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Medication Safety Course
Ph: Badr A Taher
Master Degree
DIC Supervisor. MMCH. KSA
Head Of Medication Safety Committee
Member Of: P&T Committee. Pharmacy And Nurse Committee
INSPIRED BY TRUE EVENTS
2
Medication Safety Work Flow
Prevent
From
occurring
Prevent
From
Reoccurring
3
The Extent of the Medications Error
problem
In the Institution of Medicine report:
44,000 to 98,000 Americans die each year from
medical error, with an associated cost of$17 to
$29 billion.
4
Error Occurrence
‫حدوث‬‫الخطأ‬
5
Errors are not surprising
given the fact that human
beings by their very nature
make errors.
Error Analysis Theory
‫الدوائي‬ ‫الخطأ‬ ‫تحليل‬
6
Reasons of System
Failure:
Swiss Cheese Model by James Reason
Note: In Figures 9–12, the abbreviations stand for the following: “Proc” for the procurement node; “Presc” for the prescribing node;
“Trans/Doc” for
the transcribing/documenting node; “Disp” for the dispensing node; “Admin” for the administering node; and “Monit” for the monitoring
node.
Types of Medication Errors (cont.)
‫الدوائية‬ ‫األخطاء‬ ‫أنواع‬(‫تابع‬)
Comparison of Medication Error Reports by Process Node
7
The six nodes are
(1) procurement
(2) prescribing;
(3) transcribing/documenting;
(4) dispensing,
(5) administering,; and
(6) Monitoring medication.
http://www.unmc.edu/rural/documents/pr06-08.pdf
Doctors and 10%
8
Cptopril and Mercaptopurine
Meropenem and Imipenem
Amikacin and Aminocaproic acid
Transcription Error IS
50% of medication
errors
9
 Ceftriaxone
 Cefazoline
 Cefepime
 Cefalexin
 cefuroxime
 Cefotaxime
 Ceftazidime…
3. Dispensing Error
‫الدواء‬ ‫صرف‬ ‫في‬ ‫خطأ‬
• Dispensing errors occur at a rate of 5-8
% wrong strength or product.
10
3. Dispensing Error (cont.)
‫صرف‬ ‫في‬ ‫خطأ‬‫الدواء‬(‫تابع‬)
Example of Dispensing of LASA
 Factor: 7,8 (R and P) ,9,10,13.
 Exjade (Deferasirox) once daily # Ferriprox
(Deferiprone)Three Times per day.
 Methotrexate frequency is per week not
daily.
 Pen G Sodium (IV) # Pen G benzathine(IM)
 Ampho B # Ampho B liposomal (not equal)
 Alprostadil Inj # Prostaglandin E2 Tablet.
11
4. Administration Error
‫خطأ‬‫إعطاء‬ ‫في‬‫الدواء‬
40 % of medication errors.
12
Administer the medication
Evaluate the patient
Review warning, interaction & allergy
Confirm the transcription
Review the prescription orderSteps of medication
administration:
13
4. Administration Error
‫خطأ‬‫إعطاء‬ ‫في‬‫الدواء‬
Contributing factors to drug administration errors
include :
• A failure to check the patient’s identity
• Storage of similar preparations in similar areas.
14
4. Administration Error
‫خطأ‬‫إعطاء‬ ‫في‬‫الدواء‬
4. Administration Error (cont.)
‫الدواء‬ ‫إعطاء‬ ‫في‬ ‫خطأ‬(‫تابع‬)
The intravenous route of administration
is a particularly complex process
during which errors frequently occur
15
Click here
EXAMPLE
• Extravasation
• Vancomycin
• Ranitidine
• Immunoglobulin
• Ampicillin
16
EXAMPLE
• Concentrated electrolyte and precipitation
(check diluent color/ turbidity)
• Emergency Floor stock : labetalol
17
EXAMPLE
• Insulin rate
• Insulin and NGT
• Dextrose 50%:Thrombosis
• Heparin in OR bleeding: protamine /
Automatic Stop Order
• Ketamine / respiratory / naloxone
18
EXAMPLE
• Chemo(METHO) and pregnant
• Usual vancomycin frequency q 6 but 24 hour?
• 1 mg = 1000 mcg( Digoxin)
19
EXAMPLE
• Iron toxicity could lead to liver damage
• Anaphylactic shock
20
EXAMPLE
• Iron Test dose: 25 mg over 15 minutes.
• Epipen (Adrenaline)
21
PROPHYLACTIC AB
• Cefazolin over 5 minutes
• Clindamycin / gentamicin / metronidazole:
30 minutes
• Ciprofloxacin: 1 hour
• Within one hour to start operation Or wound
infection will occur
22
4. Administration Error (cont.)
‫الدواء‬ ‫إعطاء‬ ‫في‬ ‫خطأ‬(‫تابع‬)
Unauthorized Drug error:
23
Example of administration of a
discontinued drug :
The physician prescribe captopril: hold
Captopril if BP <90 mmHg but the Nurse
administered the Captopril while the patient
BP is 80 mmHg. The patient transfer to the
Critical Care Unit.
24
A 3-day-old infant weighing 1.3 kg was prescribed total
parenteral nutrition containing 1 unit of regular insulin per each
327-mL bag. A pharmacy technician mistakenly added 1 mL of
regular insulin (100 units) rather than 1 mL of a pharmacy-
prepared dilution of 1 unit/mL regular insulin. The mistake was
caught 2 hours later when the infant's blood glucose measured 3
mg/dL. Rapid treatment with dextrose boluses ensued, and the
blood glucose returned to normal within 12 hours.
4. Administration Error (cont.)
‫الدواء‬ ‫إعطاء‬ ‫في‬ ‫خطأ‬(‫تابع‬)
4. Administration Error (cont.)
‫الدواء‬ ‫إعطاء‬ ‫في‬ ‫خطأ‬(‫تابع‬)
Types of Administration errors (cont.):
Wrong Dosage Form Error :(plain aspirin
instead of enteric-coated)
Wrong Time Error: (in 30-minute window
medications)
25
5
A covering physician admitted a patient with
Hodgkin’s lymphoma to a medical unit. At home, the
patient had been taking hydromorphone 2 to 4 mg
orally for pain. The covering physician prescribed the
same medication, but also wrote an order for
hydromorphone 2 to 4 mg IV every 3 hours for pain
if the patient was unable to tolerate oral fluids.
26
Categorization of Medication Error
according to the severity (cont.)
Like the physician, the nurses on the unit did not recognize
that oral and IV dosing of this product, as with most opiate
analgesics, is quite different. In converting an oral
hydromorphone dose to IV, the generally accepted
equianalgesic dose is between 3 to 1 and 5 to 1. A nurse
administered 4 mg IV and the patient developed respiratory
depression and became unresponsive. Two doses of
naloxone IV reversed the effects of the medication.
27
Categorization of Medication Error
according to the severity (cont.)

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Medication safety lecture 2

  • 1. Medication Safety Course Ph: Badr A Taher Master Degree DIC Supervisor. MMCH. KSA Head Of Medication Safety Committee Member Of: P&T Committee. Pharmacy And Nurse Committee
  • 2. INSPIRED BY TRUE EVENTS 2
  • 3. Medication Safety Work Flow Prevent From occurring Prevent From Reoccurring 3
  • 4. The Extent of the Medications Error problem In the Institution of Medicine report: 44,000 to 98,000 Americans die each year from medical error, with an associated cost of$17 to $29 billion. 4
  • 5. Error Occurrence ‫حدوث‬‫الخطأ‬ 5 Errors are not surprising given the fact that human beings by their very nature make errors.
  • 6. Error Analysis Theory ‫الدوائي‬ ‫الخطأ‬ ‫تحليل‬ 6 Reasons of System Failure: Swiss Cheese Model by James Reason
  • 7. Note: In Figures 9–12, the abbreviations stand for the following: “Proc” for the procurement node; “Presc” for the prescribing node; “Trans/Doc” for the transcribing/documenting node; “Disp” for the dispensing node; “Admin” for the administering node; and “Monit” for the monitoring node. Types of Medication Errors (cont.) ‫الدوائية‬ ‫األخطاء‬ ‫أنواع‬(‫تابع‬) Comparison of Medication Error Reports by Process Node 7 The six nodes are (1) procurement (2) prescribing; (3) transcribing/documenting; (4) dispensing, (5) administering,; and (6) Monitoring medication. http://www.unmc.edu/rural/documents/pr06-08.pdf
  • 8. Doctors and 10% 8 Cptopril and Mercaptopurine Meropenem and Imipenem Amikacin and Aminocaproic acid
  • 9. Transcription Error IS 50% of medication errors 9  Ceftriaxone  Cefazoline  Cefepime  Cefalexin  cefuroxime  Cefotaxime  Ceftazidime…
  • 10. 3. Dispensing Error ‫الدواء‬ ‫صرف‬ ‫في‬ ‫خطأ‬ • Dispensing errors occur at a rate of 5-8 % wrong strength or product. 10
  • 11. 3. Dispensing Error (cont.) ‫صرف‬ ‫في‬ ‫خطأ‬‫الدواء‬(‫تابع‬) Example of Dispensing of LASA  Factor: 7,8 (R and P) ,9,10,13.  Exjade (Deferasirox) once daily # Ferriprox (Deferiprone)Three Times per day.  Methotrexate frequency is per week not daily.  Pen G Sodium (IV) # Pen G benzathine(IM)  Ampho B # Ampho B liposomal (not equal)  Alprostadil Inj # Prostaglandin E2 Tablet. 11
  • 12. 4. Administration Error ‫خطأ‬‫إعطاء‬ ‫في‬‫الدواء‬ 40 % of medication errors. 12
  • 13. Administer the medication Evaluate the patient Review warning, interaction & allergy Confirm the transcription Review the prescription orderSteps of medication administration: 13 4. Administration Error ‫خطأ‬‫إعطاء‬ ‫في‬‫الدواء‬
  • 14. Contributing factors to drug administration errors include : • A failure to check the patient’s identity • Storage of similar preparations in similar areas. 14 4. Administration Error ‫خطأ‬‫إعطاء‬ ‫في‬‫الدواء‬
  • 15. 4. Administration Error (cont.) ‫الدواء‬ ‫إعطاء‬ ‫في‬ ‫خطأ‬(‫تابع‬) The intravenous route of administration is a particularly complex process during which errors frequently occur 15 Click here
  • 16. EXAMPLE • Extravasation • Vancomycin • Ranitidine • Immunoglobulin • Ampicillin 16
  • 17. EXAMPLE • Concentrated electrolyte and precipitation (check diluent color/ turbidity) • Emergency Floor stock : labetalol 17
  • 18. EXAMPLE • Insulin rate • Insulin and NGT • Dextrose 50%:Thrombosis • Heparin in OR bleeding: protamine / Automatic Stop Order • Ketamine / respiratory / naloxone 18
  • 19. EXAMPLE • Chemo(METHO) and pregnant • Usual vancomycin frequency q 6 but 24 hour? • 1 mg = 1000 mcg( Digoxin) 19
  • 20. EXAMPLE • Iron toxicity could lead to liver damage • Anaphylactic shock 20
  • 21. EXAMPLE • Iron Test dose: 25 mg over 15 minutes. • Epipen (Adrenaline) 21
  • 22. PROPHYLACTIC AB • Cefazolin over 5 minutes • Clindamycin / gentamicin / metronidazole: 30 minutes • Ciprofloxacin: 1 hour • Within one hour to start operation Or wound infection will occur 22
  • 23. 4. Administration Error (cont.) ‫الدواء‬ ‫إعطاء‬ ‫في‬ ‫خطأ‬(‫تابع‬) Unauthorized Drug error: 23 Example of administration of a discontinued drug : The physician prescribe captopril: hold Captopril if BP <90 mmHg but the Nurse administered the Captopril while the patient BP is 80 mmHg. The patient transfer to the Critical Care Unit.
  • 24. 24 A 3-day-old infant weighing 1.3 kg was prescribed total parenteral nutrition containing 1 unit of regular insulin per each 327-mL bag. A pharmacy technician mistakenly added 1 mL of regular insulin (100 units) rather than 1 mL of a pharmacy- prepared dilution of 1 unit/mL regular insulin. The mistake was caught 2 hours later when the infant's blood glucose measured 3 mg/dL. Rapid treatment with dextrose boluses ensued, and the blood glucose returned to normal within 12 hours. 4. Administration Error (cont.) ‫الدواء‬ ‫إعطاء‬ ‫في‬ ‫خطأ‬(‫تابع‬)
  • 25. 4. Administration Error (cont.) ‫الدواء‬ ‫إعطاء‬ ‫في‬ ‫خطأ‬(‫تابع‬) Types of Administration errors (cont.): Wrong Dosage Form Error :(plain aspirin instead of enteric-coated) Wrong Time Error: (in 30-minute window medications) 25 5
  • 26. A covering physician admitted a patient with Hodgkin’s lymphoma to a medical unit. At home, the patient had been taking hydromorphone 2 to 4 mg orally for pain. The covering physician prescribed the same medication, but also wrote an order for hydromorphone 2 to 4 mg IV every 3 hours for pain if the patient was unable to tolerate oral fluids. 26 Categorization of Medication Error according to the severity (cont.)
  • 27. Like the physician, the nurses on the unit did not recognize that oral and IV dosing of this product, as with most opiate analgesics, is quite different. In converting an oral hydromorphone dose to IV, the generally accepted equianalgesic dose is between 3 to 1 and 5 to 1. A nurse administered 4 mg IV and the patient developed respiratory depression and became unresponsive. Two doses of naloxone IV reversed the effects of the medication. 27 Categorization of Medication Error according to the severity (cont.)

Editor's Notes

  1. .
  2. Wrong Dosage Form Error: The administration of a medication in a dosage form different from the one that was ordered by the prescriber. This could include crushing a tablet prior to administration without an order from the prescriber. If enteric-coated aspirin was ordered, but plain aspirin was administered, a wrong form error was counted. Wrong Time Error: The failure to administer a medication to a patient within one (1) hour from its scheduled administration time. The standard hospital administration time as approved by the Pharmacy and Therapeutic Committee is considered the reference. Administration time of a dose must not be more than 60 minutes before or after the scheduled administration time. A 30-minute window was used for medications that were ordered before, with, or after a meal. Routine administration times were obtained from each site, and times assigned on the MAR were used when no other policy was available. Wrong Drug Preparation Error: such as incorrect or inaccurate dilution or reconstitution, failure to shake suspension, crushing medication that should not be crushed, mixing drug that is physically or chemically incompatible and inadequate product packaging.   Wrong Administration Technique Error: Use of an inappropriate procedure or improper technique in the administration of a drug. Examples of wrong technique error include; incorrect manipulation of inhalers, failure to maintain sanitary technique with medications, not wiping an injection site with alcohol, failure to use proper technique when crushing medications, failure to check naso­gastric (NG) tube placement or flushing NG tube before and after administration of medication, failure to wash hands or improper hand washing technique used. It is defined also defined as: Exclusion of or incorrect performance of a procedure ordered by the prescriber immediately before administering each dose of medication. Examples of this error include the lack of heart rate or blood pressure measurement before giving a dose. Wrong Patient Error: such as identification not properly verified, or patients with look-alike name.   Wrong Duration Error: such as not adhering to the proper schedule of administration,