2. What is Bioinformatics?
Major activities are,
1.Annotation of biological information
2.Transformation and Manipulation of
data
3. Areas
- Molecular biology
- Genomics
- Systems biology
- Protein design and engineering
- Pharmaceutical development
- Medicine
- Ecology/ Population genetics
4. History
The pre-70’s
-The first sequence alignment algorithms
-Preferential substitution of amino acids in protein
sequences
-Studies on protein primary structure
-Use of mol bio data in evolutionary studies
-Theory of evolution by gene duplication
-Central dogma
5. History
The 70’s
-Studies of substitution mutation rates
-Calculation of solvent accessibility on protein
structures
-Parsimonial determination of tree topology
-RNA structure prediction
-Sequence alignment methods
6. History
The 80’s
More algorithms and resources
1.Sequence analysis
2.Molecular databases
3.Protein structure prediction
4.Molecular evolution