Power Point by Julia Bridges, Scarlet Kim, and Bailey Mooney

1. Hemophilia/ Royal
Disease
Julia Bridges: Slides 1-4
Scarlet Kim: Slides 5-6
Bailey Mooney: Slides 7-10

2. Table of Con.
Intro/Background
Physical Characteristics
Mental Characteristics
Emotional Characteristics
Genetic Source or Cause
Treatment
Interesting Facts
References

3. Intro/Background
Hemophilia is a medical disorder in which the person’s blood is unable to clot.
This results in severe bleeding for even the smallest cuts. This disorder is
usually inherited from parents to their children. Clotting Factors are proteins
needed for normal blood clotting. These proteins work with platelets. When you
are cut platelets work with clotting factors to help “plug” the cut, and then form a
scab. You can either have type a or type b hemophilia. Type A is more common
and results in you missing or having low levels of clotting factor VIII. People
born with hemophilia lack these platelets and clotting proteins. Hemophilia is
also called the royal disease because it affected the royal families of England,
Germany, Russia and Spain in the 19th
and 20th
centuries.

4. Physical Characteristics
● Physical characteristics of hemophilia may include bruises (from internal
bleeding), heavy bleeding from a minor cut, nosebleeds, swelling in joints,
etc.

5. Mental Characteristics
● Mental characteristics of Hemophilia include confusion, loss of balance,
and loss of coordination

6. Emotional Characteristics
● According to a study, children with Hemophilia found more difficulties with
emotional well-being, including more depressive symptomatology and
lower self-perceptions.
● According to the parents who has children with Hemophilia, they didn’t
found any social or behavioral difficulties.

7. Genetic Source/Cause
A defect in a gene that determines whether or not the blood can clot can cause
Hemophilia. The gene is located on an X chromosome. If a male has this gene
on his X chromosome, it means he has Hemophilia. If a female has it on one of
her two X chromosomes, it means she has Hemophilia and can pass the
genetic defect onto her offspring.

8. Treatment
The most common treatment for Hemophilia is the Replacement Therapy.
Using the Replacement Therapy, clotting factors can be concentrated from
donor’s blood, or the clotting factor concentrates can be created in a laboratory
without having to use donor’s blood. After the missing factor, or clotting factor,
has been taken from the donor’s blood or made in a lab, it is injected into the
affected person’s bloodstream, and the clotting factor is replaced inside the
body, and the amount that person bleeds is now normal.

9. Interesting Facts
● Over 400,000 people worldwide have hemophilia.
● The disease occurs in 1 in 5,000 male births.
● Queen Victoria of England carried Hemophilia and passed it down to her
son and some of her daughters.
● Although it is not entirely proven, lots of people believe that Abraham
Lincoln, Genghis Khan, and Mother Teresa all had Hemophilia.
● Until the 1960s, the life expectancy of someone with the disease was only
11 years.

10. References
www.google.com
www.nhlbi.nih.gov
www.hemophiliafed.org
www.hemophilia.org
missingfactor.weebly.com
www.cdc.gov
http://www.medicalnewstoday.com/content/info/hemophilia/symptoms-and-
diagnosis.php
http://journals.lww.com/jrnldbp/Abstract/2003/08000/Social,_Emotional,
_and_Behavioral_Functioning_of.2.aspx