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Care of the kidney during daily Ortho- Rheumatology practice ,[object Object],[object Object],[object Object],[object Object]
Kidney Diagram   Capsule Renal Vein Renal Artery Cortex Pyramid Papilla Calyx Pelvis Ureter Column Medulla Nephron
Renal prostaglandins ,[object Object],[object Object],[object Object],[object Object],[object Object]
Renal  PGs ,[object Object],[object Object],[object Object],Renal cortex Renal medulla
Renal prostaglandins ,[object Object],[object Object],[object Object],[object Object]
Glomerular filtration rate (GFR) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Creatinine & Cystatin C clearance ,[object Object],[object Object],[object Object],[object Object],[object Object]
5 Stages of Chronic Kidney Disease   ( K/DOQI)  define CKD as  The presence of kidney damage or a reduction in the GFR for  >  3  months. GFR Description Stage More than 90 Risk factors for kidney disease (e.g., diabetes, high blood pressure, family history, older age. At increased risk More than 90 Kidney damage (protein in the urine) and normal GFR 1 60 to 89 Kidney damage and mild decrease in GFR 2 30 to 59 Moderate decrease in GFR 3 15 to 29 Severe decrease in GFR 4 Less than 15 Kidney failure (dialysis or kidney transplant needed) 5
Acute interstitial nephritis (AIN ( Tubulointerstitial nephritis (TIN) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
A cute TIN are caused by  hypersensitivity reactions  to drugs and are  not mediated by direct toxicity .   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
TIN are diseases involving  tubules and  or the interstitium outside the glomerulus.  The renal cortex shows a diffuse interstitial, mononuclear infiltrate with intact glomerulus.  Tubules in the center of the field are separated by inflammation and edema.
NSAIDs induced acute TIN. ,[object Object],[object Object],[object Object],[object Object]
Antibiotic-induced acute TIN. ,[object Object],[object Object],[object Object],[object Object],[object Object],Inflammatory infiltrate ( ill-defined granuloma)  with a partially destroyed tubule. Mononuclear infiltrate with abundant  eosinophils,  (allergic etiology). Severe tubular damage is observed
Cyclosporine- and tacrolimus- induced nephropathy ,[object Object],[object Object],[object Object],[object Object],Chronic TIN, with  interstitial fibrosis, distortion of tubules and periglomerular fibrosis . Intact glomeruli.
Assessment of CKD ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Imaging Studies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment of AIN ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Why CKD should be prevented and early detected ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hyperlipidemia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Analgesic nephropathy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Renal prostaglandins ,[object Object],[object Object],[object Object],[object Object]
NSAIDs  Elimination enhancement  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Chloroquine / Hydroxychloroquine Toxicity ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MTX renal handling ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Leucovorin (citrovorum factor). ,[object Object],[object Object],[object Object],[object Object]
Cyclosporin A (CSA) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Leflunomide (LF) ,[object Object],[object Object],[object Object],[object Object]
Antihypertensive agents: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pearls for Practice ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pearls for Practice ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
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33 ellabban care of the kidney during daily

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  • 2. Kidney Diagram Capsule Renal Vein Renal Artery Cortex Pyramid Papilla Calyx Pelvis Ureter Column Medulla Nephron
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  • 8. 5 Stages of Chronic Kidney Disease ( K/DOQI) define CKD as The presence of kidney damage or a reduction in the GFR for > 3 months. GFR Description Stage More than 90 Risk factors for kidney disease (e.g., diabetes, high blood pressure, family history, older age. At increased risk More than 90 Kidney damage (protein in the urine) and normal GFR 1 60 to 89 Kidney damage and mild decrease in GFR 2 30 to 59 Moderate decrease in GFR 3 15 to 29 Severe decrease in GFR 4 Less than 15 Kidney failure (dialysis or kidney transplant needed) 5
  • 9.
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  • 11. TIN are diseases involving tubules and or the interstitium outside the glomerulus. The renal cortex shows a diffuse interstitial, mononuclear infiltrate with intact glomerulus. Tubules in the center of the field are separated by inflammation and edema.
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