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International Journal of Trend in Scientific Research and Development (IJTSRD)
Volume 4 Issue 2, February 2020 Available Online: www.ijtsrd.com e-ISSN: 2456 – 6470
@ IJTSRD | Unique Paper ID – IJTSRD30192 | Volume – 4 | Issue – 2 | January-February 2020 Page 1010
Tumor Detection and Classification of
MRI Brain Images using SVM and DNN
Sanmathi. R1, Sujitha. K1, Susmitha. G1, Gnanasekaran. S2
1Student, 2Associate Professor,
1,2Department of Electronics and Communication Engineering,
1,2Paavai Engineering College, Namakkal, Tamil Nadu, India
ABSTRACT
The brain is one of the most complex organ in the human body that works
with billions of cells. A cerebral tumor occurs when there is an uncontrolled
division of cells that form an abnormal group of cells around or within the
brain. This cell group can affect the normal functioning of brain activity and
can destroy healthy cells. Brain tumors are classified as benign or low-grade
(Grade 1 and 2) and malignant tumors or high-grade (Grade 3 and 4). The
proposed methodology aims to differentiate betweennormal brainandtumor
brain (Benign or Melign). The proposed method in this paper is automated
framework for differentiate between normal brain and tumor brain. Thenour
method is used to predict the diseases accurately. Then these methods are
used to predict the disease is affected or not by using a comparison method.
These methodology are validated by a comprehensive set of comparison
against competing and well established image registration methods, by using
real medical data sets and classic measures typically employed as a
benchmark by the medical imaging community our proposed method is
mostly used in medical field. It is used to easily detect the diseases. We
demonstrate the accuracy and effectiveness of the preset framework
throughout a comprehensive set of qualitative comparisons against several
influential state-of-the-art methods on various brain image databases.
KEYWORDS: Benign, Melign, Acquisition, Pre-processing, Segmentation,
Classification, Extraction
How to cite this paper: Sanmathi. R |
Sujitha. K | Susmitha. G | Gnanasekaran. S
"Tumor Detection and Classification of
MRI Brain Images using SVM and DNN"
Published in
International
Journal of Trend in
Scientific Research
and Development
(ijtsrd), ISSN: 2456-
6470, Volume-4 |
Issue-2, February
2020, pp.1010-1012, URL:
www.ijtsrd.com/papers/ijtsrd30192.pdf
Copyright © 2019 by author(s) and
International Journal ofTrendinScientific
Research and Development Journal. This
is an Open Access article distributed
under the terms of
the Creative
CommonsAttribution
License (CC BY 4.0)
(http://creativecommons.org/licenses/by
/4.0)
I. INRODUCTION
MRI is an extensively used technique which facilitates the
diagnosis and prognosis of brain tumors in many
neurological diseases and conditions. Standard MRI
sequences are generally used to differentiate between
different types of brain tumors based on visual qualities and
contrast texture analysis of the soft tissue. More than 120
classes of brain tumors are known to be classified in four
levels according to the level malignancy by the WorldHealth
Organization (WHO). The grading from low to high (1-4)are
malignant levels from the least aggressive biological tumor
to the most aggressive tumors, as shown by histological
criteria, for example, vascularity, invasiveness, and tumor
growth rate. Gliomas are the most primary cerebral tumor
and a pretreatment evaluation grade is necessary; however,
the exclusive use of standard MRI sequences may be
insufficient for a precise diagnosis. As the support vector
machines architectures are becoming more mature, they
gradually outperform previous state-of-the-art classical
machine learning algorithms. The literature survey has
revealed that some of the techniques are invented to obtain
segmentation only; some of the techniques are invented to
obtain feature extraction and some of the techniques are
invented to obtain classification only.
Tumor is an uncontrolled growth of cancer cells in any part
of the body. Tumors are of different types and have different
characteristics and different treatments. At present, the
brain tumors are classified as: primary brain tumors and
metastatic brain tumors. The former begin in the brain and
tend to stay in the brain, the latter begin as a cancer
elsewhere in the body and spreading to the brain. Brain
tumors are divided into two types: benign and malignant. In
fact, the most widely used grading scheme has been issued
by the World Health Organization (WHO). It classifies brain
tumors into grade I to IV under the microscope. In general,
grade I and grade II are benign brain tumor (low-grade);
grade III and grade IV are malignant brain tumor (high-
grade). Usually, if low-grade brain tumor is not treated, it is
likely to deteriorate to high-grade brain tumor.
Therefore, brain tumor are seriously endangering people’s
lives and early discovery and treatment have become a
necessity. Along with the advance of medical imaging,
imaging modalities play an important role in the evaluation
of patients with brain tumors and have a significant impact
on patient care. Recent years, the emerging new imaging
modalities, such as XRay, Ultrasonography, Computed
Tomography (CT), Magneto Encephalo Graphy (MEG),
Electro Encephalo Graphy (EEG), Positron Emission
Tomography (PET), Single-Photon Emission Computed
Tomography (SPECT), and Magnetic Resonance Imaging
(MRI), not only show the detailed and complete aspects of
IJTSRD30192
International Journal of Trend in Scientific Research and Development (IJTSRD) @ www.ijtsrd.com eISSN: 2456-6470
@ IJTSRD | Unique Paper ID – IJTSRD30192 | Volume – 4 | Issue – 2 | January-February 2020 Page 1011
brain tumors, but also improve clinical doctors to study the
mechanism of brain tumors at the aim of better treatment.
Clinical doctors play an important role in brain tumor
assessment and therapy. This information is very important
and critical in deciding between the different forms of
therapy such as surgery, radiation, and chemotherapy.
Therefore, the evaluation of brain tumors with imaging
modalities is now one of the key issues of radiology
departments.
II. PROPOSED SYSTEM
In this project we discuss about the brain tumors disease
detection by using a method at MRI images.Nowadays many
peoples are affected at more Brain cell tumor disease. So
using that situation many doctors and hospitals are easily
theft more money from patients. The common peoples are
mostly affected by this problem. We propose the method is
used to predict the disease accurately. Then it detect all the
Brain tumor disease easily. That is used to detect all the
brain cell related diseases and its provide more accuracy.
Then the detection of brain tumor disease at less
computation time. Our proposed method is used to predict
all the brain cell related diseases like that Tumors. They are
easily detected and its used accurately identify the diseases
in less processing time.
Fig1. Block Diagram
III. SOFTWARE IMPLEMENTATION
A. DATA ACQUISITION
The disease affected image or not affected images are
captured from camera or to upload the images. It is used to
upload the pair of input images. However, it differs from
conventional methods by using thermal images as input.
Fig2. Data acquisition
B. PRE PROCESSING
The pair of images is preprocessed it by the alignment
process. The main process of the preprocessing is used to
separate the meaningful features. The academic community
has achieved fruitful breakthroughs in the field of brain
image in the past few decades. Processingchainisde-noising
medical thresholding techniques in noise presence for
various wavelet families. We applied Haar, Symlet, Morlet,
and Daubechies in de-noising MRI brain images.
Performance estimationand analysisareaccomplishedusing
Signal to Noise Ratio (SNR), Peak Signal to Noise Ratio
(PSNR) and Mean Square Error (MSE). We are using
wavelets to de-noise images. In medical images, edges are
places where the image brightness changesfast.Maintaining
edges while de-noising an image is severely important for
initiative quality. Traditional low pass filtering removes
noise, it often smoothensedgesandinfluencesimagequality.
Wavelets are able to remove noise while maintaining
important features. From the obtained results it can be
confirmed that the wavelets with higher level tend to give
good result. Since the SNR value correspondingtothehigher
level. The same goes for Symlet wavelets. While the best
result are obtained using the Haar wavelets, with highest
SNR value, least MSE and least entropy. It can be conclude
from above results that the wavelet that are higher level
show better results.
Fig3. Preprocessing
C. IMAGE SEGMENTATION
The segmentation method is described using its free
parametric character and unsupervised nature of threshold
choice and has the following benefits like the process is very
easy but only the zeroth and first ordercumulativemoments
of the Greylevel histogram are used. Wecanapplythesimple
extension to multi thresholding problems that is possible by
the criteria on which the method is based, we can
automatically selecting an optimal threshold or set of
threshold, that are not based on the diffraction (i.e. a local
property such as valley) but on the integration (i.e. global
property) of the histogram.
We can also analyze other aspects for example evaluation of
class separabality, estimation of class mean levels, etc. We
are able to underline the generality of themethod,itcoversa
large unsupervised decision procedure. That is used to
automatically perform clustering- basedimagethresholding
or reduction of grey-level image to a binary image in
computer vision and image processing. The algorithm
presumes that the image contains two classes of pixels
following bimodal histogram, it then calculatestheoptimum
threshold separating the two classes so that their mixed
expansion is minimal, or uniformly so that their inter class
variance is maximal.
International Journal of Trend in Scientific Research and Development (IJTSRD) @ www.ijtsrd.com eISSN: 2456-6470
@ IJTSRD | Unique Paper ID – IJTSRD30192 | Volume – 4 | Issue – 2 | January-February 2020 Page 1012
Fig4. Image Segmentation
D. IMAGE CLASSIFICATION
The classification method is used to classify the object easily
so we are detecting the object accurately. Then this method
is used to classify the disease accurately and refining a
background objects accurately. Our data hasspecificallytwo
classes we can use a support vector machine (SVM). We are
using a set of new MRI brain images. Finding the best hyper
plane that detaches all data points of one class those of the
other class means correct data classification using SVM
methods. Establishing the best hyper plane for an SVM
means the one with the largest margin between the two
classes.
The maximal width of the plate parallel to the hyper plane
that has no interior data points determine the margin.
Complicated binary classification problems do not have a
simple hyper plane as a useful separating criterion. There is
a variant of the mathematical approach that retains nearly
all the simplicity of an SVM separating hyper plane for those
problems.
Fig4. Image Classification
E. FEATURE EXTRACTION
This method is used to predict disease accurately. This
system identify from the MRI image at the brain is normal or
affected. Then the useful disease prediction from the brain
images then it provides the range of disease level. We
remove the average pooling layers from the pre-trained
model and add auxiliary convolution layers to detect large
sizes of objects. It will not be surprising for getting a better
result after adding a top-down structure inFGstage,butthat
is beyond the scope of this paper.
Fig5. Feature Extraction
IV. CONCLUSION
The brain tumor detection and classification system is
implemented using CWT, DWT and SVMs. The result shows
that SVMs having the proper sets of training data are able to
distinguish between abnormal and normal tumor regions
and classify them correctly as a benign tumor, malign tumor
or healthy brain. In practice, SVMs have significant
computational advantages Five times improvement in
computation speed (22 vs. 110 ms) for our proposed
method.
This classification is very important for the physician in
establishing a precise diagnostic and recommending a
correct further treatment. If we are interested in de-noising,
compression, restoration, then DWT is often more
appropriate. A hybrid approach is recommended in solving
properly the detection and classification problems in brain
tumors. Our method is used to predict the diseases
accurately. Then these methods are used to predict the
disease is affected or not affected by using a comparison
method. These methodology are validated by a
comprehensive set of comparisons against competing and
well-established image registration methods, by using real
medical datasets and classic measurestypicallyemployedas
a benchmark by the medical imaging community our
proposed method is mostly used in medical field.itisused to
easily detect the diseases.
REFERENCE
[1] Wang. G, Xu .J, Dong. Q, and Pan. Z, “Active contour
model coupling with higher order diffusionformedical
image segmentation,” International Journal of
Biomedical Imaging, vol. 2014, Article ID 237648, 8
pages, 2014.
[2] Oo. S. Z and Khaing. A. S, “Brain tumor detection and
segmentation using watershed segmentation and
morphological operation,” International Journal of
Research in Engineering and Technology, vol.3, no. 3,
pp. 367–374, 2014.
[3] Zanaty. E. A, “Determination of gray matter (GM) and
white matter (WM) volume in brain magnetic
resonance images (MRI),” International Journal of
Computer Applications, vol. 45, pp. 16–22, 2012.
[4] Madhukumar. S and Santhiyakumari. N, “Evaluation of
k-means and fuzzy c-means segmentation on MR
images of brain, “Egyptian Journal of Radiology and
Nuclear medicine, vol.46, no.2, pp.475-479, 2015.
[5] Rajendran. PandMadheswaran.M,“Prunedassociative
classification technique for the medical image
diagnosis system,” in Proceedings of the 2nd
International Conference on Machine Vision (ICMV
'09), pp. 293–297, Dubai, UAE, December 2009
[6] Sachdeva. J, Kumar. V, Gupta .I, Khandelwal. N, and
Ahuja. C. K, “Segmentation, feature extraction, and
multiclass brain tumor classification,” Journal ofDigital
Imaging, vol. 26, no. 6, pp. 1141– 1150, 2013.
[7] Gordillo. N, Montseny. E, and Sobrevilla .P, “State ofthe
art survey on MRI brain tumor segmentation,”
Magnetic Resonance Imaging, vol. 31, no.8, pp.1426–
1438, 2013.

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Tumor Detection and Classification of MRI Brain Images using SVM and DNN

  • 1. International Journal of Trend in Scientific Research and Development (IJTSRD) Volume 4 Issue 2, February 2020 Available Online: www.ijtsrd.com e-ISSN: 2456 – 6470 @ IJTSRD | Unique Paper ID – IJTSRD30192 | Volume – 4 | Issue – 2 | January-February 2020 Page 1010 Tumor Detection and Classification of MRI Brain Images using SVM and DNN Sanmathi. R1, Sujitha. K1, Susmitha. G1, Gnanasekaran. S2 1Student, 2Associate Professor, 1,2Department of Electronics and Communication Engineering, 1,2Paavai Engineering College, Namakkal, Tamil Nadu, India ABSTRACT The brain is one of the most complex organ in the human body that works with billions of cells. A cerebral tumor occurs when there is an uncontrolled division of cells that form an abnormal group of cells around or within the brain. This cell group can affect the normal functioning of brain activity and can destroy healthy cells. Brain tumors are classified as benign or low-grade (Grade 1 and 2) and malignant tumors or high-grade (Grade 3 and 4). The proposed methodology aims to differentiate betweennormal brainandtumor brain (Benign or Melign). The proposed method in this paper is automated framework for differentiate between normal brain and tumor brain. Thenour method is used to predict the diseases accurately. Then these methods are used to predict the disease is affected or not by using a comparison method. These methodology are validated by a comprehensive set of comparison against competing and well established image registration methods, by using real medical data sets and classic measures typically employed as a benchmark by the medical imaging community our proposed method is mostly used in medical field. It is used to easily detect the diseases. We demonstrate the accuracy and effectiveness of the preset framework throughout a comprehensive set of qualitative comparisons against several influential state-of-the-art methods on various brain image databases. KEYWORDS: Benign, Melign, Acquisition, Pre-processing, Segmentation, Classification, Extraction How to cite this paper: Sanmathi. R | Sujitha. K | Susmitha. G | Gnanasekaran. S "Tumor Detection and Classification of MRI Brain Images using SVM and DNN" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456- 6470, Volume-4 | Issue-2, February 2020, pp.1010-1012, URL: www.ijtsrd.com/papers/ijtsrd30192.pdf Copyright © 2019 by author(s) and International Journal ofTrendinScientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative CommonsAttribution License (CC BY 4.0) (http://creativecommons.org/licenses/by /4.0) I. INRODUCTION MRI is an extensively used technique which facilitates the diagnosis and prognosis of brain tumors in many neurological diseases and conditions. Standard MRI sequences are generally used to differentiate between different types of brain tumors based on visual qualities and contrast texture analysis of the soft tissue. More than 120 classes of brain tumors are known to be classified in four levels according to the level malignancy by the WorldHealth Organization (WHO). The grading from low to high (1-4)are malignant levels from the least aggressive biological tumor to the most aggressive tumors, as shown by histological criteria, for example, vascularity, invasiveness, and tumor growth rate. Gliomas are the most primary cerebral tumor and a pretreatment evaluation grade is necessary; however, the exclusive use of standard MRI sequences may be insufficient for a precise diagnosis. As the support vector machines architectures are becoming more mature, they gradually outperform previous state-of-the-art classical machine learning algorithms. The literature survey has revealed that some of the techniques are invented to obtain segmentation only; some of the techniques are invented to obtain feature extraction and some of the techniques are invented to obtain classification only. Tumor is an uncontrolled growth of cancer cells in any part of the body. Tumors are of different types and have different characteristics and different treatments. At present, the brain tumors are classified as: primary brain tumors and metastatic brain tumors. The former begin in the brain and tend to stay in the brain, the latter begin as a cancer elsewhere in the body and spreading to the brain. Brain tumors are divided into two types: benign and malignant. In fact, the most widely used grading scheme has been issued by the World Health Organization (WHO). It classifies brain tumors into grade I to IV under the microscope. In general, grade I and grade II are benign brain tumor (low-grade); grade III and grade IV are malignant brain tumor (high- grade). Usually, if low-grade brain tumor is not treated, it is likely to deteriorate to high-grade brain tumor. Therefore, brain tumor are seriously endangering people’s lives and early discovery and treatment have become a necessity. Along with the advance of medical imaging, imaging modalities play an important role in the evaluation of patients with brain tumors and have a significant impact on patient care. Recent years, the emerging new imaging modalities, such as XRay, Ultrasonography, Computed Tomography (CT), Magneto Encephalo Graphy (MEG), Electro Encephalo Graphy (EEG), Positron Emission Tomography (PET), Single-Photon Emission Computed Tomography (SPECT), and Magnetic Resonance Imaging (MRI), not only show the detailed and complete aspects of IJTSRD30192
  • 2. International Journal of Trend in Scientific Research and Development (IJTSRD) @ www.ijtsrd.com eISSN: 2456-6470 @ IJTSRD | Unique Paper ID – IJTSRD30192 | Volume – 4 | Issue – 2 | January-February 2020 Page 1011 brain tumors, but also improve clinical doctors to study the mechanism of brain tumors at the aim of better treatment. Clinical doctors play an important role in brain tumor assessment and therapy. This information is very important and critical in deciding between the different forms of therapy such as surgery, radiation, and chemotherapy. Therefore, the evaluation of brain tumors with imaging modalities is now one of the key issues of radiology departments. II. PROPOSED SYSTEM In this project we discuss about the brain tumors disease detection by using a method at MRI images.Nowadays many peoples are affected at more Brain cell tumor disease. So using that situation many doctors and hospitals are easily theft more money from patients. The common peoples are mostly affected by this problem. We propose the method is used to predict the disease accurately. Then it detect all the Brain tumor disease easily. That is used to detect all the brain cell related diseases and its provide more accuracy. Then the detection of brain tumor disease at less computation time. Our proposed method is used to predict all the brain cell related diseases like that Tumors. They are easily detected and its used accurately identify the diseases in less processing time. Fig1. Block Diagram III. SOFTWARE IMPLEMENTATION A. DATA ACQUISITION The disease affected image or not affected images are captured from camera or to upload the images. It is used to upload the pair of input images. However, it differs from conventional methods by using thermal images as input. Fig2. Data acquisition B. PRE PROCESSING The pair of images is preprocessed it by the alignment process. The main process of the preprocessing is used to separate the meaningful features. The academic community has achieved fruitful breakthroughs in the field of brain image in the past few decades. Processingchainisde-noising medical thresholding techniques in noise presence for various wavelet families. We applied Haar, Symlet, Morlet, and Daubechies in de-noising MRI brain images. Performance estimationand analysisareaccomplishedusing Signal to Noise Ratio (SNR), Peak Signal to Noise Ratio (PSNR) and Mean Square Error (MSE). We are using wavelets to de-noise images. In medical images, edges are places where the image brightness changesfast.Maintaining edges while de-noising an image is severely important for initiative quality. Traditional low pass filtering removes noise, it often smoothensedgesandinfluencesimagequality. Wavelets are able to remove noise while maintaining important features. From the obtained results it can be confirmed that the wavelets with higher level tend to give good result. Since the SNR value correspondingtothehigher level. The same goes for Symlet wavelets. While the best result are obtained using the Haar wavelets, with highest SNR value, least MSE and least entropy. It can be conclude from above results that the wavelet that are higher level show better results. Fig3. Preprocessing C. IMAGE SEGMENTATION The segmentation method is described using its free parametric character and unsupervised nature of threshold choice and has the following benefits like the process is very easy but only the zeroth and first ordercumulativemoments of the Greylevel histogram are used. Wecanapplythesimple extension to multi thresholding problems that is possible by the criteria on which the method is based, we can automatically selecting an optimal threshold or set of threshold, that are not based on the diffraction (i.e. a local property such as valley) but on the integration (i.e. global property) of the histogram. We can also analyze other aspects for example evaluation of class separabality, estimation of class mean levels, etc. We are able to underline the generality of themethod,itcoversa large unsupervised decision procedure. That is used to automatically perform clustering- basedimagethresholding or reduction of grey-level image to a binary image in computer vision and image processing. The algorithm presumes that the image contains two classes of pixels following bimodal histogram, it then calculatestheoptimum threshold separating the two classes so that their mixed expansion is minimal, or uniformly so that their inter class variance is maximal.
  • 3. International Journal of Trend in Scientific Research and Development (IJTSRD) @ www.ijtsrd.com eISSN: 2456-6470 @ IJTSRD | Unique Paper ID – IJTSRD30192 | Volume – 4 | Issue – 2 | January-February 2020 Page 1012 Fig4. Image Segmentation D. IMAGE CLASSIFICATION The classification method is used to classify the object easily so we are detecting the object accurately. Then this method is used to classify the disease accurately and refining a background objects accurately. Our data hasspecificallytwo classes we can use a support vector machine (SVM). We are using a set of new MRI brain images. Finding the best hyper plane that detaches all data points of one class those of the other class means correct data classification using SVM methods. Establishing the best hyper plane for an SVM means the one with the largest margin between the two classes. The maximal width of the plate parallel to the hyper plane that has no interior data points determine the margin. Complicated binary classification problems do not have a simple hyper plane as a useful separating criterion. There is a variant of the mathematical approach that retains nearly all the simplicity of an SVM separating hyper plane for those problems. Fig4. Image Classification E. FEATURE EXTRACTION This method is used to predict disease accurately. This system identify from the MRI image at the brain is normal or affected. Then the useful disease prediction from the brain images then it provides the range of disease level. We remove the average pooling layers from the pre-trained model and add auxiliary convolution layers to detect large sizes of objects. It will not be surprising for getting a better result after adding a top-down structure inFGstage,butthat is beyond the scope of this paper. Fig5. Feature Extraction IV. CONCLUSION The brain tumor detection and classification system is implemented using CWT, DWT and SVMs. The result shows that SVMs having the proper sets of training data are able to distinguish between abnormal and normal tumor regions and classify them correctly as a benign tumor, malign tumor or healthy brain. In practice, SVMs have significant computational advantages Five times improvement in computation speed (22 vs. 110 ms) for our proposed method. This classification is very important for the physician in establishing a precise diagnostic and recommending a correct further treatment. If we are interested in de-noising, compression, restoration, then DWT is often more appropriate. A hybrid approach is recommended in solving properly the detection and classification problems in brain tumors. Our method is used to predict the diseases accurately. Then these methods are used to predict the disease is affected or not affected by using a comparison method. These methodology are validated by a comprehensive set of comparisons against competing and well-established image registration methods, by using real medical datasets and classic measurestypicallyemployedas a benchmark by the medical imaging community our proposed method is mostly used in medical field.itisused to easily detect the diseases. REFERENCE [1] Wang. G, Xu .J, Dong. Q, and Pan. Z, “Active contour model coupling with higher order diffusionformedical image segmentation,” International Journal of Biomedical Imaging, vol. 2014, Article ID 237648, 8 pages, 2014. [2] Oo. S. Z and Khaing. A. S, “Brain tumor detection and segmentation using watershed segmentation and morphological operation,” International Journal of Research in Engineering and Technology, vol.3, no. 3, pp. 367–374, 2014. [3] Zanaty. E. A, “Determination of gray matter (GM) and white matter (WM) volume in brain magnetic resonance images (MRI),” International Journal of Computer Applications, vol. 45, pp. 16–22, 2012. [4] Madhukumar. S and Santhiyakumari. N, “Evaluation of k-means and fuzzy c-means segmentation on MR images of brain, “Egyptian Journal of Radiology and Nuclear medicine, vol.46, no.2, pp.475-479, 2015. [5] Rajendran. PandMadheswaran.M,“Prunedassociative classification technique for the medical image diagnosis system,” in Proceedings of the 2nd International Conference on Machine Vision (ICMV '09), pp. 293–297, Dubai, UAE, December 2009 [6] Sachdeva. J, Kumar. V, Gupta .I, Khandelwal. N, and Ahuja. C. K, “Segmentation, feature extraction, and multiclass brain tumor classification,” Journal ofDigital Imaging, vol. 26, no. 6, pp. 1141– 1150, 2013. [7] Gordillo. N, Montseny. E, and Sobrevilla .P, “State ofthe art survey on MRI brain tumor segmentation,” Magnetic Resonance Imaging, vol. 31, no.8, pp.1426– 1438, 2013.