI-OXIDATIVE STRESS FACTORS (20)
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INTERLEUKIN-6 PLAYS A PROTECTIVE ROLE IN DEVELOPMENT OF CISPLATIN-INDUCED ACUTE RENAL FAILURE THROUGH UPREGULATION OF ANTI-OXIDATIVE STRESS FACTORS
1. INTERLEUKIN-6 PLAYS A PROTECTIVE ROLE IN DEVELOPMENT OF CISPLATIN-INDUCED ACUTE RENAL FAILURE THROUGH UPREGULATION OF ANTI-OXIDATIVE STRESS FACTORS Daniel Saldarriaga Melissa Zapata III SEMESTER –MEDICINE UPB Satoru Mitazaki, Shigeyoshi Honma, Minwako Suto, Naho Kato, Kouichi Haraiwa, Makoto Yoshida, Sumiko Abe
3. INTRODUCTION INTERLEUKIN Function is to regulate events such as activation, differentiation or proliferation, antibody secretion, chemotaxis, regulation of cytokines and other factors. Synthesized primarily by leukocytes or endothelial cells, stromal thymus or bone marrow. Set of proteins that act as chemical messengers within walking distance.
4.
5. INTRODUCTION Abrupt and sustained deterioration of glomerular filtration expressed initially by inability to excrete nitrogenous products and a tendency to oliguria Has a high mortality - on average 50%
6. INTRODUCTION Alterations of the glomerular filtration Intrarenal vasoconstriction Tubular lumen obstruction Backscatter glomerular filtration rate CAUSES
7. INTRODUCTION Oxidative stress is caused by an imbalance between production of reactive oxygen and the ability of a biological system to detoxify reactive intermediates or quickly repair the damage resulting. OXIDATIVE STRESS
8. Can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids and DNA. INTRODUCTION
25. RESEARCHER ENDS YES NO Mitazaki et al., 2009 IL-6 produced in renal tubular cells is thought to prevent progression of acute renal failure at the early stage. Matsushima et al., 1998 lameire et al., 2005 IL-6 plays a protective role in the development of cisplatin- induced acute renal failure through upregulation of anti-oxidativ stress factors.
26. RESEARCHER ENDS YES NO Dixit et al., 2009 Increase of A-HNE modified prteins is commonly used as an indicator of lipid peroxidationt. Therefore, lack of IL-6 migh be responsible for the iincrease of lipid peroxidation. James et al., 2005 Unregulated cox-2 expression and prostaglandin synthesis influence inflammation
