B.Sc. Third Year Syllabus

1. Dose Response Relationship
Dr. Asmita Daspute .
Assistant Professor,
Dept. of Environmental Science,
Sbes College Of Science Aurangabad.(Ms)

3. Dose
 Dose: Amount of chemical administered usually express per unit Body
weight.
 If the dose is administered into the stomach or applied on the skin or into
respiratory tract,
 Transport across the membranes may be incomplete and the absorbed
dose will not the be identical with the dose adminisered
 Estimation of Dose can be made from
 Measurement of environmental and Food concentration
 Food intake
 Inhalation rate
 Appropriate deposition and retention factors

4. Dose
 The Dose in the organ and Tissues of interest may be estimated-
 Administered Dose or Intake
 Measurement of the concentration in tissues and organ samples
 Measurement of the concentration in excreta or exhaled air.

5. Responce
 Response and effect are often used interchangeably to denote the biological change either
in individual or in a population.
 Effect – is biological change
 Response – proportion of a population that demonstrates a defined effect. Or
 Incidence rate of effect .
 e,.g.- LD50 value may be described as the dose expected to cause a 50% response in a
population tested for lethal effect of a chemical

7. Response to chemicals
 Concentration at the site of respective tissue
 Rate of absorption
 Distribution
 Excretion and
 Detoxification of a chemicals
 Tolerance and hypersensitivity to a chemical
 Genetic factors
 State of health