3. Fluid and Electrolyte Transport
• PASSIVE
TRANSPORT
SYSTEMS
– Diffusion
– Filtration
– Osmosis
• ACTIVE
TRANSPORT
SYSTEM
– Pumping
– Requires energy
expenditure
4. DIFFUSION
• Process by which a solute in solution
moves
• Involves a gas or substance
• Movement of particles in a solution
• Molecules move from an area of higher
concentration to an area of lower
concentration
• Evenly distributes the solute in the
solution
• Passive transport & requires no energy
5.
6.
7. FACILITATED DIFFUSION
• Involves carrier system that moves
substance across a membrane
faster than it would with simple
diffusion
• Substance can only move from area of
higher concentration to one of lower
concentration
• Example is movement of glucose
with assistance of insulin across
cell membrane into cell
8.
9. OSMOSIS
• Movement of the solvent or water
across a membrane
• Involves solution or water
• Equalizes the concentration of ions on
each side of membrane
• Movement of solvent molecules
across a membrane to an area where
there is a higher concentration of
solute that cannot pass through the
membrane
10.
11. OSMOTIC PRESSURE
• Pull that draws solvent through the
membrane to the more concentrated
side (or side with solute )
• Amt. determined by relative number
of particles of solute on side of
greater concentration
• Proportional to # of particles per unit
volume solvent
12. COLLOID OSMOTIC PRESSURE
OR ONCOTIC PRESSURE
• Special kind of
osmotic pressure
• Created by
substances with a
high molecular
weight (like
albumin)
13. Osmosis
• Movement of solvent from an area of
lower solute concentration to one of
higher concentration
• Occurs through a semipermeable
membrane using osmotic (water pulling)
pressure
14. Active Transport System
• Solutes can be moved against a
concentration gradient
• Also called “pumping”
• Dependent on the presence of ATP
16. Isotonic Solution
• No fluid shift because solutions are
equally concentrated
• Normal saline solution (0.9% NaCl)
• Dextrose Solution (5% glucose)
17. Hypotonic Solution
• Lower solute concentration
• Fluid shifts from hypotonic solution into
the more concentrated solution to
create a balance (cells swell)
• Half-normal saline solution (0.45%
NaCl)
18. Hypertonic Solution
• Higher solute concentration
• Fluid is drawn into the hypertonic
solution to create a balance (cells
shrink)
• 5% dextrose in normal saline (D5/0.9%
NaCl)
19. HYPOTONIC HYPERTONIC
• Solution of lower
osmotic pressure
• Less salt or more
water than isotonic
• If infused into blood,
RBCs draw water
into cells ( can swell
& burst )
• Solutions move
into cells causing
them to enlarge
• Solution of higher
osmotic pressure
• 3% sodium chloride
is example
• If infused into blood,
water moves out of
cells & into solution
(cells wrinkle or
shrivel)
• Solutions pull fluid
from cells
20. OSMOLALITY
• Measure of solution’s ability to create
osmotic pressure & thus affect
movement of water
• Number of osmotically active particles per
kilogram of water
• Plasma osmolality is 280-300* mOsm/ kg
• ECF osmolality is determined by sodium
• MEASURE used in clinical practice to
evaluate serum & urine
21. Osmolality In Clinical Practice *
• Serum 280-300mOsm/kg; Urine 50-
1400mOsm/kg
• Serum osmolality can be estimated by
doubling serum sodium
• Urine specific gravity measures the
kidneys’ ability to excrete or conserve
water
• Nl range 1.010 to 1.025 (compared to
weight of distilled water with sp g of
1.000)
22. ACTIVE TRANSPORT SYSTEM
• Moves molecules or ions uphill against
concentration & osmotic pressure
• Hydrolysis of adenosine triphosphate
(ATP) provides energy needed
• Requires specific “carrier” molecule as
well as specific enzyme (ATPase)
• Sodium, potassium, calcium,
magnesium, plus some sugars, & amino
acids use it
23.
24. Filtration
• Movement of solute and solvent across a
membrane caused by hydrostatic (water
pushing) pressure
• Occurs at the capillary level
• If normal pressure gradient changes (as
occurs with right-sided heart failure)
edema results from “third spacing”
25.
26. THIRD SPACING
• Large quantities of fluid from the
intravascular compartment shift into
the interstitial space; is inaccessible to
the body
• May be caused by lowered plasma
proteins, increased capillary permeability
& lymphatic blockage
• Can be seen with trauma, inflammation,
disease
27. HYDROSTATIC PRESSURE
• Force of the fluid
pressing outward against
vessel wall
• With blood not only
refers to weight of fluid
against capillary wall
but to force with which
blood is propelled with
heartbeat
• “Fluid- pushing pressure
inside a capillary”*
32. INTAKE FLUIDS OUT
• Ingested liquids 1500
• Water in foods 800*
• Water from oxidation
300*
• TOTAL 2600*
• INSENSIBLE
• Skin 600*
• Lungs through
expired air
300*
• Feces 200
• Kidneys 1500*
• TOTAL 2600*
33.
34. MILLIEQUIVALENT (mEq)
• Unit of measure for an electrolyte
• Describes electrolyte’s ability to
combine & form other compounds
• Equivalent weight is amount of one
electrolyte that will react with a given
amount of hydrogen
• 1 mEq of any cation will react with 1
mEq of an anion
35. DEFINITIONS
• SOLUTE - substance dissolved
• SOLVENT - solution in which the solute is
dissolved
• SELECTIVELY PERMEABLE
MEMBRANES - found throughout body
cell membranes & capillary walls; allow
water & some solutes to pass through
them freely
38. Neuro Endocrine
Mechanisms
• Central Nervous System Ischemic
Response- massive hemorrhage causes
dec. in ECF volume & response that
constricts afferent arterioles & dec. GFR
• Baroreceptor Reflex- stretch receptors in
large arteries that react to a dec. in ECF &
respond with dec. in GFR
39. Baroreceptor Reflex
• Respond to a fall in arterial blood pressure
• Located in the atrial walls, vena cava,
aortic arch and carotid sinus
• Constricts afferent arterioles of the kidney
resulting in retention of fluid
40. Volume Receptors
• Respond to fluid excess in the atria and
great vessels
• Stimulation of these receptors creates a
strong renal response that increases
urine output
42. Renin-Angiotensin-Aldosterone
• Angiotensin
–Angiotensin I is converted in lungs to
angiotensin II using ACE (angiotensin
converting enzyme)
–Produces vasoconstriction to elevate
blood pressure
–Stimulates adrenal cortex to secrete
aldosterone
44. ALDOSTERONE
• Produced by adrenal cortex
• Released as part of RAA mechanism
• Acts on renal distal convoluted tubule
• Regulates water reabsorption by
increasing sodium uptake from the
tubular fluid into the blood but
potassium is excreted
• Responsible for reabsorption of sodium
& water into the vascular compartment
45.
46. Aldosterone Negative Feedback Mechanism
• ECF & Na+ levels drop secretion of
ACTH by the anterior pituitary release
of aldosterone by the adrenal cortex
fluid and Na+ retention
47. Antidiuretic Hormone
• Also called vasopressin
• Released by posterior pituitary when
there is a need to restore intravascular
fluid volume
• Release is triggered by osmoreceptors
in the thirst center of the hypothalamus
• Fluid volume excess decreased ADH
• Fluid volume deficit increased ADH
48. ADH (Antidiuretic Hormone)
• Made in hypothalamus; water
conservation hormone
• Stored in posterior pituitary gland
• Acts on renal collecting tubule to
regulate reabsorption or
elimination of water
• If blood volume decreases, then
ADH is released & water is
reabsorbed by kidney. Urine
output will be lower but
concentration will be increased.
51. Dehydration
• Loss of body fluids increased
concentration of solutes in the blood
and a rise in serum Na+ levels
• Fluid shifts out of cells into the blood to
restore balance
• Cells shrink from fluid loss and can no
longer function properly
54. What Do We Do?
• Fluid Replacement - oral or IV over 48
hrs.
• Monitor symptoms and vital signs
• Maintain I&O
• Maintain IV access
• Daily weights
• Skin and mouth care
55. Hypovolemia
• Isotonic fluid loss
from the
extracellular
space
• Can progress to
hypovolemic
shock
• Caused by:
–Excessive fluid
loss
(hemorrhage)
–Decreased fluid
intake
–Third space
fluid shifting
56. Symptoms
• Mental status
deterioration
• Thirst
• Tachycardia
• Delayed capillary
refill
• Orthostatic
hypotension
• Urine output < 30
ml/hr
• Cool, pale
extremities
• Weight loss
57. What Do We Do?
• Fluid replacement
• Albumin
replacement
• Blood transfusions
for hemorrhage
• Dopamine to
maintain BP
• MAST trousers for
severe shock
• Assess for fluid
overload with
treatment
58. Hypervolemia
• Excess fluid in the extracellular
compartment as a result of fluid or
sodium retention, excessive intake, or
renal failure
• Occurs when compensatory
mechanisms fail to restore fluid balance
• Leads to CHF and pulmonary edema
60. Edema
• Fluid is forced into tissues by the
hydrostatic pressure
• First seen in dependent areas
• Anasarca - severe generalized edema
• Pitting edema
• Pulmonary edema
61. What Do We Do?
• Fluid and Na+
restriction
• Diuretics
• Monitor vital signs
• Hourly I&O
• Breath sounds
• Monitor ABGs and
labs
• Elevate HOB and
give O2 as ordered
• Maintain IV access
• Skin & mouth care
• Daily weights
62. Water Intoxication
• Hypotonic
extracellular fluid
shifts into cells to
attempt to restore
balance
• Cells swell
• Causes:
– SIADH
– Rapid infusion of
hypotonic solution
– Excessive tap water
NG irrigation or
enemas
– Psychogenic
polydipsia
63. Symptoms
• Signs and symptoms of increased
intracranial pressure
– Early: change in LOC, N/V, muscle
weakness, twitching, cramping
– Late: bradycardia, widened pulse
pressure, seizures, coma
64. What Do We Do?
• Prevention is the best
treatment
• Assess neuro status
• Monitor I&O and vital
signs
• Fluid restrictions
• IV access
• Daily weights
• Monitor serum Na+
• Seizure precautions
69. Sodium
• Major extracellular cation
• Attracts fluid and helps preserve fluid
volume
• Combines with chloride and bicarbonate
to help regulate acid-base balance
• Normal range of serum sodium 135 - 145
mEq/L
70. Sodium and Water
• If sodium intake suddenly increases,
extracellular fluid concentration also
rises
• Increased serum Na+ increases thirst
and the release of ADH, which triggers
kidneys to retain water
• Aldosterone also has a function in water
and sodium conservation when serum
Na+ levels are low
71. Sodium-Potassium Pump
• Sodium (abundant
outside cells) tries to
get into cells
• Potassium (abundant
inside cells) tries to
get out of cells
• Sodium-potassium
pump maintains
normal concentrations
• Pump uses ATP,
magnesium and an
enzyme to maintain
sodium-potassium
concentrations
• Pump prevents cell
swelling and creates
an electrical charge
allowing
neuromuscular
impulse
transmission
72. Hyponatremia
• Serum Na+ level < 135 mEq/L
• Deficiency in Na+ related to amount of
body fluid
• Several types
–Dilutional
–Depletional
–Hypovolemic
–Hypervolemic
–Isovolemic
73. Types of Hyponatremia
• Dilutional - results from Na+ loss, water gain
• Depletional - insufficient Na+ intake
• Hypovolemic - Na+ loss is greater than
water loss; can be renal (diuretic use) or
non-renal (vomiting)
• Hypervolemic - water gain is greater than
Na+ gain; edema occurs
• Isovolumic - normal Na+ level, too much
fluid
75. What Do We Do?
• MILD CASE
– Restrict fluid intake for
hyper/isovolemic
hyponatremia
– IV fluids and/or
increased po Na+
intake for hypovolemic
hyponatremia
• SEVERE CASE
– Infuse hypertonic
NaCl solution (3% or
5% NaCl)
– Furosemide to remove
excess fluid
– Monitor client in ICU
76. Hypernatremia
• Excess Na+ relative to body water
• Occurs less often than hyponatremia
• Thirst is the body’s main defense
• When hypernatremia occurs, fluid shifts
outside the cells
• May be caused by water deficit or over-
ingestion of Na+
• Also may result from diabetes insipidus
77. What Do You See?
• Think S-A-L-T
– Skin flushed
– Agitation
– Low grade fever
– Thirst
• Neurological symptoms
• Signs of hypovolemia
78. What Do We Do?
• Correct underlying
disorder
• Gradual fluid
replacement
• Monitor for s/s of
cerebral edema
• Monitor serum Na+
level
• Seizure precautions
79. Potassium
• Major intracellular cation
• Untreated changes in K+ levels can lead
to serious neuromuscular and cardiac
problems
• Normal K+ levels = 3.5 - 5 mEq/L
80. Balancing Potassium
• Most K+ ingested is excreted by the
kidneys
• Three other influential factors in K+
balance :
– Na+/K+ pump
– Renal regulation
– pH level
86. What Do We Do?
• Increase dietary K+
• Oral KCl supplements
• IV K+ replacement
• Change to K+-sparing diuretic
• Monitor EKG changes
87. IV K+ Replacement
• Mix well when
adding to an IV
solution bag
• Concentrations
should not exceed
40-60 mEq/L
• Rates usually 10-
20 mEq/hr
NEVER GIVE IV
PUSH POTASSIUM
88. Hyperkalemia
• Serum K+ > 5 mEq/L
• Less common than
hypokalemia
• Caused by altered
kidney function,
increased intake (salt
substitutes), blood
transfusions, meds
(K+-sparing diuretics),
cell death (trauma)
92. Acid-Base Basics
• Balance depends on regulation of free
hydrogen ions
• Concentration of hydrogen ions is
measured in pH
• Arterial blood gases are the major
diagnostic tool for evaluating acid-
base balance
94. Acidosis
• pH < 7.35
• Caused by accumulation of acids or by a
loss of bases
95. Alkalosis
• pH > 7.45
• Occurs when bases accumulate or acids
are lost
96. Regulatory Systems
• Three systems come into play when pH
rises or falls
– Chemical buffers
– Respiratory system
– Kidneys
97. The pH of the body is controlled by three systems:
1. The chemical acid-base buffering by the body fluids
that immediately combine with acids or base to prevent
excessive changes in pH.
2. The respiratory center which regulates the removal of
volatile CO2 as a gas in the expired air from the plasma
and therefore also regulates bicarbonate (HCO3
-) from
the body fluids via the pulmonary circulation. This
response occurs in minutes.
3. The kidneys which can excrete either acid or alkaline
urine, thereby adjusting the pH of the blood. This
response takes place over hours or even days, but
represent a more powerful regulatory system.
98. Chemical Buffers
• Immediate acting
• Combine with
offending acid or base
to neutralize harmful
effects until another
system takes over
• Bicarb buffer - mainly
responsible for
buffering blood and
interstitial fluid
• Phosphate buffer -
effective in renal
tubules
• Protein buffers - most
plentiful - hemoglobin
99. Respiratory System
• Lungs regulate blood levels of CO2
• CO2 + H2O = Carbonic acid
• High CO2 = slower breathing (hold on
to carbonic acid and lower pH)
• Low CO2 = faster breathing (blow off
carbonic acid and raise pH)
• Twice as effective as chemical buffers,
but effects are temporary
100. Kidneys
• Reabsorb or excrete
excess acids or
bases into urine
• Produce
bicarbonate
• Adjustments by the
kidneys take hours
to days to
accomplish
• Bicarbonate levels
and pH levels
increase or
decrease together
101. Arterial Blood Gases (ABG)
• Uses blood from an arterial puncture
• Three test results relate to acid-base
balance
– pH
– PaCO2
– HCO3
103. Respiratory Acidosis
• Any compromise in breathing can result
in respiratory acidosis
• Hypoventilation carbon dioxide
buildup and drop in pH
• Can result from neuromuscular trouble,
depression of the brain’s respiratory
center, lung disease or airway
obstruction
104. Clients At Risk
• Post op abdominal surgery
• Mechanical ventilation
• Analgesics or sedation
106. What Do We Do?
• Correct underlying cause
• Bronchodilators
• Supplemental oxygen
• Treat hyperkalemia
• Antibiotics for infection
• Chest PT to remove secretions
• Remove foreign body obstruction
107. Respiratory Alkalosis
• Most commonly results from
hyperventilation caused by pain, salicylate
poisoning, use of nicotine or
aminophylline, hypermetabolic states or
acute hypoxia (overstimulates the
respiratory center)
109. What Do We Do?
• Correct underlying disorder
• Oxygen therapy for hypoxemia
• Sedatives or antianxiety agents
• Paper bag breathing for hyperventilation
110. Metabolic Acidosis
• Characterized by gain of acid or loss of
bicarb
• Associated with ketone bodies
– Diabetes mellitus, alcoholism, starvation,
hyperthyroidism
• Other causes
– Lactic acidosis secondary to shock, heart
failure, pulmonary disease, hepatic
disease, seizures, strenuous exercise
112. What Do We Do?
• Regular insulin to reverse DKA
• IV bicarb to correct acidosis
• Fluid replacement
• Dialysis for drug toxicity
• Antidiarrheals
113. Metabolic Alkalosis
• Commonly associated with hypokalemia
from diuretic use, hypochloremia and
hypocalcemia
• Also caused by excessive vomiting, NG
suction, Cushing’s disease, kidney
disease or drugs containing baking soda
115. What Do We Do?
• IV ammonium chloride
• D/C thiazide diuretics and NG suctioning
• Antiemetics
116. IV Therapy
• Crystalloids – volume
expander
– Isotonic (D5W, 0.9%
NaCl or Lactated
Ringers)
– Hypotonic (0.45%
NaCl)
– Hypertonic (D5/0.9%
NaCl, D5/0.45% NaCl)
• Colloids – plasma
expander (draw fluid
into the bloodstream)
– Albumin
– Plasma protein
– Dextran
117. Total Parenteral Nutrition
• Highly concentrated
• Hypertonic solution
• Used for clients with high caloric and
nutritional needs
• Solution contains electrolytes, vitamins,
acetate, micronutrients and amino acids
• Lipid emulsions given in addition
119. 88% of deaths from diarrhea attributed to
inadequate water for hygiene, unsafe water
ingestion, inaccessible sanitation
120. Assess %Dehydration
Mild Moderate Severe
Wt (infant) 5% 10% 15%
Wt (child) 3% 6% 9%
Pulse ↑ ↑↑ ↑↑↑
Cap Refill <2 sec 2-5 sec >5 sec
Urine sl ↓ ↓↓ ↓↓↓
Color pale gray mottled
Membranes dry very dry parched
BP normal +/- nl ↓’d
Turgor sl ↓ ↓↓ ↓↓↓
Other: fontanelle, CNS status, tears
121. Oral Rehydration
• Glucose & Sodium absorbed on a
1:1 molecular ratio
• Maximum Na & H20 absorption
occurs at glucose concentration of
56-140 mmol/l or a 1.0-2.5 %
glucose solution
• Higher glucose concentrations lead
to an osmotic diarrhea
122. Some Oral Rehydration Solutions
(good and bad)
Solution CHO g/dl Na meq/l K meq/l Osm
Rehydration:
RO WHO formula 1.3 75 20 245
WHO formula 2.0 90 20 310
Maintenance
Infalyte 3.0 50 25 200
Pedialyte 2.5 45 20 250
Home remedies
Gatorade 5.9 21 2.5 377
Gingerale 9.0 3.5 0.1 585
Apple Juice 11.9 0.4 26 700
123. ORS Packet vs. Home Remedy
• Controlled by physicians, institutions and
companies vs. family
• Precisely measured
• Less practical, more expensive
• More magical, acceptance may
be higher because of receipt of
a “medicine”
• Easier to gather data and prepare
statistics
• Causes delay in treatment
ORS Recipe: Table Salt (NaCl) ½ tsp, Salt Substitute (KCL) ½ tsp,
Baking Soda ½ tsp, Table Sugar 2 Tablespoons, Water 1 liter