2. DESCRIPTION
Rituxirel 500mg is an anticancer medicine which
prevents the growth and spread of cancer cells in the
body.
Rituxirel 500mg injection also indicated for the
treatment of Non- Hodgkin’s lymphoma or chronic
lymphocytic and with combination with another
anticancer drugs like methotrexate is used for
rheumatoid arthritis symptoms in adult treatment
Rituxirel 500mg with steroid regimen combination is
given for the treatment of some rare disorders which
cause blood vessels and other tissues inflammation
in the body.
3. INDICATION
Rituxirel 500mg and hyaluronidase human injection
are given alone or combination with other drugs to
treat certain types of non-Hodgkin's lymphoma and
chronic lymphocytic leukemia (cancer start in WBC).
Rituxirel 500mg injection is also used with
methotrexate (Otrexup, Rasuvo, Xatmep, others) for
the treatment rheumatoid arthritis symptoms in
adults that have been already treated with some type
of regimen known as tumor necrosis factor (TNF)
inhibitor.
4.
5. MECHANISM OF ACTION
Rituxirel 500mg injection is a type of class called as
monoclonal antibody and which is a new type of
"targeted" cancer treatment and an integral part of
the body's immune system.
Rituxirel 500mg works by linking to the CD20 antigen
on normal and malignant B-cells. Hence the body's
essential immune security is initiated to attack and
kill the marked B-cells.
7. PHARMACOKINETICS
ABSORPTION
Not available
DISTRIBUTION
volume of distribution is 3.1 L
METABOLISM
Rituxirel 500mg metabolized by human antimurine
antibody production.
EXCRETION
Not available
The half-life of NHL is 22 days and for RA is 18.0 days,
GPA and microscopic polyangiitis is 23 days.
8. DOSAGE MANAGEMENT
Rituxirel 500mg injection is recommended to
administer only through intravenous infusion not by
IV push or bolus.
ADMINISTRTION :
Take an Rituxirel 500mg injection amount and diluted
to final concentration of 1 mg/ml up to 4 mg/ml as
infusion (containing either 0.9% Nacl or 5% dextrose
in water). Invert gently the bag and mix the solution.
Dispose unused drug left in vial.
9. PRECAUTIONS
Allergic condition against Rituxirel 500mg or any
other medication informs your doctor.
While using Rituxirel 500mg injection do not take any
vaccination or immunization without taking advice
from doctors.
Avoid use of Rituxirel 500mg if you are pregnant. It
will harm the baby unborn, while using Rituxirel
500mg use correct birth control to prevent pregnancy
and for at least 2 weeks after your treatment ends.
Rituxirel 100mg may affect the ability to have
children in women. Inform your doctor if you planning
to pregnant.
10. SIDE EFFECTS
Common effects:
fever and chills (flu like symptoms)
Less common side effects:
Weakness; nausea; headache; cough; dyspnea;
pharyngitis
11. DRUG INTERACTION
Rituxirel 500mg injection drug interaction has limited
data is available at present.
Combination with fludarabine or cyclophosphamide
has no effects in pharmacokinetics in CLL patients.
Combination with methotrexate had no effects in
pharmacokinetics.
13. PREGNANCY
Category C: animal studies reproduction shown an
adverse effect on the fetus. The drug has no enough
and well controlled studies in humans, using in
pregnant women benefits by warrant use of the drug.
14. LACTATION
Rituxirel 500mg excreted into human milk is
unknown. Due to the drug belongs to large protein
molecule, no information is available. Women should
not breast feed during Rituxirel 500mg injection
treatment and 12 months following last dose.
15. STORAGE
• Store at 20°C – 30°C
• Use the drug before expiry date
• Protected from direct sunlight
• Do not freeze or shake.
• Keep away from the children’s
• Discard the unused drug by asking the advice from
doctor or pharmacist.
16. MISSED DOSE
If a dose missed to take at the time then have it
suddenly before next dose timing, if time reach for
next dose, then skip missed dose and continue and
continue the regular schedule. Do not have 2 doses
at a same time.
17. OVERDOSAGE
If the patients had high dose of Rituxirel 500mg then
seek immediately to the emergency department or
poison control help line. Please consult the doctor for
further clarification.
18. CONTACT US
EMAIL ID : millionhealthpharmaceuticals@gmail.com
PHONE NO : +91-9940472902
WEBSITE URL : https://millionpharma.com/rituxirel-
500mg.php
