Which is the mode of inheritance that is most likely? [That is the mode of inheritance that would mean that the pattern would HAVE to be as described, not just that is could have come out this way.] sex-limited, autosomal dominant Y-linked X-linked recessive autosomal recessive X- linked dominant autosomal dominant autosomal sex-influenced Solution Non-autosomal mode of inheritance is the one related to sex-chromosomes. The alleles associated with sex-chromosomes represent a differential kind of inheritance pattern and display a differential phenotype response in offsprings based upon their sex. Majority of the human diseases related to sex-chromosomes are X-linked in nature such as color blindness, hemophilia, Duchenne muscular dystrophy, Vitamin D resistant rickets or X-linked hypophosphatemia, Rett syndrome, Incontinentia pigmention and Goltz syndrome. Since both parents, a male and a female carry an X chromosome, they both are potential donors of X-linked allele of a disease. Since the offsprings can acquire a differential X-chromosome profile either from mother or father, their genetic make up will be dependent upon that of their parents and thus, their disease condition (carrier, affected, unaffected). Thus, X-linked (dominant or recessive) mode of sex-chromosome related diseases need to be explained theoratically and observationally, and not only be described as general procedures of genetic segregation. Since X-linked recessive diseases are more likely to cause ambiguity among inheritance pattern, a more detailed explanation would be requried for X-linked recessive alleles..

1. Which is the mode of inheritance that is most likely? [That is the mode of inheritance that would
mean that the pattern would HAVE to be as described, not just that is could have come out this
way.] sex-limited, autosomal dominant Y-linked X-linked recessive autosomal recessive X-
linked dominant autosomal dominant autosomal sex-influenced
Solution
Non-autosomal mode of inheritance is the one related to sex-chromosomes. The alleles
associated with sex-chromosomes represent a differential kind of inheritance pattern and display
a differential phenotype response in offsprings based upon their sex. Majority of the human
diseases related to sex-chromosomes are X-linked in nature such as color blindness, hemophilia,
Duchenne muscular dystrophy, Vitamin D resistant rickets or X-linked hypophosphatemia, Rett
syndrome, Incontinentia pigmention and Goltz syndrome.
Since both parents, a male and a female carry an X chromosome, they both are potential donors
of X-linked allele of a disease. Since the offsprings can acquire a differential X-chromosome
profile either from mother or father, their genetic make up will be dependent upon that of their
parents and thus, their disease condition (carrier, affected, unaffected).
Thus, X-linked (dominant or recessive) mode of sex-chromosome related diseases need to be
explained theoratically and observationally, and not only be described as general procedures of
genetic segregation. Since X-linked recessive diseases are more likely to cause ambiguity among
inheritance pattern, a more detailed explanation would be requried for X-linked recessive alleles.