Smallpox was one of the deadliest diseases known to humans, causing fever, rash, and sores. Edward Jenner invented the first vaccine for smallpox in the late 18th century, pioneering immunology. Through focused surveillance and ring vaccination led by the World Health Organization, smallpox was the only human disease to be eradicated, with the last natural case occurring in 1977.

1. • Luisa Bustos Pérez
• Camila Martínez Correa
• Kelly Sáez Argumedo

2. History of Smallpox
The history of smallpox holds a
unique place in human health and
medicine. One of the deadliest
diseases known to humans,
smallpox is also the only human
disease to have been eradicated
by vaccination

3. Symptoms and Causative Agent
Symptoms of a typical smallpox infection began with a
fever and lethargy about two weeks after exposure to the
Variola major virus. Headache, sore throat, and vomiting
were common as well. In a few days, a raised rash appeared
on the face and body, and sores formed inside the mouth,
throat, and nose.

4. Who invented the smallpox vaccine ?
•Edward Jenner( 17 May 1749 – 26 January 1823) was an English physician
and scientist who was the pioneer of smallpox vaccine, the world's first
vaccine.
•He is often called "the father of immunology", and his work is said to
have "saved more lives than the work of any other human.
•“People have been using smallpox vaccine since Edward Jenner first tested
his idea that inoculation with matter from a cowpox sore would protect a
person from smallpox.
•Jenner’s work eventually led to widespread production and
commercialization of smallpox vaccine.

5. Eradication
Smallpox eradication was
accomplished with a combination
of focused surveillance
quyickly identifying new
smallpox cases and ring
vaccination. The last case of
wild smallpox occurred in
Somalia in 1977.