What are gene expression controls on the different levels of gene regulation in transcription, translation and post translation? Solution Regulation of gene expression includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products and is informally termed gene regulation. Transcriptional Control During Transcriptional Control of Gene Expression transcription is initiated at the promoter RNA polymerase must bind here to begin transcription Transcriptional control allows variation in mRNA levels for specific enzymes. The cell avoids the production of these enzymes by utilizing regulatory proteins that prevent RNA polymerase from binding to a promoter. Translational Control It allows the cell to control the translation of an mRNA molecule that has already been transcribed. Regulatory molecules can speed up mRNA degradation by ribonucleases. Translation initiation can be altered. Translation proteins can be affected. Post translation control Post-translational control occurs when the cell controls the activity of an existing protein by chemical modification. Post-translational control provides the most rapid response but is energetically expensive.