SlideShare a Scribd company logo
1 of 18
VESICULAR STOMATITIS
AUTHOR:
DR. IHTISHAM UL HAQ
VESICULAR STOMATITIS
VESICULAR STOMATITIS
 It is a disease in which vesicle formation
and inflammation of mucus membrane
of oral cavity occurs
 Vesicles means small elevated
circumscribe area having serous fluid
 While pustule have pus and elevated
circumscribed area
ETIOLOGY
 It is a viral disease caused
by VS virus belongs to
genus vesicular virus,
family Rabdoviridae.
 It is a bullet shape and
RNA virus
 The virus is susceptible to
environmental influences
 It is a fragile virus.
 Common antiseptics can
be used i.e povidone
iodine,KMNO4 etc to kill
the virus.
EPIDEMOLOGY
 WHO:
 It is important disease of Horses &
Cattles.It can also affect
Camel,Pig,Human,Sheep & Goat.
 WHERE:
 Disease is limited to western
hemisphere, It is pandemic in
Mexico,Panama,USA ,venzuella &
Brazil.
Cont…
 WHEN:
 Disease occurs in summer & autumn.
 TRANSMISSION:
 Mainly occurs through insects i.e Blck flies
& sand fly (biological vectors).
 Mechanically disease can be transmitted
through direct contact or close indirect
contact.
 Mortality: Nil in horses, 5% in cattle.
 Morbidity: 10-20%.
PATHOGENESIS
Entry of the virus to body--- through blood
virus disseminate to different organs/tissues
but predilection site include mucosal
membrane of oral cavity, skin at interdigital
cleft& skin of teat--- virus replicates there
forming vesicles------  vesicles ruptures
forming ulcers-----  ulcers recovers within
10days if no secondary bacterial infection is
there-----  clinical signs appears
CLINICAL FINDINGS
 Fever{mild}
 Vesicles in mouth,tounge, lips,
dental pad
 Ulcer in feet and teat
 Salivation
 Lesions in teats may lead to secondary
mastitis
 Anorexia
DIAGNOSIS
On the basis of signs and symptoms
Confirmatory diagnosis by Lab test
It includes
PCR
Eliza
CFT
DIFFERENTIAL
DIAGNOSIS
 FMD:
 DIFFERENTIAL POINTS:
 In case of FMD high fever while in VS mild
fever is there
 FMD effects only cloven hooved animals
while in case of VS equines are also
effected
 Incase of FMD morbidly and mortality rate
is higher while low in VS
 Abortion also occurs in FMD
 In FMD young animals are more fatel.
 BVD:
 DIFFERENTIAL POINTS:
 It involves GIT, so there will be diarrhea,
abortion, early embryonic mortality,
congenital malformation while BVD only
effects bovine
CONT…
 MCF:
 DIFFERENTIAL POINTS:
 In FMD there is swelling of lymph nodes
while no swelling of LN in MCF
 MCF cause corneal opacity while no
corneal opacity in VS
 COW POX
 DIFFERENTIAL POINTS:
 Scabby lesions in pox while in VS
ulcerative lesions are present
 BLUE TONGUE
 DIFFERENTIAL POINTS:
 Diarrhea
 Cynotic tongue in BT
 RINDERPEST:
 DIFFERENTIAL POINTS:
 Necrotic stomatitis in rinderpest while in
VS the lesions are vesicular.
 Shooting diarrhea in rinderpest
 PPR:
 DIFFERENTIAL POINTS:
 Necrotic stomatitis in PPR
 Diarrhea in PPR
 Pneumonia in PPR while no pneumonia
in VS
 ORF
 DIFFERENTIAL POINTS:
 Scabby lesions in orf
 Lesions are proliferative
TREATMENT
 Since it is viral infection so no
specific treatment is given,
supportive therapy is given to
control infection;
 Broad spectrum antibiotics
 {amoxicllin,ampicillin,
gentamycin, oxytetracycline,
enrofloxacin etc}
 NSAIDS
 {Flunixin meglumin}
This Photo by Unknown Author is licensed under CC BY-SA-NC
 FLUID therapy
 Ringer lectate
 Topical antiseptics
 KMno4
 multivitamins
PREVENTION
 Control of insects by use of
insecticides like;
 Nagavan, sagavan, tegafon
 Use of ivermectin, cypermethrin
 Qurantine measures
 Vaccination not effective
 Isolation of sick animals
 Maintain hygienic and control condition.

More Related Content

What's hot

MDL 237 - Miscellaneous obligate intracellular bacteria
MDL 237 - Miscellaneous obligate intracellular bacteriaMDL 237 - Miscellaneous obligate intracellular bacteria
MDL 237 - Miscellaneous obligate intracellular bacteria
degarden
 
Viral & Bacterial Infections 2
Viral & Bacterial  Infections 2Viral & Bacterial  Infections 2
Viral & Bacterial Infections 2
MD Specialclass
 

What's hot (20)

Viral infections / 4th stage students / Dr. Alaa Awn
Viral infections / 4th stage students / Dr. Alaa AwnViral infections / 4th stage students / Dr. Alaa Awn
Viral infections / 4th stage students / Dr. Alaa Awn
 
Lect 6 a measles, mumps and rubella
Lect 6 a measles, mumps and rubellaLect 6 a measles, mumps and rubella
Lect 6 a measles, mumps and rubella
 
Infectious Bursal Disease Gumboro
Infectious Bursal Disease   GumboroInfectious Bursal Disease   Gumboro
Infectious Bursal Disease Gumboro
 
21. pox and herpes virus
21. pox and herpes virus21. pox and herpes virus
21. pox and herpes virus
 
Vericella zoster infection And Rubeola Virus
Vericella zoster infection And Rubeola VirusVericella zoster infection And Rubeola Virus
Vericella zoster infection And Rubeola Virus
 
Parvoviruses
ParvovirusesParvoviruses
Parvoviruses
 
Leishmaniasis (Kala Azar)
Leishmaniasis (Kala Azar)Leishmaniasis (Kala Azar)
Leishmaniasis (Kala Azar)
 
MDL 237 - Miscellaneous obligate intracellular bacteria
MDL 237 - Miscellaneous obligate intracellular bacteriaMDL 237 - Miscellaneous obligate intracellular bacteria
MDL 237 - Miscellaneous obligate intracellular bacteria
 
Orf infection
Orf infectionOrf infection
Orf infection
 
Poxviruses
PoxvirusesPoxviruses
Poxviruses
 
Chickenpox and smallpox
Chickenpox  and  smallpoxChickenpox  and  smallpox
Chickenpox and smallpox
 
Paramyxovirus
ParamyxovirusParamyxovirus
Paramyxovirus
 
Viral infections of Oral Cavity
Viral infections of Oral CavityViral infections of Oral Cavity
Viral infections of Oral Cavity
 
Viral & Bacterial Infections 2
Viral & Bacterial  Infections 2Viral & Bacterial  Infections 2
Viral & Bacterial Infections 2
 
Leishmaniasis
Leishmaniasis Leishmaniasis
Leishmaniasis
 
Infectious Bursal Disease
Infectious Bursal DiseaseInfectious Bursal Disease
Infectious Bursal Disease
 
Viral infections (oral cavity)
Viral infections (oral cavity)   Viral infections (oral cavity)
Viral infections (oral cavity)
 
Pox virus
Pox virusPox virus
Pox virus
 
Viruses of relevance to dentistry
Viruses of relevance to dentistryViruses of relevance to dentistry
Viruses of relevance to dentistry
 
Genus morbillivirus
Genus morbillivirusGenus morbillivirus
Genus morbillivirus
 

Similar to Vesicular stomatitis

Similar to Vesicular stomatitis (20)

Malignant catarrhal fever
Malignant catarrhal feverMalignant catarrhal fever
Malignant catarrhal fever
 
Viral diseases.pptx
Viral diseases.pptxViral diseases.pptx
Viral diseases.pptx
 
Viral diseases in crustaceans
Viral diseases in crustaceansViral diseases in crustaceans
Viral diseases in crustaceans
 
Pox diseases
Pox diseasesPox diseases
Pox diseases
 
Viral skin-diseases
Viral skin-diseasesViral skin-diseases
Viral skin-diseases
 
Presentation6
Presentation6Presentation6
Presentation6
 
Ulcerative and infective vesiculobullous lesions
Ulcerative and infective vesiculobullous lesionsUlcerative and infective vesiculobullous lesions
Ulcerative and infective vesiculobullous lesions
 
FOOT AND MOUTH DISEASE ( FMD)
FOOT AND MOUTH DISEASE ( FMD)FOOT AND MOUTH DISEASE ( FMD)
FOOT AND MOUTH DISEASE ( FMD)
 
Bovine Viral Diarrhea
Bovine Viral DiarrheaBovine Viral Diarrhea
Bovine Viral Diarrhea
 
YERSINIA .pptx
YERSINIA                           .pptxYERSINIA                           .pptx
YERSINIA .pptx
 
POXVIRUSES.ppt
POXVIRUSES.pptPOXVIRUSES.ppt
POXVIRUSES.ppt
 
Vesicular stomatitis (تشخيصات
Vesicular stomatitis (تشخيصات Vesicular stomatitis (تشخيصات
Vesicular stomatitis (تشخيصات
 
Chickenpox Disease Project (1).pdf
Chickenpox Disease Project (1).pdfChickenpox Disease Project (1).pdf
Chickenpox Disease Project (1).pdf
 
SMALLPOX ( Pathophysiology and Health Education Presentation )
SMALLPOX ( Pathophysiology and Health Education Presentation ) SMALLPOX ( Pathophysiology and Health Education Presentation )
SMALLPOX ( Pathophysiology and Health Education Presentation )
 
Babesiosis
BabesiosisBabesiosis
Babesiosis
 
ARI & Influenza.pptx
ARI & Influenza.pptxARI & Influenza.pptx
ARI & Influenza.pptx
 
Ibd in poultry
Ibd in poultryIbd in poultry
Ibd in poultry
 
Camel pox
Camel poxCamel pox
Camel pox
 
Infectious diseases of the skin and wound
Infectious diseases of the skin and woundInfectious diseases of the skin and wound
Infectious diseases of the skin and wound
 
WSSV Aquaculture.pptx
WSSV Aquaculture.pptxWSSV Aquaculture.pptx
WSSV Aquaculture.pptx
 

More from ihtisham114 (7)

coccidiosis.pptx
coccidiosis.pptxcoccidiosis.pptx
coccidiosis.pptx
 
Lab animal husbandry
Lab animal husbandryLab animal husbandry
Lab animal husbandry
 
Tympany
TympanyTympany
Tympany
 
Ppr
PprPpr
Ppr
 
Enucleation of eye
Enucleation of eyeEnucleation of eye
Enucleation of eye
 
Classification of veterinary protozoans
Classification of veterinary protozoansClassification of veterinary protozoans
Classification of veterinary protozoans
 
Hypersensitivity
Hypersensitivity Hypersensitivity
Hypersensitivity
 

Recently uploaded

❤️ Chandigarh Call Girls☎️98151-579OO☎️ Call Girl service in Chandigarh ☎️ Ch...
❤️ Chandigarh Call Girls☎️98151-579OO☎️ Call Girl service in Chandigarh ☎️ Ch...❤️ Chandigarh Call Girls☎️98151-579OO☎️ Call Girl service in Chandigarh ☎️ Ch...
❤️ Chandigarh Call Girls☎️98151-579OO☎️ Call Girl service in Chandigarh ☎️ Ch...
Rashmi Entertainment
 
Call Girl in Chennai | Whatsapp No 📞 7427069034 📞 VIP Escorts Service Availab...
Call Girl in Chennai | Whatsapp No 📞 7427069034 📞 VIP Escorts Service Availab...Call Girl in Chennai | Whatsapp No 📞 7427069034 📞 VIP Escorts Service Availab...
Call Girl in Chennai | Whatsapp No 📞 7427069034 📞 VIP Escorts Service Availab...
amritaverma53
 
Guntur Call Girl Service 📞6297126446📞Just Call Divya📲 Call Girl In Guntur No ...
Guntur Call Girl Service 📞6297126446📞Just Call Divya📲 Call Girl In Guntur No ...Guntur Call Girl Service 📞6297126446📞Just Call Divya📲 Call Girl In Guntur No ...
Guntur Call Girl Service 📞6297126446📞Just Call Divya📲 Call Girl In Guntur No ...
Call Girls in Nagpur High Profile Call Girls
 
Cara Menggugurkan Kandungan Dengan Cepat Selesai Dalam 24 Jam Secara Alami Bu...
Cara Menggugurkan Kandungan Dengan Cepat Selesai Dalam 24 Jam Secara Alami Bu...Cara Menggugurkan Kandungan Dengan Cepat Selesai Dalam 24 Jam Secara Alami Bu...
Cara Menggugurkan Kandungan Dengan Cepat Selesai Dalam 24 Jam Secara Alami Bu...
Cara Menggugurkan Kandungan 087776558899
 

Recently uploaded (20)

Bhawanipatna Call Girls 📞9332606886 Call Girls in Bhawanipatna Escorts servic...
Bhawanipatna Call Girls 📞9332606886 Call Girls in Bhawanipatna Escorts servic...Bhawanipatna Call Girls 📞9332606886 Call Girls in Bhawanipatna Escorts servic...
Bhawanipatna Call Girls 📞9332606886 Call Girls in Bhawanipatna Escorts servic...
 
💰Call Girl In Bangalore☎️63788-78445💰 Call Girl service in Bangalore☎️Bangalo...
💰Call Girl In Bangalore☎️63788-78445💰 Call Girl service in Bangalore☎️Bangalo...💰Call Girl In Bangalore☎️63788-78445💰 Call Girl service in Bangalore☎️Bangalo...
💰Call Girl In Bangalore☎️63788-78445💰 Call Girl service in Bangalore☎️Bangalo...
 
❤️ Chandigarh Call Girls☎️98151-579OO☎️ Call Girl service in Chandigarh ☎️ Ch...
❤️ Chandigarh Call Girls☎️98151-579OO☎️ Call Girl service in Chandigarh ☎️ Ch...❤️ Chandigarh Call Girls☎️98151-579OO☎️ Call Girl service in Chandigarh ☎️ Ch...
❤️ Chandigarh Call Girls☎️98151-579OO☎️ Call Girl service in Chandigarh ☎️ Ch...
 
Indore Call Girls ❤️🍑7718850664❤️🍑 Call Girl service in Indore ☎️ Indore Call...
Indore Call Girls ❤️🍑7718850664❤️🍑 Call Girl service in Indore ☎️ Indore Call...Indore Call Girls ❤️🍑7718850664❤️🍑 Call Girl service in Indore ☎️ Indore Call...
Indore Call Girls ❤️🍑7718850664❤️🍑 Call Girl service in Indore ☎️ Indore Call...
 
ANATOMY AND PHYSIOLOGY OF REPRODUCTIVE SYSTEM.pptx
ANATOMY AND PHYSIOLOGY OF REPRODUCTIVE SYSTEM.pptxANATOMY AND PHYSIOLOGY OF REPRODUCTIVE SYSTEM.pptx
ANATOMY AND PHYSIOLOGY OF REPRODUCTIVE SYSTEM.pptx
 
Call Girl in Chennai | Whatsapp No 📞 7427069034 📞 VIP Escorts Service Availab...
Call Girl in Chennai | Whatsapp No 📞 7427069034 📞 VIP Escorts Service Availab...Call Girl in Chennai | Whatsapp No 📞 7427069034 📞 VIP Escorts Service Availab...
Call Girl in Chennai | Whatsapp No 📞 7427069034 📞 VIP Escorts Service Availab...
 
Call girls Service Phullen / 9332606886 Genuine Call girls with real Photos a...
Call girls Service Phullen / 9332606886 Genuine Call girls with real Photos a...Call girls Service Phullen / 9332606886 Genuine Call girls with real Photos a...
Call girls Service Phullen / 9332606886 Genuine Call girls with real Photos a...
 
Guntur Call Girl Service 📞6297126446📞Just Call Divya📲 Call Girl In Guntur No ...
Guntur Call Girl Service 📞6297126446📞Just Call Divya📲 Call Girl In Guntur No ...Guntur Call Girl Service 📞6297126446📞Just Call Divya📲 Call Girl In Guntur No ...
Guntur Call Girl Service 📞6297126446📞Just Call Divya📲 Call Girl In Guntur No ...
 
Call Girls Kathua Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Kathua Just Call 8250077686 Top Class Call Girl Service AvailableCall Girls Kathua Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Kathua Just Call 8250077686 Top Class Call Girl Service Available
 
Call Girls Service Jaipur {9521753030 } ❤️VVIP BHAWNA Call Girl in Jaipur Raj...
Call Girls Service Jaipur {9521753030 } ❤️VVIP BHAWNA Call Girl in Jaipur Raj...Call Girls Service Jaipur {9521753030 } ❤️VVIP BHAWNA Call Girl in Jaipur Raj...
Call Girls Service Jaipur {9521753030 } ❤️VVIP BHAWNA Call Girl in Jaipur Raj...
 
Call Girls in Lucknow Just Call 👉👉8630512678 Top Class Call Girl Service Avai...
Call Girls in Lucknow Just Call 👉👉8630512678 Top Class Call Girl Service Avai...Call Girls in Lucknow Just Call 👉👉8630512678 Top Class Call Girl Service Avai...
Call Girls in Lucknow Just Call 👉👉8630512678 Top Class Call Girl Service Avai...
 
Cardiac Output, Venous Return, and Their Regulation
Cardiac Output, Venous Return, and Their RegulationCardiac Output, Venous Return, and Their Regulation
Cardiac Output, Venous Return, and Their Regulation
 
Call Girls Bangalore - 450+ Call Girl Cash Payment 💯Call Us 🔝 6378878445 🔝 💃 ...
Call Girls Bangalore - 450+ Call Girl Cash Payment 💯Call Us 🔝 6378878445 🔝 💃 ...Call Girls Bangalore - 450+ Call Girl Cash Payment 💯Call Us 🔝 6378878445 🔝 💃 ...
Call Girls Bangalore - 450+ Call Girl Cash Payment 💯Call Us 🔝 6378878445 🔝 💃 ...
 
(RIYA)🎄Airhostess Call Girl Jaipur Call Now 8445551418 Premium Collection Of ...
(RIYA)🎄Airhostess Call Girl Jaipur Call Now 8445551418 Premium Collection Of ...(RIYA)🎄Airhostess Call Girl Jaipur Call Now 8445551418 Premium Collection Of ...
(RIYA)🎄Airhostess Call Girl Jaipur Call Now 8445551418 Premium Collection Of ...
 
Race Course Road } Book Call Girls in Bangalore | Whatsapp No 6378878445 VIP ...
Race Course Road } Book Call Girls in Bangalore | Whatsapp No 6378878445 VIP ...Race Course Road } Book Call Girls in Bangalore | Whatsapp No 6378878445 VIP ...
Race Course Road } Book Call Girls in Bangalore | Whatsapp No 6378878445 VIP ...
 
Call Girls Rishikesh Just Call 9667172968 Top Class Call Girl Service Available
Call Girls Rishikesh Just Call 9667172968 Top Class Call Girl Service AvailableCall Girls Rishikesh Just Call 9667172968 Top Class Call Girl Service Available
Call Girls Rishikesh Just Call 9667172968 Top Class Call Girl Service Available
 
Cara Menggugurkan Kandungan Dengan Cepat Selesai Dalam 24 Jam Secara Alami Bu...
Cara Menggugurkan Kandungan Dengan Cepat Selesai Dalam 24 Jam Secara Alami Bu...Cara Menggugurkan Kandungan Dengan Cepat Selesai Dalam 24 Jam Secara Alami Bu...
Cara Menggugurkan Kandungan Dengan Cepat Selesai Dalam 24 Jam Secara Alami Bu...
 
Call Girls in Lucknow Just Call 👉👉 8875999948 Top Class Call Girl Service Ava...
Call Girls in Lucknow Just Call 👉👉 8875999948 Top Class Call Girl Service Ava...Call Girls in Lucknow Just Call 👉👉 8875999948 Top Class Call Girl Service Ava...
Call Girls in Lucknow Just Call 👉👉 8875999948 Top Class Call Girl Service Ava...
 
Call 8250092165 Patna Call Girls ₹4.5k Cash Payment With Room Delivery
Call 8250092165 Patna Call Girls ₹4.5k Cash Payment With Room DeliveryCall 8250092165 Patna Call Girls ₹4.5k Cash Payment With Room Delivery
Call 8250092165 Patna Call Girls ₹4.5k Cash Payment With Room Delivery
 
Chennai ❣️ Call Girl 6378878445 Call Girls in Chennai Escort service book now
Chennai ❣️ Call Girl 6378878445 Call Girls in Chennai Escort service book nowChennai ❣️ Call Girl 6378878445 Call Girls in Chennai Escort service book now
Chennai ❣️ Call Girl 6378878445 Call Girls in Chennai Escort service book now
 

Vesicular stomatitis

  • 3. VESICULAR STOMATITIS  It is a disease in which vesicle formation and inflammation of mucus membrane of oral cavity occurs  Vesicles means small elevated circumscribe area having serous fluid  While pustule have pus and elevated circumscribed area
  • 4. ETIOLOGY  It is a viral disease caused by VS virus belongs to genus vesicular virus, family Rabdoviridae.  It is a bullet shape and RNA virus  The virus is susceptible to environmental influences  It is a fragile virus.  Common antiseptics can be used i.e povidone iodine,KMNO4 etc to kill the virus.
  • 5. EPIDEMOLOGY  WHO:  It is important disease of Horses & Cattles.It can also affect Camel,Pig,Human,Sheep & Goat.  WHERE:  Disease is limited to western hemisphere, It is pandemic in Mexico,Panama,USA ,venzuella & Brazil.
  • 6. Cont…  WHEN:  Disease occurs in summer & autumn.  TRANSMISSION:  Mainly occurs through insects i.e Blck flies & sand fly (biological vectors).  Mechanically disease can be transmitted through direct contact or close indirect contact.  Mortality: Nil in horses, 5% in cattle.  Morbidity: 10-20%.
  • 7. PATHOGENESIS Entry of the virus to body--- through blood virus disseminate to different organs/tissues but predilection site include mucosal membrane of oral cavity, skin at interdigital cleft& skin of teat--- virus replicates there forming vesicles------  vesicles ruptures forming ulcers-----  ulcers recovers within 10days if no secondary bacterial infection is there-----  clinical signs appears
  • 8. CLINICAL FINDINGS  Fever{mild}  Vesicles in mouth,tounge, lips, dental pad  Ulcer in feet and teat  Salivation  Lesions in teats may lead to secondary mastitis  Anorexia
  • 9. DIAGNOSIS On the basis of signs and symptoms Confirmatory diagnosis by Lab test It includes PCR Eliza CFT
  • 10. DIFFERENTIAL DIAGNOSIS  FMD:  DIFFERENTIAL POINTS:  In case of FMD high fever while in VS mild fever is there  FMD effects only cloven hooved animals while in case of VS equines are also effected  Incase of FMD morbidly and mortality rate is higher while low in VS
  • 11.  Abortion also occurs in FMD  In FMD young animals are more fatel.  BVD:  DIFFERENTIAL POINTS:  It involves GIT, so there will be diarrhea, abortion, early embryonic mortality, congenital malformation while BVD only effects bovine
  • 12. CONT…  MCF:  DIFFERENTIAL POINTS:  In FMD there is swelling of lymph nodes while no swelling of LN in MCF  MCF cause corneal opacity while no corneal opacity in VS
  • 13.  COW POX  DIFFERENTIAL POINTS:  Scabby lesions in pox while in VS ulcerative lesions are present  BLUE TONGUE  DIFFERENTIAL POINTS:  Diarrhea  Cynotic tongue in BT
  • 14.  RINDERPEST:  DIFFERENTIAL POINTS:  Necrotic stomatitis in rinderpest while in VS the lesions are vesicular.  Shooting diarrhea in rinderpest  PPR:  DIFFERENTIAL POINTS:  Necrotic stomatitis in PPR
  • 15.  Diarrhea in PPR  Pneumonia in PPR while no pneumonia in VS  ORF  DIFFERENTIAL POINTS:  Scabby lesions in orf  Lesions are proliferative
  • 16. TREATMENT  Since it is viral infection so no specific treatment is given, supportive therapy is given to control infection;  Broad spectrum antibiotics  {amoxicllin,ampicillin, gentamycin, oxytetracycline, enrofloxacin etc}  NSAIDS  {Flunixin meglumin} This Photo by Unknown Author is licensed under CC BY-SA-NC
  • 17.  FLUID therapy  Ringer lectate  Topical antiseptics  KMno4  multivitamins
  • 18. PREVENTION  Control of insects by use of insecticides like;  Nagavan, sagavan, tegafon  Use of ivermectin, cypermethrin  Qurantine measures  Vaccination not effective  Isolation of sick animals  Maintain hygienic and control condition.