The disease bullous pemphigoid results in the destruction of proteins within the basement
membrane that hold the epidermis and dermis together. How would this likely affect the
epidermis?
Solution
Bullous pemphigoid is an autoimmune disease.
Due to the nature of the disease, the cohesion between the dermis and the epidermis is destroyed.
The epidermis tends to separate from the dermis and in the intervening space, body fluids fill up,
giving the appearance of lesions. The colour and size of the lesions vary. In some patients they
may cover large parts of the anatomy. The lesions when disturbed burst, spilling their contents.
This may further lead to secondary infections and provide a pathway for pathogens to enter the
body..
The disease bullous pemphigoid results in the destruction of protein.pdf
1. The disease bullous pemphigoid results in the destruction of proteins within the basement
membrane that hold the epidermis and dermis together. How would this likely affect the
epidermis?
Solution
Bullous pemphigoid is an autoimmune disease.
Due to the nature of the disease, the cohesion between the dermis and the epidermis is destroyed.
The epidermis tends to separate from the dermis and in the intervening space, body fluids fill up,
giving the appearance of lesions. The colour and size of the lesions vary. In some patients they
may cover large parts of the anatomy. The lesions when disturbed burst, spilling their contents.
This may further lead to secondary infections and provide a pathway for pathogens to enter the
body.
