2. a group of hereditary genetic disorders that impair
the body's ability to control blood clotting
or coagulation
Most common to males
Hemophilia has featured prominently in European
royalty and thus is sometimes known as 'the royal
disease'.
3. The first medical professional to describe a
disease was Abulcasis during the 10th century.
The term "haemophilia" is derived from the term
"haemorrhaphilia" which was used in a description
of the condition written by Friedrich Hopff in 1828,
while he was a student at the University of Zurich.
4. Genetic mutation:
- genes that code for proteins that
are essential in the blood clotting
process
The protein involved with
hemophilia A is factor VIII (factor
8)
hemophilia B is factor IX (factor
9).
5.
6. known family history of the condition
series of blood tests
platelet (a blood particle essential for the clotting
process)
the prothrombin time (PT) and activated partial
thromboplastin time (aPTT)
7. Mild hemophilia
bleed excessively
in response to
injury or trauma
Severe hemophilia
Heavy bleeding
can occur
anywhere in the
body.
8. Hemarthrosis
Bleeding into the muscles
Bleeding from the mouth or nosebleeds
Bleeding from the gastrointestinal tract
Bleeding from the urinary tract
Intracranial hemorrhage
Increased bleeding after surgery or trauma
9. Replacement of the blood clotting factors.
- purified from human donor blood or made in the
laboratory using methods that do not use donor
blood
- infusing the clotting factor concentrates into a vein
Drug desmopressin
Acetaminophen (Tylenol and others)
10. Hemophilia is rare, with only about 1 instance in
every 10,000 births (or 1 in 5,000 male births) for
hemophilia A and 1 in 50,000 births for hemophilia
B. About 18,000 people in the United States have
hemophilia. Each year in the US, about 400
babies are born with the disorder. It is estimated
that about 2500 Canadians have hemophilia A,
and about 500 Canadians have hemophilia B.
