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Anatomy And Connections Of Prefrontal Cortex


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Anatomy And Connections Of Prefrontal Cortex

  1. 1. In the name of God Basic neurosciences with clinical applications
  2. 2. Anatomy and connections of prefrontal cortex <ul><li>Lateral prefrontal cortex : with lots of reciprocal areas is well suited to regulate behavior and control of response to environmental stimuli </li></ul><ul><li>Orbitomedial prefrontal cortex : via its reciprocal neocortical and limbic connections ,is suited to integrate information about emotion and memory related to environmental stimuli </li></ul>
  3. 3. Lateral prefrontal cortex <ul><li>It is divided in to 3 parts: </li></ul><ul><li>The dorso lateral prefrontal cortex:areas 9 &46 </li></ul><ul><li>Ventrolateral prefrontal cortex:44 & 45 & 47 & 12 </li></ul><ul><li>Frontopolar cortex: including the superior polar(areas 9 & 10) and inferior polar(10,47/12&14) </li></ul>
  4. 5. The connections of lateral prefrontal cortex <ul><li>The main connections are with paralimbic areas,particular the cingulate gyrus . </li></ul><ul><li>This connections myelinate late during cerebral development. </li></ul>
  5. 7. dorsolateral prefrontal cortex Spatial attention <ul><li>Superior longitudinal fasciculus connects caudal portion of inferior parietal lobule and parietooccipital region and dosral lateral prefrontal cortex </li></ul><ul><li>This connection involve in visual and oculomotor aspects of spatial attention </li></ul>
  6. 9. Ventrolateral prefrontal cortex actin imitation, gestural communication ,monitoring orofacial & hand action <ul><li>Inputs from anterior portion of inferior parietal lobe including supramarginal gyrus and adjacent parietal opercular region , terminate in VLTPC & frontal operculum(44) & ventral premotor area? </li></ul><ul><li>This Provide high order somatosensory input for action imitation,gestural communication,orofacial and hand action </li></ul>
  7. 11. Ventrolateral prefrontal cortex visual object identification <ul><li>Occipitotemporal visual association areas terminate primarily in inferior temporal cortex and adjacent parahippocampal region via inferior longitudinal fasciculus and then to VLPFC </li></ul><ul><li>This system transmits highly processed visual information necessary for object identification. </li></ul>
  8. 13. ventral prefrontal cortex auditory spatial info/object recognition <ul><li>Posterior portion of Superior temporal gyrus projects to area 8 via arcuate fasciculus, information for </li></ul><ul><li>auditory spatial information </li></ul><ul><li>Midportion of superior temporal gyrus projects to area 45 via the extreme capsule ,provides info for </li></ul><ul><li>auditory object recognition </li></ul>
  9. 15. ventral prefrontal cortex of left hemisphere recieve distinct inputs for speech production <ul><li>Thus,the VPFC involved in speech production receive distinct sensory inputs </li></ul><ul><li>Area 44: somatosensory inputs from the supramarginal gyrus </li></ul><ul><li>Area 45:auditory info from midsuperior temporal cortex </li></ul>