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DIFFERENTIAL DIAGNOSIS OF
MEMBRANE OVER THE TONSIL
Dr .Muhammad Tariq
Assist.Prof ,PIMS
MEMBRANOUS TONSILLIITIS
 It occurs due to pyogenic organisms.
 An exudative membrane forms over the medial
surface of the tonsils ,along with the features of
acute tonsillitis.
DIPHTHERIA
 Diphtheria unlike acute tonsillitis slower in
onset,with less local discomfort.
 The membrane in diphtheria extends beyond the
tonsils on to the soft palate and is dirty in colour.
 Membrane is adherent and its removal leaves a
bleeding surface.
 Urine may show albumin .
 Smear and culture of throat swab will reveal
Corynebacterium diphtherae.
VINCENT’S ANGINA
 It is insidious in onset with less fever and less
discomfort in throat.
 Membrane ,which usually forms over one tonsil
,can be easily removed.
 Throat swab will show both the organisms typical of
disease ,namely fusiform bacilli and spirochaetes.
INFECTIOUS MONONUCLEOSIS
 This often affects young adults.
 Both tonsils are very much enlarged,congested and
covered with membrane.
 Lymph nodes are enlarged in the posterior triangle
of neck along with splenomegaly.
 Blood smear may show more than 50%
lymphocytes of which 10% are atypical.
 WBC may be normal in the first week but rises in
the second week.
 Paul Bunnell test will show hih titre of heterophil
antibody.
AGRANULOCYTOSIS
 It presents with ulcerative necrotic lesion not only
the on the tonsils but elsewhere in the oropharynx.
 Patient is severely sick.
 In acute fulminant form ,total leucocyte count is
decreased to<2000/cu mm.
 In chronic or recurrent form it is reduced to 2000/cu
mm with less marked granulocytopenia.
APHTHOUS ULCERS
 They may involve any part of oral cavity or
oropharynx.
 Sometimes ,it is solitary and may involve the tonsil
and pillars .
 It may be small or quite large and alarming .it is
very painful also.
TRAUMATIC ULCER
 Any injury to oropharynx heals by formation of a
membrane .
 Trauma to the tonsil area may occur accidently
when hit with a tooth brush ,a pencil held in mouth
or fingering in the throat.
 Membrane appear within 24 hours.

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  • 1. DIFFERENTIAL DIAGNOSIS OF MEMBRANE OVER THE TONSIL Dr .Muhammad Tariq Assist.Prof ,PIMS
  • 2. MEMBRANOUS TONSILLIITIS  It occurs due to pyogenic organisms.  An exudative membrane forms over the medial surface of the tonsils ,along with the features of acute tonsillitis.
  • 3. DIPHTHERIA  Diphtheria unlike acute tonsillitis slower in onset,with less local discomfort.  The membrane in diphtheria extends beyond the tonsils on to the soft palate and is dirty in colour.  Membrane is adherent and its removal leaves a bleeding surface.  Urine may show albumin .  Smear and culture of throat swab will reveal Corynebacterium diphtherae.
  • 4.
  • 5. VINCENT’S ANGINA  It is insidious in onset with less fever and less discomfort in throat.  Membrane ,which usually forms over one tonsil ,can be easily removed.  Throat swab will show both the organisms typical of disease ,namely fusiform bacilli and spirochaetes.
  • 6. INFECTIOUS MONONUCLEOSIS  This often affects young adults.  Both tonsils are very much enlarged,congested and covered with membrane.  Lymph nodes are enlarged in the posterior triangle of neck along with splenomegaly.  Blood smear may show more than 50% lymphocytes of which 10% are atypical.  WBC may be normal in the first week but rises in the second week.  Paul Bunnell test will show hih titre of heterophil antibody.
  • 7. AGRANULOCYTOSIS  It presents with ulcerative necrotic lesion not only the on the tonsils but elsewhere in the oropharynx.  Patient is severely sick.  In acute fulminant form ,total leucocyte count is decreased to<2000/cu mm.  In chronic or recurrent form it is reduced to 2000/cu mm with less marked granulocytopenia.
  • 8. APHTHOUS ULCERS  They may involve any part of oral cavity or oropharynx.  Sometimes ,it is solitary and may involve the tonsil and pillars .  It may be small or quite large and alarming .it is very painful also.
  • 9. TRAUMATIC ULCER  Any injury to oropharynx heals by formation of a membrane .  Trauma to the tonsil area may occur accidently when hit with a tooth brush ,a pencil held in mouth or fingering in the throat.  Membrane appear within 24 hours.