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Intussusception Diagnosis and Management
1.
2. Introduction
Types of intususception
Clinical approach
Investigations
Management options
Post op complications and recurrence
Summery
Reference
3. Wilson (1831) reported the first successful
operative reduction in an adult,
Hutchinson reported it in an infant
40 years later (1871)
But with high mortality rate
As operative technique evolved, results
improved.
4. 1876 Hirschsprung
published the first of a series of reports on
hydrostatic reduction with much decreased
mortality (23%) than operation
5. In 1913 Ladd reported bismuth enemas and
published the first photographs of
roentgenologic pictures of an intussusception
Fourteen years later (1927), Olsson and
Pallin, Poulquien, and Retan used barium-
guided fluoroscopy
6. Till 1948 operation was the choise in USA till
Ravitch and McCune reported a surgical
mortality of 32%
By 1958, nonoperative reduction rates of up
to 75% were achieved with a mortality rate
close to zero.
7. Burke and Clarke (1977) used only
ultrasonography (US) for screening, diagnosis,
and monitoring the reduction of intussusception
Guo and colleagues (1986)
successfully tried delayed repeat enema
reduction attempts
Today, operation is the accepted norm for failed
radiologicguided reduction of intussusception.
8. intussusception is derived from the Latin
word
intus (within)
suscipere (to receive)
invagination of one part of the intestine into
another
9. Three cylinders of intestinal wall are involved.
The inner and middle cylinders are the
invaginated bowel (intussusceptum)
the outer cylinder is the recipient of the
invaginated bowel (intussuscipiens)
10.
11.
12. It is the second cause of abdominal pain in
pre school children after constipation
diagnosis and treatment is a combined effort
among the pediatrician, the pediatric
radiologist, and the pediatric surgeon
13. 1 to 4 in 2000 infants and children
more males than females ( 2:1 or 3:2 ratio)
(78% males) after 9 months of age than
before (55%)
14. 75% of cases occur within the first 2 years of
life
90% in children within 3 years of age.
More than 40% are seen between 3 and 9
months of age
15. Intussusception has been reported in families
and relatives viral cause rather than a genetic
cause
seasonal variation that usually correlates with
viral infections (respiratory,gastrointestinal)
incidence of a preceding viral illness has
been reported as high as 20%
17. prograde bowel peristalisis
(intussusceptum) carries its mesentery in
to(intussuscipiens).
The mesenteric vessels are angulated,
squeezed, and compressed between the
layers of the intussusceptum.
This causes intense local edema of the
intussusceptum
18. four main types:
general,
specific,
anatomic, and
other
19. (1) The two general types are
permanent (fixed, 80%) symptomatic
(85%), and all require treatment
transient (spontaneousreduction, 20%); small and
freq <2cm, reduces spontaneously, incidental
findings
most are small bowel,asymptomatic, 6% could
have PLPs
20. (2) the specific types can be described as
idiopathic (no pathologic lead point [PLP],
95%),
PLP (4%),
postoperative (1%);
21. (Peyer patches) functions as a lead point
Majority of all cases (95%)
Peyer patches are usually located in the
antimesenteric area of the bowel wall.
In the distal ileum, Peyer patches
involve the entire circumference of the bowel
22. distal ileal wall lymphoid tissues and the
nearby mesenteric lymph nodes may enlarge
and form a lead point useally 2ry to infection
However, in a mouse model, the Peyer
patches did not appear to act as the anatomic
lead point for intussusception
Rotavirus vaccine (RRV-TV)
23. Malnourished children have a lower risk of
intussusception because of less
prominent intestinal lymphoid tissue
infants who consumed soy milk–based
formula
had a much lower risk, and infants who
consumed cow’s milk
formula had an increased risk for
intussusception
24. (3) when classified by anatomic
types
ileocolic (85%);
ileoileocolic(10%);
appendicocolic, cecocolic, or colocolic (2.5%)
jejunojejunal, ileoileal (2.5%)
occurring around indwelling tubes
25. (4) the fourth type is “other”
recurrent (5%)
neonatal (0.3%) intussusception.
26. 1.5% to 12% of all intuss.
increases with age from about 5% in the first
year to 44% within the first 5 years of life and
60% in 5- to 14-yearolds
in 4% of infants and children who
have one recurrence
19% with multiple recurrences
27. most common focal cause of a PLP is
Meckel diverticulum(inverted)
intestinal polyps
duplications
Others
periappendicitis;
Appendiceal stump;
inversion appendectomy
appendiceal mucocele;
local suture line;
30. Most PLPs manifest as ileoileocolic
intussusceptions(40%)
jejunojejunal, ileoileal, ileocolic, appendicocolic,
cecocolic, and colocolic
intussusceptions
Recurrence vs PLP
5% of patients with one recurrence
19% of children with multiple recurrent episodes
31. manifests as a small bowel obstruction (SBO)
third most common intussusception (1%)
found most often in the small bowel
after prolonged laparotomy
significant bowel handling
32. no lead point present
SBO after pediatric laparotomy is about 5%
(with 80% occurring within the first 2 years
after laparotomy).
Three to ten percent of those are caused by
postoperative intussusceptions
SBO after pediatric laparotomy is about 5%
(with 80% in 1st 2 yr)
33. gastrojejunostomy tubes with a reported
incidence of 16%
Antegrade jejunal intussusceptions,
Usually asymptomatic
treatment may be clinical monitoring
Removal or conversion to a gastrostomy or
nasogastric tube will cure the problem
34. 8% to 15%following barium enema reduction,
5.2% to 20% following sonography-guided
hydrostatic enema reduction,
5.4% to15.4% following fluoroscopy-guided
air enema reduction,
6.25% to 7% after sonography-guided air
enema
35. Recurrence rates are lower after manual
operative reduction (3% to 4%)
operative resection and anastomosis of an
intussusception(0%)
occur within the first few days after the
initial reduction, some within hours
36. Reduciblity>>> 100% for initial recurrence
and 95% for multiple recurrences
pathologic lead point
4% in children with one recurrence
14% withmultiple recurrences
37. infrequent (0.3%of all cases)
caused by a pathologic lead point
NEC like manifestation
abdominal distension (17/17),
bilious gastric aspirates (13/17),
bloody stools (10/17), and
palpable abdominal mass (5/17)
38. suspected with any of the two classic symptoms
and signs
Abdominal
pain(85%)sudden,colicky,intemittent
Vomiting (45% of infants)
signs
abdominal mass or
rectal bleeding
39. In USA Most cases are diagnosed within 24
hours of the onset of symptoms.
recurrent intussusception diagnosed early
crampy abdominal pain>>>>high index of
suspicion
40. All four classic signs and symptoms can only
be found late (<30% of cases)
diarrhea precedes and may mislead to
incorrect diagnosis and triage(20%)
absence of pain(15%), delays the
diagnosis>>pale and listless and appear
quite ill
41. curved, sausage-shaped
right upper quadrant(65%)
usually extends to the left along the
transversecolon
42. Slightly tender
Easily palpable and visiblemass in silent child
Dance sign
palpated on rectal examination (5%)
Rectal bleeding>>>last sign to occur
43. Rectal bleeding
mucus-like texture
Dueto sloughing of the mucosa dueto
congestion and subsequent ischemia
44. Delayed presentation
Fever
Tachycardia
hypotension >>>>bacteremia and bowel
perforation
N.B>Rapid diagnosis and emergent operation
are essential to prevent a fatal outcome
45. Lab
No lab investigation is diagnostic
leucocytosis,
Acidosis
electrolyte
46. Clinical diagnosis only is 50% sensitive
radiologic imaging and US to either confirm
or make the correct diagnosis(100%)
47.
48. Up to 100% accuracy for the diagnosis of
intussusception
portable, noninvasive, and without radiation
Characteristic finding>>>>3- to 5-cm diameter
mass,
typical target or doughnut sign
found just deep to the anterior abdominal wall on
the right side
49. can detect a possible pathologic lead
point with higher frequency (66%) than
contrast (40%) or air enema (11%)
Can also detect Other DDX that mimic
intussuscepption
50. it leads to a second study, increased health
care costs since the US could have been
avoided??
Ultrasound cannot predict well if the
intussusception is already necrotic or
amendable to nonoperative reduction and
should therefore not preclude reduction by
enema
51. the absence of blood flow on Doppler
a thick peripheral hypoechoic rim,
free intraperitoneal fluid,
fluid trapped within the intussusceptum,
enlarged lymph nodes dragged with the
mesentery into the intussusception
52. Are not routinely used
Intussusception found incidentally on
imaging performed for another suspected
diagnosis
target or doughnut sign
immediate CT scanning
target sign with a diameter 3 cm(US)
atypical location in the (Lt Abd & ublicus)
53. Was a gold standard Before ultrasound
became widely available
In some institutions it is still the preferred
diagnostic modality
accuracy of 100%
Is both dignostic and therapeutic
54. invasive (radiation)
More than 50% of diagnostic BE suspected
intussusception turn out to be negative
55. Evaluation by surgeon if there is need for
emergent operation
Fluid resuscitation
NG tube decompression
Broad-spectrum antibiotic
cross-matched blood
radiologic confirmation
N.B>>The operating room should be notified
56. medical (under occasional and specific
situations),
radiologic reduction or operative reduction,
resection,
closure of an enema perforation
excision of a PLP by laparotomy or
laparoscopy
57. differentiate suitable candidates
Contraindications (BE and AE)
Dehydration>>>corrected
shock
peritonitis, or
radiographic evidence of perforation with free
air
58. younger age (<6 months),
Rectal bleeding,
radiographic signs of intestinal obstruction,
or
longer duration of signs and symptoms (>72
hours)
hydrostatic or pneumatic enema should be
attempted in all children without peritonitis
59. operative management remains the usual
primary treatment in much of the developing
world(Nigeria and Kenya)
mortality rate up to 20%
AE reduction in developing world success rate
was 60% without mortality
60.
61. Currently used options
pneumatic or hydrostatic pressure enemas
under fluoroscopy or US
USA and Europe management of
intussusception varied greatly with a trend to
pneumatic reduction techniques with greater
use of ultrasound
62. it avoids radiation exposure
provides more information than fluoroscopic
techniques do
high accuracy and reliability for monitoring
the reduction process,
visualizes all components of the
intussusception
easily recognize pathologic lead points
63. the need for a radiologist who is comfortable
using US for reduction guidance.
less experience with pneumatic reduction
under US guidance,
Difficulty of early identification of perforation
64. The enema tip should be placed within the child’s
rectum and taped securely in place
child is placed in a prone position to squeeze the
buttocks closed and prevent air from leaking
Air is insufilated into the colon under
fluoroscopic observation
reduction is followed fluoroscopically until it is
completely reduced
65. Air should flow freely from the cecum into the
distal small bowel loops to signify complete
reduction
keep air pressure below a maximum limit of
120 mm Hg to avoid the risk of perforation
66. it is easy to perform
can be done quickly
less messy
delivers less radiation exposure
is more comfortable,
results in smaller perforations
Less peritoneal contamination
67. passage of air into the terminal ileum without
complete reduction of the ileocolic
intussusception
tension pneumoperitoneum (rare)
68.
69.
70.
71. the liquid enema is simple, safe, and
effective, and most radiologists have
experience with its use than AE
US is relatively easy to use and the imaging
modality of choice in many centers
72. messy
perforation occur with larger colonic tears,
increased peritoneal contamination
rapid fluid shifts with hypertonic water-
soluble
agents
Barium is no longer the liquid contrast
medium of
choice (peritonitis, infection, and adhesions
when perforates)
73. three attempts
each of 3 minutes duration
enema bags 3 feet above the table
reduction may occur rapidly or stubbornly
slowly
pause when the barium column meets the
intussusception
74. the rounded barium column suddenly
becomes concave
forms a meniscus around the head of the
intussusception
When the intussusception is displaced, the
meniscus flattens out
75. barium seeps between the two and produces
the characteristic radiologic appearance of a
coiled spring
Filling of the cecum is often slow, the sudden
rush of barium into the distal ileum indicative
of reduction
76.
77. If the enema is not freely filling in to the
ileum>>>incomplete reduction
Once the reduction is successful, the infant or
child is relieved of the pain and usually falls
asleep
79. improved their reduction rate with air enema
from 58% to 76%
this technique may be more widely used than
reported in the literature
80. In the past it was standard practice that
immediate operative intervention was
required for all patients, if intussusception
was irreducible by enema techniques
10% of intussusceptions were found to be
already reduced, and another 40% were easily
reduced manually in the OR
81. i.e surgical intervention could possibly have been
avoided in half the cases if radiologists used a
different or more aggressive approach to their
enema technique
Interval>>>ranged between minutes and days
Success rates between 50% and 84%
Usually done under GA
No. of attempt should be tailored to the
individual patient and experience of radiologist
82. Close cooperation between experienced
pediatric radiologists and surgeons and
careful clinical monitoring is a must
83. observed closely for at least a few hours
Discharge If parents are reliabe,pt is
aymptomatic and tolerated post reduction
fluid
Still most of the Pts need admission for
followup and further Tx
If NGT was needed initially for SBO, better to
keep it insitu overnight ,keep NPO and put on
MF
84. IV antibiotic is continued if the child is febrile
or the reduction is difficult (48hr)
10% recurrence rate is expected
Place of repeat Abd US study??>>the
edematous part at ieocecal area mimic
recurrence
85. Indication
radiographic reduction is contraindicated, has
failed or is incomplete,
peritonitis
pneumoperitoneum is detected
pathologic lead point is found
86. Fluid resuscitation
NGT decompression
IV antibiotic(for all minmum of 48hr)
Take to OR,keep in supine position
GA will be given
The mass is felt
The place of incision depends on the site of
the mass
87. Previously used for diagnostic purpose
Currently used for therapeutic reason too
Onset<36hr and no sign of
peritonitis>>good ourcome(60%)
88. right-sided transverse incision above or
below the umbilicus is the standard incision
If the incision is lower on the right
side>>appendectomy should be done
serosanguineous peritoneal fluid is
encountered on entering the
abdomen>>suspect necrosis
89. slow constant pinching and squeezing of the
most distal part of the intussusceptum, just
like squeezing a tube of toothpaste
90. ileoileocolic intussusception, the ileocolic
component is reduced first and then the
remaining ileoileal
leading edge of the intussusceptum may look
particularly ischemic>>become pink and vital
after application of warm saline towels for
less than 10 minutes
91. Up to 50% of all nonviable intussusceptions
can be reduced manually>>gives chance to
save as long bowel as possible saved
a primary end-to-end anastomosis can be
fashioned after the ischemic bowel is
resected
the ischemic bowel can be quickly resected
and both bowel ends exteriorized as
temporary stomas in critical child
92. Perforations during enema reduction usually
occur early during the procedure
Still 50% can be reduced manually
If the reduction is not possible, the
intussusception should be resected en mass
93. Radiologic reduction
bowel perforation(less than 1%)
occur in the outer intussuscipiens and in
the absence of necrosis
94. infants younger than 6 months
longer duration of symptoms (>36 hours)
High pressure(>120mmHg)
Rapid increasment in pressure
95. wound infection
fascial dehiscence
SBO. Reported complications rates >> (4%)
when no enterotomy or bowel
resection had to be performed (26%)
Post OP complication after perforation of Ba
enema reduction>>50%
96. in up to 20% of the cases (average in published
series 5%)
Recur within 6 months of the original episode
with 3rd within the first 24 hours
Enema reduction for recurrence is as successful
as for the initial episode
If multiple recurrences can occur in the same
child>>search for a pathologic lead point(tumor)
97. Is gradually declining even in developing
world
But still as high as 20%
Is <1% for both non operative and operative
reduction
The interval between onset of symptoms and
institution of treatment is of paramount
importance
Near zero if presentation is within 24hr
98. mothers
younger than 20 years,
nonwhite,
Unmarried
education level below grade 12
99. Pediatric intussusception often presents with
a wide range of nonspecific symptoms
The four classic symptoms of pain, emesis,
and bloody stools +-mass are together
present in less than 25% of children
Clinical dx is 50%sensitive
US and contrast enema makes accuracy reach
100%
100. The success rate of non operative reduction is
reaching >90%
This days in westerns setup most are
managed non operaatively
Duration of the complaint is the key for
successful reduction
Delayed repeat enemas are up to 82%
successful
101. suspected ischemic bowel and peritonitis,
unsuccessful enema reduction, suspected
pathologic lead point, or, rarely, perforation
after pressure enema (<1%) are indications
for operation
Recurrence after BE and AE reduction is up to
20%(average 5%)
102. Pediatric surgery,Arnolo G.coran,7th edition
Aschcraft’s pediatric surgery,6th edition
Schwartz principles of surgery,10th edition
Sabiston text book of surgery,20th edition
Uptodate 20.1
Editor's Notes
Diagram of the most common (idiopathic, ileocolic) type of intussusception. As it develops in the terminal ileum with its prograde bowelperistalsis, the proximal invaginated bowel (intussusceptum) carries its mesentery into the recipientbowel (intussuscipiens) and the mesenteric vesselsare angulated, squeezed, and compressed betweenthe layers of the intussusceptum. This causes intenselocal edema of the intussusceptum, which producesvenous compression, stasis, and congestion leadingto an outpouring of mucus and blood from theengorged intussusceptum, often producing stoolwith the appearance of currant jelly. If this viciouscycle continues, ischemic changes will lead to bowelgangrene. The outermostlayer ofthe intussusceptumbecomes devitalized first, the innermost layer of theintussusceptum becomes gangrenous much later,and the outermost layer of bowel (intussuscipiens)loses its viability last. Most perforations, however,are located in the colon near the intussusceptum.
In utero, intussusception may lead to intestinal atresia,most commonly ileal atresia.32–35 Perinatal intussusceptionin newborns (0.3% of all intussusceptions) is more likelycaused by a pathologic lead point like in older patients.
Intussusception has been reported in families and relatives(identical twins, sibling cases, as well as in fathers and sons), viral cause rather than a genetic cause
Transient intussusception may also be seen with gastroenteritis, probably because of hyperactivity of the inflamed bowel.Eighty-six percent of these transient intussusceptions involveonly the small bowel and are noted in the central and leftabdominal regions
, RotaShield) has a strong association betweenvaccination with RotaShield and intussusception
WHO’s Global Advisory Committee the benefits of rotavirus vaccination exceedthe possibly increased risk of intussusception
Intussusception caused by a PLP remains a diagnostic challengeUS sensitivity>>>Diagnosis
74% of all focal PLPs,
40% of diffuse PLPs,
32% has been reported(diagnosis of the exact type of PLP)
Less sensitive for a Meckel diverticulum
>>>>repeat US increases the yield
In 35% of all PLP cases the intussusception is caused bythickened bowel wall, abnormal motility, impaction of secretions, or the presence of multiple polyps. Other important riskfactors are ileoileocolic intussusception, an older child, theassociation of a long duration of symptoms with weight loss,and recurrent intussusception
The time between onset ofsymptoms and arrival in the hospital is shorter because ofthe awareness of the parents. The earlier the diagnosis, thegreater is the chance for successful reduction. Recurrentintussusceptions may be looser and easier to reduce but alsohave a greater chance of repeat recurrence.
sudden onset of severe, colicky, intermittent abdominal pain, which makes infants pull up their legs, is the mostcommon classic symptom of pediatric intussusception inabout 85% of patients. This pain episode typically lasts onlya few minutes
The two classic signs, abdominal mass and rectal bleeding,can be found with about the same frequency
se children are often pale and listlessand appear quite ill. Infants present more often with vomiting than older children do (up to 45%). Bilious vomitingtends to be found in delayed cases of intussusception withSBO
Several serieshave achieved equally high reduction rates using hydrostatic orpneumatic reduction under sonographic guidanceigh as 95%.108,137,162In conclusion, successful reductions can be achievedwhether one chooses to use the hydrostatic or pneumaticreduction technique under fluoroscopic or sonographic guidance. The choice of technique used will depend largely on theexperience, personal preference, and expertise of the radiologist involved, as well as on the local conditions in a particularinstitution and the type of patient population seen
Recurrence rates did not differ between children observedas inpatients and those discharged home, and there were nomissed pathologic lead points
ficult.The presence of fever usually indicates bacteremia, endotoxemia, cytokine (tumor necrosis factor, interleukin) andlysozyme release, and even the production of reactive lymphocytes, in which case antibiotics may be continued for48 hoursA repeat abdominal US study should be performed if anydoubt remains about the success of the enema reduction orthe abdominal pain recursthe ileocecal valve often remains edematousand thickened for a day or more.108 This appearance can easilybe differentiated from a recurrence because it lacks the typicalconcentric rings. The invaginated mesentery is smaller thanthe typical target sign of a true intussusception and will disappear with time.193 The ileocecal thickening can also be appreciated as a filling defect or narrowing if a contrast enema isperformed
r the initial episode.Multiple recurrences can occur in the same child and shouldprompt a search for a pathologic lead point such as an occultmalignancy. The recommended imaging modality is US.108Operative exploration is indicated when the ultrasoundsuggests a pathologic lead point, the reduction enema wasunsuccessful, or clinical symptoms persist postreduction