Maladaptive Responses to Immune Disorders Maladaptive responses to disorders are compensatory mechanisms that ultimately have adverse health effects for patients. For instance, a patient’s allergic reaction to peanuts might lead to anaphylactic shock, or a patient struggling with depression might develop a substance-abuse problem. To properly diagnose and treat patients, advanced practice nurses must understand both the pathophysiology of disorders and potential maladaptive responses that some disorders cause. Consider immune disorders, such as HIV, psoriasis, inflammatory bowel disease, and systemic lupus E. What are resulting maladaptive responses for patients with these disorders? To prepare: Review Chapter 5 and Chapter 7 in the Huether and McCance text, as well as the Yi, et al, article in the Learning Resources. Reflect on the concept of maladaptive responses to disorders. Select two of the following immune disorders: HIV, psoriasis, inflammatory bowel disease, and/or systemic lupus E (SLE). Think about the pathophysiology of each disorder you selected. Consider the compensatory mechanisms that the disorders trigger. Then, compare the resulting maladaptive and physiological responses of the two disorders. Consider the types of drugs that would be prescribed to patients to treat symptoms associated with these disorders and why. Select one of the following patient factors: genetics, gender, ethnicity, age, or behavior. Consider how your selected factor might impact the disorder. Then, reflect on how your selected factor might impact the effects of prescribed drugs, as well as any measures you might take to help reduce any negative side effects. Questions to be addressed in my paper: A brief description of the pathophysiology of the immune disorders you selected. Explain how the maladaptive and physiological responses of the two disorders differ. Then, describe the types of drugs that would be prescribed to patients to treat symptoms associated with these immune disorders and why. Explain how the factor you selected might impact the pathophysiology of each disorder as well as the effects of prescribed drugs. E xplain any measures you might take to help reduce any negative side effects. Summary with Conclusion REMINDERS: 1) 2-3 pages (addressing the 5 questions above excluding the title page and reference page). 2) Kindly follow APA format for the citation and references! References should be between the period of 2011 and 2016. Please utilize the references at least three below as much as possible and the rest from yours. 3) Make headings for each question. RESOURCES: Readings Huether, S. E., & McCance, K. L. (2012).  Understanding pathophysiology  (Laureate custom ed.). St. Louis, MO: Mosby. Chapter 5, “Innate Immunity: Inflammation and Wound Healing” This chapter examines how the body responds to injury and infection by exploring the first, second, and third lines of defense. It also covers wound healing and alterations of th.

1. Maladaptive Responses to Immune Disorders
Maladaptive responses to disorders are compensatory
mechanisms that ultimately have adverse health effects for
patients. For instance, a patient’s allergic reaction to peanuts
might lead to anaphylactic shock, or a patient struggling with
depression might develop a substance-abuse problem. To
properly diagnose and treat patients, advanced practice nurses
must understand both the pathophysiology of disorders and
potential maladaptive responses that some disorders cause.
Consider immune disorders, such as HIV, psoriasis,
inflammatory bowel disease, and systemic lupus E. What are
resulting maladaptive responses for patients with these
disorders?
To prepare:
Review Chapter 5 and Chapter 7 in the Huether and McCance
text, as well as the Yi, et al, article in the Learning Resources.
Reflect on the concept of maladaptive responses to disorders.
Select two of the following immune disorders: HIV, psoriasis,
inflammatory bowel disease, and/or systemic lupus E (SLE).
Think about the pathophysiology of each disorder you selected.
Consider the compensatory mechanisms that the disorders
trigger. Then, compare the resulting maladaptive and
physiological responses of the two disorders.
Consider the types of drugs that would be prescribed to patients
to treat symptoms associated with these disorders and why.
Select one of the following patient factors: genetics, gender,
ethnicity, age, or behavior. Consider how your selected factor
might impact the disorder. Then, reflect on how your selected
factor might impact the effects of prescribed drugs, as well as
any measures you might take to help reduce any negative side
effects.
Questions to be addressed in my paper:
A
brief description of the pathophysiology of the immune
disorders you selected.

2. Explain how the maladaptive and physiological responses of the
two disorders differ.
Then, describe the types of drugs that would be prescribed to
patients to treat symptoms associated with these immune
disorders and why.
Explain how the factor you selected might impact the
pathophysiology of each disorder as well as the effects of
prescribed drugs.
E
xplain any measures you might take to help reduce any negative
side effects.
Summary with Conclusion
REMINDERS:
1)
2-3 pages (addressing the 5 questions above excluding the title
page and reference page).
2)
Kindly follow APA format for the citation and references!
References should be between the period of 2011 and 2016.
Please utilize the references at least three below as much as
possible and the rest from yours.
3)
Make headings for each question.
RESOURCES:
Readings
Huether, S. E., & McCance, K. L. (2012).
Understanding pathophysiology
(Laureate custom ed.). St. Louis, MO: Mosby.

3. Chapter 5, “Innate Immunity: Inflammation and Wound
Healing”
This chapter examines how the body responds to injury and
infection by exploring the first, second, and third lines of
defense. It also covers wound healing and alterations of the
wound-healing process.
Chapter 6, “Adaptive Immunity”
This chapter examines the third line of defense, adaptive
immunity. It also covers the roles of antigens and immunogens,
the humoral immune response, cell-mediated immunity, and the
production of B and T lymphocytes in the immune response.
Chapter 7, “Infection and Defects in Mechanisms of Defense”
This chapter covers the epidemiology, clinical presentation, and
treatment of disorders resulting from infection, deficiencies in
immunity, and hypersensitivity. It also examines the
pathophysiology of an important immune disorder: HIV/AIDS.
Chapter 8, “Stress and Disease”
This chapter evaluates the impact of stress on various body
systems and the immune system. It also examines coping
mechanisms and disorders related to stress.
Chapter 39, “Structure, Function, and Disorders of the
Integument”
This chapter begins with an overview of the structure and
function of skin. It then covers effects of aging on skin, as well
as disorders of the skin, hair, and nails.
Chapter 40, “Alterations of Integument in Children”
This chapter covers alterations of the integument that affect
children. These include acne vulgaris, dermatitis, infections of
the skin, insect bites and parasites, vascular disorders, and other
skin disorders.
Poole Arcangelo, V., & Peterson, A. M. (Eds.). (2013).
Pharmacotherapeutics for advanced practice: A practical
approach
(3rd ed.). Ambler, PA: Lippincott Williams & Wilkins.
Chapter 8, “Principles of Antimicrobial Therapy”
This chapter covers factors that impact the selection of an

4. antimicrobial treatment regimen. It also examines the clinical
uses, adverse events, and drug interactions of various
antimicrobial agents, such as penicillin
Chapter 12, “Fungal Infections of the Skin”
This chapter explores the pathophysiology of several fungal
infections of the skin, as well as related drug treatments. It also
examines the importance of patient education when managing
these infections.
Chapter 14, “Bacterial Infections of the Skin”
This chapter begins by examining causes of bacterial infections.
It then explores the importance of selecting an appropriate agent
for treating bacterial infections.
Chapter 32, “Urinary Tract Infection”
This chapter covers drugs used to treat urinary tract infections.
It also identifies special considerations when treating geriatric
patients, pediatric patients, and women.
Chapter 35, “Sexually Transmitted Infections”
This chapter outlines the causes, pathophysiology, and drug
treatment of six sexually transmitted infections, including
gonorrhea, syphilis, and human papilloma virus infection
(HPV). It also examines the importance of selecting the proper
agent and monitoring patient response to treatment.
Chapter 48, “Human Immunodeficiency Virus”
This chapter presents the causes, pathophysiology, diagnostic
criteria, and prevention methods for HIV. It also covers various
methods of drug treatment and patient factors to consider when
selecting, administering, and managing drug treatments.
Yi, H., Shidlo, A., & Sandfort, T. (2011). Assessing
maladaptive responses to the stress of being at risk of HIV
infection among HIV-negative gay men in New York City.
Journal of Sex Research
,
48
(1), 62–73.
Retrieved from the Walden Library databases.
This study assesses behaviors and attitudes toward HIV based

5. on knowledge about infection and advances in medical
treatment. It also examines the impact of maladaptive responses
to the stress of HIV risk.
Scourfield, A., Waters, L., & Nelson, M. (2011). Drug
combinations for HIV: What's new?
Expert Review of Anti-Infective Therapy
,
9
(11), 1001–1011. Retrieved from
http://www.expert-reviews.com/doi/abs/10.1586/eri.11.125
This article examines current therapies and strategies for
treating HIV patients. It also examines factors that impact the
selection of therapy, including drug interactions,
personalization of therapy, costs, management of comorbidities,
and patient response.
Drugs.com. (2012). Retrieved from
www.drugs.com
This website presents a comprehensive review of prescription
and over-the-counter drugs, including information on common
uses and potential side effects. It also provides updates relating
to new drugs on the market, support from health professionals,
and a drug-drug interactions checker.
Media
Laureate Education, Inc. (Executive Producer). (2012b).
Antimicrobials
. Baltimore, MD: Author.
This media presentation outlines principles of antimicrobial
therapy.
Optional Resources
Centers for Disease Control and Prevention. (n.d.). Retrieved
August 10, 2012, from
http://www.cdc.gov
Haymarket Media, Inc. (2012). Monthly prescribing reference
[Online database]. Retrieved from

6. http://www.empr.com/
Institute for Safe Medication Practices. (2012). Retrieved from
http://www.ismp.org/
Medscape. (2012). Retrieved from
http://www.medscape.com/