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Student Work Hemophilia


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Student Work Hemophilia

  1. 1. HEMOPHILIA By Lammi Adem, Jasmine Warfield, Gerardo Ceballos, Doan Doan.
  2. 2. OVERVIEW
  3. 3. DEFINITIONS OF RELEVANT TERMS <ul><li>Genetic disease- A genetic disease is a disease that is caused by a change in your DNA. </li></ul><ul><li>Clotting Factor- Clotting Factor is the part of the blood that prevent the blood from continuing to flow. </li></ul><ul><li>Chromosomes-Chromosomes are the DNA that have been paired off. </li></ul><ul><li>Gene- A gene is a piece of the DNA that determines a particular trait. </li></ul>
  4. 4. WHAT IS HEMOPHILIA <ul><li>Hemophilia is a genetic disease that causes non-stop bleeding. This is because there is no clotting in the blood. </li></ul><ul><li>It is generally passed from mother to son, except in rare cases. </li></ul><ul><li>The bleeding from Hemophilia can be internal and cause bruising under the skin. </li></ul><ul><li>Most treatments for Hemophilia are to add clotting factor to the person’s blood. </li></ul>
  5. 5. HISTORY <ul><li>Hemophilia wasn’t generally known because the people affected usually died before much was known about it. </li></ul><ul><li>The most famous case of hemophilia, is that of Alexei Nikolaevich, Tsarevich of Russia. Alexei’s disease was kept hidden from the public because it would upset the public to have a Czar that couldn’t lead. </li></ul>
  7. 7. THINGS TO KNOW <ul><li>Hemophilia is not contagious like a cold or flu </li></ul><ul><li>It is usually inherited, which means that it often runs in families. Hemophilia almost exclusively affects boys. </li></ul><ul><li>Hemophilia A and Hemophilia B are caused by and inherited defect in a pair of chromosomes. </li></ul><ul><li>The defects affect how much the clotting factor a person will produce and hoe the factor will function </li></ul><ul><li>It is caused by a defective gene that is unintentionally passed from mothers to sons via the X chromosome </li></ul><ul><li>Some males with the disorder are born to mothers who aren’t carriers. In these cases, a mutation (random change) occurs in the gene as it is passed to the child </li></ul>
  8. 8. <ul><li>If you have inherited hemophilia, you’re born with the condition. It is caused by a defect in one of the genes that determine how the body makes blood clotting factors VIII or IX. These genes are located on the X chromosomes </li></ul><ul><li>Chromosomes come in pairs. </li></ul><ul><li>Females have two X chromosomes </li></ul><ul><li>Males have one X and one Y chromosome. </li></ul><ul><li>Only the X chromosome carries the genes related to clotting factors. </li></ul><ul><li>A male who has the abnormal gene on his X chromosome will have hemophilia. </li></ul><ul><li>A female must have the abnormal gene on both of her X chromosomes to have hemophilia THIS IS VERY RARE! </li></ul><ul><li>A female is a “carrier” of hemophilia if she has the abnormal gene on one of her X chromosomes. </li></ul><ul><li>Even though you can’t tell if she has the hemophilia gene she is still carrying it in her X chromosome and can pass it on to her child. </li></ul>
  10. 11. THE FIRST SIGNS <ul><li>First discovered during infancy or early childhood </li></ul><ul><ul><li>Bleeding into muscle </li></ul></ul><ul><ul><li>Deep bruises after receiving shots </li></ul></ul><ul><ul><li>Prolonged bleeding after male child is circumcised </li></ul></ul><ul><ul><li>Prolonged bleeding after umbilical cord is cut </li></ul></ul>
  12. 13. HEMARTHROSIS <ul><li>Symptoms of bleeding into joints includes: </li></ul><ul><ul><li>Warmth/tingling feeling in joints, known as aura </li></ul></ul><ul><ul><li>Swelling/inflammation in joints, caused by repeated episodes of bleeding </li></ul></ul><ul><ul><li>Child/ Infants are reluctant to move arm or legs due to pain </li></ul></ul>
  13. 14. BLEEDING INTO MUSCLES <ul><li>Symptoms: </li></ul><ul><ul><li>Bruising </li></ul></ul><ul><ul><li>Swelling </li></ul></ul><ul><ul><li>Muscle hardening </li></ul></ul><ul><ul><li>Tenderness </li></ul></ul><ul><ul><li>Pain </li></ul></ul><ul><ul><ul><li>Especially when large muscle groups are affected </li></ul></ul></ul>
  14. 15. COMPARTMENT SYNDROME <ul><li>Complication of bleeding to in certain muscles which puts pressure on arteries and nerves </li></ul><ul><li>Symptoms: </li></ul><ul><ul><li>Weakness and paleness in affected extremity </li></ul></ul><ul><ul><li>Swelling and numbness </li></ul></ul><ul><ul><li>Severe pain during movement </li></ul></ul><ul><ul><li>Inability to move an extremity </li></ul></ul><ul><ul><ul><li>PARALYSIS </li></ul></ul></ul>
  16. 17. TREATMENT OVERVIEW <ul><li>Genetic </li></ul><ul><li>- Only women can be carriers </li></ul><ul><li>- Can be determined by a blood test </li></ul><ul><li>Treatment starts at birth </li></ul><ul><li>Donated blood products can be injected aiding the replacement of absent or abnormal clotting factors </li></ul><ul><li>*Clotting Factors- prevent major blood loss and keep bodily complications from bleeding </li></ul>
  17. 18. Hemophilia Care <ul><li>Children with Hemophilia can learn to self-administer their replacement clotting factors as young as 10 years old. </li></ul>
  18. 19. When do I treat my Hemophilia? <ul><li>Clotting Factors are replaced: </li></ul><ul><li>-Everyday at the same time to regulate with bodily functions (severe cases only) </li></ul><ul><li>-On demand when bleeding occurs </li></ul><ul><li>-Prior to an event in which bleeding is possible </li></ul>
  19. 20. CURRENT RESEARCH <ul><li>The FDA, Food and Drug Association, has approved a new drug that would help people with Hemophilia. The usual treatment, is to give the person clotting factor. </li></ul><ul><li>This new formula for the clotting factor would allow the drug to be kept at room temperature. This makes it easier for small hospitals to keep the clotting drugs because of their lack of freezers. </li></ul><ul><li>But there is a negative factor towards it. The clotting factor can only be kept for two years instead of three. </li></ul>
  20. 21. LONG TERM & SHORT TERM EFFECTS <ul><li>The people have to take medicine for the rest of their lives. </li></ul><ul><li>Have to be very careful about injuries. </li></ul><ul><li>Have to learn to recognize all of the symptoms of their disease. </li></ul><ul><li>Long Term </li></ul><ul><li>Short Term </li></ul>
  21. 22. SOURCES <ul><li> </li></ul><ul><li> </li></ul><ul><li> </li></ul><ul><li> - - 41k </li></ul><ul><li> </li></ul><ul><li> gi=11hpalbeo&sigb=12s62drra&tt=11934 </li></ul><ul><li> </li></ul><ul><li> </li></ul><ul><li> </li></ul>