Amyotrophic Lateral Sclerosis Paper

Amyotrophic Lateral Sclerosis Paper
Mental health is a fragile thing and terminal conditions such as Amyotrophic Lateral Sclerosis (ALS) greatly impact it. ALS is a neurodegenerative
disease that attacks a person's physical function. It progressively saps a person's strength and leads to the failure of organs. Unfortunately, this disease
is not fully understood and is difficult to diagnose (Rosenfeld & Strong, 2015, pp. 318–319). Knowing fully well that this disease is a death sentence,
ALS patients generally have a negative outlook and this significantly influences their mental health. Amyotrophic Lateral Sclerosis can be diagnosed
mainly through the medical perspective and has been extensively researched to determine the components and controversies it contains. Determining
whether or not an individual has ALS falls under the medical perspective in psychology. Being able to determine a cause of abnormal symptoms
through physical examinations and tests describes the medical perspective. ... Show more content on Helpwriting.net ...
The Brief COPE was one method utilized to gather data on the coping strategies employed by patients. Another research method used by professionals
is the General Health Questionnaire. This provided an effective way to subjectively evaluate a patient's mental health by obtaining first–hand
information directly from the patient (Albertini, Desnuelle, Montel, & Spitz, 2012, p. 600). The Kaplan–Meier model also determined mental health
status by using gathered data from other tests to determine the effectiveness of the coping strategies on the patient's overall mental health. To get an
overall understanding of how the patient is doing based on their mental health, coping strategies, and disease progress, the Bravais–Pearson correlation
test is performed (Albertini et al., 2012, p. 600). Accumulating the results from the previously stated tests has to an accurate insight on the mental health
of ALS
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Amyotrophic Lateral Sclerosis Case Study
Amyotrophic lateral sclerosis (Lou Gehrig's disease) is a group of neurological diseases that mainly involve the nerve cells responsible for coordinating
voluntary movements in body muscles (Salameh, Brown Jr, and Berry 26). Voluntary muscles are responsible for movements like talking, walking, and
chewing. Amyotrophic lateral sclerosis (ALS) is progressive in nature, and with no known cure, a victim can expect to live between 2 and 5 years
after diagnosis (Salameh et al. 27).
The ALS Association is the sole organization in the United States leading the fight to discover an effective cure forLou Gehrig's disease from all angles
– through research, public policy programs, and care. The ALS Association is at the forefront of global research... Show more content on
Helpwriting.net ...
Therefore, internal links on the website should provide information on the history of the association, regional offices, leadership, partner organizations,
and the services offered. However, the most significant thing in a web campaign towards building support for a social course is the authenticity of
information and the truthfulness of the leaders. This calls on the ALS Association to provide internal links to information on the total amount of money
donated on a regular basis, as well as how the funds have been utilized (Oppenheimer and Olivola 106). Similarly, external links detailing previous
successes will motivate individuals to donate further.
Concerning the domain name for the ALS Association, it should be .ngo. The rationale is that the organization is not engaged in business activities, but
rather a nonprofit entity devoted to finding a remedy for Lou Gehrig's disease. Therefore, they should change their existing domain. The rationale is
that .org is used by many organization and cannot identify the main course of the ALS Association (Rogers, Sharp, and Preece 53). Even though a
relatively new domain, .ngo will better identify the ALS

Amyotrophic Lateral Sclerosis: Lou Gehrig's Disease
The ALS ice bucket challenge spread infectiously across the nation. On social media sites, you are sure to see videos of people tossing freezing
buckets of ice water on themselves in hopes of spreading awareness of ALS. The cold sensation causes the person to feel a brief second of being
"paralyzed", much like an ALS patient would. Although this challenge has given ALS more awareness, most people still don't know the specifics of
this disease like symptoms, life expectancy, and generally what it is. Despite the fact ALS is also referred to as Lou Gehrig's disease, many notable
people are suffering or have died from it. Since we are citizens of one of the most powerful nations, people need to be informed about this disability in
order to find... Show more content on Helpwriting.net ...
"A–myo–trophic comes from the Greek language 'A' meaning no or negative. 'Myo' refers to muscle, and "Trophic" means nourishment–'No muscle
nourishment'... 'Lateral' identifies the areas in a person's spinal cord where portions of the nerve cells that signal and control the muscles are located."
("What is ALS?"). Literally,Amyotrophic lateral sclerosis means no muscle nourishment in the spine. In this disease, nerve cells in both the brain
and spinal cord slowly die over a period of time. The cells, referred to as motor neurons, control the muscles throughout the body, resulting in death or
paralyzation as they degenerate. At any given time, ALS can strike anyone. It is not contagious, however, in about 10% of cases, ALS runs in the
family making it somewhat hereditary ("What is amyotrophic lateral sclerosis?"). "The incidence of ALS is two per 100,000 people" ("Facts You
Should Know). Most of the time, Lou Gehrig's disease (ALS), acts on middle–aged and older adults, however there have been noted cases of patients
much younger. Considering that a friend or family member can be diagnosed with this horrible disease, everyone should pitch into ALS charities in
hope to find a

Amyotrophic Lateral Sclerosis Essay
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive neurological disorder that destroy nerve cells causing
death of motor neuron cells in the brain and spinal cord controlling voluntary muscle movements. It is considered a rare disease as only two out of
100,000 in a general population can develop it and there are approximately 20,000 to 30,000 cases in the United States (Miller et al 2004). It has also
been shown that the disease affect men more than it does women with a ratio of three to two (Kiernan et al 2011).
For most people early signs of ALS begins as local atrophy in one part of the body such as a foot, hand, or arm. Usually the weakening starts at the
lower motor neurons that are responsible for carrying messages from the spinal cord to the muscles (Miller et al 2004). Some common early symptoms
when the disease initially affect the lower motor neurons includes foot slapping or difficulty opening jars ... Show more content on Helpwriting.net ...
In the research done by Deng et al 1993, they concluded that the loss of function was responsible by measuring the enzymatic activity of SOD1
mutants and found it to be on average which is less than half of wild–type SOD1. Since the original findings of linking SOD1 to ALS there now more
than a hundred mutations that have been found on SOD1, most these mutations being missense mutations that affect the stability and folding of the
enzyme (Beckman et al 2001). The aim of this research paper is to review recent researches and understand the role of oxidative stress that is
associated with SOD1 mutations that can possibly lead to

Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis – Muscular Atrophy: An Annotated Bibliography
Abramovitz, Melissa. "Lou Gehrig's Disease" p17–61. Treatment for ALS or Lou Gehrig's disease has found that Vitamin E and the drug known as
Riluzole can help the progression of the disease. When taking the medication Riluzole it has shown to prolong survival in patients by two to three
months and it has also delayed the use for breathing support. There is a few side effects to taking Riluzole, such as headache, dizziness, fatigue, and
it has also shown that it can do damage to your liver and kidney's. There is no cure for ALS, but researchers are trying to find out what actually causes
this disease and how they can cure it.
Aebisher, Patrick. "Playing ... Show more content on Helpwriting.net ...
CNN Online.3Dec2004.
This article discusses that there are two ways you can get this disease it is either by Inherited ALS or Sporadic ALS. In all the articles that were
read about this disease very few mentioned how this disease is contracted. Researchers say that 10 percent of cases of ALS appear to be inherited
due to some form of gene mutation. Sporadic ALS , more than 90 percent of cases of ALS appear to occur randomly, with no identifiable risk factors.
Majority of the articles say they don't know how this disease comes about and why people get it.
Encyclopedia Britannica 2007. Encyclopedia Britannica Online. 13 2007. Muscle disease: Muscle weakness, Classification of muscle weakness, and
lower motor neuron disease>http://www.brittannica.com/eb/article–58886.
This article seeks to define that diseases of the peripheral nerves can also produce symptoms similar to the motor neuron disease such as ALS.
"Sensory disturbance due to involvement of the nerve fibres carrying sensory impulses is usually involve." Affected individuals are between ages 50
to 70 years of age and have upper and lower motor neuron weakness. Paralysis progresses rapidly, and death often occurs with three years of diagnosis.
Encyclopedia Britannica 2007. Encyclopedia Britannica Online. 13 2007."Amyotrophic Lateral Sclerosis"http://www.britannica.com/eb
/article–9007301

The Effects Of Amyotrophic Lateral Sclerosis ( Als )
I.Introduction
Amyotrophic lateral sclerosis (ALS) is a late onset neurological disorder characterized by motor neuron degeneration in brain stem, spinal cord and
primary motor cortex. There is no single gene strictly associated with all ALS cases, the disease is thought to be caused by the interaction of many
genetic factors as well as environmental influences. Most of ALS patients have no family history of this disease, familiar form accounts for only 5 to
10% and seems to be dominant in most cases. The dominance and high heritability of familiar ALS (FALS) led to identification of several high–risk
alleles of few genes (among those, SOD1, FUS, TARDEP, C9ORF72 are the most frequent)
There are 3 main neuropathological findings associated with ALS. First is degeneration of the corticospinal tract that connects axons from primary
motor cortex to the motor neurons and extensive degeneration of lower motor neurons. This is connected to the second characteristics, which is loss of
Bertz cells that are found in primary motor cortex and connect to the motor neurons. The third characteristics is hypertrophy of glial cells that either
lose their original neuroprotective abilities or gain neurotoxic effects.
ALS usually starts in one part of a body (either a limb or bulbar region) and then slowly spreads to the rest of the body by non–cell autonomous or
prion–like propagation. A presence ofprotein aggregates in the affected neurons was observed, but the nature of these aggregates

Amyotrophic Lateral Sclerosis Case Study
3
ALS – The Fight for Life
One may wonder how ALS works through the body. The meaning is defined within the name Amyotrophic Lateral Sclerosis. Amyotrophic means that
the muscles become small and weak causing them to break down. Lateral occurs where the nerves nourish the muscles, these nerves are located on both
sides of the spinal cord.
Sclerosis means that the hardened or scarred tissue develops in place of the healthy nerves within the affected part of the spinal cord. Additionally, the
nerves, or motor neurons, that control the muscle movement are divided into two categories: Upper motor neurons and lower motor neurons. The upper
motor neurons send messages to the spinal cord from the brain. The lower motor neurons send messages to the ... Show more content on Helpwriting.net
...
Another risk of death for the nerve cells is mishandled proteins in the nerve cells (Clinic, 2014).
While there is no cure for Amyotrophic Lateral Sclerosis, a medicine has been determined to aid in slowing down the process. According to the ALS
Hope Foundation, a medicine called Riluzole (Rilutek) is believed to slow down progression of the disease by decreasing release glutamate levels and
damage to motor neurons. Based on the symptoms there are specific treatments to help work through the problem at hand. For
Example, if someone with ALS began to have speech problems, they can see a special speech therapists. There is ongoing effort to find a cure for
ALS. Currently there are several clinical trials and extensive research being conducted to discover a cure
(Foundation, 2012). The clinical trial with Riluzole has shown extend survival by several months for those patients with difficulty swallowing. Riluzole
also extends the amount of time for an individual before they reach the ventilation stage. Riluzole cannot reverse any damage already done to the motor
neurons. The downside of the medicine is the
5
ALS – The Fight for

Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic Lateral Sclerosis (ALS), also knows at Lou Gehrig's diseases is a motor neuron disease that affect the motor system specially the anterior
motor horn cells, corticobulbar/corticospinal tracts, and motor cranial nerves. ALS is a fatal and the causes are unknown. A small percent of the ALS
patients are known to have familial amyotrophic lateral sclerosis. ALS causes severe muscle atrophy since the neuron cell connections to the muscle are
lost. After many studies the scientist were able to find evidence that imply that the skeletal muscle tissue is the principal target of ALS toxicity. Until
today the pathophysiological mechanism of both familial and sporadic ALS are unknown. After many years of research the scientific community was...
Show more content on Helpwriting.net ...
After many years of studies there is a way to manage the symptoms and to extend the life of the patients. In 1994, Rilutek was approved and is the
only drug used for ALS (Bensimon G, Lacomblez L. Meninger V 1994). This drugs benefits still really low when the progression of ALS is really
fast, Rilutek only slow the progression of the disease by ten percent. Unfortunately, the benefit is not the same for every patient and many can not
tolerated or see any benefits from taking the medication. Also, the high prices for Rilutek make it even more difficult for patient without any insurance
or monetary availability to pay for the drug. The care for an ALS patient required a lot of education, counseling and symptoms

Amyotrophic lateral sclerosis is commonly referred to as ALS. This disease is also known to many as Lou Gehrig's disease. ALS is a disease
characterized by the slow death of certain nerve cells in the brain and spine. As described by research done through the Mayo Clinic, nerve cells
called motor neurons control the muscles that allow you to move muscles of your body. ALS effects these particular neurons and produce serious
neurological effects that can start as muscle weakness that eventually leads to disability and then to death. For some people diagnosed with ALS
they may find it difficult to walk, talk, eat food, swallow, and even breathe. These problems can, and will lead to injury, illness, and eventually
death. For most people who suffer with ALS, death will occur within three to five years after the first symptoms begin; some people may live for
many years beyond that. One of the early symptoms of ALS is footdrop, where lifting the anterior part of the foot or toes becomes problematic. Other
early symptoms include muscle twitching and weakness in the arms or the legs. Also, other early symptoms include hand weakness and noticeable
clumsiness. This may include things like having difficulty buttoning shirts or tying shoes. Trouble swallowing and slurred speech can also be an early
sign of ALS. Doctors don't know what actually causes ALS. What is known in about 1 case out of 10 is that it is hereditary. This means that 9 times
out of 10, someone with ALS does not

Amyotrophic Lateral Sclerosis Case Study Essay
Case Study: A thirty six year old male has developed severe muscle weakness throughout the body. The condition began fifteen months ago with a left
foot drop and within a year, he described difficulty with speech and swallowing, muscle twitching and cramping, and muscular atrophy throughout the
upper and lower limbs. Within the last two months, his breathing has become more difficult, and there has been a noticeable difference in his voice.
Prior to the fifteen months, he presented little to no symptoms. The patient, a medical doctor, has a wife and two young children. What began as
seemingly innocent muscle weakness and cramping has lead to this patient's fatal diagnosis. He is one of 2.5 per 100,000 people worldwide who have
been... Show more content on Helpwriting.net ...
Typically, the muscle weakness will affect a limb, and nasal or slurred speech will soon develop. If the patient is limb onset ALS, the symptoms
will first occur in the arms and legs. They may have difficulty with dexterous tasks such as writing or opening a door. If the lower limbs are
affected, they may notice trouble walking and experience tripping or stumbling. Dropped foot, as demonstrated in the above case study, can also
develop from muscle weakness and can cause the individual to drag his or her foot. Limb onset ALS is more typical than all other types, occurring in
about 75% of diagnosed individuals. The other 25% may present symptoms described as bulbar onset ALS. These patients may first notice difficulty
with proper speech and swallowing. Patients will often lose their voice and have difficulty forming words, caused by a loss of tongue mobility. In rare
cases, patients might demonstrate respiratory onset ALS where the intercostal muscles are compromised first. Regardless of which occur first, affected
individuals will generally experience most of the symptoms as the disease progresses. Specifically, symptoms that include difficulty swallowing,
moving, forming words, tight muscles, spasticity, and/or exaggerated reflexes occur when the upper motor neurons have been damaged. When lower
motor neurons are damaged, symptoms such as muscle weakness, atrophy, cramping, and twitching will occur. In some cases, a few of the muscle
neurons that

Motor Neuron Disease Maladie de Charcot Lou Gehrig's Disease
What is the Disease?
ALS is an extremely deadly disease affecting the nerve cells that control the victim's voluntary muscles. These nerves shrink and eventually die, leaving
the muscles without stimulation. As these muscles go without stimulation, they too eventually shrink and die. The victim progressively weakens to the
point of complete paralysis of all voluntary muscles and some involuntary muscles, such as breathing and swallowing, and soon after this point, death is
inevitable.
'A' means "Without" 'Myo' means "Muscle" 'Trophic' means "Nourishment" 'Lateral' refers to uneven ... Show more
content on Helpwriting.net ...
Another third find a weakness in their legs and may trip because of a mild foot drop. The remaining one–third notice slurring in their speech or
difficulty swallowing. Because all of these symptoms happen naturally, it is generally not characterized as ALS until the symptom progressively
worsens.
This happens as the affected area's muscle cells deteriorate, resulting in muscle tenseness. Frequently one side of the body is affected first and it then
gradually passes to the other side. Muscles in the eyes, anus and bladder are generally left unaffected.
Diagnoses
As there is no known way to prevent this disease, there is also no specific clinical test to identify ALS. It generally involves a physical examination,
perusing through the patient's medical history, and neurological testing. To test muscle activity specialists often use an EMG, or electromyogram, and
will often use CT scans, MRIs, and thorough blood examination. There is also a recently developed SOD1 scan, the gene now thought to be the cause
for ALS, especially familial ALS. Only 20%, however, of patients with familial ALS show positive on the SOD1 scan.
Progress of ALS

Until

Essay about Amyotrophic Lateral Sclerosis
ABSTRACT
At this time, Amyotrophic Lateral Sclerosis(ALS) is a very confusing and elusive disorder. While the clinical presentation and diagnosis of ALS dates
back to the early 1900's, with Charcot being the first to scientifically report and document his findings, there simply has not been definitive evidence
since that time for the etiology for ALS. This fundamental problem has befuddled the most qualified researchers and its ensuing answer has eluded the
most clever experiments for some 80 years.
This paper is being written to address some of the most plausible candidate causes which have come to the forefront of ALS research in the last few
years. This paper will also try to tackle the ... Show more content on Helpwriting.net ...
The average age of onset is roughly 60. Even so, much more attention is giving to younger, healthy individuals who succumb to the disease.
The typical history usually involves early recognition of an onset of clumsiness in the hands and fingers, with a weakness in the legs soon to follow.
There is also bulbar involvement that usually manifests in problems with speech and swallowing. This bulbar involvement is interesting in that it may
be cytologically distinct from the corticospinal manifestation. The degenerative process itself is unforgivingly progressive, except for a few permanent
plateaus, and for all reasonable assessments, will yield a fatal outcome. Even so, it should be noted that patients most often do not die from ALS, but
from secondary causes such as infection and pneumonia.
When considering ALS, the relevant question is not what has been proposed as the causative agent, but what has not been proposed. Over the years,
there has been a myriad of theories concerning the etiology of ALS, some with a valid premise and decent evidence, and others being way off the
mark. Some of the theories that have been advanced include viruses, actions of specific neurotoxins or heavy metals, failure of DNA repair
mechanisms, altered axonal transport, or some type of unusual autoimmune disease. With a significant volume of scientific literature being devoted to
ALS 'progress' each year, it becomes painfully obvious how confusing it is to extract one or two well

Causes Of Amyotrophic Lateral Sclerosis
Imagine living in a hopeless body with a perfectly working brain. Amyotrophic lateral sclerosis (ALS) is one of the worst diseases to develop.
Seeing your own body slowly die is a painful thing to go through and not being able to do anything about it is even worse. Chronic traumatic
encephalopathy or rather known as CTE's is a disease found in people who are repeatedly hit in the head. Head trauma and concussions are mainly
the reason of these diseases and being in sports highers the risk of getting a concussion and head trauma. Rules are important in playing sports so the
players won't get seriously injured. Rules in sports have to be made so that players will not get hit in the head as much to cause a concussion, and
rules not only need to... Show more content on Helpwriting.net ...
Athletes, on average, are getting ALS and CTE's at a younger age than non athletes. The average age athletes are being diagnosed with these diseases
is thirty compared to regular people which is fifty five. There is not an exact explanation on why athletes get these diseases at a younger age, but
researchers believe that during sports players get hit on the head during practices or games and lead to concussions. Sometimes athletes don't rest after
getting a concussion and that leads to serious brain damage in the future. Athletes are also not getting the right protection they need in sports to keep
them safe. Rules are sometimes not enforced during games and players can seriously get injured.The difference between head trauma and concussions
is that head trauma is damage in the brain and a concussion is when the brain touches the skull and causes a shock. A neurological examination can be
given to check vision, hearing, balance, coordination, strength, and

Causes of and Treatments for Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) Amyotrophic Lateral Sclerosis (ALS) otherwise known as Lou Gehrig's disease in the U.S. is a widely
known debilitating disease that effects the upper and lower motor neurons in the nervous system. The degeneration of the upper and lower motor
neurons in turn cause muscle atrophy and chronic loss of muscle use. ALS is the most common of the five motor neuron disease. Heredity is a
major cause of ALS but can show up in any patients. ALS usually presents itself in late middle age but can show up in children and even young
adults. The cause of ALS is not known. It seems to be caused by a genetic mutation, but the mutation has to have an environmental trigger to cause
the disease. In the past the disease was believed to have one cause, but that does not hold true to current findings. The majority of ALS cases are
sporadic in nature and can pop up anywhere, but 5 to 10 percent of cases has some sort of heredity involved. What is interesting is that sporadic ALS
and familial ALS may have the same genetic mutation and the environment is the key factor in contracting the disease. Some of the signs and
symptoms of Lou Gehrig's disease is loss of voluntary muscle use. Cramping and twitching is common as the degrading axons become damaged and
cannot transmit the action potential needed to muscle contraction. Sometimes symptoms start showing up in a specific region but can be mild loss of
use to multiple areas also. The loss of use of

Analysis Of Amyotrophic Lateral Sclerosis Genetics Essay
Analysis of Amyotrophic Lateral Sclerosis Genetics
Christopher Elliott
Brandman University
Analysis of Amyotrophic Lateral Sclerosis Genetics
Over the past decade, the medical community's understanding of chronic illnesses has greatly increased. This increase is the result of improvements in
technology and techniques that have clarified some of the unknown mechanisms associated with disease. For example, innovations in genetic
sequencing have allowed researchers to analyze the genetic variables and abnormalities that could contribute to an individual's development of
Amyotrophic Lateral Sclerosis (ALS). In fact, over 20 different genes have been identified that increase one's susceptibility of developing ALS.
Therefore, an analysis of a recent research study, which elaborates on the genetics of ALS, is essential to understanding these types of investigations
and how they are significant in modern medicine. With that being said, the purpose of this paper is to review a recently published investigation
pertaining to ALS genetics by Cady et al. (2014) in JAMA Neurology.
Review
ALS is a devastating disorder that has an incidence rate of 5,000 individuals and a prevalence rate of 30,000 (Abel, Powell, Andersen & Al–Chalabi,
2012). According to Abel et al. (2012), the onset of ALS is between the ages of 40 and 70 and has no distinct ethnic or racial boundaries. ALS can be
subdivided into two categories: Sporadic and Familial. Individuals with sporadic ALS do not

Essay about Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis is a motor neuron type disease. The disease was first discovered in 1869 by French neurologist Jean–Martin Charcot.
Though we have known of this disease and its capabilities for well over a century; there is still information that is unclear. This past decade has
been successful for research, giving us new information and optimism for years ahead. New hope is arriving in thoughts that stem cell research and
gene therapy will advance our knowledge for a possible cure. ALS is also known as, Lou Gehrig's disease. Lou Gehrig was a talented and popular
professional baseball player. Before being diagnosed with ALS in 1939, Lou Gehrig was known for his abilities at the plate and his longevity. Because
of his... Show more content on Helpwriting.net ...
The SOD1 enzyme is a powerful antioxidant that protects the body from damage caused by free radicals. Free radicals are highly reactive molecules
that are produced by cells during normal metabolism. If these free radicals are not neutralized, they can accumulate and cause random damage to the
DNA and proteins within cells. Even with the knowledge of this gene mutation; scientists have been unable to connect this happening to motor neuron
deterioration. Some research has shown the gene mutation to affect the motor skills of some animals. Glutamate is a neurotransmitter in the brain. A
reoccurring theme with glutamate is that people with ALS have higher levels of it in their serum and spinal fluid than that of a healthy person. When
neurons are exposed to high amounts of glutamate over an extended period of time they tend to die off. Researchers are trying to come up with an
explanation for high levels of unnecessary glutamate in a person. In addition, they are trying to piece together how this would lead to the development
of ALS. Autoimmune responses and the environment are possible causes as well. An autoimmune response is where the body's immune system attacks
regular cells. Some theories state that antibodies may attack motor neurons, which would have an effect on the communication of signals between the
brain and muscles. The possibility of the environment causing ALS deals with questions on modern day diets or the amount of pollution that the

Amyotrophic Lateral Sclerosis (lou Gherigs Disease) Essay
Amyotrophic Lateral Sclerosis (Lou Gherig's Disease)
Amyotrophic Lateral Sclerosis is a deadly disease of the nervous system.
Also known as Lou Gehrig's disease, ALS at this time affects 25,000 people in the U.S. today. One in 50,000 people will be affected in any one year.
The average age for diagnosis of ALS is between 30 and 70, although there have been cases of teenagers contracting it.The average life span after
diagnosis are three to 10 years, although 20 percent of those affected will outlive their prognosis by a number of years. ALS affects more men than
women. Approximately
60 percent of those affected are male, 40 percent are female.
Little is known about the exact ... Show more content on Helpwriting.net ...
The patient cannot eat, breathe or communicate with others. Totallife support may be the only thing keeping them alive. ALS can lead to total paralysis.
Although there is no cure, medications such as siazepam can assist with controlling spasms and muscle cramps and saliva. Siazepam can also help
control muscle twitching. Physical therapy is important for patients with ALS to maintain flexibility in joints and to prevent contractures, or fixations
of muscles. Diagnosis of ALS is difficult, since there is no clinical or laboratory test to identify it. Diagnosis is done through careful examination of a
patient' s history, neurological testing, and electromyograms.
Researchers have been studying whether a defective metabolism of glutamate, an amino acid, is detrimental to the nerve cells in the muscles of
ALS patients. Scientists are trying to determine whether they can prevent the toxic effects of glutamate. Other scientists are studying Threostat, which
may increase the amino acid called glycine, which might neutralize glutamate found in ALS patients.
ALS and Muscular Dystrophy are commonly confused due to their similar

Symptoms And Symptoms Of Amyotrophic Lateral Sclerosis (...
Amyotrophic lateral sclerosis (ALS) Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive neurodegenerative
disease that affects the brain and spinal cord nerve cells. The degeneration of these neurons result in their death, which prevents the brain from
initiating voluntary muscle movement. Patients may not experience the same symptoms throughout the phases, early symptoms include difficulties
swallowing, breathing, speaking, and increasing muscle weakness. Muscle atrophy occurs and paralysis may result in the later stages of the
disease. The cause of ALS is unknown and although there is no cure, current treatment can halt the progression or possibly reverse it (ALS
Association, 2010). Many people do not think twice about the early signs and symptoms of ALS, as the disorder progresses, the signs and
symptoms can mimic other illnesses. Early signs usually begin in the upper and lower extremities. The patient appears to be clumsy. As ALS
progresses, all voluntary muscle movements will be affected. The patient will have difficulty speaking, chewing, swallowing, breathing, and holding
their head up. The average person lives 3 to 5 years after diagnosis, death of the motor neurons lead to death of the patient (Mayo Clinic, 2015). ALS
is seen more in men than in women and more in Caucasian's than any other race. Most patients are diagnosed between the ages of 40 and 75 (CDC,
2014). Case Study Mrs. Suzanne Mayflower is a 48 year–old

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease, which means there's an increasing loss of neuron structure and function as the
disease progresses. This is when there's an unusual hardening of body tissue due to a lack of muscle nourishment and poor nerve cell transmission.
ALS typically affects the ages of 40–70 years old, and for some unknown reason, military veterans are almost double the chance of developing ALS in
comparison to the general public. The first large–scale effort to track ALS and its outcomes is the ALS CARE Database, where it stated that, of the
people in the database, 60% were men, and 93% were Caucasian (Amyotrophic Lateral Sclerosis (ALS) Fact Sheet, 2016). There are 2 main types of
ALS; sporadic and ... Show more content on Helpwriting.net ...
Under normal conditions, satellite cells are inactive, but become activated when there's a serious injury, and when muscles lose their nerve supply.
Satellite cells repair muscle fibres, but when they become old, they disrupt signals and skeletal muscle cannot be prepared and regenerated effectively.
This results in muscle fibre degeneration, an increase in connective tissue between single muscle cells, and weakens the single muscle cell and
neuromuscular junction connection (Tsitkanou, Della Gatta, Russell,

Personal Narrative: Amyotrophic Lateral Sclerosis
My world flipped upside down as the doctor told me I had Amyotrophic lateral sclerosis and that it was progressing fast. The fact that I didn't even
know what that long medical word meant scared me even more. I instantly turned to the window and stared at the busy highway, tears started
rushing down my face like raindrops, unwelcome and unstoppable. I woke up dreading today, my first day back to the jail I call high school. I had
a surprisingly wonderful time over the summer, but now it's back to waking up early and late nights filling my brain up with subjects I won't even
remember when SAT testing comes. As I was walking into my first period class I noticed I was struggling to carry my belongings. I ignored it until
after school, when JV... Show more content on Helpwriting.net ...
I started being able to pick up objects that weighed more than seven pounds. My muscles were not as strong as they were before I got diagnosed,
but I believed that I could regain all the frail muscle I had into strong, beautiful muscles. Tomorrow would be the second day of school for me. I
took off almost three months of school and all my sports were postponed until I started getting better. "Bri, you are making a spectacular recovery,
this is the first case this whole hospital has seen where only one dose of Riluzole has almost cured you from ALS!" he exclaimed to me. He told
me to take it slow, only pick up items less than five pounds and be careful with cuts or sores getting infected. I went home that day with a smile on
my face and a hop in my step. It was satisfied to know that I was the first person to have this type of recovery. Even though I still have the diagnosis
of ALS, I go back to doing my normal things. Now I play for my school soccer team and this past season I got over $2,000 in donations for me and
my condition, I donated all the donations I received to the ALS Association for people that are going through this disease that can't afford the medication

Amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig's disease, is a disease of the nerve cells in the brain and spinal cord that control
voluntary muscle movement. Jean–Marie Charcot was the first to recognize ALS as a distinct neurological disease with its own unique pathology. In
ALS, nerve cells degenerate and deteriorate, and are unable to transmit messages to muscles. In around 90% of the cases of ALS, the cause remains
unknown. Studies have concentrated on the responsibility of glutamate in motor neuron degeneration. Glutamate is one of several neurotransmitters in
the brain. While there is no known cure for ALS, strides in medicine have allowed for the development of a wide variety of medications to treat the
various... Show more content on Helpwriting.net ...
The predicament of the patient gradually declines. Once the disease progresses to the stage where muscles in the chest area stop working, it grows
increasing difficult or nearly impossible to breath.
History of ALS
Jean–Marie Charcot was the first to recognize ALS as a distinct neurological disease with its own unique pathology (Kumar, Aslinia, Yale, and Mazza
2011). Studies conducted from 1865 to 1869 by Charcot and his colleague Joffroy found that lesions in the interior of the lateral column in the spinal
cord gave rise to chronic progressive paralysis and contractures (no atrophy of muscles), while lesions of the anterior horn of the spinal cord resulted in
paralysis devoid of contractures (with atrophy of muscles). These discoveries reinforced Charcot's hypothesis, at the time, was that the motor
component of the spinal cord contained a two–part system, and that the location of the lesion results in a varying clinical presentation. Charcot did not
propose the term "amyotrophic lateral sclerosis" until 1874 when his lectures were accumulated into a compilation of his research entitled "Oeuvres
Completes". In many parts of the world, ALS is still known as Charcot's disease. While numerous molecular and genetic discoveries have allowed for a
greater understanding of this disease, his innovative descriptions of the associated clinical and

Amyotrophic Lateral Sclerosis Or Lou Gehrig Disease
Amyotrophic lateral sclerosis (ALS) or Lou Gehrig disease . Amyotrophic lateral is the neurodegenerative disease which the nerve cell (neurons)
destroy and lose an ability to control muscles movement , so Patient can't do the normal activities walking ,moving until now there is no cure for
amyotrophic lateral sclerosis , but there are some Therapies that may help the patient to mitigate the pain . Amyotrophic lateral sclerosis is the deadly
disease . It begins when Motor neurons (nerve cell) in the brain system send the signal via the spinal cord to the voluntary muscles like arms , legs,
face so the nerve cell degenerates than the muscles lose ... Show more content on Helpwriting.net ...
Patient muscles in this point gradually become weaker. Moreover, the disease – if it is truly ALS – generally spreads from one part of the body to
another
(almost always in parts adjacent to each other) so that eventually the problem can no ignored (1). longer be
The Patient cannot do the normal activities like speaking .At the beginning, he can talk , but in a hard way ,slow then gradually he loses an ability to
talk They use devices to help them to contact with others. Other early symptoms vary but can include tripping dropping things , uncontrollable periods
of laughing or crying (2).
1
Khowalh ahmed alsayil.
Definition essay .
Oct 2016

ALS ALS stands for Amyotrophic Lateral Sclerosis, and is also referred to as Lou Gehrig's disease. After this disease is contracted, it weakens
skeletal muscles and the body is eventually paralyzed. In some cases, ALS affects the limbs first, causing difficulty to move. Due to being a
progressive condition, patients will suffer from many different symptoms as time goes by. After being diagnosed, only about fifty percent of
patients live for at least two more years (Facts You Should Know 2010). Moreover, about twenty percent live five years after being diagnosed and only
ten percent of people can expect to live for over ten years after the diagnosis (NINDS 2013). This being said, ALS is typically very rare. Approximately
two out of one hundred... Show more content on Helpwriting.net ...
ALS is inherited in five to ten percent of cases, while other cases just seem to appear randomly (Learn About ALS 2014). Some believe that the nerve
cells that control movement just gradually die off. It is also said by doctors and scientists that this condition is the result of a gene mutation. Others, on
the other hand, believe there is a chemical imbalance where there are higher than normal levels of glutamate, which is a chemical messenger in the brain
around the nerve cells in their spinal fluid (Learn About ALS 2012). Earlier in class, we established that glutamate is a salt or ester of glutamic acid,
and too much glutamate is known to be toxic to some nerve cells. Some cases could be a result of a disorganized immune response where the immune
system begins attacking normal cells, leading to the death of nerve cells. When a body's own cells begin attacking its normal cells, it's almost
guaranteed that the body is at risk for shutting down. There could also be some sort of protein mishandling; mishandled proteins with the nerve cells
may lead to gradual accumulation of abnormal forms of these proteins in the cells, eventually causing nerve cell death. Some scientists believe that they
have found genetic links related to acquiring this disease, but not legitimate cure has been settled on or established (Learn About ALS

Case Study: Amyotrophic Lateral Sclerosis
Interesting ALS Facts:
There are two kinds: familial and sporadic
Ages 40–70 are most affected
Military vets are twice as likely to be diagnosed
Average life expectancy is 2–5 years
There is no cure
In 2014 the famous ALS Bucket challenge raised approximately $115 million for research
Famous people diagnosed with ALS: Lou Gherig, Steven Hawking, football great Steve Gleason, former VP Henry Wallace, Seasame Street creator
Jon Stone
Amyotrophic Lateral Sclerosis A progressive, fatal disease that affects those from all walks of life
In 1869 French neurologist Jean–Martin Charcot first discovered ALS based on presenting symptoms. He was aware of symptoms that accompanied
upper motor neuron damage which was: muscle weakness, stiffness an altered muscle reflexes. He was also aware of symptoms associated with lower
motor neuron damage which included: muscle atrophy, twitching and decreased muscle reflexes. Who also observed a decrease in muscles associated
with mastication. After studying these symptoms, the "Father of Neurology" termed the disease "Amyotrophic Lateral Sclerosis". ... Show more content
on Helpwriting.net ...
He was known as the "iron man" of baseball, playing in the most consecutive games than any other player. It was that fateful day he realized
"something wasn't right" and he removed himself from the game. Lou
Gherig was diagnosed with ALS and succumbed to the disease in 1941. ALS is still most known as "Lou Gherigs

Amyotrophic Lateral Sclerosis Research Paper
"Today, I consider myself the luckiest man on the face of the earth"said Lou Gehrig on Lou Gehrig Appreciation Day(Greenberger 81). While
thousands of people chanted, "We want Gehrig, We want Gehrig". This day was very emotional for Lou, fans, and players because they would not see
the great play ever again.
There are quite a few symptoms for amyotrophic lateral sclerosis, also known as ALS. one of the first signs a patient will have is muscle twitches.
Then the patient will have slurred speech and will start to trip or fall randomly. They will also have muscle cramps and foot drop, which means having
trouble lifting the foot. Then they will drop things frequently, and have difficulty swallowing. Lastly they will have fatigue in arms or legs (ALS Assn)
... Show more content on Helpwriting.net ...
The first season he did not play much at all, manly sitting the bench.For the next couple seasons, Lou was a great baseball player and played 2,130
games consecutively, even with a broken finger (Greenberger 5). During the 1939 season Lou's batting average plummeted, and he could not field
that well at all. Soon Lou started to trip or fall randomly and was in pain.Lou benched himself in the 1939 season (79). Finally, Lou was taken to the
doctor and was diagnosed with amyotrophic lateral sclerosis, also known as ALS. This was heartbreaking for Lou because he could not play what he
loved, baseball. Soon all he could do was watch the games and bring up the players line up to the umpire (Greenberger

Amyotrophic Lateral Sclerosis was discovered in 1869 by a French neurologist named Jean–Martin Charcot. However, the disease did not become
known worldwide until 1939 when famous baseball player, Lou Gehrig was diagnosed. The disease later took his life. Amyotrophic Lateral Sclerosis,
also known as ALS, or more commonly known as Lou Gehrig's disease, is a progressive neurodegenerative disease that attacks nerve cells in the brain
and the spinal cord. Motor neurons extend from the brain to the spinal cord and from the spinal cord to the muscles distributed throughout the human
body. Degeneration of motor neurons eventually lead to death. Amyotrophic comes from the Greek language which translate into "No muscle
nourishment. ALS can be summed ... Show more content on Helpwriting.net ...
There are numerous tests that have to be ran including, electromyography (EMG) and nerve conduction velocity (NCV), blood and urine studies,
thyroid and parathyroid hormone levels, spinal taps, x–rays, magnetic resonance imaging (MRI), myelogram of cervical spine, muscle and/or nerve
biopsy, and a neurological examination. Even with the results of various tests, there are still 6 other major diseases that are similar to ALS, but most of
which are treatable. They include Primary Lateral Sclerosis, Huntington's disease, Parkinson's disease, Multiple Sclerosis, Muscular Dystrophy, and
Neurological Disorders. The doctors use the given results from each test and the information from the many repeated physical examinations to help
with their diagnosis. When each individual "copycat disease" is ruled out, they can diagnose the patient's condition as Amyotrophic Lateral Sclerosis.
Lou Gehrig, David Niven, George Yardley, Eddie Adams, Dennis Day, Henry A. Wallace, Maxwell Taylor, and Steve Gleason are just some of the
many influential people who were personally diagnosed with

Aisha Fain
St. Mary's University
Amyotrophic Lateral Sclerosis, also known as Lou Gehrig's disease, is a progressive and degenerative neurological disorder that affects the cells in
both the brain and the spinal chord and has affected nearly twelve to twenty thousand people, according to Moglia and Margolis (2017). This disease
may have a great affect on the musculoskeletal system, the nervous system, as well as the respiratory system. Initially, there is no actual known cause
to this disease; however, researchers may have an idea of what may play a possible role including genes. In addition, there are a number of symptoms
that may also be experienced in patients with Lou Gehrig's disease including "slurred speech, weakening grip, clumsiness/unsteadiness, and weakened
limbs," (Moglia & ... Show more content on Helpwriting.net ...
(2015). End–of–life management in patients with amyotrophic lateral sclerosis. The Lancet. Neurology, 14(4), 435–442. doi:10.1016
/S1474–4422(14)70221–2
Jakobsson Larsson, B., Nordin, K., & Nygren, I. (2016). Coping with amyotrophic lateral sclerosis; from diagnosis and during disease progression.
Journal Of The Neurological Sciences, 361235–242. doi:10.1016/j.jns.2015.12.042
Moglia, P. P., & Margolis, D. D. (2017). Amyotrophic lateral sclerosis. Magill'S Medical Guide (Online Edition)
National Institute of Neurological Disorders and Stroke (2013). Amyotrophic lateral sclerosis fact sheet. National Institutes of Health. van Groenestijn,
A. C., SchrГ¶der, C. D., Visser–Meily, J. A., Reenen, E. K., Veldink, J. H., & van den Berg, L. H. (2015). Cognitive behavioural therapy and quality of
life in psychologically distressed patients with amyotrophic lateral sclerosis and their caregivers: Results of a prematurely stopped randomized
controlled trial. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 16(5–6), 309–315.

Als : Short For Amyotrophic Lateral Sclerosis
ALS Jose Ramirez 2nd hour ALS is short for amyotrophic lateral sclerosis. It's sometimes called Lou Gehrig's disease. It's a very deadly disease
that has taken MANY people's lives. It's a slow and painful process. It usually starts from the bottom and works its way up north till you eventually
die. It attacks your nerve cells which it eventually makes you immobile. Motor neurons located in the brain are the cells that are attacked by this
deadly disease. ALS causes weakness with a wide range of disabilities eventually, all muscles under voluntary control are affected, and individuals lose
their strength and the ability to move their arms, legs, and body. When muscles in the diaphragm and chest wall fail, people lose the ability to... Show
more content on Helpwriting.net ...
You're pretty much going to die. Let's be real nobody could handle that. Knowing that a disease will make you immobile and will eventually kill
you. It will deprive you of everything you loved doing. Any outdoor activities you enjoyed, any sports. Most likely people with ALS will be in a
wheelchair because they won't be able to walk. The patients will not go out and party or go on a vacation. Its pretty stressful to be having the
disease. Although it is rare to get. Doctors don 't know what causes ALS. In about 1 case out of 10, it runs in families. This means that 9 times out
of 10, a person with ALS doesn 't have a family member with the disease. ALS has symptoms that may give you a heads up of what's going to
happen. For example weakness in a foot or leg. It doesn't always start there either. It can begin anywhere like in your hand or even your face. The
muscles get smaller and weaker eventually because of the attacked motor neurons. Some symptoms could be repertory problems and trouble
swallowing food. But ALS doesn't cause numbness or loss of feeling. ALS is usually found in older people. Usually white males and non–Hispanics.
So I consider myself lucky haha jkjk. Its found in 1/12 people. Currently there 's no way to prevent or cure Lou Gehrig 's disease but a number of
treatments are available to people with the disease. Medicines can control symptoms, such as muscle cramping and difficulty swallowing, and other
drugs can slow the development of the disease.

Amvotronhic Lateral Sclerosis
What is It? Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal age–dependent degeneration of motor neurons in the
spinal cord, brain system, and cortex.39–12 A Plaracteristic of the disease is the loss of all voluntary motor function, with the exception of Ocular
muscles and sphincter.8 The average age of onset is 55–60 years and the male to female ratio is 1.3 to 1.10 Following onset it is fatal after 3 to 5 years
on average's once respiratory functions are paralyzed." It affects all races' I and is the most common of the human motor neuron diseases3'7' occurring
in roughly one in every 2000 people." There are two types of ALS, sporadic and familial', with approximately 10% being ... Show more content on
Helpwriting.net ...
Genetic factors not only affect the familial cases, but they also are likely to play a role in some of 4 the sporadic cases.9 Among the familial cases
about 200/s 3'12 contain causative genetic lesions in copper–zinc superoxide dismutase (SOD 1). 3'7 ALS could be an oxidative neurotoxicity brought
on by this mutation in the SOD 1 protein:1'11 A leading hypothesis of the development of ALS is /glutamate excitotoxicity.1В°'12 Concepts of
excitotoxicity may help explain the selective neuronal death that occurs.10 Excitatory neurotransmitters, such as glutamate, can damage postsynaptic
cells with excess concentrations.IВ° Glutamate levels are elevated in serum, spinal fluid, and brain tissue of ALS patients.11'12 It is also hypothesized
that deficiency of nerve growth factor may cause ALS.II Neurotrophic growth factors might rescue the cells that are destroyed in ALS.I "12 Additional
cause for ALS may be derivative of industrial pollutants and occupational exposure to chemicals associated with welding and soldering." Symptoms
ALS is characterized by a combination of both upper and lower motor neuron вњ“ symptoms9'I2 that lead to respiratory insufficiency within a few
years.1В° Lower motor neuron symptoms include weakness, muscle wasting, hyporefexia, muscle cramps, and fasciculations.9'11 Spasticity,
hyperreflexia, Hoffmann sign, extensor plantar responses, hyperactive jerk and gag reflex,

ALS, or amyotrophic lateral sclerosis, is a disease that damages motor neurons in the brain and spinal cord. It is a deadly disease that cripples its
victims due to breakdown in the body's motor neurons. Motor neurons are nerve cells that control muscle movement. They are important part of the
body's neuromuscular system. The neuromuscular system allows our bodies to move and is made up of the brain, many nerves, and muscles. People that
are diagnose with ALS disease causes for the motor neurons in the brain and the spinal cord to shrink and disappear, so that the muscles no longer
receive signals to move eventually causing the muscles to become smaller and weaker. Slowly the body becomes paralyzed, which means that the
muscles no longer function. The average life expectancy for a person that has ALS after being... Show more content on Helpwriting.net ...
ALS is not contagious, but research is still unclear on the causes of the disease.
Discussion
Early signs and symptoms of ALS are very minor and overlooked. They begin as simple things, such as tripping or dropping things. The person has
difficulty walking and doing their normal daily activities. They experience weakness in their leg, feet or ankles. This disease normally begins in
your hands, feet, or limbs, and spreads to other parts of your body. As the disease develops, the muscles become gradually weaker. This weakness
sooner or later affects chewing, speaking, and breathing. Some drooling may occur at this point. In its more progressive stages, breathing problems
result often lead to respiratory failure to death. Since the motor neurons of the brain and spinal cord degenerate, the brain is unable to send signals to
the muscles of the limbs. At this time, experts do not know what causes ALS. It can affect anyone, regardless of gender, race, ethnicity, or
geographical location. Cases of ALS appear to be inherited in up to 10%, but in cases it appears to occur randomly. Researchers are investigating

The Impact Of Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord (Plowman,
2015, p.1151). The motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles in the body. When ALS is in a
degenerate stage, this causes paralyzation and loss of muscle control, which can lead to one's death. The ALS Association is a national nonprofit
organization that is dedicated to fighting Lou Gehrig's disease by providing support and information to those that have this disease, as well as
spreading awareness effective for change. The ALS Association aims to discover new treatment for those living with Lou Gehrig's disease, while
actively seeking a cure... Show more content on Helpwriting.net ...
Social media was very effective in this campaign because the audience was able to participate in a more active stance and allow their video
postings to reach not only their followers but others as well. Social media is very inclusive of all age groups and various types of people and is more
influential than a commercial on a given channel that may or may not reach the same wide audience. Social media encourages having a conversation
which is a 2 way communication process between the audience and the organization. The ALS Association was able to communicate with their
audience using social media and the videos posted by their audience helped their cause in a positive way. Social media also allowed the organization to
keep track of what is going on with their audience in response to their campaign. According to Sutton & Paulson, theory of planned behavior (TPB),
there are three major determinants that permit the explanation and prediction of most human social behavior – attitudes, perceived norms, and
perceptions of behavioral control (2016, p.411). With social media, theory of planned behavior comes into play because majority of the participants
perceived social media, and making their own videos, as a social norm that was deemed socially acceptable during the campaign. Participants had a
positive experience while making their social media video, which

Amyotrophic Lateral Sclerosis (ALS) is a disease in which certain nerve cells in the brain and spinal cord slowly die. These nerve cells are also
called motor neurons, and they control the voluntary muscles that allow you to move the parts of your body. ALS can also be referred to as Lou
Gehrig's disease. (1) There are three classifications of ALS; sporadic, familial, and gumanian. Sporadic is the most common form of ALS and it
makes up approximately 90 to 95 percent of all cases. Familial is the form of ALS that occurs in a family's genetic line, a 50 percent chance each
offspring will inherit the gene mutation. This form of ALS makes up about 5 to 10 percent of all cases in the U.S. the last form of ALS is
Gumanian, an extremely high incidence of this ALS was observed in Guam and the Trust Territories of the Pacific in the 1950's. (3) People who
develop ALS are most often between the ages of 40 and 70, with the average age of 55 at the time of diagnosis. However, cases of this disease do
occur in people younger than 40, some even as young as their twenties and thirties. ALS is also more common in women than it is in men,... Show more
content on Helpwriting.net ...
These symptoms include muscle twitching, Trouble using your hands and fingers for a specific task, problems with speaking, eating and swallowing,
walking, and even breathing. ALS can also cause problems with memory, thinking, and can cause changes in personality a well. Despite what movies
might have portrayed, ALS does not cause numbness, tingling, or loss of feeling. However, respiratory problems and problems with swallowing are
the most common serious complications of ALS. As the muscles in the throat and chest weaken, swallowing, coughing and breathing problems tend to
get worse. ALS can also cause a number of other problems as well. Pneumonia, pulmonary embolism, lung failure, and heart failure are the most
common causes of death, and are also side effects of having ALS.

Amyotrophic Lateral Sclerosis is an insidiously developing, adult–onset, progressive anterior horn cell degeneration with associated degeneration of
descending motor pathways. Despite increasing clinical and research interest, its cause remains obscure. Although many theories as to its cause have
been proposed, no intervention has yet been shown to modify biologically determined motor system degeneration.
There is no clear cut neuropathological diagnosis for Amyotrophic Lateral Sclerosis (ALS). Instead, clinicians must rely on both the topographic
distribution of the neuronal loss and the finding of some characteristic cytological changes. The precise pattern of these changes, however, varies to
some ... Show more content on Helpwriting.net ...
Lower brain stem nuclei are almost always more consistently and extensively involved than the upper brain–stem nuclei (2). However, changes in the
occulomotor nuclei are rarely associated with clinical signs.
In recent studies, it has been shown that the occulomotor and sacral nuclei have been associated with patients whose course of illness has been
extended over a longer period of time with the help of respirators and other medical equipment. This finding suggests that these neuronal phenotypes are
vulnerable to the pathophysiologic process but are inexplicably more resistant to it than are lower cranial and spinal motor neurons (4).
Standard nerve conduction studies and electromyography have long been used in the diagnosis of ALS. The characteristics of standard nerve
conduction studies and standard electromyography reflect the underlying pathophysiologic process. Features that support a diagnosis of ALS include
reduced numbers and increased amplitude and duration of motor unit action potentials, in addition to fibrillation's and fasciculations in many muscles
not innervated by the same nerve or spinal cord segment. Fibrillation's, positive sharp waves, and complex repetitive discharges are features of
denervation. As the number of functional motor units in a muscle diminishes in ALS, the mean motor unit amplitude and motor unit potential area
increase. Increased duration and amplitude of motor unit action potentials reflect

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative autoimmune disease. This means that the neurons ( nerve cells of the brain and spinal
cord), particularly the ones that control voluntary muscles (motor neurons), degenerate and die. Naturally, motor neurons in the brain send signals to
the motor neurons in the spinal cord, which in turn, sends signals to the muscles. However, the degeneration and death of these neurons (upper and
lower motor neurons) doesn't allow the body to transmit signals to permit the movement of muscles. This eventually causes the weakening of the
muscles, and the brain's loss of controlling voluntary muscle movement. By this, people lose their ability to speak, walk, and breathe.
Generally, family history and genetics play a big role in the cause of ... Show more content on Helpwriting.net ...
People worldwide, with different ethnicity backgrounds and ages can be affected by ALS. Nonetheless, ALS is more common among males, people
aged between 40 and 70 years old, and Caucasians (93% of the database). ALS symptoms vary from patient to patient, but usually the person will have
difficulty in walking, speech, and swallowing. The patient will also feel weakness and clumsiness of the hands, legs, feet, and ankle. The disease will
start affecting one muscle and will then spread to other muscles. Since reversing the effect of ALS is not possible, treatments focus on decelerating
symptoms, avoiding complications, and making the patient feel more at ease. Riluzole (Rilutek) is a drug that seems to slow the development of ALS
in some patients. This drug works by reducing glutamate, which, as previously mentioned, appears to be higher in ALS patients. Moreover, medications
can be given to relieve symptoms, such as muscle cramping, fatigue, pain, depression, and sleep problems. Patients can also be offered breathing,
speech, occupational, physical, nutritional, and psychological

Amyotrophic Lateral Sclerosis: Degenerative Disease
Als which is an acronym for Amyotrophic lateral sclerosis has gained a lot of fame due to the Fundraiser "Als Ice Bucket Challenge". Many
celebrities, famous athletes and everyday people have participated in it and in doing so they have raised a substantial amount of money for research.
Although, many people are still left wondering what exactly Als even is. Then, there are the people who know all too well about Als and those
people are the sports world. Along with Als he's Malicious relative Cte is not far behind getting the attention of many people as well. Cte stands for
Chronic Traumatic Encephalopathy it is a degenerative disease found in the brain. They are both Gruesome Diseases that have many people wondering
"how can i protect myself".... Show more content on Helpwriting.net ...
It is a progressive incurable fatal neurological disease. In the body we have these things called motor neurons which control muscle movement.
When the process of Als starts these motor neurons die 1 after the other. As of today there is no known explanation on how people get Als.
Although there is some sort of explanation on why young athletes get the disease. It has to do with toxic proteins that are found in the brain, these
toxins start to form after suffering consecutive blows to the head. They start to form in the brain and then they slowly leak down the spinal cord
which triggers Als. It all starts with the first symptoms of feeling muscle weakness, trouble chewing and slurred speech. In any random body part the
feeling of it starts to go away. Which then spreads to the rest of the body parts and then ultimately leaving paralysed. It leaves the person unable to
do anything, but there are some things you still use such as vision, hearing and the strangest of them all the brain. The average range of those
diagnosed is from 40 to 70 years of age. The life expectancy after contracting the disease is from 2–5 years but in some cases the person has lived up to
10

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease affecting both the upper and lower motor neurons in the cerebral
cortex, brainstem, and spinal cord. It is the most common motor neuron disease in the adult population with a prevalence of two to seven cases per
100,000 individuals. Survival rates in persons with ALS show considerable variation. Five–year survival rates vary from 7% to 40%, whereas 10–year
survival rates range from 8% to 16% (cite). Amyotrophic lateral sclerosis (ALS) presents clinically with upper motor neuron, and lower motor neuron
signs. ALS is characterized by progressive death of UMNs in the motor cortex and corticospinal tracts, the LMNs in the anterior horn cells of the spinal
cord, and ... Show more content on Helpwriting.net ...
There has been recent support for exercising those diagnosed with ALS, but a substantial amount of the research available on this subject has been
performed on mice. This has made it increasingly difficult to justify these same treatment guidelines on humans. However, these research studies that
have been completed in recent years have shown exercise to be an intervention that can help improve function, slow disease progression, and lessen
caregiver burden. For example, aquatic therapy has been found to significantly delay spinal motor neuron death in mice with ALS, as well as preserve
astrocyte and oligodendrocyte populations in the spinal cord in a study published in 2009 (cite). In 2003, research demonstrated that a lifetime of
vigorous exercise did not promote the onset and/or progression of motor degeneration in mice, revealing the running group of mice demonstrated a
non–significant 6–day improvement in survival, compared with the sedentary group, and a 4–day improvement when compared to the control (cite).
Lastly, in 2004 a study revealed that exercise delayed the onset of disease in female but not in male hSOD1 mice. Also, exercise delayed the total
survival time in female high–copy hSOD1 mice. Sedentary female hSOD1 mice showed more frequently irregular estrous cycles suggesting a higher
estrogen exposure

Essay on What is Amyotrophic lateral sclerosis?
Amyotrophic lateral sclerosis is short for ALS, and is often referred to as "Lou Gehrig's disease." Lou Gehrig was born in New York in June 19, 1903.
In April of 1923, Lou Gehrig signed his first contract with the New York Yankees. He played for the Yankees for 15 years and lead them to 6 World
Series between 1927 and 1938. Gehrig was known as a seven–time all–star champion, for his batting average and was named twice the American
League's MVP; He later earned the name of the Iron Horse (Lou Gehrig Biography). Unfortunately, his career ended, when he was stricken with
amyotrophic lateral sclerosis in 1939 . On May 2, 1939 he pulled himself away from the Yankees. At 36 years old, Lou retired from baseball. On June 4,
1939, Lou Gehrig ... Show more content on Helpwriting.net ...
There is also evidence that the patient might develop dementia over a time. Dementia is a loss of brain function, it affects memory, language, thinking
and judgment. Also they have a high risk of pneumonia during a later stage of ALS (Amyotrophic Lateral Sclerosis Fact Sheet).
Amyotrophic does not affect the ability to see, smell, hear or recognize touch. A person with ALS have control of eye muscles and bladder control.
Lou Gehrig's diseases mostly affects the nervous system (Amyotrophic Lateral Sclerosis Fact Sheet). When the muscles in the diaphragm and chest
wall fail, thats when the patients start to lose the ability to breath without ventilatory support. Respiratory failure is a big cause of deaths with patients
who have ALS; Patients die usually within 3 to 5 years from onset of symptoms (Amyotrophic Lateral Sclerosis Fact Sheet). ALS is one of the most
common neuromuscular diseases worldwide (Amyotrophic Lateral Sclerosis Fact Sheet).There are three different types of ALS causes there is,
familial, sporadic, and guamanian. Familial is 5–10% , sporadic is the most common which is 90–95% of all ALS causes and guamanian is rare
variant. Guamanian is very similar to ALS almost the same and it happens because of something toxic that they are eating which messes with their
nervous system (ALS[Lou Gehrig's Disease]). It is also a disease varied with etiology characterized by rapidly progressive in weakness in the muscles.

Symptoms And Treatment Of Amyotrophic Lateral Sclerosis Essay
Amyotrophic Lateral Sclerosis, also known as ALS or sometimes called Lou Gehrig's Disease, is a progressive neurological disease affecting the
nerves that control voluntary muscle movement. It is the most common type of motor neuron disease. The body isn't able to operate as it normally
does due to the muscles weakening overtime. As the disease progresses, it starts to damage nerves of other vital areas of the body. When the body isn't
able to breath the way it should causing respiratory failure and other things start to go wrong, the body has no choice, but to shut down and die. (ALS
Association)
Lou Gehrig's disease came into public awareness from a famous New York Yankees baseball player who was forced to retire after developing the
disease and died two years later. It was originally discovered in 1869 by a French neurologist named Jean–Martin Charcot. He was the first man to be
able to connect motor neurons in the spinal cord to the ALS disease. (Medical News Today)
The name Amyotrophic Lateral Sclerosis is derived from Greek origin. Amyotrophic broken down with A meaning no, myo referring to muscles, and
trophic meaning nourishment. The three roots equal the meaning of "no muscle nourishment". When muscles lose their nourishment, they are not able
to stay strong and can withhold their shape. Lateral being the spinal cord and its position to the body and sclerosis is defined as abnormal hardening
of body tissue. When body tissue is hardened, it is not able to have new

Long before Amyotrophic Lateral Sclerosis was brought to the world's spotlight by the ice bucket challenge, ALS had made an immense impact on
my life. I was in seventh grade when my parents told me that my grandmother had been diagnosed with ALS. ALS is a rapidly progressive,
unfailingly fatal neurological disease that attacks the nerve cells responsible for controlling voluntary muscles, with a median survival of 3 years.
Over the course of just a few months I witnessed this disease transform my energetic, independent grandmother into a shell of her former self. ALS
leads to immobility, respiratory and muscular failure, which limits a person's ability to experience life. When the early stages and symptoms of ALS
begin to develop, most people... Show more content on Helpwriting.net ...
This means that their mind is completely healthy, yet their body decays and malfunctions around them. Their mind is a slave to the diseased
body. The last time I saw my grandma she was lying in her bed surrounded by family and various machines. Her eyes were closed because all her
voluntary muscles were paralyzed. The machines were keeping her heart pumping and the medications relieved the discomfort. She appeared to be
in a coma, but my mom assured me she was conscious and just couldn't show it. We all said our goodbyes, and I imagined her real self, inside the shell
of what was left of her body. She was trapped and I knew that she was ready to

Amyotrophic Lateral Sclerosis Paper

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Amyotrophic Lateral Sclerosis Paper